메뉴 건너뛰기




Volumn 42, Issue 11, 2012, Pages 2937-2948

Enhancement of plasmid DNA immunogenicity with linear polyethylenimine

Author keywords

Adjuvants; DNA; PEI; Polymers; Vaccines

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; EPITOPE; PLASMID DNA; POLYETHYLENEIMINE;

EID: 84868110235     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242410     Document Type: Article
Times cited : (34)

References (50)
  • 2
    • 33645871300 scopus 로고    scopus 로고
    • Human clinical trials of plasmid DNA vaccines
    • Liu, M. A. and Ulmer, J. B., Human clinical trials of plasmid DNA vaccines. Adv. Genet. 2005. 55: 25-40.
    • (2005) Adv. Genet. , vol.55 , pp. 25-40
    • Liu, M.A.1    Ulmer, J.B.2
  • 3
    • 22844432496 scopus 로고    scopus 로고
    • Overview of recent DNA vaccine development for fish
    • Kurath, G., Overview of recent DNA vaccine development for fish. Dev. Biol. (Basel). 2005. 121: 201-213.
    • (2005) Dev. Biol. (Basel). , vol.121 , pp. 201-213
    • Kurath, G.1
  • 4
    • 0037389779 scopus 로고    scopus 로고
    • Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial
    • Bergman, P. J., McKnight, J., Novosad, A., Charney, S., Farrelly, J., Craft, D., Wulderk, M. et al., Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial. Clin. Cancer Res. 2003. 9: 1284-1290.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1284-1290
    • Bergman, P.J.1    McKnight, J.2    Novosad, A.3    Charney, S.4    Farrelly, J.5    Craft, D.6    Wulderk, M.7
  • 6
    • 0038703642 scopus 로고    scopus 로고
    • Expression and immunogenicity of sequence-modified human immunodeficiency virus type 1 subtype B pol and gagpol DNA vaccines
    • Zur Megede, J., Otten, G. R., Doe, B., Liu, H., Leung, L., Ulmer, J. B., Donnelly, J. J. et al., Expression and immunogenicity of sequence-modified human immunodeficiency virus type 1 subtype B pol and gagpol DNA vaccines. J. Virol. 2003. 77: 6197-6207.
    • (2003) J. Virol. , vol.77 , pp. 6197-6207
    • Zur Megede, J.1    Otten, G.R.2    Doe, B.3    Liu, H.4    Leung, L.5    Ulmer, J.B.6    Donnelly, J.J.7
  • 7
    • 33646840487 scopus 로고    scopus 로고
    • Relative contributions of codon usage, promoter efficiency and leader sequence to the antigen expression and immunogenicity of HIV-1 Env DNA vaccine
    • Wang, S., Farfan-Arribas, D. J., Shen, S., Chou, T. H., Hirsch, A., He, F. and Lu, S., Relative contributions of codon usage, promoter efficiency and leader sequence to the antigen expression and immunogenicity of HIV-1 Env DNA vaccine. Vaccine 2006. 24: 4531-4540.
    • (2006) Vaccine , vol.24 , pp. 4531-4540
    • Wang, S.1    Farfan-Arribas, D.J.2    Shen, S.3    Chou, T.H.4    Hirsch, A.5    He, F.6    Lu, S.7
  • 8
    • 0030855188 scopus 로고    scopus 로고
    • Development of improved vectors for DNA-based immunization and other gene therapy applications
    • Norman, J. A., Hobart, P., Manthorpe, M., Felgner, P. and Wheeler, C., Development of improved vectors for DNA-based immunization and other gene therapy applications. Vaccine 1997. 15: 801-803.
    • (1997) Vaccine , vol.15 , pp. 801-803
    • Norman, J.A.1    Hobart, P.2    Manthorpe, M.3    Felgner, P.4    Wheeler, C.5
  • 10
    • 19944432919 scopus 로고    scopus 로고
    • Induction of gp120-specific protective immune responses by genetic vaccination with linear polyethylenimine-plasmid complex
    • Garzon, M. R., Berraondo, P., Crettaz, J., Ochoa, L., Vera, M., Lasarte, J. J., Vales, A. et al., Induction of gp120-specific protective immune responses by genetic vaccination with linear polyethylenimine-plasmid complex. Vaccine 2005. 23: 1384-1392.
    • (2005) Vaccine , vol.23 , pp. 1384-1392
    • Garzon, M.R.1    Berraondo, P.2    Crettaz, J.3    Ochoa, L.4    Vera, M.5    Lasarte, J.J.6    Vales, A.7
  • 11
    • 0037471402 scopus 로고    scopus 로고
    • Nasal delivery of chitosan-DNA plasmid expressing epitopes of respiratory syncytial virus (RSV) induces protective CTL responses in BALB/c mice
    • Iqbal, M., Lin, W., Jabbal-Gill, I., Davis, S. S., Steward, M. W. and Illum, L., Nasal delivery of chitosan-DNA plasmid expressing epitopes of respiratory syncytial virus (RSV) induces protective CTL responses in BALB/c mice. Vaccine 2003. 21: 1478-1485.
    • (2003) Vaccine , vol.21 , pp. 1478-1485
    • Iqbal, M.1    Lin, W.2    Jabbal-Gill, I.3    Davis, S.S.4    Steward, M.W.5    Illum, L.6
  • 12
    • 0142199964 scopus 로고    scopus 로고
    • Hepatitis B DNA vaccine induces protective antibody responses in human non-responders to conventional vaccination
    • Rottinghaus, S. T., Poland, G. A., Jacobson, R. M., Barr, L. J. and Roy, M. J., Hepatitis B DNA vaccine induces protective antibody responses in human non-responders to conventional vaccination. Vaccine 2003. 21: 4604-4608.
    • (2003) Vaccine , vol.21 , pp. 4604-4608
    • Rottinghaus, S.T.1    Poland, G.A.2    Jacobson, R.M.3    Barr, L.J.4    Roy, M.J.5
  • 13
    • 15244352727 scopus 로고    scopus 로고
    • Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines
    • Sumida, S. M., McKay, P. F., Truitt, D. M., Kishko, M. G., Arthur, J. C., Seaman, M. S., Jackson, S. S. et al., Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines. J. Clin. Invest. 2004. 114: 1334-1342.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1334-1342
    • Sumida, S.M.1    McKay, P.F.2    Truitt, D.M.3    Kishko, M.G.4    Arthur, J.C.5    Seaman, M.S.6    Jackson, S.S.7
  • 14
    • 12344320234 scopus 로고    scopus 로고
    • TLR9 pathway is involved in adjuvant effects of plasmid DNA-based vaccines
    • Tudor, D., Dubuquoy, C., Gaboriau, V., Lefevre, F., Charley, B. and Riffault, S., TLR9 pathway is involved in adjuvant effects of plasmid DNA-based vaccines. Vaccine 2005. 23: 1258-1264.
    • (2005) Vaccine , vol.23 , pp. 1258-1264
    • Tudor, D.1    Dubuquoy, C.2    Gaboriau, V.3    Lefevre, F.4    Charley, B.5    Riffault, S.6
  • 15
    • 0041707861 scopus 로고    scopus 로고
    • Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines
    • Barouch, D. H., McKay, P. F., Sumida, S. M., Santra, S., Jackson, S. S., Gorgone, D. A., Lifton, M. A. et al., Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines. J. Virol. 2003. 77: 8729-8735.
    • (2003) J. Virol. , vol.77 , pp. 8729-8735
    • Barouch, D.H.1    McKay, P.F.2    Sumida, S.M.3    Santra, S.4    Jackson, S.S.5    Gorgone, D.A.6    Lifton, M.A.7
  • 16
    • 27844495150 scopus 로고    scopus 로고
    • Current developments in gene transfection agents
    • Azzam, T. and Domb, A. J., Current developments in gene transfection agents. Curr. Drug Deliv. 2004. 1: 165-193.
    • (2004) Curr. Drug Deliv. , vol.1 , pp. 165-193
    • Azzam, T.1    Domb, A.J.2
  • 18
    • 33645891183 scopus 로고    scopus 로고
    • Polyethylenimine (PEI)
    • Demeneix, B. and Behr, J. P., Polyethylenimine (PEI). Adv. Genet. 2005. 53: 217-230.
    • (2005) Adv. Genet. , vol.53 , pp. 217-230
    • Demeneix, B.1    Behr, J.P.2
  • 19
    • 0035286969 scopus 로고    scopus 로고
    • Polyethylenimine-mediated gene delivery: a mechanistic study
    • Kichler, A., Leborgne, C., Coeytaux, E. and Danos, O., Polyethylenimine-mediated gene delivery: a mechanistic study. J. Gene. Med. 2001. 3: 135-144.
    • (2001) J. Gene. Med. , vol.3 , pp. 135-144
    • Kichler, A.1    Leborgne, C.2    Coeytaux, E.3    Danos, O.4
  • 20
    • 0036157772 scopus 로고    scopus 로고
    • Overcoming the nuclear barrier: cell cycle independent nonviral gene transfer with linear polyethylenimine or electroporation
    • Brunner, S., Furtbauer, E., Sauer, T., Kursa, M. and Wagner, E., Overcoming the nuclear barrier: cell cycle independent nonviral gene transfer with linear polyethylenimine or electroporation. Mol. Ther. 2002. 5: 80-86.
    • (2002) Mol. Ther. , vol.5 , pp. 80-86
    • Brunner, S.1    Furtbauer, E.2    Sauer, T.3    Kursa, M.4    Wagner, E.5
  • 21
    • 77952240642 scopus 로고    scopus 로고
    • Delivery of DNA-based cancer vaccine with polyethylenimine
    • Ma, Y. F. and Yang, Y. W., Delivery of DNA-based cancer vaccine with polyethylenimine. Eur. J. Pharm. Sci. 2010. 40: 75-83.
    • (2010) Eur. J. Pharm. Sci. , vol.40 , pp. 75-83
    • Ma, Y.F.1    Yang, Y.W.2
  • 22
    • 68849112640 scopus 로고    scopus 로고
    • Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity
    • Cubillos-Ruiz, J. R., Engle, X., Scarlett, U. K., Martinez, D., Barber, A., Elgueta, R., Wang, L. et al., Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J. Clin. Invest. 2009. 119: 2231-2244.
    • (2009) J. Clin. Invest. , vol.119 , pp. 2231-2244
    • Cubillos-Ruiz, J.R.1    Engle, X.2    Scarlett, U.K.3    Martinez, D.4    Barber, A.5    Elgueta, R.6    Wang, L.7
  • 23
    • 78650672166 scopus 로고    scopus 로고
    • Intranasal immunization with plasmid DNA encoding spike protein of SARS-coronavirus/polyethylenimine nanoparticles elicits antigen-specific humoral and cellular immune responses
    • Shim, B. S., Park, S. M., Quan, J. S., Jere, D., Chu, H., Song, M. K., Kim, D. W. et al., Intranasal immunization with plasmid DNA encoding spike protein of SARS-coronavirus/polyethylenimine nanoparticles elicits antigen-specific humoral and cellular immune responses. BMC Immunol. 2010. 11: 65.
    • (2010) BMC Immunol. , vol.11 , pp. 65
    • Shim, B.S.1    Park, S.M.2    Quan, J.S.3    Jere, D.4    Chu, H.5    Song, M.K.6    Kim, D.W.7
  • 24
    • 77951992275 scopus 로고    scopus 로고
    • Efficient generation of mucosal and systemic antigen-specific CD8+ T-cell responses following pulmonary DNA immunization
    • Bivas-Benita, M., Bar, L., Gillard, G. O., Kaufman, D. R., Simmons, N. L., Hovav, A. H. and Letvin, N. L., Efficient generation of mucosal and systemic antigen-specific CD8+ T-cell responses following pulmonary DNA immunization. J. Virol. 2010. 84: 5764-5774.
    • (2010) J. Virol. , vol.84 , pp. 5764-5774
    • Bivas-Benita, M.1    Bar, L.2    Gillard, G.O.3    Kaufman, D.R.4    Simmons, N.L.5    Hovav, A.H.6    Letvin, N.L.7
  • 26
    • 17644418754 scopus 로고    scopus 로고
    • Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung
    • Thomas, M., Lu, J. J., Ge, Q., Zhang, C., Chen, J. and Klibanov, A. M., Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. Proc. Natl. Acad. Sci. USA 2005. 102: 5679-5684.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5679-5684
    • Thomas, M.1    Lu, J.J.2    Ge, Q.3    Zhang, C.4    Chen, J.5    Klibanov, A.M.6
  • 29
    • 0028015936 scopus 로고
    • Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T-cell responses on Listeria monocytogenes infection
    • Ladel, C. H., Flesch, I. E., Arnoldi, J. and Kaufmann, S. H., Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T-cell responses on Listeria monocytogenes infection. J. Immunol. 1994. 153: 3116-3122.
    • (1994) J. Immunol. , vol.153 , pp. 3116-3122
    • Ladel, C.H.1    Flesch, I.E.2    Arnoldi, J.3    Kaufmann, S.H.4
  • 30
    • 0032982624 scopus 로고    scopus 로고
    • Synergistic effect of formulated plasmid and needle-free injection for genetic vaccines
    • Anwer, K., Earle, K. A., Shi, M., Wang, J., Mumper, R. J., Proctor, B., Jansa, K. et al., Synergistic effect of formulated plasmid and needle-free injection for genetic vaccines. Pharm. Res. 1999. 16: 889-895.
    • (1999) Pharm. Res. , vol.16 , pp. 889-895
    • Anwer, K.1    Earle, K.A.2    Shi, M.3    Wang, J.4    Mumper, R.J.5    Proctor, B.6    Jansa, K.7
  • 31
    • 0032977833 scopus 로고    scopus 로고
    • Induction of immunity to antigens expressed by recombinant adeno-associated virus depends on the route of administration
    • Brockstedt, D. G., Podsakoff, G. M., Fong, L., Kurtzman, G., Mueller-Ruchholtz, W. and Engleman, E. G., Induction of immunity to antigens expressed by recombinant adeno-associated virus depends on the route of administration. Clin. Immunol. 1999. 92: 67-75.
    • (1999) Clin. Immunol. , vol.92 , pp. 67-75
    • Brockstedt, D.G.1    Podsakoff, G.M.2    Fong, L.3    Kurtzman, G.4    Mueller-Ruchholtz, W.5    Engleman, E.G.6
  • 32
  • 35
    • 18944376588 scopus 로고    scopus 로고
    • Activation of dendritic cells by microparticles containing Bacillus anthracis protective antigen
    • Westwood, A., Healey, G. D., Williamson, E. D. and Eyles, J. E., Activation of dendritic cells by microparticles containing Bacillus anthracis protective antigen. Vaccine 2005. 23: 3857-3863.
    • (2005) Vaccine , vol.23 , pp. 3857-3863
    • Westwood, A.1    Healey, G.D.2    Williamson, E.D.3    Eyles, J.E.4
  • 36
    • 39249084875 scopus 로고    scopus 로고
    • Nanoparticles built by self-assembly of amphiphilic gamma-PGA can deliver antigens to antigen-presenting cells with high efficiency: a new tumor-vaccine carrier for eliciting effector T cells
    • Yoshikawa, T., Okada, N., Oda, A., Matsuo, K., Kayamuro, H., Ishii, Y., Yoshinaga, T. et al., Nanoparticles built by self-assembly of amphiphilic gamma-PGA can deliver antigens to antigen-presenting cells with high efficiency: a new tumor-vaccine carrier for eliciting effector T cells. Vaccine 2008. 26: 1303-1313.
    • (2008) Vaccine , vol.26 , pp. 1303-1313
    • Yoshikawa, T.1    Okada, N.2    Oda, A.3    Matsuo, K.4    Kayamuro, H.5    Ishii, Y.6    Yoshinaga, T.7
  • 37
    • 0036371914 scopus 로고    scopus 로고
    • Side-effects of a systemic injection of linear polyethylenimine-DNA complexes
    • Chollet, P., Favrot, M. C., Hurbin, A. and Coll, J. L., Side-effects of a systemic injection of linear polyethylenimine-DNA complexes. J. Gene. Med. 2002. 4: 84-91.
    • (2002) J. Gene. Med. , vol.4 , pp. 84-91
    • Chollet, P.1    Favrot, M.C.2    Hurbin, A.3    Coll, J.L.4
  • 40
    • 77749254882 scopus 로고    scopus 로고
    • Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8+ T cells
    • Nchinda, G., Amadu, D., Trumpfheller, C., Mizenina, O., Uberla, K. and Steinman, R. M., Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8+ T cells. Proc. Natl. Acad. Sci. USA 2010. 107: 4281-4286.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 4281-4286
    • Nchinda, G.1    Amadu, D.2    Trumpfheller, C.3    Mizenina, O.4    Uberla, K.5    Steinman, R.M.6
  • 41
    • 80051921852 scopus 로고    scopus 로고
    • Lentivector prime and vaccinia virus vector boost generate high-quality CD8 memory T cells and prevent autochthonous mouse melanoma
    • Xiao, H., Peng, Y., Hong, Y., Liu, Y., Guo, Z. S., Bartlett, D. L., Fu, N. and He, Y., Lentivector prime and vaccinia virus vector boost generate high-quality CD8 memory T cells and prevent autochthonous mouse melanoma. J. Immunol. 2011. 187: 1788-1796.
    • (2011) J. Immunol. , vol.187 , pp. 1788-1796
    • Xiao, H.1    Peng, Y.2    Hong, Y.3    Liu, Y.4    Guo, Z.S.5    Bartlett, D.L.6    Fu, N.7    He, Y.8
  • 42
    • 17144454609 scopus 로고    scopus 로고
    • Protective CD4+ and CD8+ T cells against influenza virus induced by vaccination with nucleoprotein DNA
    • Ulmer, J. B., Fu, T. M., Deck, R. R., Friedman, A., Guan, L., DeWitt, C., Liu, X. et al., Protective CD4+ and CD8+ T cells against influenza virus induced by vaccination with nucleoprotein DNA. J. Virol. 1998. 72: 5648-5653.
    • (1998) J. Virol. , vol.72 , pp. 5648-5653
    • Ulmer, J.B.1    Fu, T.M.2    Deck, R.R.3    Friedman, A.4    Guan, L.5    DeWitt, C.6    Liu, X.7
  • 43
    • 0031135321 scopus 로고    scopus 로고
    • HIV-1 env DNA vaccine administered to rhesus monkeys elicits MHC class II-restricted CD4+ T helper cells that secrete IFN-gamma and TNF-alpha
    • Lekutis, C., Shiver, J. W., Liu, M. A. and Letvin, N. L., HIV-1 env DNA vaccine administered to rhesus monkeys elicits MHC class II-restricted CD4+ T helper cells that secrete IFN-gamma and TNF-alpha. J. Immunol. 1997. 158: 4471-4477.
    • (1997) J. Immunol. , vol.158 , pp. 4471-4477
    • Lekutis, C.1    Shiver, J.W.2    Liu, M.A.3    Letvin, N.L.4
  • 44
    • 0038004448 scopus 로고    scopus 로고
    • A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity
    • Fischer, D., Bieber, T., Li, Y., Elsasser, H. P. and Kissel, T., A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm. Res. 1999. 16: 1273-1279.
    • (1999) Pharm. Res. , vol.16 , pp. 1273-1279
    • Fischer, D.1    Bieber, T.2    Li, Y.3    Elsasser, H.P.4    Kissel, T.5
  • 45
    • 0035408714 scopus 로고    scopus 로고
    • Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo
    • Wightman, L., Kircheis, R., Rossler, V., Carotta, S., Ruzicka, R., Kursa, M. and Wagner, E., Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo. J. Gene. Med. 2001. 3: 362-372.
    • (2001) J. Gene. Med. , vol.3 , pp. 362-372
    • Wightman, L.1    Kircheis, R.2    Rossler, V.3    Carotta, S.4    Ruzicka, R.5    Kursa, M.6    Wagner, E.7
  • 46
    • 20144388888 scopus 로고    scopus 로고
    • Regulatory sequences of H19 and IGF2 genes in DNA-based therapy of colorectal rat liver metastases
    • Ohana, P., Schachter, P., Ayesh, B., Mizrahi, A., Birman, T., Schneider, T., Matouk, I. et al., Regulatory sequences of H19 and IGF2 genes in DNA-based therapy of colorectal rat liver metastases. J. Gene. Med. 2005. 7: 366-374.
    • (2005) J. Gene. Med. , vol.7 , pp. 366-374
    • Ohana, P.1    Schachter, P.2    Ayesh, B.3    Mizrahi, A.4    Birman, T.5    Schneider, T.6    Matouk, I.7
  • 47
    • 55549102623 scopus 로고    scopus 로고
    • Phase I/II marker lesion study of intravesical BC-819 DNA plasmid in H19 over expressing superficial bladder cancer refractory to bacillus Calmette-Guerin
    • Sidi, A. A., Ohana, P., Benjamin, S., Shalev, M., Ransom, J. H., Lamm, D., Hochberg, A. and Leibovitch, I., Phase I/II marker lesion study of intravesical BC-819 DNA plasmid in H19 over expressing superficial bladder cancer refractory to bacillus Calmette-Guerin. J. Urol. 2008. 180: 2379-2383.
    • (2008) J. Urol. , vol.180 , pp. 2379-2383
    • Sidi, A.A.1    Ohana, P.2    Benjamin, S.3    Shalev, M.4    Ransom, J.H.5    Lamm, D.6    Hochberg, A.7    Leibovitch, I.8
  • 48
    • 84876200815 scopus 로고    scopus 로고
    • NCI, Cancer Drug Information - Trastuzumab
    • NCI, Cancer Drug Information - Trastuzumab 2012 http://www.cancer.gov/cancertopics/druginfo/trastuzumab.
    • (2012)
  • 49
    • 84876200395 scopus 로고    scopus 로고
    • NCI, Cancer Drug Information - Rituximab
    • NCI, Cancer Drug Information - Rituximab 2012 http://www.cancer.gov/cancertopics/druginfo/rituximab.
    • (2012)
  • 50
    • 0037069319 scopus 로고    scopus 로고
    • Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells
    • Thomas, M. and Klibanov, A. M., Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells. Proc. Natl. Acad. Sci. USA 2002. 99: 14640-14645.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14640-14645
    • Thomas, M.1    Klibanov, A.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.