Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age

Blood

Volumn 120, Issue 16, 2012, Pages 3229-3236

  Kenyon, Jonathan ^a   Fu, Pingfu ^b   Lingas, Karen ^a   Thomas, Emily ^a   Saurastri, Anshul ^a   Guasch, Gabriela Santos ^a   Wald, David ^b   Gerson, Stanton L ^a,b  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; PROTEIN MLH1; PROTEIN MSH2;

AGING; ARTICLE; CD34 SELECTION; COLONY FORMING CELL; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENETIC VARIABILITY; GENOMIC INSTABILITY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROSATELLITE INSTABILITY; MLH1 GENE; MSH2 GENE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION;

EID: 84868104092     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-12-401950     Document Type: Article

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