Improvement of multiple stress tolerance in yeast strain by sequential mutagenesis for enhanced bioethanol production

Journal of Bioscience and Bioengineering

Volumn 114, Issue 6, 2012, Pages 622-629

  Kumari, Rajni ^a   Pramanik, Krishna ^a  

^a NATIONAL INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Ethanol fermentation; Fermentation inhibitors; Mutagenesis; Mutants; Stress tolerance

Indexed keywords

BIO-ETHANOL PRODUCTION; COMBINED EFFECT; ETHANOL CONCENTRATIONS; ETHANOL FERMENTATION; ETHANOL YIELD; ETHYL METHANE SULFONATES; HIGH TEMPERATURE; MOLECULAR CHARACTERIZATION; MULTIPLE STRESS; MUTANTS; STRESS TOLERANCE; SYNERGISTIC EFFECT; YEAST STRAIN;

ACETIC ACID; ALDEHYDES; ETHANOL; FERMENTATION; FURFURAL; GLUCOSE; METHANE; MUTAGENESIS; PH; PRODUCTIVITY; ULTRAVIOLET RADIATION; YEAST;

YIELD STRESS;

ACETIC ACID; ALCOHOL; FURFURAL; GLUCOSE; MESYLIC ACID ETHYL ESTER; METHYLNITRONITROSOGUANIDINE; SUGAR; VANILLIN; XYLOSE;

ALCOHOL PRODUCTION; ALCOHOL TOLERANCE; ARTICLE; CELL VIABILITY; FUNGAL STRAIN; HEAT TOLERANCE; HYBRID; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTOPLAST; STRESS; TEMPERATURE STRESS; ULTRAVIOLET RADIATION; YEAST;

ACETIC ACID; BIOREACTORS; ETHANOL; FERMENTATION; FURALDEHYDE; GLUCOSE; HOT TEMPERATURE; METHYLNITRONITROSOGUANIDINE; MUTAGENESIS; MUTAGENS; SACCHAROMYCES CEREVISIAE; STRESS, PHYSIOLOGICAL; ULTRAVIOLET RAYS; XYLOSE;

EID: 84868103108     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2012.07.007     Document Type: Article

References (37)

1. Ho N.W.Y., Chen Z., Brainard A.P. Genetically engineered Saccharomyces yeast capable of effective co-fermentation of glucose and xylose. Appl. Environ. Microbiol. 1998, 64:1852-1859.
2. +-dependent xylitol dehydrogenase, and xylulokinase. J. Biosci. Bioeng. 2008, 105:296-299.
3. Aldiguier A.S., Alfenore S., Cameleyre X., Goma G., Uribelarrea J.L., Guillouet S.E., Molina-Jouve C. Synergistic temperature and ethanol effect on Saccharomyces cerevisiae dynamic behaviour in ethanol bio-fuel production. Bioprocess Biosyst. Eng. 2004, 26:217-222.
4. Sajbidor J. Effect of some environmental factors on the content and composition of microbial membrane lipids. Crit. Rev. Biotechnol. 1997, 17:87-103.
5. Cot M., Loret M.O., Francois J., Benbadis L. Physiological behaviour of Saccharomyces cerevisiae in aerated fed-batch fermentation for high level production of bioethanol. FEMS Yeast Res. 2007, 7:22-32.
6. Sridhar M., KiranSree N., Rao L.V. Effect of UV radiation on thermotolerance, ethanol tolerance and osmotolerance of Saccharomyces cerevisiae VS1 and VS3 strains. Bioresour. Technol. 2002, 83:199-202.
7. Almeida J.R.M., Modig T., Petersson A., Hahn-Hagerdal B., Liden G., Gorwa-Grauslund M.F. Increased tolerance and conversion of inhibitors in lignocellulosic hydrolysates by Saccharomyces cerevisiae. J. Chem. Technol. Biotechnol. 2007, 82:340-349.
8. Russell J.B. Another explanation for the toxicity of fermentation acids at low pH: anion accumulation versus uncoupling. J. Appl. Bacteriol. 1992, 73:363-370.
9. Sasano Y., Watanabe D., Ukibe K., Inai T., Ohtsu I., Shimoi H., Takagi H. Overexpression of the yeast transcription activator Msn2 confers furfural resistance and increases the initial fermentation rate in ethanol production. J. Biosci. Bioeng. 2012, 113:451-455.
10. Isono N., Hayakawa H., Usami A., Mishima M., Hisamatsu M. A comparative study of ethanol production by Issatchenkia orientalis strains under stress condition. J. Biosci. Bioeng. 2012, 113:76-78.
11. Liu, Z. L. (Ed.): Microbial stress tolerance for biofuels. Steinbüchel, A. (Ed.), Microbiology monographs, vol. 22. Springer-Verlag, Berlin, Heidelberg (2012).
12. Watanabe T., Watanabe I., Yamamoto M., Ando A., Nakamura T. A UV-induced mutant of Pichia stipitis with increased ethanol production from xylose and selection of a spontaneous mutant with increased ethanol tolerance. Bioresour. Technol. 2011, 102:1844-1848.
13. Pasha C., Kuhad R.C., Rao L.V. Strain improvement of thermotolerant Saccharomyces cerevisiae VS3 strain for better utilization of lignocellulosic substrates. J. Appl. Microbiol. 2007, 103:1480-1489.
14. Mobini-Dehkordi M., Nahvi I., Zarkesh-Esfahani H., Ghaedi K., Tavassoli M., Akada R. Isolation of a novel mutant strain of Saccharomyces cerevisiae by an ethyl methane sulfonate-induced mutagenesis approach as a high producer of bioethanol. J. Biosci. Bioeng. 2008, 105:403-408.
15. Wahlbom C.F., Cordero Otero R.R., van Zyl W.H., Hahn-Hagerdal B., Jonsson L. Molecular analysis of a Saccharomyces cerevisiae mutant with improved ability to utilize xylose shows enhanced expression of proteins involved in transport, initial xylose metabolism and the pentose phosphate pathway. Appl. Environ. Microbiol. 2003, 69:740-746.
16. Smolinska U. Mitochondrial mutagenesis in yeast: mutagenic specificity of EMS and the effects of RAD9 and REV3 gene products. Mutat. Res. 1987, 179:167-174.
17. Calmann M.A., Marinus M.G. Differential effects of cisplatin and MNNG on dna mutants of Escherichia coli. Mutat. Res. Fund. Mol. Mech. Mut. 2005, 158:406-416.
18. Capiaghi C., Ho V., Thoma F. Kinetochores prevent repair of UV damage in Saccharomyces cerevisiae centromeres. Mol. Cell. Biol. 2004, 24:6907-6918.
19. Machida I., Saeki T., Nakai S. Effects of near-ultraviolet light on mutations, intragenic and intergenic recombinations in Saccharomyces cerevisiae. Mutat. Res. Fund. Mol. Mech. Mut. 1986, 160:11-17.
20. Kumari R., Pramanik K. Improved bioethanol production using fusants of Saccharomyces cerevisiae and xylose-fermenting yeasts. Appl. Biochem. Biotechnol. 2012, 167:873-884.
21. Katsuragi T., Kawabata N., Sakai T. Selection of hybrids from protoplast fusion of yeast by double fluorescence labelling and automatic cell sorting. Lett. Appl. Microbiol. 1994, 19:92-94.
22. Puria R., Mannan M.A., Dewasthaly R.C., Ganesan K. Critical role of RPI1 in the stress tolerance of yeast during ethanolic fermentation. FEMS Yeast Res. 2009, 9:1161-1171.
23. Miller G.M. Use of dinitrosalicylic acid reagent for determination of reducing sugar. Anal. Chem. 1959, 31:426-428.
24. Swan T.M., Watson K. Stress tolerance in a yeast sterol auxotroph: role of ergosterol, heat shock proteins and trehalose. FEMS Microbiol. Lett. 1998, 169:191-197.
25. Baltz R.H., Seno E.T. Genetics of Streptomyces fradiae and tylosin biosynthesis. Annu. Rev. Microbiol. 1988, 42:547-574.
26. Horvath I.S., Franzen C.J., Taherzadeh M.J., Niklasson C.L.G. Effects of furfural on the respiratory metabolism of Saccharomyces cerevisiae in glucose-limited chemostats. Appl. Environ. Microbiol. 2003, 69:4076-4086.
27. Delgenes J.P., Moletta R., Navarro J.M. Effects of lignocellulose degradation products on ethanol fermentations of glucose and xylose by Saccharomyces cerevisiae, Zymomonas mobilis, Pichia stipitis, and Candida shehatae. Enzyme Microb. Technol. 1996, 19:220-222.
28. Aguilera F., Peinado R.A., Millan C., Ortega J.M., Mauricio J.C. Relationship between ethanol tolerance, H+-ATPase activity and the lipid composition of the plasma membrane in different wine yeast strains. Int. J. Food Microbiol. 2006, 110:34-42.
29. Mahmud S.A., Hirasawa T., Shimizu H. Differential importance of trehalose accumulation in Saccharomyces cerevisiae in response to various environmental stresses. J. Biosci. Bioeng. 2010, 109:262-266.
30. Ogawa Y., Nitta A., Uchiyama H., Imamura T., Shimoe H., Ito K. Tolerance mechanism of the ethanol-tolerant mutant of sake yeast. J. Biosci. Bioeng. 2000, 90:313-320.
31. Singer M.A., Lindquist S. Multiple effects of trehalose on protein folding in vitro and in vivo. Mol. Cell 1998, 1:639-648.
32. Benjaphokee S., Hasegawa D., Yokota D., Asvarak T., Auesukaree C., Sugiyama M., Kaneko Y., Boonchird C., Harashima S. Highly efficient bioethanol production by a Saccharomyces cerevisiae strain with multiple stress tolerance to high temperature, acid and ethanol. N. Biotechnol. 2012, 29:379-386.
33. Jimenez J., Benitez T. Selection of ethanol tolerant yeast hybrids in pH regulated continuous culture. Appl. Environ. Microbiol. 1988, 54:917-922.
34. Kiran Sree N., Sridhan M., Suresh K., Banat I.M., Rao L.V. Isolation of thermotolerant, osmotolerant, flocculating Saccharomyces cerevisiae for ethanol production. Bioresour. Technol. 2000, 72:43-46.
35. Oliva J.M., Negro M.J., Saez F., Ballesteros I., Manzanares P., Gonzalez A., Ballesteros M. Effects of acetic acid, furfural and catechol combinations on ethanol fermentation of Kluyveromyces marxianus. Process Biochem. 2006, 41:1223-1228.
36. Hughes D.B., Tudrosen N.J., Moye C.J. The effect of temperature on kinetics of ethanol production by a thermotolerant strain of Kluyveromyces marxianus. Biotechnol. Lett. 1994, 6:1-5.
37. Lu Y., Cheng Y., He X., Guo X., Zhang B. Improvement of robustness and ethanol production of ethanologenic Saccharomyces cerevisiae under co-stress of heat and inhibitors. J. Ind. Microbiol. Biotechnol. 2012, 39:73-80.