A study on antioxidant and apoptotic effect of Azadirachta Indica (neem) in cases of cervical cancer

Archives of Gynecology and Obstetrics

Volumn 286, Issue 5, 2012, Pages 1255-1259

  Vasenwala, Shaista M ^a   Seth, Reema ^a   Haider, Nazima ^a   Islam, Najmul ^a   Khan, Tamkin ^a   Maheshwari, Veena ^a   Ur Rehman, Suhail ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

Antioxidant; Azadirachta indica; Cancer cervix

Indexed keywords

AZADIRACHTA INDICA EXTRACT; CASPASE 3; CASPASE 8; CASPASE 9; ENZYME INHIBITOR; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CANCER CELL; CELL CULTURE; CELL LEVEL; CELL STRUCTURE; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DOSE RESPONSE; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MONOCYTE; TISSUE CULTURE; UTERINE CERVIX BIOPSY; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA;

APOPTOSIS; AZADIRACHTA; CARCINOMA, SQUAMOUS CELL; CASPASE 3; CASPASE 8; CASPASE 9; FEMALE; HUMANS; INTERFERON-GAMMA; MONOCYTES; PHYTOTHERAPY; PLANT PREPARATIONS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; UTERINE CERVICAL NEOPLASMS;

EID: 84868093501     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-012-2428-x     Document Type: Article

References (15)

1. WHO (2006) Comprehensive cervical cancer control. A guide to essential practice, pp 13-24
2. Harish Kumar G, Vidyapriyadarshini R, Vinothini G, Latchoumy Vidya, Nagini S (2009) The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce cell proliferation and induce apoptosis in an animal model of oral oncogenesis. Invest New Drugs 27(3):246-252
3. Priyadarshini RV, Manikandan P, Kumar GH, Nagini GS (2009) The neem limonoids azadirachtin and nimbolide inhibit hamster cheek pouch carcinogenesis by modulating xenobiotic-metabolizing enzymes, DNA damage, antioxidants, invasion and angiogenesis. Free Radic Res 43(5):492-504
4. Subapriya R, Bhuvneshwari V, Nagini S (2005) Ethanolic neem (Azadirachta indica) leaf extract induces apoptosis in hamster buccal pouch carcinogenesis model by modulating of Bcl-2, Bim, caspase 8 and caspase 3. Asian Pac J Cancer Prev 6(4):515-520
5. Dabash R, Vajpayee J, Jacob M, Dzuba I, Lal N, Bradley J, Prasad LB (2005) A strategic assessment of cervical cancer prevention and treatment services in 3 districts of Uttar Pradesh, India. Reprod Health 2:11. doi: 10.1186/1742-4755-2-11
6. Kumar V, Abbas AK, Fausto N (2004) Pathologic basis of disease, 7th edn. Saunders, Philadelphia, pp 269-342
7. Gastman BR (2001) Apoptosis and its clinical impact. Head Neck 23(5):409-425
8. Dash PR, Whitley GS, Ayling LJ, Johnstone AP, Cartwright JE (2005) Trophoblast apoptosis is inhibited by hepatocyte growth factor through the Akt and beta- catenin mediated up-regulation of inducible nitric oxide synthase. Cell Signal 17:571-580
9. Nanduri S, Thunuguntala SS, Nyavanandi VK et al (2003) Biological investigation and structure activity relationship studies on azadirone from Azadirachta indica A. Juss. Bioorg Med Chem Lett 13(22):4111-4115
10. Sastry BS, Suresh BK, Hari Babu T et al (2006) Synthesis and biological activity of amide derivatives of nimbolide. Bioorg Med Chem Lett 16(16):4391-4394
11. Dhongade RK, Kavade SG, Damle RS (2008) Neem oil poisoning. Indian Pediatr 45(1):56-57
12. Waterston A, Bower M (2004) TNF and cancer: good or bad? Cancer Ther 2:131-148
13. Hidalgo K, Rojas IG, Penissi AB, Rudolph MI (2005) TNF α increases in vitro migrations of human HPV- 18 positive SW- 756 cervical carcinoma cells. Biocell 29(3):303-311
14. Tartour E, Gey A, Sastre-Garau X, Lombard Surin I, Mosseri V, Feidman WH (1998) Prognostic value of intratumoral interferon γ messenger RNA expression in invasive cervical carcinomas. J Natl Cancer Inst 90:287-294
15. Bose A, Baral R (2007) Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L-mediated endogenous production of interleukin-12. Hum Immunol 68(10):823-831