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Volumn 26, Issue 10, 2012, Pages 3993-4002

Induction of quinone reductase by tamoxifen or DPN protects against mammary tumorigenesis

Author keywords

Aromatase; Hyperplasia; Oxidative DNA damage

Indexed keywords

AROMATASE; DIARYLPROPIONITRILE; DOXYCYCLINE; ESTROGEN; ESTROGEN RECEPTOR BETA; PLACEBO; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TAMOXIFEN;

EID: 84868089323     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-208330     Document Type: Article
Times cited : (3)

References (48)
  • 1
    • 0034463957 scopus 로고    scopus 로고
    • Is estradiol a genotoxic mutagenic carcinogen?
    • Liehr, J. G. (2000) Is estradiol a genotoxic mutagenic carcinogen? Endocr. Rev. 21, 40-54
    • (2000) Endocr. Rev. , vol.21 , pp. 40-54
    • Liehr, J.G.1
  • 2
    • 30944469849 scopus 로고    scopus 로고
    • Estrogen carcinogenesis in breast cancer
    • Yager, J. D., and Davidson, N. E. (2006) Estrogen carcinogenesis in breast cancer. N. Engl. J. Med. 354, 270-282
    • (2006) N. Engl. J. Med. , vol.354 , pp. 270-282
    • Yager, J.D.1    Davidson, N.E.2
  • 4
    • 0029820178 scopus 로고    scopus 로고
    • Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients
    • Agarwal, V. R., Bulun, S. E., Leitch, M., Rohrich, R., and Simpson, E. R. (1996) Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients. J. Clin. Endocrinol. Metab. 81, 3843-3849
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 3843-3849
    • Agarwal, V.R.1    Bulun, S.E.2    Leitch, M.3    Rohrich, R.4    Simpson, E.R.5
  • 6
    • 0029937278 scopus 로고    scopus 로고
    • Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities
    • Tekmal, R. R., Ramachandra, N., Gubba, S., Durgam, V. R., Mantione, J., Toda, K., Shizuta, Y., and Dillehay, D. L. (1996) Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities. Cancer Res. 56, 3180-3185
    • (1996) Cancer Res. , vol.56 , pp. 3180-3185
    • Tekmal, R.R.1    Ramachandra, N.2    Gubba, S.3    Durgam, V.R.4    Mantione, J.5    Toda, K.6    Shizuta, Y.7    Dillehay, D.L.8
  • 7
    • 0035266182 scopus 로고    scopus 로고
    • Overexpression of aromatase leads to hyperplasia and changes in the expression of genes involved in apoptosis, cell cycle, growth, and tumor suppressor functions in the mammary glands of transgenic mice
    • Kirma, N., Gill, K., Mandava, U., and Tekmal, R. R. (2001) Overexpression of aromatase leads to hyperplasia and changes in the expression of genes involved in apoptosis, cell cycle, growth, and tumor suppressor functions in the mammary glands of transgenic mice. Cancer Res. 61, 1910-1918
    • (2001) Cancer Res. , vol.61 , pp. 1910-1918
    • Kirma, N.1    Gill, K.2    Mandava, U.3    Tekmal, R.R.4
  • 8
    • 67449136137 scopus 로고    scopus 로고
    • History of aromatase: Saga of an important biological mediator and therapeutic target
    • Santen, R. J., Brodie, H., Simpson, E. R., Siiteri, P. K., and Brodie, A. (2009) History of aromatase: saga of an important biological mediator and therapeutic target. Endocr. Rev. 30, 343-375
    • (2009) Endocr. Rev. , vol.30 , pp. 343-375
    • Santen, R.J.1    Brodie, H.2    Simpson, E.R.3    Siiteri, P.K.4    Brodie, A.5
  • 9
    • 0038210242 scopus 로고    scopus 로고
    • Aromatase inhibitors in breast cancer
    • Smith, I. E., and Dowsett, M. (2003) Aromatase inhibitors in breast cancer. N. Engl. J. Med. 348, 2431-2442
    • (2003) N. Engl. J. Med. , vol.348 , pp. 2431-2442
    • Smith, I.E.1    Dowsett, M.2
  • 10
    • 33847793068 scopus 로고    scopus 로고
    • Long-term results of tamoxifen prophylaxis for breast cancer-96-month follow-up of the randomized IBIS-I trial
    • Cuzick, J., Forbes, J. F., Sestak, I., Cawthorn, S., Hamed, H., Holli, K., and Howell, A. (2007) Long-term results of tamoxifen prophylaxis for breast cancer-96-month follow-up of the randomized IBIS-I trial. J. Natl. Cancer Inst. 99, 272-282
    • (2007) J. Natl. Cancer Inst. , vol.99 , pp. 272-282
    • Cuzick, J.1    Forbes, J.F.2    Sestak, I.3    Cawthorn, S.4    Hamed, H.5    Holli, K.6    Howell, A.7
  • 12
    • 33846018559 scopus 로고    scopus 로고
    • Estrogen receptor-beta: Recent lessons from in vivo studies
    • Harris, H. A. (2007) Estrogen receptor-beta: recent lessons from in vivo studies. Mol. Endocrinol. 21, 1-13
    • (2007) Mol. Endocrinol. , vol.21 , pp. 1-13
    • Harris, H.A.1
  • 13
    • 9344264630 scopus 로고    scopus 로고
    • Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer
    • Hopp, T. A., Weiss, H. L., Parra, I. S., Cui, Y., Osborne, C. K., and Fuqua, S. A. (2004) Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer. Clin. Cancer Res. 10, 7490-7499
    • (2004) Clin. Cancer Res. , vol.10 , pp. 7490-7499
    • Hopp, T.A.1    Weiss, H.L.2    Parra, I.S.3    Cui, Y.4    Osborne, C.K.5    Fuqua, S.A.6
  • 15
    • 28744458215 scopus 로고    scopus 로고
    • Clinical significance of estrogen receptor beta in breast cancer
    • Saji, S., Hirose, M., and Toi, M. (2005) Clinical significance of estrogen receptor beta in breast cancer. Cancer Chemother. Pharmacol. 56(Suppl. 1), 21-26
    • (2005) Cancer Chemother. Pharmacol. , vol.56 , Issue.SUPPL. 1 , pp. 21-26
    • Saji, S.1    Hirose, M.2    Toi, M.3
  • 16
    • 0034868904 scopus 로고    scopus 로고
    • ER beta inhibits proliferation and invasion of breast cancer cells
    • Lazennec, G., Bresson, D., Lucas, A., Chauveau, C., and Vignon, F. (2001) ER beta inhibits proliferation and invasion of breast cancer cells. Endocrinology 142, 4120-4130
    • (2001) Endocrinology , vol.142 , pp. 4120-4130
    • Lazennec, G.1    Bresson, D.2    Lucas, A.3    Chauveau, C.4    Vignon, F.5
  • 17
    • 0042388370 scopus 로고    scopus 로고
    • Estrogen receptor (ER) beta1 and ERβcx/β2 inhibit ERα function differently in breast cancer cell line MCF7
    • Omoto, Y., Eguchi, H., Yamamoto-Yamaguchi, Y., and Hayashi, S. (2003) Estrogen receptor (ER) beta1 and ERβcx/β2 inhibit ERα function differently in breast cancer cell line MCF7. Oncogene 22, 5011-5020
    • (2003) Oncogene , vol.22 , pp. 5011-5020
    • Omoto, Y.1    Eguchi, H.2    Yamamoto-Yamaguchi, Y.3    Hayashi, S.4
  • 18
    • 1642535535 scopus 로고    scopus 로고
    • Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest
    • Paruthiyil, S., Parmar, H., Kerekatte, V., Cunha, G. R., Firestone, G. L., and Leitman, D. C. (2004) Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res. 64, 423-428
    • (2004) Cancer Res. , vol.64 , pp. 423-428
    • Paruthiyil, S.1    Parmar, H.2    Kerekatte, V.3    Cunha, G.R.4    Firestone, G.L.5    Leitman, D.C.6
  • 19
    • 0035935731 scopus 로고    scopus 로고
    • Estrogen receptor-beta potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues
    • Meyers, M. J., Sun, J., Carlson, K. E., Marriner, G. A., Katzenellenbogen, B. S., and Katzenellenbogen, J. A. (2001) Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J. Med. Chem. 44, 4230-4251
    • (2001) J. Med. Chem. , vol.44 , pp. 4230-4251
    • Meyers, M.J.1    Sun, J.2    Carlson, K.E.3    Marriner, G.A.4    Katzenellenbogen, B.S.5    Katzenellenbogen, J.A.6
  • 20
    • 27144524273 scopus 로고    scopus 로고
    • Estrogen receptors alfa (ERα) and beta (ERβ) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11
    • Helguero, L. A., Faulds, M. H., Gustafsson, J. A., and Haldosen, L. A. (2005) Estrogen receptors alfa (ERα) and beta (ERβ) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene 24, 6605-6616
    • (2005) Oncogene , vol.24 , pp. 6605-6616
    • Helguero, L.A.1    Faulds, M.H.2    Gustafsson, J.A.3    Haldosen, L.A.4
  • 21
    • 43149093785 scopus 로고    scopus 로고
    • Estrogen receptor beta increases the efficacy of antiestrogens by effects on apoptosis and cell cycling in breast cancer cells
    • Hodges-Gallagher, L., Valentine, C. D., El Bader, S., and Kushner, P. J. (2008) Estrogen receptor beta increases the efficacy of antiestrogens by effects on apoptosis and cell cycling in breast cancer cells. Breast Cancer Res. Treat. 109, 241-250
    • (2008) Breast Cancer Res. Treat. , vol.109 , pp. 241-250
    • Hodges-Gallagher, L.1    Valentine, C.D.2    El Bader, S.3    Kushner, P.J.4
  • 22
    • 0032566547 scopus 로고    scopus 로고
    • Transcriptional regulation of the human quinone reductase gene by antiestrogen-liganded estrogen receptor-α and estrogen receptor-β
    • Montano, M. M., Jaiswal, A. K., and Katzenellenbogen, B. S. (1998) Transcriptional regulation of the human quinone reductase gene by antiestrogen-liganded estrogen receptor-α and estrogen receptor-β. J. Biol. Chem. 273, 25443-25449
    • (1998) J. Biol. Chem. , vol.273 , pp. 25443-25449
    • Montano, M.M.1    Jaiswal, A.K.2    Katzenellenbogen, B.S.3
  • 23
    • 0037634342 scopus 로고    scopus 로고
    • Functional implications of antiestrogen induction of quinone reductase: Inhibition of estrogen-induced deoxyribonucleic acid damage
    • Bianco, N. R., Perry, G., Smith, M. A., Templeton, D. J., and Montano, M. M. (2003) Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. Mol. Endocrinol. 17, 1344-1355
    • (2003) Mol. Endocrinol. , vol.17 , pp. 1344-1355
    • Bianco, N.R.1    Perry, G.2    Smith, M.A.3    Templeton, D.J.4    Montano, M.M.5
  • 24
    • 34249309939 scopus 로고    scopus 로고
    • Protective roles of quinone reductase and tamoxifen against estrogen-induced mammary tumorigenesis
    • Montano, M. M., Chaplin, L. J., Deng, H., Mesia-Vela, S., Gaikwad, N., Zahid, M., and Rogan, E. (2007) Protective roles of quinone reductase and tamoxifen against estrogen-induced mammary tumorigenesis. Oncogene 26, 3587-3590
    • (2007) Oncogene , vol.26 , pp. 3587-3590
    • Montano, M.M.1    Chaplin, L.J.2    Deng, H.3    Mesia-Vela, S.4    Gaikwad, N.5    Zahid, M.6    Rogan, E.7
  • 25
    • 12744280974 scopus 로고    scopus 로고
    • Differential induction of quinone reductase by phytoestrogens and protection against oestrogen-induced DNA damage
    • Bianco, N. R., Chaplin, L. J., and Montano, M. M. (2005) Differential induction of quinone reductase by phytoestrogens and protection against oestrogen-induced DNA damage. Biochem. J. 385, 279-287
    • (2005) Biochem. J. , vol.385 , pp. 279-287
    • Bianco, N.R.1    Chaplin, L.J.2    Montano, M.M.3
  • 26
    • 54549104700 scopus 로고    scopus 로고
    • HPMC2 is required for recruiting an ERβ coactivator complex to mediate transcriptional upregulation of NQO1 and protection against oxidative DNA damage by tamoxifen
    • Sripathy, S. P., Chaplin, L. J., Gaikwad, N. W., Rogan, E. G., and Montano, M. M. (2008) hPMC2 is required for recruiting an ERβ coactivator complex to mediate transcriptional upregulation of NQO1 and protection against oxidative DNA damage by tamoxifen. Oncogene 27, 6376-6384
    • (2008) Oncogene , vol.27 , pp. 6376-6384
    • Sripathy, S.P.1    Chaplin, L.J.2    Gaikwad, N.W.3    Rogan, E.G.4    Montano, M.M.5
  • 27
    • 23744458336 scopus 로고    scopus 로고
    • Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice
    • Tekmal, R. R., Liu, Y. G., Nair, H. B., Jones, J., Perla, R. P., Lubahn, D. B., Korach, K. S., and Kirma, N. (2005) Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice. J. Steroid Biochem. Mol. Biol. 95, 9-15
    • (2005) J. Steroid Biochem. Mol. Biol. , vol.95 , pp. 9-15
    • Tekmal, R.R.1    Liu, Y.G.2    Nair, H.B.3    Jones, J.4    Perla, R.P.5    Lubahn, D.B.6    Korach, K.S.7    Kirma, N.8
  • 29
    • 0033731641 scopus 로고    scopus 로고
    • Rapid development of tamoxifen-stimulated mutant p53 breast tumors (T47D) in athymic mice
    • Schafer, J. M., Lee, E. S., O'Regan, R. M., Yao, K., and Jordan, V. C. (2000) Rapid development of tamoxifen-stimulated mutant p53 breast tumors (T47D) in athymic mice. Clin. Cancer Res. 6, 4373-4380
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4373-4380
    • Schafer, J.M.1    Lee, E.S.2    O'regan, R.M.3    Yao, K.4    Jordan, V.C.5
  • 30
    • 0037972896 scopus 로고    scopus 로고
    • Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) α activity by ERβ in the uterus
    • Frasor, J., Barnett, D. H., Danes, J. M., Hess, R., Parlow, A. F., and Katzenellenbogen, B. S. (2003) Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) α activity by ERβ in the uterus. Endocrinology 144, 3159-3166
    • (2003) Endocrinology , vol.144 , pp. 3159-3166
    • Frasor, J.1    Barnett, D.H.2    Danes, J.M.3    Hess, R.4    Parlow, A.F.5    Katzenellenbogen, B.S.6
  • 32
    • 79958768946 scopus 로고    scopus 로고
    • Estrogen receptor-beta activation in combination with letrozole blocks the growth of breast cancer tumors resistant to letrozole therapy
    • Nair, H. B., Kirma, N. B., Ganapathy, M., Vadlamudi, R. K., and Tekmal, R. R. (2011) Estrogen receptor-beta activation in combination with letrozole blocks the growth of breast cancer tumors resistant to letrozole therapy. Steroids 76, 792-796
    • (2011) Steroids , vol.76 , pp. 792-796
    • Nair, H.B.1    Kirma, N.B.2    Ganapathy, M.3    Vadlamudi, R.K.4    Tekmal, R.R.5
  • 33
    • 0033775041 scopus 로고    scopus 로고
    • Functional characteristics of a novel murine estrogen receptor-beta isoform, estrogen receptor-beta 2
    • Lu, B., Leygue, E., Dotzlaw, H., Murphy, L. J., and Murphy, L. C. (2000) Functional characteristics of a novel murine estrogen receptor-beta isoform, estrogen receptor-beta 2. J. Mol. Endocrinol. 25, 229-242
    • (2000) J. Mol. Endocrinol. , vol.25 , pp. 229-242
    • Lu, B.1    Leygue, E.2    Dotzlaw, H.3    Murphy, L.J.4    Murphy, L.C.5
  • 35
    • 0035714310 scopus 로고    scopus 로고
    • Aromatase overexpression transgenic mice model: Cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiology
    • Mandava, U., Kirma, N., and Tekmal, R. R. (2001) Aromatase overexpression transgenic mice model: cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiology. J. Steroid Biochem. Mol. Biol. 79, 27-34
    • (2001) J. Steroid Biochem. Mol. Biol. , vol.79 , pp. 27-34
    • Mandava, U.1    Kirma, N.2    Tekmal, R.R.3
  • 36
    • 0033050076 scopus 로고    scopus 로고
    • Aromatase overexpression and breast hyperplasia, an in vivo model-continued overexpression of aromatase is sufficient to maintain hyperplasia without circulating estrogens, and aromatase inhibitors abrogate these preneoplastic changes in mammary glands
    • Tekmal, R. R., Kirma, N., Gill, K., and Fowler, K. (1999) Aromatase overexpression and breast hyperplasia, an in vivo model-continued overexpression of aromatase is sufficient to maintain hyperplasia without circulating estrogens, and aromatase inhibitors abrogate these preneoplastic changes in mammary glands. Endocr. Relat. Cancer 6, 307-314
    • (1999) Endocr. Relat. Cancer , vol.6 , pp. 307-314
    • Tekmal, R.R.1    Kirma, N.2    Gill, K.3    Fowler, K.4
  • 37
    • 0035969989 scopus 로고    scopus 로고
    • Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1
    • Asher, G., Lotem, J., Cohen, B., Sachs, L., and Shaul, Y. (2001) Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. Proc. Natl. Acad. Sci. U. S. A. 98, 1188-1193
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 1188-1193
    • Asher, G.1    Lotem, J.2    Cohen, B.3    Sachs, L.4    Shaul, Y.5
  • 38
    • 68849097622 scopus 로고    scopus 로고
    • The redox-sensing quinone reductase Lot6p acts as an inducer of yeast apoptosis
    • Sollner, S., Durchschlag, M., Frohlich, K. U., and Macheroux, P. (2009) The redox-sensing quinone reductase Lot6p acts as an inducer of yeast apoptosis. FEMS Yeast Res. 9, 885-891
    • (2009) FEMS Yeast Res. , vol.9 , pp. 885-891
    • Sollner, S.1    Durchschlag, M.2    Frohlich, K.U.3    MacHeroux, P.4
  • 39
    • 16844383502 scopus 로고    scopus 로고
    • Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis
    • Iskander, K., Gaikwad, A., Paquet, M., Long, D. J., 2nd, Brayton, C., Barrios, R., and Jaiswal, A. K. (2005) Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis. Cancer Res. 65, 2054-2058
    • (2005) Cancer Res. , vol.65 , pp. 2054-2058
    • Iskander, K.1    Gaikwad, A.2    Paquet, M.3    Long, D.J.4    Brayton II, C.5    Barrios, R.6    Jaiswal, A.K.7
  • 40
    • 20444396613 scopus 로고    scopus 로고
    • Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity
    • Iskander, K., and Jaiswal, A. K. (2005) Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity. Chem. Biol. Interact. 153-154, 147-157
    • (2005) Chem. Biol. Interact. , vol.153-154 , pp. 147-157
    • Iskander, K.1    Jaiswal, A.K.2
  • 42
    • 2942652871 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
    • Shou, J., Massarweh, S., Osborne, C. K., Wakeling, A. E., Ali, S., Weiss, H., and Schiff, R. (2004) Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J. Natl. Cancer Inst. 96, 926-935
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 926-935
    • Shou, J.1    Massarweh, S.2    Osborne, C.K.3    Wakeling, A.E.4    Ali, S.5    Weiss, H.6    Schiff, R.7
  • 43
    • 0037219744 scopus 로고    scopus 로고
    • Effect of tamoxifen on venous thrombosis risk factors in women without cancer: The Breast Cancer Prevention Trial
    • Cushman, M., Costantino, J. P., Bovill, E. G., Wickerham, D. L., Buckley, L., Roberts, J. D., and Krag, D. N. (2003) Effect of tamoxifen on venous thrombosis risk factors in women without cancer: the Breast Cancer Prevention Trial. Br. J. Haematol. 120, 109-116
    • (2003) Br. J. Haematol. , vol.120 , pp. 109-116
    • Cushman, M.1    Costantino, J.P.2    Bovill, E.G.3    Wickerham, D.L.4    Buckley, L.5    Roberts, J.D.6    Krag, D.N.7
  • 44
    • 0032848782 scopus 로고    scopus 로고
    • Health-related quality of life and tamoxifen in breast cancer prevention: A report from the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    • Day, R., Ganz, P. A., Costantino, J. P., Cronin, W. M., Wickerham, D. L., and Fisher, B. (1999) Health-related quality of life and tamoxifen in breast cancer prevention: a report from the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J. Clin. Oncol. 17, 2659-2669
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2659-2669
    • Day, R.1    Ganz, P.A.2    Costantino, J.P.3    Cronin, W.M.4    Wickerham, D.L.5    Fisher, B.6
  • 46
    • 37449028688 scopus 로고    scopus 로고
    • Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial
    • Forbes, J. F., Cuzick, J., Buzdar, A., Howell, A., Tobias, J. S., and Baum, M. (2008) Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol. 9, 45-53
    • (2008) Lancet Oncol. , vol.9 , pp. 45-53
    • Forbes, J.F.1    Cuzick, J.2    Buzdar, A.3    Howell, A.4    Tobias, J.S.5    Baum, M.6
  • 47
    • 54049130931 scopus 로고    scopus 로고
    • Estradiol or diarylpropionitrile decrease anxiety-like behavior of wildtype, but not estrogen receptor beta knockout, mice
    • Walf, A. A., Koonce, C. J., and Frye, C. A. (2008) Estradiol or diarylpropionitrile decrease anxiety-like behavior of wildtype, but not estrogen receptor beta knockout, mice. Behav. Neurosci. 122, 974-981
    • (2008) Behav. Neurosci. , vol.122 , pp. 974-981
    • Walf, A.A.1    Koonce, C.J.2    Frye, C.A.3
  • 48
    • 63849111566 scopus 로고    scopus 로고
    • Estrogen receptor-β agonist diarylpropionitrile: Biological activities of Rand S-enantiomers on behavior and hormonal response to stress
    • Weiser, M. J., Wu, T. J., and Handa, R. J. (2009) Estrogen receptor-β agonist diarylpropionitrile: biological activities of Rand S-enantiomers on behavior and hormonal response to stress. Endocrinology 150, 1817-1825
    • (2009) Endocrinology , vol.150 , pp. 1817-1825
    • Weiser, M.J.1    Wu, T.J.2    Handa, R.J.3


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