메뉴 건너뛰기




Volumn 95, Issue 1-5, 2005, Pages 9-15

Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice

Author keywords

Aromatase; Estrogen receptor; Mammary carcinogenesis; Transgenic mice

Indexed keywords

AROMATASE; CYCLIN D1; CYCLINE; ESTROGEN RECEPTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA;

EID: 23744458336     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2005.04.007     Document Type: Conference Paper
Times cited : (28)

References (20)
  • 2
    • 0002285785 scopus 로고    scopus 로고
    • Local estrogen production: Is aromatase an oncogene
    • A. Amanni Humana Press
    • R.R. Tekmal, and R.J. Santen Local estrogen production: is aromatase an oncogene A. Amanni Endocrinology of the Breast 1999 Humana Press 79 92
    • (1999) Endocrinology of the Breast , pp. 79-92
    • Tekmal, R.R.1    Santen, R.J.2
  • 3
  • 4
    • 0029937278 scopus 로고    scopus 로고
    • Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities
    • R.R. Tekmal, N. Ramachandra, S. Gubba, V.R. Durgam, J. Mantione, K. Toda, Y. Shizuta, and D.L. Dillehay Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities Cancer Res. 56 1996 3180 3185
    • (1996) Cancer Res. , vol.56 , pp. 3180-3185
    • Tekmal, R.R.1    Ramachandra, N.2    Gubba, S.3    Durgam, V.R.4    Mantione, J.5    Toda, K.6    Shizuta, Y.7    Dillehay, D.L.8
  • 5
    • 0035266182 scopus 로고    scopus 로고
    • Overexpression of aromatase leads to hyperplasia and changes in the expression of genes involved in apoptosis, cell cycle, growth, and tumor suppressor functions in the mammary glands of transgenic mice
    • N. Kirma, K. Gill, U. Mandava, and R.R. Tekmal Overexpression of aromatase leads to hyperplasia and changes in the expression of genes involved in apoptosis, cell cycle, growth, and tumor suppressor functions in the mammary glands of transgenic mice Cancer Res. 61 2001 1910 1918
    • (2001) Cancer Res. , vol.61 , pp. 1910-1918
    • Kirma, N.1    Gill, K.2    Mandava, U.3    Tekmal, R.R.4
  • 6
    • 0033836079 scopus 로고    scopus 로고
    • Overexpression of aromatase leads to development of testicular Leydig cell tumors: An in vivo model for hormone-mediated testicular cancer
    • K.A. Fowler, K. Gill, N. Kirma, D.L. Dillehay, and R.R. Tekmal Overexpression of aromatase leads to development of testicular Leydig cell tumors: an in vivo model for hormone-mediated testicular cancer Am. J. Pathol. 156 2000 347 353
    • (2000) Am. J. Pathol. , vol.156 , pp. 347-353
    • Fowler, K.A.1    Gill, K.2    Kirma, N.3    Dillehay, D.L.4    Tekmal, R.R.5
  • 7
    • 0035023117 scopus 로고    scopus 로고
    • Overexpression of aromatase in transgenic male mice results in the induction of gynecomastia and other biochemical changes in mammary glands
    • K. Gill, N. Kirma, and R.R. Tekmal Overexpression of aromatase in transgenic male mice results in the induction of gynecomastia and other biochemical changes in mammary glands J. Steroid Biochem. Mol. Biol. 177 2000 13 18
    • (2000) J. Steroid Biochem. Mol. Biol. , vol.177 , pp. 13-18
    • Gill, K.1    Kirma, N.2    Tekmal, R.R.3
  • 8
    • 0035714310 scopus 로고    scopus 로고
    • Aromatase overexpression transgenic mice model: Cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiology
    • U. Mandava, N. Kirma, and R.R. Tekmal Aromatase overexpression transgenic mice model: cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiology J. Steroid Biochem. Mol. Biol. 79 2001 27 34
    • (2001) J. Steroid Biochem. Mol. Biol. , vol.79 , pp. 27-34
    • Mandava, U.1    Kirma, N.2    Tekmal, R.R.3
  • 9
    • 0033050076 scopus 로고    scopus 로고
    • Aromatase overexpression and breast hyperplasia, an in vivo model-continued overexpression of aromatase is sufficient to maintain hyperplasia without circulating estrogens, and aromatase inhibitors abrogate these preneoplastic changes in mammary glands
    • R.R. Tekmal, N. Kirma, K. Gill, and K.A. Fowler Aromatase overexpression and breast hyperplasia, an in vivo model-continued overexpression of aromatase is sufficient to maintain hyperplasia without circulating estrogens, and aromatase inhibitors abrogate these preneoplastic changes in mammary glands Endocr. Relat. Cancer 6 1999 307 314
    • (1999) Endocr. Relat. Cancer , vol.6 , pp. 307-314
    • Tekmal, R.R.1    Kirma, N.2    Gill, K.3    Fowler, K.A.4
  • 10
    • 0028018928 scopus 로고
    • Aromatase and its inhibitors in breast cancer treatment - Overview and perspective
    • A.M. Brodie, and R.J. Santen Aromatase and its inhibitors in breast cancer treatment - overview and perspective Breast Cancer Res. Treat. 30 1994 1 6
    • (1994) Breast Cancer Res. Treat. , vol.30 , pp. 1-6
    • Brodie, A.M.1    Santen, R.J.2
  • 11
    • 84936433788 scopus 로고    scopus 로고
    • Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: Analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group
    • A.U. Buzdar Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group J. Clin. Oncol. 22 2004 3199 3200 (author reply 3200-3191)
    • (2004) J. Clin. Oncol. , vol.22 , pp. 3199-3200
    • Buzdar, A.U.1
  • 12
    • 0035954237 scopus 로고    scopus 로고
    • Acceleration of mammary neoplasia in aromatase transgenic mice by 7, 12-dimethylbenz[a]anthracene
    • N. Keshava, U. Mandava, N. Kirma, and R.R. Tekmal Acceleration of mammary neoplasia in aromatase transgenic mice by 7, 12-dimethylbenz[a]anthracene Cancer Lett. 167 2001 125 133
    • (2001) Cancer Lett. , vol.167 , pp. 125-133
    • Keshava, N.1    Mandava, U.2    Kirma, N.3    Tekmal, R.R.4
  • 14
    • 0035666856 scopus 로고    scopus 로고
    • The effects of aromatase overexpression on mammary growth and gene expression in the aromatase × transforming growth factor alpha double transgenic mice
    • N. Kirma, U. Mandava, K. K. Wuichet, and R.R. Tekmal The effects of aromatase overexpression on mammary growth and gene expression in the aromatase × transforming growth factor alpha double transgenic mice J. Steroid Biochem. Mol. Biol. 78 2001 419 426
    • (2001) J. Steroid Biochem. Mol. Biol. , vol.78 , pp. 419-426
    • Kirma, N.1    Mandava, U.2    Wuichet, K.K.3    Tekmal, R.R.4
  • 16
    • 0034735853 scopus 로고    scopus 로고
    • Estrogen receptor beta in the breast: Role in estrogen responsiveness and development of breast cancer
    • J.A. Gustafsson, and M. Warner Estrogen receptor beta in the breast: role in estrogen responsiveness and development of breast cancer J. Steroid Biochem. Mol. Biol. 74 2000 245 248
    • (2000) J. Steroid Biochem. Mol. Biol. , vol.74 , pp. 245-248
    • Gustafsson, J.A.1    Warner, M.2
  • 18
    • 0030728930 scopus 로고    scopus 로고
    • Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse
    • J.F. Couse, J. Lindzey, K. Grandien, J.A. Gustafsson, and K.S. Korach Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse Endocrinology 138 1997 4613 4621
    • (1997) Endocrinology , vol.138 , pp. 4613-4621
    • Couse, J.F.1    Lindzey, J.2    Grandien, K.3    Gustafsson, J.A.4    Korach, K.S.5
  • 19
    • 0034487751 scopus 로고    scopus 로고
    • The normal and malignant mammary gland: A fresh look with ER beta onboard
    • M. Warner, S. Saji, and J.A. Gustafsson The normal and malignant mammary gland: a fresh look with ER beta onboard J. Mammary Gland Biol. Neoplasia 5 2000 289 294
    • (2000) J. Mammary Gland Biol. Neoplasia , vol.5 , pp. 289-294
    • Warner, M.1    Saji, S.2    Gustafsson, J.A.3
  • 20
    • 1642359815 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in breast carcinogenesis
    • J.R. Benson Role of transforming growth factor beta in breast carcinogenesis Lancet Oncol. 5 2004 229 239
    • (2004) Lancet Oncol. , vol.5 , pp. 229-239
    • Benson, J.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.