Regional pulmonary response to a methacholine challenge using hyperpolarized 3He magnetic resonance imaging

Respirology

Volumn 17, Issue 8, 2012, Pages 1237-1246

  Costella, Stephen ^a,b   Kirby, Miranda ^a,c   Maksym, Geoffrey N ^e   McCormack, David G ^d   Paterson, Nigel A M ^d   Parraga, Grace ^a,b,c  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b Graduate Program in Biomedical Engineering   (Canada)

^c Department of Medical Biophysics ^*  (Canada)

^d UNIVERSITY OF WESTERN ONTARIO   (Canada)

^e DALHOUSIE UNIVERSITY   (Canada)

Author keywords

apparent diffusion coefficient; asthma; helium 3; magnetic resonance imaging; methacholine

Indexed keywords

FRACTIONAL EXHALED NITRIC OXIDE; HELIUM; METHACHOLINE; NITRIC OXIDE; SALBUTAMOL; UNCLASSIFIED DRUG;

ADULT; AIRWAY RESISTANCE; ANALYSIS OF VARIANCE; ARTICLE; ASTHMA; AUTOMATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DIAGNOSTIC TEST ACCURACY STUDY; DIFFUSION COEFFICIENT; DYSPNEA; EXHALATION; FEMALE; HUMAN; HYPERPOLARIZATION; IMAGE ANALYSIS; LUNG FUNCTION; LUNG FUNCTION TEST; LUNG VENTILATION; MALE; METHACHOLINE CHALLENGE TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PLETHYSMOGRAPHY; PRIORITY JOURNAL; PROVOCATION TEST; REGION OF INTEREST; SCORING SYSTEM; SEMIAUTOMATED SEGMENTATION; SPIROMETRY; TISSUE STRUCTURE; VENTILATION DEFECT PERCENTAGE;

ADULT; AIRWAY RESISTANCE; ALBUTEROL; ASTHMA; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTION; BRONCHOCONSTRICTOR AGENTS; FEMALE; HELIUM; HUMANS; LUNG; MAGNETIC RESONANCE IMAGING; MALE; METHACHOLINE CHLORIDE; MIDDLE AGED; PULMONARY VENTILATION; RESPIRATORY FUNCTION TESTS; YOUNG ADULT;

EID: 84867977770     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2012.02250.x     Document Type: Article

References (38)

1. Celli BR,. The importance of spirometry in COPD and asthma: effect on approach to management. Chest 2000; 117: 15S-9S.
2. Busse WW,. Asthma diagnosis and treatment: filling in the information gaps. J. Allergy Clin. Immunol. 2011; 128: 740-50.
3. Macklem PT, Mead J,. Resistance of central and peripheral airways measured by a retrograde catheter. J. Appl. Physiol. 1967; 22: 395-401.
4. Burgel PR,. The role of small airways in obstructive airway diseases. Eur. Respir. Rev. 2011; 20: 23-33.
5. Enright PL, Lebowitz MD, Cockroft DW,. Physiologic measures: pulmonary function tests. Asthma outcome. Am. J. Respir. Crit. Care Med. 1994; 149: S9-18.
6. Farah CS, King GG, Brown NJ, et al,. The role of the small airways in the clinical expression of asthma in adults. J. Allergy Clin. Immunol. 2011; 129: 381-7.
7. Bourdin A, Paganin F, Prefaut C, et al,. Nitrogen washout slope in poorly controlled asthma. Allergy 2006; 61: 85-9.
8. King GG, Eberl S, Salome CM, et al,. Differences in airway closure between normal and asthmatic subjects measured with single-photon emission computed tomography and technegas. Am. J. Respir. Crit. Care Med. 1998; 158: 1900-6.
9. King GG, Eberl S, Salome CM, et al,. Airway closure measured by a technegas bolus and SPECT. Am. J. Respir. Crit. Care Med. 1997; 155: 682-8.
10. Pellegrino R, Biggi A, Papaleo A, et al,. Regional expiratory flow limitation studied with Technegas in asthma. J. Appl. Physiol. 2001; 91: 2190-8.
11. Nitt-Gray MF, Goldin JG, Johnson TD, et al,. Development and testing of image-processing methods for the quantitative assessment of airway hyperresponsiveness from high-resolution CT images. J. Comput. Assist. Tomogr. 1997; 21: 939-47.
12. Grenier P, Mourey-Gerosa I, Benali K, et al,. Abnormalities of the airways and lung parenchyma in asthmatics: CT observations in 50 patients and inter- and intraobserver variability. Eur. Radiol. 1996; 6: 199-206.
13. King GG, Carroll JD, Muller NL, et al,. Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT. Eur. Respir. J. 2004; 24: 211-8.
14. Tgavalekos NT, Tawhai M, Harris RS, et al,. Identifying airways responsible for heterogeneous ventilation and mechanical dysfunction in asthma: an image functional modeling approach. J. Appl. Physiol. 2005; 99: 2388-97.
15. Venegas JG, Winkler T, Musch G, et al,. Self-organized patchiness in asthma as a prelude to catastrophic shifts. Nature 2005; 434: 777-82.
16. Ohno Y, Koyama H, Matsumoto K, et al,. Oxygen-enhanced MRI vs. quantitatively assessed thin-section CT: pulmonary functional loss assessment and clinical stage classification of asthmatics. Eur. J. Radiol. 2011; 77: 85-91.
17. de Lange EE, Altes TA, Patrie JT, et al,. Changes in regional airflow obstruction over time in the lungs of patients with asthma: evaluation with 3He MR imaging. Radiology 2009; 250: 567-75.
18. de Lange EE, Altes TA, Patrie JT, et al,. The variability of regional airflow obstruction within the lungs of patients with asthma: assessment with hyperpolarized helium-3 magnetic resonance imaging. J. Allergy Clin. Immunol. 2007; 119: 1072-8.
19. de Lange EE, Altes TA, Patrie JT, et al,. Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry. Chest 2006; 130: 1055-62.
20. Altes TA, Powers PL, Knight-Scott J, et al,. Hyperpolarized 3He MR lung ventilation imaging in asthmatics: preliminary findings. J. Magn. Reson. Imaging 2001; 13: 378-84.
21. Tzeng YS, Lutchen K, Albert M,. The difference in ventilation heterogeneity between asthmatic and healthy subjects quantified using hyperpolarized 3He MRI. J. Appl. Physiol. 2009; 106: 813-22.
22. Campana L, Kenyon J, Zhalehdoust-Sani S, et al,. Probing airway conditions governing ventilation defects in asthma via hyperpolarized MRI image functional modeling. J. Appl. Physiol. 2009; 106: 1293-300.
23. Samee S, Altes T, Powers P, et al,. Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: assessment of response to methacholine and exercise challenge. J. Allergy Clin. Immunol. 2003; 111: 1205-11.
24. Kirby M, Mathew L, Heydarian M, et al,. Chronic obstructive pulmonary disease: quantification of bronchodilator effects by using hyperpolarized (3)He MR imaging. Radiology 2011; 261: 283-92.
25. Kirby M, Heydarian M, Wheatley A, et al,. Evaluating bronchodilator effects in chronic obstructive pulmonary disease using diffusion-weighted hyperpolarized helium-3 magnetic resonance imaging. J. Appl. Physiol. 2011; 112: 651-7.
26. Evans A, McCormack D, Ouriadov A, et al,. Anatomical distribution of 3He apparent diffusion coefficients in severe chronic obstructive pulmonary disease. J. Magn. Reson. Imaging 2007; 26: 1537-47.
27. Crapo RO, Casaburi R, Coates AL, et al,. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am. J. Respir. Crit. Care Med. 2000; 161: 309-29.
28. Kendrick KR, Baxi SC, Smith RM,. Usefulness of the modified 0-10 Borg scale in assessing the degree of dyspnea in patients with COPD and asthma. J. Emerg. Nurs. 2000; 26: 216-22.
29. Mathew L, Kirby M, Etemad-Rezai R, et al,. Hyperpolarized (3)He magnetic resonance imaging: preliminary evaluation of phenotyping potential in chronic obstructive pulmonary disease. Eur. J. Radiol. 2011; 79: 140-6.
30. Parraga G, Ouriadov A, Evans A, et al,. Hyperpolarized 3He ventilation defects and apparent diffusion coefficients in chronic obstructive pulmonary disease: preliminary results at 3.0 Tesla. Invest. Radiol. 2007; 42: 384-91.
31. Kirby M, Svenningsen S, Ahmed H, et al,. Quantitative evaluation of hyperpolarized helium-3 magnetic resonance imaging of lung function variability in cystic fibrosis. Acad. Radiol. 2011; 18: 1006-13.
32. O'Halloran RL, Holmes JH, Altes TA, et al,. The effects of SNR on ADC measurements in diffusion-weighted hyperpolarized He-3 MRI. J. Magn. Reson. 2007; 185: 42-9.
33. Kirby M, Heydarian M, Svenningsen S, et al,. Hyperpolarized 3He magnetic resonance functional imaging semiautomated segmentation. Acad. Radiol. 2012; 19: 141-52.
34. Wang C, Altes TA, Mugler JP III, et al,. Assessment of the lung microstructure in patients with asthma using hyperpolarized 3He diffusion MRI at two time scales: comparison with healthy subjects and patients with COPD. J. Magn. Reson. Imaging 2008; 28: 80-8.
35. Leary D, Bhatawadekar SA, Parraga G, et al,. Modeling stochastic and spatial heterogeneity in a human airway tree to determine variation in respiratory system resistance. J. Appl. Physiol. 2012; 112: 167-75.
36. Fain SB, Gonzalez-Fernandez G, Peterson ET, et al,. Evaluation of structure-function relationships in asthma using multidetector CT and hyperpolarized He-3 MRI. Acad. Radiol. 2008; 15: 753-62.
37. Driehuys B, Martinez-Jimenez S, Cleveland ZI, et al,. Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients. Radiology 2012; 262: 279-89.
38. Fain SB, Korosec FR, Holmes JH, et al,. Functional lung imaging using hyperpolarized gas MRI. J. Magn. Reson. Imaging 2007; 25: 910-23.