Evaluating bronchodilator effects in chronic obstructive pulmonary disease using diffusion-weighted hyperpolarized helium-3 magnetic resonance imaging

Journal of Applied Physiology

Volumn 112, Issue 4, 2012, Pages 651-657

  Kirby, Miranda ^a,b   Heydarian, Mohammadreza ^b   Wheatley, Andrew ^b   McCormack, David G ^c   Parraga, Grace ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c Division of Respirology   (Canada)

Author keywords

Apparent diffusion coefficients; Chronic obstructive pulmonary disease

Indexed keywords

BRONCHODILATING AGENT; DIAGNOSTIC AGENT; HELIUM; ISOTOPE; SALBUTAMOL;

AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; DRUG EFFECT; FEMALE; HUMAN; LUNG; LUNG VENTILATION; MALE; MIDDLE AGED;

AGED; ALBUTEROL; BRONCHODILATOR AGENTS; FEMALE; HELIUM; HUMANS; ISOTOPES; LUNG; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY VENTILATION;

EID: 84859612576     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01295.2011     Document Type: Article

References (44)

1. Bartel SE, Haywood SE, Woods JC, Chang YV, Menard C, Yablonskiy DA, Gierada DS, Conradi MS. Role of collateral paths in longrange diffusion in lungs. J Appl Physiol 104: 1495-1503, 2008.
2. Belman MJ, Botnick WC, Shin JW. Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 153: 967-975, 1996. (Pubitemid 26081647)
3. Choy S, Wheatley A, McCormack DG, Parraga G. Hyperpolarized (3)He magnetic resonance imaging derived pulmonary pressure-volume curves. J Appl Physiol 109: 574-585, 2010.
4. de Lange EE, Mugler JP, III, Brookeman JR, Knight-Scott J, Truwit JD, Teates CD, Daniel TM, Bogorad PL, Cates GD. Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas. Radiology 210: 851-857, 1999. (Pubitemid 29124051)
5. Diaz S, Casselbrant I, Piitulainen E, Magnusson P, Peterson B, Wollmer P, Leander P, Ekberg O, Akeson P. Validity of apparent diffusion coefficient hyperpolarized 3He-MRI using MSCT and pulmonary function tests as references. Eur J Radiol 71: 257-263, 2009.
6. Diaz S, Casselbrant I, Piitulainen E, Pettersson G, Magnusson P, Peterson B, Wollmer P, Leander P, Ekberg O, Akeson P. Hyperpolarized 3He apparent diffusion coefficient MRI of the lung: reproducibility and volume dependency in healthy volunteers and patients with emphysema. J Magn Reson Imaging 27: 763-770, 2008. (Pubitemid 351508090)
7. Evans A, McCormack D, Ouriadov A, Etemad-Rezai R, Santyr G, Parraga G. Anatomical distribution of (3)He apparent diffusion coefficients in severe chronic obstructive pulmonary disease. J Magn Reson Imaging 26: 1537-1547, 2007. (Pubitemid 350291282)
8. Evans A, McCormack DG, Santyr G, Parraga G. Mapping and quantifying hyperpolarized 3He magnetic resonance imaging apparent diffusion coefficient gradients. J Appl Physiol 105: 693-699, 2008.
9. Fain SB, Altes TA, Panth SR, Evans MD, Waters B, Mugler JP, III, Korosec FR, Grist TM, Silverman M, Salerno M, Owers-Bradley J. Detection of age-dependent changes in healthy adult lungs with diffusionweighted 3He MRI. Acad Radiol 12: 1385-1393, 2005. (Pubitemid 41512831)
10. Fain SB, Gonzalez-Fernandez G, Peterson ET, Evans MD, Sorkness RL, Jarjour NN, Busse WW, Kuhlman JE. Evaluation of structurefunction relationships in asthma using multidetector CT and hyperpolarized He-3 MRI. Acad Radiol 15: 753-762, 2008. (Pubitemid 351662749)
11. Fain SB, Panth SR, Evans MD, Wentland AL, Holmes JH, Korosec FR, O'Brien MJ, Fountaine H, Grist TM. Early emphysematous changes in asymptomatic smokers: detection with 3He MR imaging. Radiology 239: 875-883, 2006. (Pubitemid 43830626)
12. Heydarian M, Kirby M, Choy S, Wheatley A, Costella S, Etemad-Rezai R, McCormack DG, Parraga G. Semi-automated segmentation of pulmonary ventilation using hyperpolarized 3He magnetic resonance imaging. In: Biomedical Engineering Society Annual Meeting 2010, Imaging the Lung-The New Frontier, 82: 2010.
13. Heydarian M, Kirby M, Wheatley A, Fenster A, Parraga G. Two and three-dimensional segmentation of hyperpolarized 3He magnetic resonance functional imaging. In: Proceedings of SPIE, The Biomedical Applications in Molecular, Structural, and Functional Imaging, edited by Molthen RC and Weaver JB, 8317: 2011
14. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, Pare PD. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350: 2645-2653, 2004. (Pubitemid 38787999)
15. James AL, Wenzel S. Clinical relevance of airway remodelling in airway diseases. Eur Respir J 30: 134-155, 2007. (Pubitemid 47074016)
16. Jones PW. Health status measurement in chronic obstructive pulmonary disease. Thorax 56: 880-887, 2001. (Pubitemid 32999838)
17. Kauczor HU, Ebert M, Kreitner KF, Nilgens H, Surkau R, Heil W, Hofmann D, Otten EW, Thelen M. Imaging of the lungs using 3He MRI: preliminary clinical experience in 18 patients with and without lung disease. J Magn Reson Imaging 7: 538-543, 1997. (Pubitemid 28360872)
18. Kirby M, Mathew L, Heydarian M, Etemad-Rezai R, McCormack DG, Parraga G. Chronic obstructive pulmonary disease: quantification of bronchodilator effects by using hyperpolarized He MR imaging. Radiology 261: 283-292, 2011.
19. Kirby M, Mathew L, Wheatley A, Santyr GE, McCormack DG, Parraga G. Chronic obstructive pulmonary disease: longitudinal hyperpolarized (3)He MR imaging. Radiology 256: 280-289, 2010.
20. Kirby M, Svenningsen S, Ahmed H, Wheatley A, Etemad-Rezai R, Paterson NA, Parraga G. Quantitative evaluation of hyperpolarized helium-3 magnetic resonance imaging of lung function variability in cystic fibrosis. Acad Radiol 18: 1006-1013, 2011.
21. MacQueen, J. Some methods for classification and analysis of multivariate observations. In: Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability 1 (Statistics), edited by Le Cam LM and Neyman J. Berkeley, CA: University of California Press, 1967, p. 281-297.
22. Mathew L, Evans A, Ouriadov A, Etemad-Rezai R, Fogel R, Santyr G, McCormack DG, Parraga G. Hyperpolarized 3He magnetic resonance imaging of chronic obstructive pulmonary disease: reproducibility at 3.0 tesla. Acad Radiol 15: 1298-1311, 2008.
23. Mathew L, Kirby M, Etemad-Rezai R, Wheatley A, McCormack DG, Parraga G. Hyperpolarized 3He magnetic resonance imaging: preliminary evaluation of phenotyping potential in chronic obstructive pulmonary disease. Eur J Radiol 79: 140-146, 2011.
24. Matsuba K, Thurlbeck WM. The number and dimensions of small airways in nonemphysematous lungs. Am Rev Respir Dis 104: 516-524, 1971.
25. Moller HE, Chen XJ, Saam B, Hagspiel KD, Johnson GA, Altes TA, de Lange EE, Kauczor HU. MRI of the lungs using hyperpolarized noble gases. Magn Reson Med 47: 1029-1051, 2002. (Pubitemid 34587394)
26. Morbach AE, Gast KK, Schmiedeskamp J, Dahmen A, Herweling A, Heussel CP, Kauczor HU, Schreiber WG. Diffusion-weighted MRI of the lung with hyperpolarized helium-3: a study of reproducibility. J Magn Reson Imaging 21: 765-774, 2005. (Pubitemid 40770869)
27. Morrell NW, Wignall BK, Biggs T, Seed WA. Collateral ventilation and gas exchange in emphysema. Am J Respir Crit Care Med 150: 635-641, 1994. (Pubitemid 24291488)
28. O'Donnell DE, Aaron S, Bourbeau J, Hernandez P, Marciniuk DD, Balter M, Ford G, Gervais A, Goldstein R, Hodder R, Kaplan A, Keenan S, Lacasse Y, Maltais F, Road J, Rocker G, Sin D, Sinuff T, Voduc N. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease-2007 update. Can Respir J 14, Suppl B: 5B-32B, 2007. (Pubitemid 350090390)
29. O'Donnell DE, Forkert L, Webb KA. Evaluation of bronchodilator responses in patients with "irreversible" emphysema. Eur Respir J 18: 914-920, 2001. (Pubitemid 34092863)
30. O'Donnell DE, Lam M, Webb KA. Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158: 1557-1565, 1998.
31. O'Halloran RL, Holmes JH, Altes TA, Salerno M, Fain SB. The effects of SNR on ADC measurements in diffusion-weighted hyperpolarized He-3 MRI. J Magn Reson 185: 42-49, 2007. (Pubitemid 46484396)
32. Ochs M, Nyengaard JR, Jung A, Knudsen L, Voigt M, Wahlers T, Richter J, Gundersen HJ. The number of alveoli in the human lung. Am J Respir Crit Care Med 169: 120-124, 2004. (Pubitemid 38233898)
33. Parraga G, Ouriadov A, Evans A, McKay S, Lam WW, Fenster A, Etemad-Rezai R, McCormack D, Santyr G. Hyperpolarized 3He ventilation defects and apparent diffusion coefficients in chronic obstructive pulmonary disease: preliminary results at 3.0 Tesla. Invest Radiol 42: 384-391, 2007. (Pubitemid 46788737)
34. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS, GOLD Scientific Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD): Workshop summary. Am J Respir Crit Care Med 163: 1256-1276, 2001. (Pubitemid 32378468)
35. Pauwels RA, Rabe KF. Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 364: 613-620, 2004. (Pubitemid 39094180)
36. Petty TL, Silvers GW, Stanford RE. Radial traction and small airways disease in excised human lungs. Am Rev Respir Dis 133: 132-135, 1986. (Pubitemid 16189110)
37. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, Zielinski J. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 176: 532-555, 2007. (Pubitemid 47403272)
38. Saam BT, Yablonskiy DA, Kodibagkar VD, Leawoods JC, Gierada DS, Cooper JD, Lefrak SS, Conradi MS. MR imaging of diffusion of (3)He gas in healthy and diseased lungs. Magn Reson Med 44: 174-179, 2000. (Pubitemid 30616020)
39. Salerno M, de Lange EE, Altes TA, Truwit JD, Brookeman JR, Mugler JP, III. Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes-initial experience. Radiology 222: 252-260, 2002. (Pubitemid 34031496)
40. Walter SD, Eliasziw M, Donner A. Sample size and optimal designs for reliability studies. Stat Med 17: 101-110, 1998. (Pubitemid 28020212)
41. Woods JC, Choong CK, Yablonskiy DA, Bentley J, Wong J, Pierce JA, Cooper JD, Macklem PT, Conradi MS, Hogg JC. Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema. Magn Reson Med 56: 1293-1300, 2006. (Pubitemid 44865311)
42. Woods JC, Yablonskiy DA, Choong CK, Chino K, Pierce JA, Hogg JC, Bentley J, Cooper JD, Conradi MS, Macklem PT. Long-range diffusion of hyperpolarized 3He in explanted normal and emphysematous human lungs via magnetization tagging. J Appl Physiol 99: 1992-1997, 2005. (Pubitemid 41547202)
43. Yablonskiy DA, Sukstanskii AL, Leawoods JC, Gierada DS, Bretthorst GL, Lefrak SS, Cooper JD, Conradi MS. Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI. Proc Natl Acad Sci USA 99: 3111-3116, 2002. (Pubitemid 34240594)
44. Yablonskiy DA, Sukstanskii AL, Woods JC, Gierada DS, Quirk JD, Hogg JC, Cooper JD, Conradi MS. Quantification of lung microstructure with hyperpolarized 3He diffusion MRI. J Appl Physiol 107: 1258-1265, 2009.