Brown, white, beige: The color of fat and new therapeutic perspectives for obesity...;Brun, blanc, beige: La couleur du gras et nouvelles perspectives thérapeutiques de l'obésité...

Annales d'Endocrinologie

Volumn 73, Issue SUPPL.1, 2012, Pages

  Kuhn, E ^a,b   Binart, N ^a,b,c   Lombes M ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c BICÊTRE HOSPITAL   (France)

Author keywords

Beigeing; Brown adipose tissue; Irisin; PRDM16; Thermogenesis

Indexed keywords

HORMONE; IRISIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PRDM16; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ADRENERGIC SYSTEM; ARTICLE; BEIGE ADIPOSE TISSUE; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; CELL LINEAGE; CELL TYPE; FEEDBACK SYSTEM; HUMAN; INNERVATION; LIPODYSTROPHY; OBESITY; PARAVENTRICULAR THALAMIC NUCLEUS; PATHOGENESIS; SENSORY NERVE; THERMOGENESIS; WHITE ADIPOSE TISSUE;

ADIPOCYTES; ADIPOCYTES, BROWN; ADIPOCYTES, WHITE; ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; FIBRONECTINS; HUMANS; OBESITY; THERMOGENESIS; TRANSCRIPTION FACTORS;

EID: 84867916345     PISSN: 00034266     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4266(12)70009-4     Document Type: Article

References (31)

1. Cypess A.M., Lehman S., Williams G., Tal I., Rodman D., Goldfine A.B., et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009, 360:1509-1517.
2. van Marken Lichtenbelt W.D., Vanhommerig J.W., Smulders N.M., Drossaerts J.M., Kemerink G.J., Bouvy N.D., et al. Coldactivated brown adipose tissue in healthy men. N Engl J Med 2009, 360:1500-1508.
3. Virtanen K.A., Lidell M.E., Orava J., Heglind M., Westergren R., Niemi T., et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009, 360:1518-1525.
4. Lowell B.B., V S.S., Hamann A., Lawitts J.A., Himms-Hagen J., Boyer B.B., et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 1993, 366:740-742.
5. Kopecky J., Clarke G., Enerback S., Spiegelman B., Kozak L.P. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 1995, 96:2914-2923.
6. Cederberg A., Gronning L.M., Ahren B., Tasken K., Carlsson P., Enerback S. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 2001, 106:563-573.
7. Feldmann H.M., Golozoubova V., Cannon B., Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 2009, 9:203-209.
8. Seale P., Bjork B., Yang W., Kajimura S., Chin S., Kuang S., et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008, 454:961-967.
9. Bartness T.J., Vaughan C.H., Song C.K. Sympathetic and sensory innervation of brown adipose tissue. Int J Obes (Lond) 2010, 34(Suppl1):S36-S42.
10. Barbera M.J., Schluter A., Pedraza N., Iglesias R., Villarroya F., Giralt M. Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell. J Biol Chem 2001, 276:1486-1493.
11. Handschin C., Spiegelman B.M. Peroxisome proliferatoractivated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev 2006, 27:728-735.
12. Timmons J.A., Wennmalm K., Larsson O., Walden T.B., Lassmann T., Petrovic N., et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci U S A 2007, 104:4401-4406.
13. Kajimura S., Seale P., Kubota K., Lunsford E., Frangioni J.V., Gygi S.P., et al. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature 2009, 460:1154-1158.
14. Enerback S. The origins of brown adipose tissue. N Engl J Med 2009, 360:2021-2023.
15. Petrovic N., Walden T.B., Shabalina I.G., Timmons J.A., Cannon B., Nedergaard J. Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J Biol Chem 2010, 285:7153-7164.
16. Ishibashi J., Seale P. Medicine. Beige can be slimming. Science 2010, 328:1113-1114.
17. Cousin B., Cinti S., Morroni M., Raimbault S., Ricquier D., Penicaud L., et al. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci 1992, 103(Pt4):931-942.
18. Ghorbani M., Himms-Hagen J. Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats. Int J Obes Relat Metab Disord 1997, 21:465-475.
19. Guerra C., Koza R.A., Yamashita H., Walsh K., Kozak L.P. Emergence of brown adipocytes in white fat in mice is under genetic control Effects on body weight and adiposity. J Clin Invest 1998, 102:412-420.
20. Himms-Hagen J., Melnyk A., Zingaretti M.C., Ceresi E., Barbatelli G., Cinti S. Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes. Am J Physiol Cell Physiol 2000, 279:C670-C681.
21. Huttunen P., Hirvonen J., Kinnula V. The occurrence of brown adipose tissue in outdoor workers. Eur J Appl Physiol Occup Physiol 1981, 46:339-345.
22. Xue B., Coulter A., Rim J.S., Koza R.A., Kozak L.P. Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. Mol Cell Biol 2005, 25:8311-8322.
23. Barbatelli G., Murano I., Madsen L., Hao Q., Jimenez M., Kristiansen K., et al. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am J Physiol Endocrinol Metab 2010, 298:E1244-E1253.
24. Collins S., Daniel K.W., Petro A.E., Surwit R.S. Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology 1997, 138:405-413.
25. Cousin B., Casteilla L., Dani C., Muzzin P., Revelli J.P., Penicaud L. Adipose tissues from various anatomical sites are characterized by different patterns of gene expression and regulation. Biochem J 1993, 292(Pt 3):873-876.
26. Seale P., Conroe H.M., Estall J., Kajimura S., Frontini A., Ishibashi J., et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 2011, 121:96-105.
27. Auffret J., Viengchareun S., Carre N., Denis R.G., Magnan C., Marie P.Y., et al. Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-dietinduced obesity. Faseb J 2012, 26. (in press).
28. Wenz T., Rossi S.G., Rotundo R.L., Spiegelman B.M., Moraes C.T. Increased muscle PGC-1alpha expression protects from sarcopeniaand metabolic disease during aging. Proc Natl Acad Sci U S A 2009, 106:20405-20410.
29. Bostrom P., Wu J., Jedrychowski M.P., Korde A., Ye L., Lo J.C., et al. A PGC1-alpha-dependent myokine that drives brownfat-like development of white fat and thermogenesis. Nature 2012, 481:463-468.
30. Wu J., Boström P., Sparks L.M., Ye L., Choi J.H., Giang A.H., et al. Beige adipocytes are a distinct type of thermogenic fact cell in mouse and human. Cell 2012, 150:1-11.
31. Ursino M.G., Vasina V., Raschi E., Crema F., De Ponti F. The beta3-adrenoceptor as a therapeutic target: current perspectives. Pharmacol Res 2009, 59:221-234.