A natural tetrahydropyrimidine, ectoine, ameliorates ischemia reperfusion injury after intestinal transplantation in rats

Pathobiology

Volumn 80, Issue 2, 2012, Pages 102-110

  Pech, Thomas ^a   Ohsawa, Ichiro ^a,b   Praktiknjo, Michael ^a   Overhaus, Marcus ^a   Wehner, Sven ^a   Von Websky, Martin ^a   Abu Elmagd, Kareem ^c   Van Echten Deckert, Gerhild ^a   Kalff, Joerg C ^a   Schaefer, Nico ^a  

^a UNIVERSITY OF BONN   (Germany)

^b MIE UNIVERSITY   (Japan)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Ectoine; Ischemia reperfusion injury; Small bowel transplantation; Tetrahydropyrimidine

Indexed keywords

ECTOINE; INTERLEUKIN 6; MESSENGER RNA; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DRUG MECHANISM; INTESTINE TRANSPLANTATION; MACROPHAGE; MALE; MONOCYTE; MUSCLE FUNCTION; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SMOOTH MUSCLE CONTRACTILITY;

AMINO ACIDS, DIAMINO; ANIMALS; ANTI-INFLAMMATORY AGENTS; INTERLEUKIN-6; INTESTINE, SMALL; MACROPHAGES; MALE; MONOCYTES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NEUTROPHIL INFILTRATION; NEUTROPHILS; NITRIC OXIDE; POSTOPERATIVE COMPLICATIONS; RATS; RATS, INBRED LEW; REPERFUSION INJURY; TRANSPLANTATION, ISOGENEIC; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; RATTUS;

EID: 84867896257     PISSN: 10152008     EISSN: 14230291     Source Type: Journal    
DOI: 10.1159/000342792     Document Type: Article

References (30)

1. Land WG: The role of postischemic reperfusion injury and other nonantigen-dependent inflammatory pathways in transplantation. Transplantation 2005; 79: 505-514. (Pubitemid 40372243)
2. Wei L, Wedeking A, Buttner R, Kalff JC, Tolba RH, van Echten-Deckert G: A natural tetrahydropyrimidine protects small bowel from cold ischemia and subsequent warm in vitro reperfusion injury. Pathobiology 2009; 76: 212-220.
3. Galinski EA, Pfeiffer HP, Truper HG: 1,4,5,6-Tetrahydro-2-methyl-4- pyrimidinecarboxylic acid. A novel cyclic amino acid from halophilic phototrophic bacteria of the genus Ectothiorhodospira. Eur J Biochem 1985; 149: 135-139. (Pubitemid 15013494)
4. Rengpipat S, Lowe SE, Zeikus JG: Effect of extreme salt concentrations on the physiology and biochemistry of Halobacteroides acetoethylicus . J Bacteriol 1988; 170: 3065-3071.
5. Arora A, Ha C, Park CB: Inhibition of insulin amyloid formation by small stress molecules. FEBS Lett 2004; 564: 121-125. (Pubitemid 38490710)
6. Schnoor M, Voss P, Cullen P, Boking T, Galla HJ, Galinski EA, Lorkowski S: Characterization of the synthetic compatible solute homoectoine as a potent PCR enhancer. Biochem Biophys Res Commun 2004; 322: 867-872. (Pubitemid 39164432)
7. Andersson MM, Breccia JD, Hatti-Kaul R: Stabilizing effect of chemical additives against oxidation of lactate dehydrogenase. Biotechnol Appl Biochem 2000; 32: 145-153. (Pubitemid 32053166)
8. Buenger J, Driller H: Ectoin: An effective natural substance to prevent UVA-induced premature photoaging. Skin Pharmacol Physiol 2004; 17: 232-237. (Pubitemid 39370254)
9. Buenger J, Degwert J, Driller H: The protective function of compatible solute ectoin on the skin, skin cells and its biomolecules with respect to UV-radiation, immunosupression and membrane damage. IFSCC Magazine 2001.
10. Sydlik U, Gallitz I, Albrecht C, Abel J, Krutmann J, Unfried K: The compatible solute ectoine protects against nanoparticle-induced neutrophilic lung inflammation. Am J Respir Crit Care Med 2009; 180: 29-35.
11. Park PO, Haglund U, Bulkley GB, Falt K: The sequence of development of intestinal tissue injury after strangulation ischemia and reperfusion. Surgery 1990; 107: 574-580.
12. Park PO, Wallander J, Tufveson G, Haglund U: Cold ischemic and reperfusion injury in a model of small bowel transplantation in the rat. Eur Surg Res 1991; 23: 1-8.
13. Kanapathipillai M, Lentzen G, Sierks M, Park CB: Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer's beta-Amyloid. FEBS Lett 2005; 579: 4775-4780. (Pubitemid 41218662)
14. Kolp S, Pietsch M, Galinski EA, Gutschow M: Compatible solutes as protectants for zymogens against proteolysis. Biochim Biophys Acta 2006; 1764: 1234-1242. (Pubitemid 44080861)
15. Schaefer N, Tahara K, Schuchtrup S, Websky MV, Overhaus M, Schmidt J, Wirz S, Abu-Elmagd KM, Kalff JC, Hirner A, Turler A: Perioperative glycine treatment attenuates ischemia/reperfusion injury and ameliorates smooth muscle dysfunction in intestinal transplantation. Transplantation 2008; 85: 1300-1310. (Pubitemid 351670481)
16. Schaefer N, Tahara K, von Websky M, Wehner S, Pech T, Tolba R, Abu-Elmagd K, Kalff JC, Hirner A, Turler A: Role of resident macrophages in the immunologic response and smooth muscle dysfunction during acute allograft rejection after intestinal transplantation. Transpl Int 2008; 21: 778-791.
17. Schmittgen TD, Zakrajsek BA, Mills AG, Gorn V, Singer MJ, Reed MW: Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: Comparison of endpoint and real-time methods. Anal Biochem 2000; 285: 194-204.
18. Kalff JC, Schraut WH, Simmons RL, Bauer AJ: Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus. Ann Surg 1998; 228: 652-663.
19. Schaefer N, Tahara K, Schmidt J, Wehner S, Kalff JC, Abu-Elmagd K, Hirner A, Turler A: Resident macrophages are involved in intestinal transplantation-Associated inflammation and motoric dysfunction of the graft muscularis. Am J Transplant 2007; 7: 1062-1070. (Pubitemid 46643100)
20. Schaefer N, Tahara K, Websky MV, Koscielny A, Pantelis D, Kalff JC, Abu-Elmagd K, Hirner A, Turler A: Acute rejection and the muscularis propria after intestinal transplantation: The alloresponse, inflammation, and smooth muscle function. Transplantation 2008; 85: 1465-1475.
21. Takeyoshi I, Zhang S, Nomoto M, Zhu Y, Kokudo Y, Suzuki T, Hamada N, Nemoto A, Starzl TE, Todo S: Mucosal damage and recovery of the intestine after prolonged preservation and transplantation in dogs. Transplantation 2001; 71: 1-7. (Pubitemid 32105770)
22. Schaefer N, Tahara K, Schmidt J, Zobel S, Kalff JC, Hirner A, Turler A: Mechanism and impact of organ harvesting and ischemia-reperfusion injury within the graft muscularis in rat small bowel transplantation. Transplant Proc 2006; 38: 1821-1822. (Pubitemid 44190051)
23. Schaefer N, Tahara K, Pech T, Websky MV, Fujishiro J, Pantelis D, Abu-Elmagd K, Kalff JC, Hirner A, Turler A: Inducible nitric oxide synthase expression in the intestinal muscularis mediates severe smooth muscle dysfunction during acute rejection in allogenic rodent small bowel transplantation. J Surg Res 2008; 150: 159-168.
24. Graf R, Anzali S, Buenger J, Pfluecker F, Driller H: The multifunctional role of ectoine as a natural cell protectant. Clin Dermatol 2008; 26: 326-333.
25. Zhang L, Wang Y, Zhang C, Wang Y, Zhu D, Wang C, Nagata S: Supplementation effect of ectoine on thermostability of phytase. J Biosci Bioeng 2006; 102: 560-563. (Pubitemid 46172544)
26. Nagata S, Maekawa Y, Ikeuchi T, Wang YB, Ishida A: Effect of compatible solutes on the respiratory activity and growth of Escherichia coli K-12 under NaCl stress. J Biosci Bioeng 2002; 94: 384-389. (Pubitemid 36246177)
27. Pastor JM, Salvador M, Argandona M, Bernal V, Reina-Bueno M, Csonka LN, Iborra JL, Vargas C, Nieto JJ, Canovas M: Ectoines in cell stress protection: Uses and biotechnological production. Biotechnol Adv 2010; 28: 782-801.
28. Furusho K, Yoshizawa T, Shoji S: Ectoine alters subcellular localization of inclusions and reduces apoptotic cell death induced by the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch. Neurobiol Dis 2005; 20: 170-178. (Pubitemid 41219213)
29. Kanapathipillai M, Ku SH, Girigoswami K, Park CB: Small stress molecules inhibit aggregation and neurotoxicity of prion peptide 106-126. Biochem Biophys Res Commun 2008; 365: 808-813. (Pubitemid 350245380)
30. Harishchandra RK, Wulff S, Lentzen G, Neuhaus T, Galla HJ: The effect of compatible solute ectoines on the structural organization of lipid monolayer and bilayer membranes. Biophys Chem 2010; 150: 37-46.