Preventive effect of dexmedetomidine in ischemia-reperfusion injury

Journal of Craniofacial Surgery

Volumn 23, Issue 5, 2012, Pages 1287-1291

  Uysal, Hale Yarkan ^a   Cuzdan, Suat Sedat ^a   Kayíran, Oǧuz ^a   Başar, Hülya ^a   Fidancí, Vildan ^a   Afyoncu, Ebru ^a   Üstün, Hüseyin ^a   Gülbahçe, Rukiye ^a  

^a ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Dexmedetomidine; Flaps; Ischemia reperfusion injury

Indexed keywords

DEXMEDETOMIDINE; MALONALDEHYDE; NITRIC OXIDE; PEROXIDASE;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; METABOLISM; NONPARAMETRIC TEST; RANDOMIZATION; RAT; REPERFUSION INJURY; SURGICAL FLAPS; WISTAR RAT;

ANALYSIS OF VARIANCE; ANIMALS; DEXMEDETOMIDINE; MALONDIALDEHYDE; NITRIC OXIDE; PEROXIDASE; RANDOM ALLOCATION; RATS; RATS, WISTAR; REPERFUSION INJURY; STATISTICS, NONPARAMETRIC; SURGICAL FLAPS;

EID: 84867885816     PISSN: 10492275     EISSN: None     Source Type: Journal    
DOI: 10.1097/SCS.0b013e3182519f24     Document Type: Article

References (42)

1. Arslan E, Basterzi Y, Aksoy A, et al. The additive effects of carnitine and ascorbic acid on distally burned dorsal skin flap in rats. Med Sci Monit 2005;11:176-180
2. Kerrigan CL, Stotland MA. Ischemia reperfusion injury: a review. Microsurgery 1993;14:165-175
3. van den Heuvel MG, Buurman WA, Bast A, et al. Review: ischaemia-reperfusion injury in flap surgery. J Plast Reconstr Aesthet Surg 2009;62:721-726
4. Valenzuela A. The biological significance of malondialdehyde determination in the assessment of tissue oxidative stress. Life Sci 1991;48:301-309
5. Meldrum DG, Stephenson LL, Zamboni WA. Effects of L-NAME and L-arginine on ischemia-reperfusion injury in rat skeletal muscle. Plast Reconstr Surg 1999;103:935-940
6. Radi R, Beckman JS, Bush KM, et al. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys 1991;288:481-487
7. Cetin C, Köse AA, Aral E, et al. Protective effect of fucoidin (a neutrophil rolling inhibitor) on ischemia reperfusion injury: experimental study in rat epigastric island flaps. Ann Plast Surg 2001;47:540-546
8. Aydogan H, Gurlek A, Parlakpinar H, et al. Beneficial effects of caffeic acid phenethyl ester (CAPE) on the ischaemia-reperfusion injury in rat skin flaps. J Plast Reconstr Aesthet Surg 2007;60:563-568
9. Cetinkale O, Bilgic L, Bolayirli M, et al. Involvement of neutrophils in ischemia-reperfusion injury of inguinal island skin flaps in rats. Plast Reconstr Surg 1998;102:153-160
10. Simpson R, Alon R, Kobzik L, et al. Neutrophil and nonneutrophil-mediated injury in intestinal ischemia-reperfusion. Ann Surg 1993;218:444-453; discussion 453-454
11. Siemionow M, Arslan E. Ischemia/reperfusion injury: a review in relation to free tissue transfers. Microsurgery 2004;24:468-475
12. Shin MS, Angel MF, Im MJ, et al. Effects of 21-aminosteroid U74389F on skin-flap survival after secondary ischemia. Plast Reconstr Surg 1994;94:661-666
13. Engelhard K, Werner C, Eberspächer E, et al. The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats. Anesth Analg 2003;96:524-531
14. Dahmani S, Rouelle D, Gressens P, et al. Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions. Anesthesiology 2005;103:969-977
15. Okada H, Kurita T, Mochizuki T, et al. The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts. Resuscitation 2007;74:538-545
16. Petry JJ, Wortham KA. The anatomy of the epigastric flap in the experimental rat. Plast Reconstr Surg 1984;74:410-413
17. Kuo YR, Jeng SF, Wang FS, et al. Platelet glycoprotein IIb/IIIa receptor antagonist (abciximab) inhibited platelet activation and promoted skin flap survival after ischemia/reperfusion injury. J Surg Res 2002;107:50-55
18. Smarason AK, Allman KG, Young D, et al. Elevated levels of serum nitrate, a stable endproduct of nitric oxide, in women with preeclampsia. Br J Obstet Gynecol 1997;104:538-543
19. Wasowicz W, Neve J, Peretz A. Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence of sample preservation and storage. Clin Chem 1993;39:2522-2526
20. Bradley PP, Priebat DA, Christensen RD, et al. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982;78:206-209
21. Roth E. The impact of L-arginine-nitric oxide metabolism on ischemia/reperfusion injury [review]. Curr Opin Clin Nutr Metab Care 1998;1:97-99
22. Kuo YR, Wang FS, Jeng SF, et al. Nitrosoglutathione improves blood perfusion and flap survival by suppressing iNOS but protecting eNOS expression in the flap vessels after ischemia/reperfusion injury. Surgery 2004;135:437-446
23. Kuo YR, Wang FS, Jeng SF, et al. Nitrosoglutathione promotes flap survival via suppression of reperfusion injury-induced superoxide and inducible nitric oxide synthase induction. J Trauma 2004;57:1025-1031
24. Radi R, Peluffo G, Alvarez MN, et al. Unraveling peroxynitrite formation in biological systems. Free Radic Biol Med 2001;30:463-488
25. Gürlek A, Celik M, Parlakpinar H, et al. The protective effect of melatonin on ischemia-reperfusion injury in the groin (inferior epigastric) flap model in rats. J Pineal Res 2006;40:312-317
26. Giderolu K, Yilmaz F, Aksoy F, et al. Montelukast protects axial pattern rat skin flaps against ischemia/reperfusion injury. J Surg Res 2009; 157: 181-186
27. Knight KR. Review of postoperative pharmacological infusions in ischemic skin flaps. Microsurgery 1994;15:675-684
28. Pang CY, Forrest CR, Morris SF. Pharmacological augmentation of skin flap viability: a hypothesis to mimic the surgical delay phenomenon or a wishful thought. Ann Plast Surg 1989;22:293-306
29. Davis RE, Wachholz JH, Jassir D, et al. Comparison of topical anti-ischemic agents in the salvage of failing random-pattern skin flaps in rats. Arch Facial Plast Surg 1999;1:27-32
30. Paris A, Tonner PH. Dexmedetomidine in anaesthesia. Curr Opin Anaesthesiol 2005;18:412-418
31. Yagmurdur H, Ozcan N, Dokumaci F, et al. Dexmedetomidine reduces the ischemia-reperfusion injury markers during upper extremity surgery with tourniquet. J Hand Surg Am 2008;33:941-947
32. Kuhmonen J, Pokorn] J, Miettinen R, et al. Neuroprotective effects of dexmedetomidine in the gerbil hippocampus after transient global ischemia. Anesthesiology 1997;87:371-377
33. Kuhmonen J, Haapalinna A, Sivenius J. Effects of dexmedetomidine after transient and permanent occlusion of the middle cerebral artery in the rat. J Neural Transm 2001;108:261-271
34. Kakinohana M, Oshiro M, Saikawa S, et al. Intravenous infusion of dexmedetomidine can prevent the degeneration of spinal ventral neurons induced by intrathecal morphine after a noninjurious interval of spinal cord ischemia in rats. Anesth Analg 2007;105:1086-1093
35. Bickler PE, Hansen BM. alpha 2-Adrenergic agonists reduce glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices during hypoxia. Neuropharmacology 1996;35:679-687
36. Talke P, Bickler PE. Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices. Anesthesiology 1996;85:551-557
37. Hanci V, Erol B, Bektaş S, et al. Effect of dexmedetomidine on testicular torsion/detorsion damage in rats. Urol Int 2010;84:105-111
38. Hoffman WE, Kochs E, Werner C, et al. Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole. Anesthesiology 1991;75:328-332
39. Maier C, Steinberg GK, Sun GH, et al. Neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia. Anesthesiology 1993;79:306-312
40. Taniguchi T, Kidani Y, Kanakura H, et al. Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats. Crit Care Med 2004;32:1322-1326
41. Can M, Gul S, Bektas S, et al. Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury. Acta Anaesthesiol Scand 2009;53:1068-1072
42. Nishina K, Akamatsu H, Mikawa K, et al. The effects of clonidine and dexmedetomidine on human neutrophil functions. Anesth Analg 1999;88:452-458