α2-Adrenergic agonists reduce glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices during hypoxia

Neuropharmacology

Volumn 35, Issue 6, 1996, Pages 679-687

  Bickler, Philip E ^a,b   Hansen, Bonnie M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cerebral protection; Cytosolic free calcium; Hippocampus; NMDA receptor; 2 adrenergic receptors

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; CONOTOXIN; GLUTAMIC ACID; MIVAZEROL; N METHYL DEXTRO ASPARTIC ACID; RAUWOLSCINE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CALCIUM CELL LEVEL; CONTROLLED STUDY; HIPPOCAMPUS; HYPOXIA; INTRACELLULAR RECORDING; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030174951     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(96)84639-9     Document Type: Article

References (30)

1. Albers G. W., Goldberg M. P. and Choi D. W. (1992) Do NMDA antagonists prevent neuronal injury? Yes. Arch. Neurol. 49 (4): 418-420.
2. Ascher P. and Nowak L. (1987) Electrophysiological studies of NMDA receptors. Trends Neurosci. 10: 284-288.
3. Bickler P. E., Gallego S. M. and Hansen B. M. (1993) Developmental changes in intracellular calcium regulation in rat cerebral cortex during hypoxia. J. Cereb. Blood Flow Metab. 13 (5): 811-819.
4. Bickler P. E. and Hansen B. M. (1994) Causes of calcium accumulation in rat cortical brain slices during hypoxia and ischemia: role of ion channels and membrane damage. Brain Res. 665 (2): 269-276.
5. Bloor B. (1993) General pharmacology of alpha-2 adrenoceptors. Anesthetic Pharm. Rev. 1: 221-232.
6. 2+-channel blocker prevents CA1 injury 24 h following severe forebrain ischemia and reduces infarction volume following focal ischemia. J. Cereb. Blood Flow Metab. 14: 903-910.
7. Choi D. W. (1990a) Cerebral hypoxia: Some new approaches and unanswered questions. J. Neurosci. 10(8): 2493-2501.
8. Choi D. W. (1990b) Limitations of in vitro models of ischemia. Prog. Clin. Biol. Res. 361: 291-299.
9. Dodt H. U., Pawelzik H. and Zieglgansberger W. (1991) Actions of noradrenaline on neocortical neurons in vitro. Brain Res. 545 (1-2): 307-311.
10. Doze V. A., Chen B. X., Tinklenberg J. A., Segal I. S. and Maze M. (1990) Pertussis toxin and 4-aminopyridine differentially affect the hypnotic-anesthetic action of dexmedetomidine and pentobarbital. Anesthesiology 73 (2): 304-307.
11. Globus M. Y., Busto R., Dietrich W. D., Martinez E., Valdes I. and Ginsberg M. D. (1989) Direct evidence for acute and massive norepinephrine release in the hippocampus during transient ischemia. J. Cereb. Blood Flow Metab. 9 (6): 892-896.
12. 2+ indicators with greatly improved fluorescence properties. J. Biol Chem. 260: 3440-3450.
13. Guo T. Z., Tinklenberg J., Oliker R. and Maze M. (1991) Central alpha 1-adrenoceptor stimulation functionally antagonizes the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Anesthesiology 75 (2): 252-256.
14. Gustafson I., Westerberg E. J. and Wieloch T. (1991) Extracellular brain cortical levels of noradrenaline in ischemia: effects of desipramine and postischemic administration of idazoxan. Exp. Brain Res. 86 (3): 555-561.
15. Heal D. J., Butler S. A., Prow M. R. and Buckett W. R. (1993) Quantification of presynaptic alpha 2-adrenoceptors in rat brain after short-term DSP-4 lesioning. Eur. J. Pharmacol. 249 (1): 37-41.
16. Hoffman W. E., Kochs E., Werner C., Thomas C. and Albrecht R. F. (1991) Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole. Anesthesiology 75 (2): 328-332.
17. Kamisaki Y., Hamahashi T., Hamada T., Maeda K. and Itoh T. (1992) Presynaptic inhibition by clonidine of neurotransmitter amino acid release in various brain regions. Eur. J. Pharmacol. 217 (1): 57-63.
18. Lipscombe D., Kongasamut S. and Tsien R. W. (1989) Alpha-adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium channel gating. Nature 340: 639-642.
19. Madison D. V. and Nicoll R. A. (1986) Actions of noradrenaline recorded intracellularly in rat hippocampal pyramidal neurons, in vitro. J. Physiol. 372: 221-244.
20. Maiese K., Pek L., Berger S. B. and Reis D. J. (1992) Reduction in focal cerebral ischemia by agents acting at imidazole receptors. J. Cereb. Blood Flow Metab. 12 (1): 53-63.
21. Matsumoto M., Zornow M. H., Rabin B. C. and Maze M. (1993) The alpha-2 adrenergic agonist, dexmedetomidine, selectively atttenuates ischemia-induced increases in striatal norepinephrine concentrations. Brain Res. 627: 325-329.
22. 2+ and energy levels during in vitro ischemia in the gerbil hippocampal slice. J. Neurochem. 62: 626-634.
23. Miyazaki M., Nazarali A. J., Boisvert D. P., Bayens-Simmonds J. and Baker G. B. (1989) Inhibition of ischemia-induced brain catecholamine alterations by clonidine. Brain Res. Bull. 22 (2): 207-211.
24. Mori-Okamoto J., Namii Y. and Tatsuno J. (1991) Subtypes of adrenergic receptors and intracellular mechanisms involved in modulatory effects of noradrenaline on glutamate. Brain Res. 539: 67-75.
25. North R. and Williams J. (1985) On the potassium conductance increased by opiods in rat locus coeruleus neurones. J. Physiol. 364: 265-280.
26. Scheinin M., Lomasney J. W., Hayden-Hixson D. M., Schambra U. B., Caron M. G. and Lefkowitz R. J. (1994) Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain. Brain Res. molec. Brain Res. 21: 133-149.
27. Shibata S., Kodama K., Tominaga K., Ueki S. and Watanabe S. (1992) Assessment of the role of adrenoceptor function in ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potential in rat hippocampal slices. Eur. J. Pharmacol. 221: 255-260.
28. Szatkowski M. and Attwell D. (1994) Triggering and execution of neuronal death in brain ischemia: two phases of glutamate release by different mechanisms. Trends Neurosci. 17: 359-365.
29. Wu L. G. and Saggau P. (1994) Pharmacological identification of two types of presynaptic voltage-dependent calcium channels at CA3-CA1 synapses of the hippocampus. J. Neurosci. 14: 5613.
30. 2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters. Neuron 6: 333-344.