Are mould hepatotoxins responsible for kava hepatotoxicity?

Phytotherapy Research

Volumn 26, Issue 11, 2012, Pages 1768-1770

  Rowe, Anthony ^a   Ramzan, Iqbal ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

aflatoxin; hepatotoxicity; kava; mould

Indexed keywords

AFLATOXIN; FLAVOKAVAIN B; KAVALACTONE DERIVATIVE; PIPERMETHYSTINE; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG;

AFLATOXICOSIS; ARTICLE; BACILLUS; BACTERIUM CONTAMINATION; BEVERAGE; CELLULOMONAS; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); DISEASE ASSOCIATION; DRUG IMPURITY; DRUG USE; ENTEROCOCCUS; EVIDENCE BASED MEDICINE; FOOD CONTAMINATION; HUMAN; LACTIC ACID BACTERIUM; LIVER CELL CARCINOMA; LIVER HEMORRHAGE; LIVER NECROSIS; LIVER TOXICITY; MOULD; PECTOBACTERIUM; PIPER METHYSTICUM; PSEUDOMONAS; PUBLIC HEALTH; RHIZOME; STAPHYLOCOCCUS; YEAST;

AFLATOXINS; DRUG-INDUCED LIVER INJURY; FUNGI; HUMANS; KAVA;

PIPER METHYSTICUM;

EID: 84867861733     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4620     Document Type: Article

References (33)

1. Brown AC, Onopa J, Holck P, et al,. 2007. Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii. Clin Toxicol 45: 549-556.
2. Clough AR, Bailie RS, Currie B,. 2003a. Liver function test abnormalities in users of aqueous kava extracts. J Toxicol Clin Toxicol 41: 821-829.
3. Clough AR, Jacups SP, Wang Z, et al,. 2003b. Health effects of kava use in an eastern Arnhem Land Aboriginal community. Intern Med J 33: 336-340.
4. Dong J, Kandukuru P, Huang AS, Li Y,. 2011. PCR-DGGE analysis of bacterial community dynamics in kava beverages during refrigeration. Lett Appl Microbiol 53: 30-34.
5. Dragull K, Yoshida WY, Tang C-S,. 2003. Piperidine alkaloids from Piper methysticum. Phytochemistry 63: 193-198.
6. Escher M, Desmeules J, Giostra E, Mentha G,. 2001. Hepatitis associated with Kava, a herbal remedy for anxiety. Br Med J 322: 139.
7. Everley RA, Ciner FL, Zhan D, Scholl PF, Groopman JD, Croley TR,. 2007. Measurement of aflatoxin and aflatoxin metabolites in urine by liquid chromatography-tandem mass spectrometry. J Anal Toxicol 31: 150-156.
8. Fu PP, Xia Q, Guo L, Yu H, Chan P-C,. 2008a. Toxicity of kava kava. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 26: 89-112.
9. Fu S, Korkmaz E, Braet F, Ngo Q, Ramzan I,. 2008b. Influence of kavain on hepatic ultrastructure. World J Gastroenterol 14: 541-546.
10. Henry SH, Bosch FX, Bowers JC,. 2002. Aflatoxin, hepatitis and worldwide liver cancer risks. Adv Exp Med Biol 504: 229-233.
11. Jhoo JW, Freeman JP, Heinze TM, et al,. 2006. In vitro cytotoxicity of nonpolar constituents from different parts of kava plant (Piper methysticum). J Agr Food Chem 54: 3157-3162.
12. Kandukuru P, Huang AS, Dong J, Bittenbender HC, Li Y,. 2009. Rapid identification of bacterial isolates from aqueous kava (Piper methysticum) extracts by polymerase chain reaction and DNA sequencing. Lett Appl Microbiol 49: 764-768.
13. Lim STS, Dragull K, Tang C-S, Bittenbender HC, Efird JT, Nerurkar PV,. 2007. Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344rats. Toxicol Sci 97: 214-221.
14. Liu Y, Wu F,. 2010. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environ Health Perspect 118: 818-824.
15. McCoy LF, Scholl PF, Sutcliffe AE, et al,. 2008. human aflatoxin albumin adducts quantitatively compared by ELISA, HPLC with fluorescence detection, and hplc with isotope dilution mass spectrometry. Cancer Epidemiol Biomarkers Prev 17: 1653-1657.
16. Nerurkar PV, Dragull K, Tang C-S,. 2004. In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones. Toxicol Sci 79: 106-111.
17. Norton SA, Ruze P,. 1994. Kava dermopathy. J Am Acad Dermatol 31: 89-97.
18. Probst C, Njapau H, Cotty PJ,. 2007. Outbreak of an acute aflatoxicosis in Kenya in 2004: Identification of the causal agent. Appl Environ Microbiol 73: 2762-2764.
19. Russmann S, Lauterburg BH, Helbling A,. 2001. Kava hepatotoxicity. Ann Intern Med 135: 68-69.
20. Strosnider H, Azziz-Baumgartner E, Banziger M, et al,. 2006. Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries. Environ Health Perspect 114: 1898-1903.
21. Tang J, Dunlop RA, Rowe A, Rodgers KJ, Ramzan I,. 2010. Kavalactones yangonin and methysticin induce apoptosis in human hepatocytes (HepG2) in vitro. Phytother Res 25: 417-423.
22. Teschke R, Qiu SX, Xuan TD, Lebot V,. 2011. Kava and kava hepatotoxicity: requirements for novel experimental, ethnobotanical and clinical studies based on a review of the evidence. Phytother Res 25: 1263-1274.
23. Teschke R, Sarris J, Schweitzer I,. 2012. Kava hepatotoxicity in traditional and modern use: The presumed Pacific kava paradox hypothesis revisited. Br J Clin Pharmacol 73: 170-174.
24. Trucksess M, Weaver C, Oles C, D'Ovidio K, Rader J,. 2006. Determination of aflatoxins and ochratoxin A in ginseng and other botanical roots by immunoaffinity column cleanup and liquid chromatography with fluorescence detection. J AOAC Int 89: 624-630.
25. Trucksess MW, Scott PM,. 2008. Mycotoxins in botanicals and dried fruits: A review. Food Add Contam Part A 25: 181-192.
26. Ulbricht C, Basch E, Boon H, et al,. 2005. Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration. Expert Opin Drug Saf 4: 779-794.
27. Villar S, Le Roux-Goglin E, Gouas DA, et al,. 2011. Seasonal variation in TP53 R249S-mutated serum DNA with aflatoxin exposure and hepatitis B virus infection. Environ Health Perspect 119: 1635-1640.
28. Weaver C, Trucksess M,. 2010. Determination of aflatoxins inbotanical roots by a modification of AOAC Official Method 991.31: single-laboratory validation. J AOAC Int 93: 184-189.
29. Whitton PA, Lau A, Salisbury A, Whitehouse J, Evans CS,. 2003. Kava lactones and the kava-kava controversy. Phytochemistry 64: 673-679.
30. Williams JH, Phillips TD, Jolly PE, Stiles JK, Jolly CM, Aggarwal D,. 2004. Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. Am J Clin Nutr 80: 1106-1122.
31. Xuan T, Fukuta M, Wei A, Elzaawely A, Khanh T, Tawata S,. 2008. Efficacy of extracting solvents to chemical components of kava (Piper methysticum) roots. J Nat Med 62: 188-194.
32. Zhang LY, Rowe A, Ramzan I,. 2011. Does inflammation play a role in kava hepatotoxicity? Phytother Res 25: 629-630.
33. Zhou P, Gross S, Liu J-H, et al,. 2010. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kB and MAPK signaling pathways. FASEB J 24: 4722-4732.