Intravenous lornoxicam is more effective than paracetamol as a supplemental analgesic after lower abdominal surgery: A randomized controlled trial

World Journal of Surgery

Volumn 36, Issue 9, 2012, Pages 2039-2044

  Mowafi, Hany A ^a   Elmakarim, Ehab Abou ^a   Ismail, Salah ^b   Al Mahdy, Mohammed ^a   El Saflan, Abd Elhady ^a   Elsaid, Ayman S ^a  

^a IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY   (Saudi Arabia)

^b Suez Canal University Faculty of Medicine   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; DRUG DERIVATIVE; LORNOXICAM; MORPHINE; PARACETAMOL; PIROXICAM;

ABDOMEN; ABDOMINAL SURGERY; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; MIDDLE AGED; PAIN ASSESSMENT; PATIENT CONTROLLED ANALGESIA; POSTOPERATIVE PAIN; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; UROLOGIC SURGERY;

ABDOMEN; ACETAMINOPHEN; ADULT; AGED; ANALGESIA, PATIENT-CONTROLLED; ANALGESICS; DIGESTIVE SYSTEM SURGICAL PROCEDURES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; MORPHINE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PIROXICAM; PROSPECTIVE STUDIES; UROGENITAL SURGICAL PROCEDURES;

EID: 84867845864     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-012-1649-2     Document Type: Article

References (31)

1. Keita H, Tubach F, Maalouli J et al (2008) Age-adapted morphine titration produces equivalent analgesia and adverse effects in younger and older patients. Eur J Anaesthesiol 25:352-356
2. Jin F, Chung F (2001) Multimodal analgesia for postoperative pain control. J Clin Anesth 13:524-539
3. Kehlet H, Wilmore DW (2002) Multimodal strategies to improve surgical outcome. Am J Surg 183:630-641
4. Nuutinen LS, Laitinen JO, Salomaki TE (1993) A risk-benefit appraisal of injectable NSAIDs in the management of postoperative pain. Drug Safety 9:380-393
5. Smith HS (2011) Perioperative intravenous acetaminophen and NSAIDs. Pain Med 12:961-981
6. Karaman Y, Kebapci E, Gurkan A (2008) The preemptive analgesic effect of lornoxicam in patients undergoing major abdominal surgery: a randomised controlled study. Int J Surg 6:193-196
7. Kocaayan E, Ozkardeler S, Ozzeybek D et al (2007) Comparison of effects of preoperatively administered lornoxicam and tenoxicam on morphine consumption after laparoscopic cholecystectomy. Eur J Anaesthesiol 24:714-719
8. Gorocs TS, Lambert M, Rinne T et al (2009) Efficacy and tolerability of ready-to-use intravenous paracetamol solution as monotherapy or as an adjunct analgesic therapy for postoperative pain in patients undergoing elective ambulatory surgery: open, prospective study. Int J Clin Pract 63:112-120
9. Atef A, Fawaz AA (2008) Intravenous paracetamol is highly effective in pain treatment after tonsillectomy in adults. Eur Arch Otorhinolaryngol 265:351-355
10. Kemppainen T, Kokki H, Tuomilehto H et al (2006) Acetaminophen is highly effective in pain treatment after endoscopic sinus surgery. Laryngoscope 116:2125-2128
11. Hernandez-Palazon J, Tortosa JA, Martinez-Lage JF et al (2001) Intravenous administration of propacetamol reduces morphine consumption after spinal fusion surgery. Anesth Analg 92:1473-1476
12. Peduto VA, Ballabio M, Stefanini S (1998) Efficacy of propacetamol in the treatment of postoperative pain. Morphine-sparing effect in orthopedic surgery. Italian collaborative group on propacetamol. Acta Anaesthesiol Scand 42:293-298
13. Cakan T, Inan N, Culhaoglu S et al (2008) Intravenous paracetamol improves the quality of postoperative analgesia but does not decrease narcotic requirements. J Neurosurg Anesthesiol 20:169-173
14. Ozhan C, Ozhan MO, Suzer MA et al (2010) Lornoxicam versus paracetamol: effects on endocrine stress response at the postoperative period. Eur J Anaesthesiol 27:223
15. Korkmaz Dilmen O, Tunali Y, Cakmakkaya OS et al (2010) Efficacy of intravenous paracetamol, metamizol and lornoxicam on postoperative pain and morphine consumption after lumbar disc surgery. Eur J Anaesthesiol 27:428-432
16. Ramsay MA, Savege TM, Simpson BR et al (1974) Controlled sedation with alphaxalone-alphadolone. BMJ 2:656-659
17. Jiao H, Ren F (2009) Pretreatment with lornoxicam, a cyclooxygenase inhibitor, relieves postoperative immuno-suppression after total abdominal hysterectomy. Tohoku J Exp Med 219:289-294
18. Xuerong Y, Yuguang H, Xia J et al (2008) Ketamine and lornoxicam for preventing a fentanyl-induced increase in postoperative morphine requirement. Anesth Analg 107:2032-2037
19. Sapolya O, Karamanhoglu B, Memis D (2007) Analgesic effects of lornoxicam after total abdominal hysterectomy. J Opioid Manag 3:155-159
20. Rosenow DE, Albrechtsen M, Stolke D (1998) A comparison of patient-controlled analgesia with lornoxicam versus morphine in patients undergoing lumbar disk surgery. Anesth Analg 86: 1045-1050
21. Rosenow DE, Kreiken F, Stolke D et al (1996) Intravenous administration of lornoxicam, a new NSAID and pethidine for postoperative pain. Clin Drug Investig 11:11-19
22. Hitzenberger G, Radhofer-Welte F, Takacs F et al (1990) Pharmacokinetics of lornoxicam in man. Postgrad Med J 66:22-27
23. Likar R, Krumpholz R, Mathiaschitz K et al (1997) The preemptive action of ketoprofen: randomized, double-blind study with gynecologic operation. Anaesthesist 46:186-190
24. Trampitsch E, Pipam W, Moertl M et al (2003) Preemptive randomized, double-blind study with lornoxicam in gynecological surgery. Schmerz 17:4-10
25. Kullich W, Klein G (1992) Ausschuttung der korpereigenen. Opiatpeptide Dynorphin und b-Endorphin unter dem Einflub des nichtsteroidalen Antirheumatikums Lornoxicam i.v. Akt Rheumatol 17:128-132
26. White PF (2005) The changing role of non-opioid analgesic techniques in the management of postoperative pain. Anesth Analg 101(5 Suppl):S5-S22
27. Norholt SE, Sindet-Pedersen S, Bugge C et al (1995) A randomized, double-blind, placebo-controlled, dose-response study of the analgesic effect of lornoxicam after surgical removal of mandibular third molars. J Clin Pharmacol 35:606-615
28. Takmaz SA, Inan N, Goktug A et al (2008) The analgesic effect of 8 and 16 mg lornoxicam administered before shock wave lithotripsy: a randomized, double-blind, controlled study. Urology 72:282-285
29. Mowafi HA, Telmessani L, Ismail SA et al (2011) Preoperative lornoxicam for pain prevention after tonsillectomy in adults. J Clin Anesth 23:97-101
30. Ismail SA, Mowafi HA (2010) Preoperative peritonsillar lornoxicam infiltration is not superior to intravenous lornoxicam for pain relief following tonsillectomy in adults. Eur J Anaesthesiol 27:807-811
31. Maund E, McDaid C, Rice S et al (2011) Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery: a systematic review. Br J Anaesth 106:292-297