Intravenous Administration of Lornoxicam, a New NSAID, and Pethidine for Postoperative Pain a Placebo-Controlled Pilot Study

Clinical Drug Investigation

Volumn 11, Issue 1, 1996, Pages 11-19

  Rosenow, Detlef E ^a   Van Krieken, Frans ^a   Stolke, Dietmar ^a   Kursten, Friedrich W ^b  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b Nycomed Holdings AS   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; LORNOXICAM; NONSTEROID ANTIINFLAMMATORY AGENT; PETHIDINE;

ADULT; ANALGESIA; ARTICLE; BRADYCARDIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; NAUSEA; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; VOMITING;

EID: 0030071385     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-199611010-00002     Document Type: Article

References (18)

1. Brune K, Menzel-Soglowek S, Zeilhofer HU. Differential analgesic effects of aspirin-like drugs. Drugs 1992; 44 Suppl. 5: 52-9
2. Catania A, Arnold J, Macaluso A, et al. Inhibition of acute inflammation in the periphery by central action of salicylates. Proc Natl Acad Sci USA 1991; 88: 8544-7
3. Okuyama S, Aihara H. The mode of action of analgesic drugs in adjuvant arthritic rats as an experimental model of chronic inflammatory pain: possible central analgesic action of acidic nonsteroidal antiinflammatory drugs. Jpn J Pharmacol 1984; 35: 95-103
4. Hodsman NBA, Burns J, Blyth A, et al. The morphine sparing effects of diclofenac sodium after surgery. Anaesthesia 1987; 42: 1005
5. Moote C. Efficacy of nonsteroidal anti-inflammatory drugs in the management of postoperative pain. Drugs 1992; 44 Suppl. 5: 14-30
6. Stubbs DF, Freeman BE, Johnson JH. Efficacy of flurbiprofen for nonarthritic pain. Curr Ther Res 1989; 46: 1179-95
7. Todd PA, Clissold SP. Naproxen: a reappraisal of its pharmacology and therapeutic use in rheumatic diseases and pain states. Drugs 1990; 40: 91-137
8. Buckley M-T, Brogden RN. Ketorolac: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential. Drugs 1990; 39: 86-109
9. Camu F, Van Lersberghe C, Lauwers MH. Cardiovascular risks and benefits of perioperative nonsteroidal anti-inflammatory drug treatment. Drugs 1992; 44 Suppl. 5: 42-51
10. Kahlet H, Dahl JB. Are perioperative nonsteroidal anti-inflammatory drugs ulcerogenic in the short term? Drugs 1992; 44 Suppl. 5: 38-41
11. Kenny GNC. Potential renal, haematological and allergic adverse effects associated with nonsteroidal anti-inflammatory drugs. Drugs 1992; 44 Suppl. 5: 31-7
12. Stroissnig H, Frenzel W. Lornoxicam. A novel highly potent anti-inflammatory and analgesic agent. Clinical Investigator's Brochure. 6th ed. Vienna: Hafslund Nycomed Pharma AG, 1992
13. Ross DA, Drasner K, Weinstein PR, et al. Use of intrathecally administered morphine in the treatment of postoperative pain after lumbar spinal surgery: a prospective, double-blind, placebo-controlled study. Neurosurgery 1991; 28: 700-4
14. Ozuna J, Burchiel KJ, Pencek T. Routine use of epidural morphine in patients following lumbar spine surgery. Clin J Pain 1988; 4: 209-12
15. Rechtine GR, Love LC. Postoperative laminectomy pain control using bupivacaine and epidural morphine. Orthopedics 1986; 9: 1711-2
16. Rechtine GR, Reinert CM. The use of epidural morphine to decrease postoperative pain in patients undergoing lumbal laminectomy. J Bone Joint Surg 1984; 66: 113-6
17. King JS. Dexamethasone - a helpful adjunct in management after lumbar discectomy. Neurosurgery 1984; 14: 697-700
18. Max MB, Portenoy RK, Laska EM, editors. Advances in pain research and therapy: the design of analgesic clinical trials. Vol. 18. New York: Raven Press, 1991