Age-adapted morphine titration produces equivalent analgesia and adverse effects in younger and older patients

European Journal of Anaesthesiology

Volumn 25, Issue 5, 2008, Pages 352-356

  Keita, H ^a,c   Tubach, F ^b   Maalouli, J ^b   Desmonts, J M ^b   Mantz, J ^a  

^a HÔPITAL LOUIS MOURIER   (France)

^b BICHAT HOSPITAL   (France)

^c Department of Anaesthesia ^*  (France)

Author keywords

Age groups; Aged; Morphine; Pain postoperative; Postoperative period

Indexed keywords

MORPHINE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; INCIDENCE; KIDNEY CLEARANCE; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; RATING SCALE; RECOVERY ROOM; SEDATION; SIDE EFFECT;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANALGESICS, OPIOID; AREA UNDER CURVE; CLINICAL PROTOCOLS; FEMALE; HUMANS; KIDNEY FUNCTION TESTS; MALE; MIDDLE AGED; MORPHINE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 41549089310     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1017/S0265021507003080     Document Type: Article

References (28)

1. Clergue F, Auroy Y, Péquignot F, Jougla E, Lienhart A, Laxemarie MC. French survey of anaesthesia in 1996. Anesthesiology 1999; 91: 1509-1520.
2. Rooke GA, Reves JG, Rosow C. Anesthesiology and geriatric medicine (editorial). Anesthesiology 2002; 96: 2-4.
3. Berry HB, Chapman CR, Covington EC et al. Pain: current understanding of assessment, management, and treatments. National Pharmaceutical Council, Inc. Joint Commission on Accreditation of Healthcare Organizations, December 2001.
4. Ferrell BR, Shaffner M. Pharmacoeconomics and medical outcomes in pain management. Semin Anesth 1997; 16: 152-159.
5. Karani R, Meier DE. Systemic pharmacologic postoperative pain management in the geriatric orthopaedic patient. Clin Orthop 2004; 425: 26-34.
6. Edward WT, Breed RJ. The treatment of acute postoperative pain in postanesthesia care unit. Anesthesiol Clin 1990; 8: 235-265.
7. Dahmani S, Dupont H, Mantz J, Desmonts JM, Keita H. Predictive factors of early morphine requirements in the post-anaesthesia care unit (PACU). Br J Anaesth 2001; 87: 385-389.
8. Aubrun F, Monsel S, Langeron O, Coriat P, Riou B. Postoperative titration of intravenous morphine. Eur J Anaesthesiol 2001; 18: 159-165.
9. Aubrun F, Monsel S, Langeron O, Coriat P, Riou B. Postoperative titration of intravenous morphine in the elderly patient. Anesthesiology 2002; 96: 17-23.
10. Paqueron X, Lumbroso A, Mergoni P et al. Is morphine-induced sedation synonymous with analgesia during intravenous morphine titration? Br J Anaesth 2002; 89: 697-701.
11. Gagliese L, Jakson M, Ritvo P, Wowk A, Katz J. Age is not an impediment to effective use of patient-controlled analgesia by surgical patients. Anesthesiology 2000; 93: 601-610.
12. Macintyre PE, Jarvis DA. Age is the best predictor of postoperative morphine requirements. Pain 1995; 64: 357-364.
13. Keita H, Geachan N, Dahmani S et al. Comparison between patient-controlled analgesia and subcutaneous morphine in elderly patients after total hip replacement. Br J Anaesth 2003; 90: 53-57.
14. Pico L, Hernot S, Zlotine N, Nègre I, Samii K, Fletcher D. Peroperative titration of morphine for postoperative analgesia after total hip arthroplasty. Can J Anaesth 2000; 47: 309-314.
15. Owen JA, Sitar DS, Berger L, Brwnell L, Duke PC, Mitenko PA. Age-related morphine kinetics. Clin Pharmacol Ther 1983; 34: 364-368.
16. Burns JW, Hodsman NBA, McLintock TTC, Gillies GWA, Kenny GNC, McArdle CS. The influence of patient characteristics on the requirements for postoperative analgesia. Anaesthesia 1989; 44: 2-6.
17. Wall RT. Use of analgesics in the elderly. Clin Geriatr Med 1990; 6: 345-364.
18. Kaiko RF. Age and morphine analgesia in cancer patients with postoperative pain. Clin Pharmacol Ther 1980; 28: 823-826.
19. Kaiko RF, Wallenstein SL, Rogers AG, Grabinski PY, Houde RW. Narcotics in the elderly. Med Clin North Am 1982; 66: 1079-1089.
20. Belleville JW, Forrest WH, Miller E, Brown BW. Influence of age on pain relief from analgesics. JAMA 1971; 217: 1835-1841.
21. Muravchick S. Anesthesia for the elderly. In: Miller RD, ed. Anesthesia, 4th edn. New York, NY: Churchill Livingstone, 1994: 2143-2156.
22. Osborne R, Joel S, Grbenik K, Trew D, Slevin M. The pharmacokinetics of morphine and morphine glucuronides in kidney failure. Clin Pharmacol Ther 1993; 54: 158-167.
23. Chauvin C, Sandouk P, Scherrmann JM, Farinotti R, Strumza P, Duvaldestin P. Morphine pharmacokinetics in renal failure. Anesthesiology 1987; 66: 327-331.
24. Kalkman CJ, Visser K, Moen J, Bonsel GJ, Grobbee DE, Moons KG. Preoperative prediction of severe postoperative pain. Pain 2003; 105: 415-423.
25. Bisgaard T, Klarskov B, Rosenberg J, Kehlet H. Characteristics and prediction of early pain after laparoscopic cholecystectomy. Pain 2001; 90: 261-269.
26. Gagliese L, Katz J. Age differences in postoperative pain are scale dependent: a comparison of measures of pain intensity and quality in younger and older surgical patients. Pain 2003; 103: 11-20.
27. Gagliese L, Weizblit N, Ellis W, Chan VWS. The measurement of postoperative pain: a comparison of intensity scales in younger and older surgical patients. Pain 2005; 117: 412-420.
28. Aubrun F, Salvi N, Coriat P, Riou B. Sex- and age-related differences in morphine requirements for postoperative pain relief. Anesthesiology 2005; 103: 156-160.