On the different roles of AT 1 and AT 2 receptors in stretch-induced changes of connexin43 expression and localization

Pflugers Archiv European Journal of Physiology

Volumn 464, Issue 5, 2012, Pages 535-547

  Salameh, Aida ^a   Apel, Daniel ^a   Gonzalez Casanova, Jorge ^a   Von Salisch, Sandy ^a   Mohr, Friedrich Wilhelm ^a   Daehnert, Ingo ^a   Dhein, Stefan ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Angiotensin II; Angiotensin receptors; Cx43; Stretch

Indexed keywords

1 (4 AMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDROIMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; CONNEXIN 43; LOSARTAN; MESSENGER RNA; ANGIOTENSIN 1 RECEPTOR ANTAGONIST;

ANIMAL CELL; ARTICLE; BIOMECHANICS; CELL ELONGATION; CONTROLLED STUDY; CX43 GENE; CYCLIC MECHANICAL STRETCH; GENE; GENE EXPRESSION REGULATION; HEART CELL CULTURE; IMMUNOHISTOLOGY; NEWBORN; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR BLOCKING; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; GENETICS; HEART MUSCLE CELL; MECHANICAL STRESS; MECHANOTRANSDUCTION; METABOLISM;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; CONNEXIN 43; GENE EXPRESSION REGULATION; LOSARTAN; MECHANOTRANSDUCTION, CELLULAR; MYOCYTES, CARDIAC; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RNA, MESSENGER; STRESS, MECHANICAL;

EID: 84867845760     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-012-1161-4     Document Type: Article

References (43)

1. Barac DY, Reisner Y, Silberman M, Zeevi-Levin N, Danon A, Salomon O, Shoham M, Shilkrut M, Kostin S, Schaper J, Binah O (2008) Mechanical load induced by glass microspheres releases angiogenic factors from neonatal rat ventricular myocytes cultures and causes arrhythmias. J Cell Mol Med 12:2037-2051
2. Beardslee MA, Laing JG, Beyer EC, Saffitz JE (1998) Rapid turnover of connexin 43 in the adult rat heart. Circ Res 83:629-653
3. Boldt A, Scholl A, Garbade J, Resetar ME, Mohr FW, Gummert JF, Dhein S (2006) ACE-inhibitor treatment attenuates atrial structural remodeling in patients with lone chronic atrial fibrillation. Basic Res Cardiol 101:261-267
4. Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF, Kitsis RN, Molkentin JD (2000) The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J 19:6341-6350
5. Chiu AT, Herblin WF, McCall DE, Ardecky RJ, Carini DJ, Duncia JV, Pease LJ, Wong PC, Wexler RR, Johnson AL, Pieter BMWM (1989) Identification of angiotensin II receptor subtypes. Biochem Biophys Res Commun 165:196-203
6. Davis LM, Rodefeld ME, Green K, Beyer EC, Saffitz JE (1995) Gap junction protein phenotypes of the human heart and conduction system. J Cardiovasc Electrophysiol 6:813-822
7. De Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T (2000) International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 52:415-472
8. Dhein S, Rothe S, Busch A, Rojas Gomez DM, Boldt A, Reutemann A, Seidel T, Salameh A, Pfannmüller B, Rastan A, Kostelka M, Mohr FW (2011) Effects of metoprolol therapy on cardiac gap junction remodelling and conduction inhuman chronic atrial fibrillation. Br J Pharmacol 164:607-616
9. Dodge SM, Beardslee MA, Darrow BJ, Green KG, Beyer EC, Saffitz JE (1998) Effects of angiotensin II on expression of the gap junction channel protein connexin43 in neonatal rat ventricular myocytes. J Am Coll Cardiol 32:800-807
10. Dostal DE, Rothblum KN, Conrad KM, Cooper GR, Baker KM (1992) Detection of angiotensin I and II in cultured rat cardiac myocytes and fibroblasts. Am J Physiol 263:C851-C863
11. Duarte DR, Minicucci MF, Azevedo PS, Chiuso-Minicucci F, Matsubara BB, Matsubara LS, Campana AO, Paiva SA, Zornoff LA (2010) Influence of lisinopril on cardiac remodeling induced by tobacco smoke exposure. Med Sci Monit 16:BR255-BR259
12. Dupont E, Matsushita T, Kaba RA, Vozzi C, Coppen SR, Kahn N, Kaprielian R, Yacoub MH, Severs NJ (2001) Altered connexin expression in human congestive heart failure. J Mol Cell Cardiol 33:359-371
13. Inoue N, Ohkusa T, Nao T, Lee JK, Matsumoto T, Hisamatsu Y, Satoh T, Yano M, Yasui K, Kodama I, Matsuzaki M (2004) Rapid electrical stimulation of contraction modulates gap junction protein in neonatal rat cultured cardiomyocytes: involvement of mitogenactivated protein kinases and effects of angiotensin II-receptor antagonist. J Am Coll Cardiol 44:914-922
14. Ishida J, Kai M, Ohkura Y (1986) High-performance liquid chromatography of tyrosine-containing peptides by pre-column derivatization involving formylation followed by fluorescence reaction with 1,2-diamino-4,5- dimethoxybenzene. J Chromatogr 356:171-177
15. Jozwiak J, Dhein S (2008) Local effects and mechanisms of antiarrhythmic peptide AAP10 in acute regional myocardial ischemia: electrophysiological and molecular findings. Naunyn Schmiedebergs Arch Pharmacol 378:459-470
16. KijimaK,Matsubara H,Murasawa S,Maruyama K,Mori Y, Ohkubo N, Komuro I, Yazaki Y, Iwasaka T, Inada M (1996) Mechanical stretch induces enhanced expression of angiotensin II receptor subtypes in neonatal rat cardiac myocytes. Circ Res 79:887-897
17. Kitamura H, Ohnishi Y, Yoshida A, Okajima K, Azumi H, Ishida A, Galeano EJ, Kubo S, Hayashi Y, Itoh H, Yokoyama M (2002) Heterogeneous loss of connexin43 protein in nonischemic dilated cardiomyopathy with ventricular tachycardia. J Cardiovasc Electrophysiol 13:865-870
18. Kostin S (2007) Zonula occludens-1 and connexin 43 expression in the failing human heart. J Cell Mol Med 11:892-895
19. Kostin S, Dammer S, Hein S, Klovelorn WP, Bauer EP, Schaper J (2004) Connexin 43 expression and distribution in compensated and decompensated cardiac hypertrophy in patients with aortic stenosis. Cardiovasc Res 62:426-436
20. Kostin S, Rieger M, Dammer S, Hein S, Richter M, Klövekorn WP, Bauer EP, Schaper J (2003) Gap junction remodeling and altered connexin43 expression in the failing human heart. Mol Cell Biochem 242:135-144
21. Lemarié CA, Schiffrin EL (2010) The angiotensin II type 2 receptor in cardiovascular disease. J Renin Angiotensin Aldosterone Syst 11:19-31
22. Malhotra R, Sadoshima J, Brosius FC III, Izumo S (1999) Mechanical stretch and angiotensin II differentially upregulate the renin-angiotensin system in cardiac myocytes in vitro. Circ Res 85:137-146
23. Peters NS, Severs NJ, Rothery SM, Lincoln C, Yacoub MH, Green CR (1994) Spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium. Circulation 90:713-725
24. Polontchouk L, Ebelt B, Jackels M, Dhein S (2002) Chronic effects of endothelin 1 and angiotensin II on gap junctions and intercellular communication in cardiac cells. FASEB J 16:87-89
25. Polontchouk L, Haefliger J-A, Ebelt B, Schaefer T, Stuhlmann D, Mehlhorn U, Kuhn-Reignier F, DeVivie ER, Dhein S (2001) Effects of chronic atrial fibrillation on gap junction distribution in human and rat atria. J Am Coll Cardiol 38:883-891
26. Reisner Y, Meiry G, Zeevi-Levin N, Barac DY, Reiter I, Abassi Z, Ziv N, Kostin S, Schaper J, Rosen MR, Binah O (2009) Impulse conduction and gap junctional remodelling by endothelin-1 in cultured neonatal rat ventricular myocytes. J Cell Mol Med 13:562-573
27. Sadoshima J, Xu Y, Slayter HS, Izumo S (1993) Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 75:977-984
28. Saffitz JE, Schuessler RB, Yamada KA (1999) Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias. Cardiovasc Res 42:309-317
29. Sakabe M, Fujiki A, Nishida K, Sugao M, Nagasawa H, Tsuneda T, Mizumaki K, Inoue H (2004) Enalapril prevents perpetuation of atrial fibrillation by suppressing atrial fibrosis and over-expression of connexin43 in a canine model of atrial pacing-induced left ventricular dysfunction. J Cardiovasc Pharmacol 43:851-859
30. Salameh A, Dhein S (2012) Effects of mechanical forces and stretch on intercellular gap junction coupling. Biochim Biophys Acta 2012 Jan 4. [Epub ahead of print]
31. Sameh A, Frenzel C, Boldt A, Rassler B, Glawe I, Schulte J, Mühlberg K, Zimmer HG, Pfeiffer D, Dhein S (2006) Subchronic alpha- and beta-adrenergic regulation of cardiac gap junction protein expression. FASEB J 20:365-367
32. Salameh A, Karl S, Djilali H, Dhein S, Janousek J, Daehnert I (2010) Opposing and synergistic effects of cyclic mechanical stretch and α- or β-adrenergic stimulation on the cardiac gap junction protein Cx43. Pharmacol Res 62:506-513
33. Salameh A, Krautblatter K, Baeßler S, Karl S, Rojas Gomez D, Dhein S, Pfeiffer D (2008) Signal transduction and transcriptional control of cardiac connexin43 up-regulation after α1-adrenoceptor stimulation. JPET 326:315-322
34. Salameh A, Krautblatter S, Karl S, Blanke K, Rojas Gomez D, Dhein S, Pfeiffer D, Janousek J (2009) The signal transduction cascade regulating the expression of the gap junction protein connexin43 by β-adrenoceptors. Brit J Pharmacol 158:198-208
35. Salameh A, Wustmann A, Karl S, Blanke K, Apel D, Rojas-Gomez D, Franke H, Mohr FW, Janousek J, Dhein S (2010) Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43. Circ Res 106:1592-1602
36. Sepp R, Severs NJ, Gourdie RG (1996) Altered patterns of cardiac intercellular junction distribution in hypertrophic cardiomyopathy. Heart 76:412-417
37. Shanmugam P, Valente AJ, Prabhu SD, Venkatesan B, Yoshida T, Delafontaine P, Chandrasekar B (2011) Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy. J Mol Cell Cardiol 50:928-938
38. Shimoni Y, Emmett T, Schmidt R, Nygren A, Kargacin G (2009) Sex-dependent impairment of cardiac action potential conduction in type 1 diabetic rats. Am J Physiol Heart Circ Physiol 296: H1442-H1450
39. Shyu KG, Chen CC, Wang BW, Kuan P (2001) Angiotensin II receptor antagonist blocks the expression of connexin43 induced by cyclical mechanical stretch in cultured neonatal rat cardiac myocytes. J Mol Cell Cardiol 33:691-698
40. Yamada K, Green KG, Samarel AM, Saffitz JE (2005) Distinct pathways regulate expression of cardiac electrical and mechanical junction proteins in response to stretch. Circ Res 97:346-353
41. Yamazaki T, Komuro I, Kudoh S, Zou Y, Shiojima I, Mizuno T, Takano H, Hiroi Y, Ueki K, Tobe K, Kadowaki T, Nagai R, Yazaki Y (1995) Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy. Circ Res 77:258-265
42. Yamazaki T, Komuro I, Yazaki Y (1999) Role of the renin-angiotensin system in cardiac hypertrophy. Am J Cardiol 83:53H-57H
43. Yamazaki T, Yazaki Y (1999) Role of tissue angiotensin II in myocardial remodelling induced by mechanical stress. J Hum Hypertens 13:S43-S47