메뉴 건너뛰기




Volumn 54, Issue 1-3, 2012, Pages 266-274

Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer

Author keywords

Head and neck squamous cell carcinoma (HNSCC); Immune suppression; Immunotherapy; Myeloid derived suppressive cells (MDSC); Regulatory T cells; Tumor immunology; Tumor infiltrating lymphocytes; Tumor mediated immunosuppression

Indexed keywords

CELECOXIB; IPILIMUMAB; MAJOR HISTOCOMPATIBILITY ANTIGEN; MONOCLONAL ANTIBODY; SUNITINIB;

EID: 84867841670     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-012-8306-6     Document Type: Article
Times cited : (63)

References (94)
  • 1
    • 78649681592 scopus 로고    scopus 로고
    • Head and neck squamous cell carcinoma: New translational therapies
    • 21105129 10.1002/msj.20216
    • Prince A, et al. Head and neck squamous cell carcinoma: new translational therapies. Mt Sinai J Med. 2010;77(6):684-99.
    • (2010) Mt Sinai J Med , vol.77 , Issue.6 , pp. 684-699
    • Prince, A.1
  • 2
    • 5044220681 scopus 로고    scopus 로고
    • Molecular and clinicopathologic comparisons of head and neck squamous carcinoma variants: Common and distinctive features of biological significance
    • 15371945 10.1097/01.pas.0000138003.46650.dc
    • Choi HR, et al. Molecular and clinicopathologic comparisons of head and neck squamous carcinoma variants: common and distinctive features of biological significance. Am J Surg Pathol. 2004;28(10):1299-310.
    • (2004) Am J Surg Pathol , vol.28 , Issue.10 , pp. 1299-1310
    • Choi, H.R.1
  • 3
    • 33746260370 scopus 로고    scopus 로고
    • Intratumor genomic heterogeneity correlates with histological grade of advanced oral squamous cell carcinoma
    • 16455286 10.1016/j.oraloncology.2005.11.018 1:CAS:528: DC%2BD28XntlGiurY%3D
    • Wang X, et al. Intratumor genomic heterogeneity correlates with histological grade of advanced oral squamous cell carcinoma. Oral Oncol. 2006;42(7):740-4.
    • (2006) Oral Oncol , vol.42 , Issue.7 , pp. 740-744
    • Wang, X.1
  • 4
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • 18039110 10.1146/annurev.pathol.1.110304.100224 1:CAS:528: DC%2BD28XktVOitb0%3D
    • Tlsty TD, Coussens LM. Tumor stroma and regulation of cancer development. Annu Rev Pathol. 2006;1:119-50.
    • (2006) Annu Rev Pathol , vol.1 , pp. 119-150
    • Tlsty, T.D.1    Coussens, L.M.2
  • 5
    • 0034791377 scopus 로고    scopus 로고
    • Cyclin D1 and p16 alterations in advanced premalignant lesions of the upper aerodigestive tract: Role in response to chemoprevention and cancer development
    • 11595705 1:CAS:528:DC%2BD3MXnvF2ku7Y%3D
    • Papadimitrakopoulou VA, et al. Cyclin D1 and p16 alterations in advanced premalignant lesions of the upper aerodigestive tract: role in response to chemoprevention and cancer development. Clin Cancer Res. 2001;7(10):3127-34.
    • (2001) Clin Cancer Res , vol.7 , Issue.10 , pp. 3127-3134
    • Papadimitrakopoulou, V.A.1
  • 6
    • 37349055876 scopus 로고    scopus 로고
    • TP53 mutations and survival in squamous-cell carcinoma of the head and neck
    • 18094376 10.1056/NEJMoa073770 1:CAS:528:DC%2BD2sXhsVKht7rP
    • Poeta ML, et al. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med. 2007;357(25):2552-61.
    • (2007) N Engl J Med , vol.357 , Issue.25 , pp. 2552-2561
    • Poeta, M.L.1
  • 7
    • 33751038688 scopus 로고    scopus 로고
    • 11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours
    • 17003776 10.1038/sj.bjc.6603394 1:CAS:528:DC%2BD28XhtF2ns77I
    • Ragin CC, et al. 11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours. Br J Cancer. 2006;95(10):1432-8.
    • (2006) Br J Cancer , vol.95 , Issue.10 , pp. 1432-1438
    • Ragin, C.C.1
  • 8
    • 34347323902 scopus 로고    scopus 로고
    • Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: A meta-analysis
    • 17617273 10.1016/S0140-6736(07)61050-2
    • Grulich AE, et al. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet. 2007;370(9581):59-67.
    • (2007) Lancet , vol.370 , Issue.9581 , pp. 59-67
    • Grulich, A.E.1
  • 9
    • 0028905258 scopus 로고
    • Increased prevalence of dysplastic and malignant lip lesions in renal-transplant recipients
    • 7898522 10.1056/NEJM199504203321602 1:STN:280:DyaK2M3gs1egsw%3D%3D
    • King GN, et al. Increased prevalence of dysplastic and malignant lip lesions in renal-transplant recipients. N Engl J Med. 1995;332(16):1052-7.
    • (1995) N Engl J Med , vol.332 , Issue.16 , pp. 1052-1057
    • King, G.N.1
  • 10
    • 77649194157 scopus 로고    scopus 로고
    • Effect of reduced immunosuppression after kidney transplant failure on risk of cancer: Population based retrospective cohort study
    • 20150194 10.1136/bmj.c570
    • van Leeuwen MT, et al. Effect of reduced immunosuppression after kidney transplant failure on risk of cancer: population based retrospective cohort study. BMJ. 2010;340:c570.
    • (2010) BMJ , vol.340 , pp. 570
    • Van Leeuwen, M.T.1
  • 11
    • 74849109925 scopus 로고    scopus 로고
    • HPV-induced oropharyngeal cancer, immune response and response to therapy
    • 19628331 10.1016/j.canlet.2009.06.026 1:CAS:528:DC%2BC3cXhtlSjurw%3D
    • Vu HL, et al. HPV-induced oropharyngeal cancer, immune response and response to therapy. Cancer Lett. 2010;288(2):149-55.
    • (2010) Cancer Lett , vol.288 , Issue.2 , pp. 149-155
    • Vu, H.L.1
  • 12
    • 26844579408 scopus 로고    scopus 로고
    • Human leukocyte antigen (HLA) class i defects in head and neck cancer: Molecular mechanisms and clinical significance
    • 16234579 10.1385/IR:33:2:113 1:CAS:528:DC%2BD2MXht1Cls73M
    • Ferris RL, Hunt JL, Ferrone S. Human leukocyte antigen (HLA) class I defects in head and neck cancer: molecular mechanisms and clinical significance. Immunol Res. 2005;33(2):113-33.
    • (2005) Immunol Res , vol.33 , Issue.2 , pp. 113-133
    • Ferris, R.L.1    Hunt, J.L.2    Ferrone, S.3
  • 13
    • 17644413210 scopus 로고    scopus 로고
    • Defects in the human leukocyte antigen class i antigen processing machinery in head and neck squamous cell carcinoma: Association with clinical outcome
    • 15814633 10.1158/1078-0432.CCR-04-2146 1:CAS:528:DC%2BD2MXivFKisro%3D
    • Meissner M, et al. Defects in the human leukocyte antigen class I antigen processing machinery in head and neck squamous cell carcinoma: association with clinical outcome. Clin Cancer Res. 2005;11(7):2552-60.
    • (2005) Clin Cancer Res , vol.11 , Issue.7 , pp. 2552-2560
    • Meissner, M.1
  • 14
    • 79952301912 scopus 로고    scopus 로고
    • T cell-tumor interaction directs the development of immunotherapies in head and neck cancer
    • 21234340 10.1155/2010/236378 1:STN:280:DC%2BC3M7hsFWnug%3D%3D
    • Albers AE, et al. T cell-tumor interaction directs the development of immunotherapies in head and neck cancer. Clin Dev Immunol. 2010;2010:236378.
    • (2010) Clin Dev Immunol , vol.2010 , pp. 236378
    • Albers, A.E.1
  • 15
    • 2942674463 scopus 로고    scopus 로고
    • Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses
    • 15207823 10.1016/j.micinf.2004.03.007 1:CAS:528:DC%2BD2cXltVOgur0%3D
    • Wang S, Chen L. Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses. Microbes Infect. 2004;6(8):759-66.
    • (2004) Microbes Infect , vol.6 , Issue.8 , pp. 759-766
    • Wang, S.1    Chen, L.2
  • 16
    • 33750046899 scopus 로고    scopus 로고
    • Role of cytokines in head and neck squamous cell carcinoma
    • 17020454 10.1586/14737140.6.9.1195 1:CAS:528:DC%2BD28XhtVCntL3N
    • Pries R, Nitsch S, Wollenberg B. Role of cytokines in head and neck squamous cell carcinoma. Expert Rev Anticancer Ther. 2006;6(9):1195-203.
    • (2006) Expert Rev Anticancer Ther , vol.6 , Issue.9 , pp. 1195-1203
    • Pries, R.1    Nitsch, S.2    Wollenberg, B.3
  • 17
    • 33845524970 scopus 로고    scopus 로고
    • Transforming growth factor-beta in cancer and metastasis
    • 16951986 10.1007/s10555-006-9006-2 1:CAS:528:DC%2BD28Xht1yktb3N
    • Jakowlew SB. Transforming growth factor-beta in cancer and metastasis. Cancer Metastasis Rev. 2006;25(3):435-57.
    • (2006) Cancer Metastasis Rev , vol.25 , Issue.3 , pp. 435-457
    • Jakowlew, S.B.1
  • 18
    • 1642554780 scopus 로고    scopus 로고
    • The multifaceted relationship between IL-10 and adaptive immunity: Putting together the pieces of a puzzle
    • 14746814 10.1016/j.cytogfr.2003.11.001 1:CAS:528:DC%2BD2cXmvFKktQ%3D%3D
    • Mocellin S, et al. The multifaceted relationship between IL-10 and adaptive immunity: putting together the pieces of a puzzle. Cytokine Growth Factor Rev. 2004;15(1):61-76.
    • (2004) Cytokine Growth Factor Rev , vol.15 , Issue.1 , pp. 61-76
    • Mocellin, S.1
  • 19
    • 12844278687 scopus 로고    scopus 로고
    • Oral squamous cell carcinoma: Histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival
    • 15644773 10.1097/01.pas.0000149687.90710.21
    • Brandwein-Gensler M, et al. Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. Am J Surg Pathol. 2005;29(2):167-78.
    • (2005) Am J Surg Pathol , vol.29 , Issue.2 , pp. 167-178
    • Brandwein-Gensler, M.1
  • 20
    • 0031953864 scopus 로고    scopus 로고
    • Possible prognostic value of histopathologic parameters in patients with carcinoma of the oral tongue
    • 9592681 10.1007/s004050050046 1:STN:280:DyaK1c3lsFSgtg%3D%3D
    • Hosal AS, Unal OF, Ayhan A. Possible prognostic value of histopathologic parameters in patients with carcinoma of the oral tongue. Eur Arch Otorhinolaryngol. 1998;255(4):216-9.
    • (1998) Eur Arch Otorhinolaryngol , vol.255 , Issue.4 , pp. 216-219
    • Hosal, A.S.1    Unal, O.F.2    Ayhan, A.3
  • 21
    • 77955384579 scopus 로고    scopus 로고
    • Gr-1+ CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung
    • 20631080 10.1158/0008-5472.CAN-10-0706 1:CAS:528:DC%2BC3cXpsVCntLo%3D
    • Yan HH, et al. Gr-1+ CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung. Cancer Res. 2010;70(15):6139-49.
    • (2010) Cancer Res , vol.70 , Issue.15 , pp. 6139-6149
    • Yan, H.H.1
  • 22
    • 5444225991 scopus 로고    scopus 로고
    • Expansion of myeloid immune suppressor Gr+ CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
    • 15488763 10.1016/j.ccr.2004.08.031 1:CAS:528:DC%2BD2cXpsF2rtLo%3D
    • Yang L, et al. Expansion of myeloid immune suppressor Gr+ CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell. 2004;6(4):409-21.
    • (2004) Cancer Cell , vol.6 , Issue.4 , pp. 409-421
    • Yang, L.1
  • 23
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • 19279573 10.1038/nrc2618 1:CAS:528:DC%2BD1MXivFCjsLg%3D
    • Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer. 2009;9(4):239-52.
    • (2009) Nat Rev Cancer , vol.9 , Issue.4 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 24
    • 0036023415 scopus 로고    scopus 로고
    • Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance
    • 12171883
    • Hoffmann TK, et al. Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance. Clin Cancer Res. 2002;8(8):2553-62.
    • (2002) Clin Cancer Res , vol.8 , Issue.8 , pp. 2553-2562
    • Hoffmann, T.K.1
  • 25
    • 0036795213 scopus 로고    scopus 로고
    • Signaling abnormalities, apoptosis, and reduced proliferation of circulating and tumor-infiltrating lymphocytes in patients with oral carcinoma
    • 12374681
    • Reichert TE, et al. Signaling abnormalities, apoptosis, and reduced proliferation of circulating and tumor-infiltrating lymphocytes in patients with oral carcinoma. Clin Cancer Res. 2002;8(10):3137-45.
    • (2002) Clin Cancer Res , vol.8 , Issue.10 , pp. 3137-3145
    • Reichert, T.E.1
  • 26
    • 84875273512 scopus 로고    scopus 로고
    • Loss of TGF-beta signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation
    • Bian Y et al. Loss of TGF-beta signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation. Oncogene, 2011.
    • (2011) Oncogene
    • Bian, Y.1
  • 27
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • 18650914 10.1038/nature07205 1:CAS:528:DC%2BD1cXovV2mtbg%3D
    • Mantovani A, et al. Cancer-related inflammation. Nature. 2008;454(7203):436-44.
    • (2008) Nature , vol.454 , Issue.7203 , pp. 436-444
    • Mantovani, A.1
  • 28
    • 0034551670 scopus 로고    scopus 로고
    • Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells
    • 11090068 1:CAS:528:DC%2BD3cXosVGntbg%3D
    • Bronte V, et al. Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood. 2000;96(12):3838-46.
    • (2000) Blood , vol.96 , Issue.12 , pp. 3838-3846
    • Bronte, V.1
  • 29
    • 1642536454 scopus 로고    scopus 로고
    • Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species
    • 14707072 1:CAS:528:DC%2BD2cXnvVGl
    • Kusmartsev S, et al. Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. J Immunol. 2004;172(2):989-99.
    • (2004) J Immunol , vol.172 , Issue.2 , pp. 989-999
    • Kusmartsev, S.1
  • 30
    • 11844277698 scopus 로고    scopus 로고
    • Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease
    • 15634881 1:CAS:528:DC%2BD2MXotFSg
    • Sinha P, Clements VK, Ostrand-Rosenberg S. Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease. J Immunol. 2005;174(2):636-45.
    • (2005) J Immunol , vol.174 , Issue.2 , pp. 636-645
    • Sinha, P.1    Clements, V.K.2    Ostrand-Rosenberg, S.3
  • 31
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • 18633355 10.1038/nrc2444 1:CAS:528:DC%2BD1cXovV2lsrY%3D
    • Murdoch C, et al. The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer. 2008;8(8):618-31.
    • (2008) Nat Rev Cancer , vol.8 , Issue.8 , pp. 618-631
    • Murdoch, C.1
  • 32
    • 36849013036 scopus 로고    scopus 로고
    • Bv8 regulates myeloid-cell-dependent tumour angiogenesis
    • 18064003 10.1038/nature06348 1:CAS:528:DC%2BD2sXhtl2gsbjO
    • Shojaei F, et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature. 2007;450(7171):825-31.
    • (2007) Nature , vol.450 , Issue.7171 , pp. 825-831
    • Shojaei, F.1
  • 33
    • 48549085973 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells
    • 18593947 10.1158/0008-5472.CAN-07-6621 1:CAS:528:DC%2BD1cXnvFyjur4%3D
    • Serafini P, et al. Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. Cancer Res. 2008;68(13):5439-49.
    • (2008) Cancer Res , vol.68 , Issue.13 , pp. 5439-5449
    • Serafini, P.1
  • 34
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • 19197294 10.1038/nri2506 1:CAS:528:DC%2BD1MXhsFeqsbw%3D
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009;9(3):162-74.
    • (2009) Nat Rev Immunol , vol.9 , Issue.3 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 35
    • 81155131681 scopus 로고    scopus 로고
    • Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism
    • 22110722 10.1371/journal.pone.0027690 1:CAS:528:DC%2BC3MXhs1Sjs7vP
    • Waight JD, et al. Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism. PLoS ONE. 2011;6(11):e27690.
    • (2011) PLoS ONE , vol.6 , Issue.11 , pp. 27690
    • Waight, J.D.1
  • 36
    • 0034266661 scopus 로고    scopus 로고
    • Tumor associated macrophages in human prostate cancer: Relation to clinicopathological variables and survival
    • 10938382 1:STN:280:DC%2BD3M%2FjtVKnsQ%3D%3D
    • Lissbrant IF, et al. Tumor associated macrophages in human prostate cancer: relation to clinicopathological variables and survival. Int J Oncol. 2000;17(3):445-51.
    • (2000) Int J Oncol , vol.17 , Issue.3 , pp. 445-451
    • Lissbrant, I.F.1
  • 37
    • 0032867830 scopus 로고    scopus 로고
    • Tumor-associated macrophage infiltration in pulmonary adenocarcinoma: Association with angiogenesis and poor prognosis
    • 10461061 10.1159/000012021 1:STN:280:DyaK1MzptFykug%3D%3D
    • Takanami I, Takeuchi K, Kodaira S. Tumor-associated macrophage infiltration in pulmonary adenocarcinoma: association with angiogenesis and poor prognosis. Oncology. 1999;57(2):138-42.
    • (1999) Oncology , vol.57 , Issue.2 , pp. 138-142
    • Takanami, I.1    Takeuchi, K.2    Kodaira, S.3
  • 38
    • 24744454660 scopus 로고    scopus 로고
    • Macrophage infiltration and its prognostic implications in breast cancer: The relationship with VEGF expression and microvessel density
    • 16012726 1:CAS:528:DC%2BD2MXnslyqu70%3D
    • Tsutsui S, et al. Macrophage infiltration and its prognostic implications in breast cancer: the relationship with VEGF expression and microvessel density. Oncol Rep. 2005;14(2):425-31.
    • (2005) Oncol Rep , vol.14 , Issue.2 , pp. 425-431
    • Tsutsui, S.1
  • 39
    • 31544455880 scopus 로고    scopus 로고
    • Prognostic value of tumor-infiltrating CD4+ T-cell subpopulations in head and neck cancers
    • 16428488 10.1158/1078-0432.CCR-05-1886 1:CAS:528:DC%2BD28XmtlKitg%3D%3D
    • Badoual C, et al. Prognostic value of tumor-infiltrating CD4+ T-cell subpopulations in head and neck cancers. Clin Cancer Res. 2006;12(2):465-72.
    • (2006) Clin Cancer Res , vol.12 , Issue.2 , pp. 465-472
    • Badoual, C.1
  • 40
    • 33144460217 scopus 로고    scopus 로고
    • Galectin-1: A link between tumor hypoxia and tumor immune privilege
    • 16219933 10.1200/JCO.2005.02.0206 1:CAS:528:DC%2BD28XktVCgtQ%3D%3D
    • Le QT, et al. Galectin-1: a link between tumor hypoxia and tumor immune privilege. J Clin Oncol. 2005;23(35):8932-41.
    • (2005) J Clin Oncol , vol.23 , Issue.35 , pp. 8932-8941
    • Le, Q.T.1
  • 41
    • 0022534820 scopus 로고
    • Lymphocyte subpopulations infiltrating squamous carcinomas of the head and neck: Correlations with extent of tumor and prognosis
    • 2954014 1:STN:280:DyaL2s3jtVehug%3D%3D
    • Wolf GT, et al. Lymphocyte subpopulations infiltrating squamous carcinomas of the head and neck: correlations with extent of tumor and prognosis. Otolaryngol Head Neck Surg. 1986;95(2):142-52.
    • (1986) Otolaryngol Head Neck Surg , vol.95 , Issue.2 , pp. 142-152
    • Wolf, G.T.1
  • 42
    • 35448948183 scopus 로고    scopus 로고
    • Prognostic significance of tumor-infiltrating lymphocytes in oropharyngeal cancer
    • 17915676
    • Rajjoub S, et al. Prognostic significance of tumor-infiltrating lymphocytes in oropharyngeal cancer. Ear Nose Throat J. 2007;86(8):506-11.
    • (2007) Ear Nose Throat J , vol.86 , Issue.8 , pp. 506-511
    • Rajjoub, S.1
  • 43
    • 57349127314 scopus 로고    scopus 로고
    • Focus on TILs: Prognostic significance of tumor infiltrating lymphocytes in head and neck cancers
    • 19053167
    • Uppaluri R, Dunn GP, Lewis JS Jr. Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in head and neck cancers. Cancer Immun. 2008;8:16.
    • (2008) Cancer Immun , vol.8 , pp. 16
    • Uppaluri, R.1    Dunn, G.P.2    Lewis Jr., J.S.3
  • 44
    • 52449125138 scopus 로고    scopus 로고
    • T regulatory type 1 cells in squamous cell carcinoma of the head and neck: Mechanisms of suppression and expansion in advanced disease
    • 18559587 10.1158/1078-0432.CCR-07-5126 1:CAS:528:DC%2BD1cXntlWrsr0%3D
    • Bergmann C, et al. T regulatory type 1 cells in squamous cell carcinoma of the head and neck: mechanisms of suppression and expansion in advanced disease. Clin Cancer Res. 2008;14(12):3706-15.
    • (2008) Clin Cancer Res , vol.14 , Issue.12 , pp. 3706-3715
    • Bergmann, C.1
  • 45
    • 0141953994 scopus 로고    scopus 로고
    • Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer
    • 14559840 1:CAS:528:DC%2BD3sXotV2is7g%3D
    • Hartmann E, et al. Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer. Cancer Res. 2003;63(19):6478-87.
    • (2003) Cancer Res , vol.63 , Issue.19 , pp. 6478-6487
    • Hartmann, E.1
  • 46
    • 79251563421 scopus 로고    scopus 로고
    • Expression of the T cell receptor alphabeta on a CD123+ BDCA2+ HLA-DR+ subpopulation in head and neck squamous cell carcinoma
    • 21264308 10.1371/journal.pone.0015997 1:CAS:528:DC%2BC3MXhtFWgu78%3D
    • Thiel A, et al. Expression of the T cell receptor alphabeta on a CD123+ BDCA2+ HLA-DR+ subpopulation in head and neck squamous cell carcinoma. PLoS ONE. 2011;6(1):e15997.
    • (2011) PLoS ONE , vol.6 , Issue.1 , pp. 15997
    • Thiel, A.1
  • 47
    • 10044248559 scopus 로고    scopus 로고
    • Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity
    • 15599852 10.1053/j.seminoncol.2004.09.011
    • Gillison ML. Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity. Semin Oncol. 2004;31(6):744-54.
    • (2004) Semin Oncol , vol.31 , Issue.6 , pp. 744-754
    • Gillison, M.L.1
  • 48
    • 42149123438 scopus 로고    scopus 로고
    • Therapeutic human papillomavirus vaccines: Current clinical trials and future directions
    • 18352847 10.1517/14712598.8.4.421 1:CAS:528:DC%2BD1cXjsFWkuro%3D
    • Hung CF, et al. Therapeutic human papillomavirus vaccines: current clinical trials and future directions. Expert Opin Biol Ther. 2008;8(4):421-39.
    • (2008) Expert Opin Biol Ther , vol.8 , Issue.4 , pp. 421-439
    • Hung, C.F.1
  • 49
    • 0033153564 scopus 로고    scopus 로고
    • Vaccination with HPV16 peptides of patients with advanced cervical carcinoma: Clinical evaluation of a phase I-II trial
    • 10533477 10.1016/S0959-8049(99)00048-9
    • van Driel WJ, et al. Vaccination with HPV16 peptides of patients with advanced cervical carcinoma: clinical evaluation of a phase I-II trial. Eur J Cancer. 1999;35(6):946-52.
    • (1999) Eur J Cancer , vol.35 , Issue.6 , pp. 946-952
    • Van Driel, W.J.1
  • 50
    • 34548127036 scopus 로고    scopus 로고
    • A phase II study of Hsp-7 (SGN-00101) in women with high-grade cervical intraepithelial neoplasia
    • 17631950 10.1016/j.ygyno.2007.05.038 1:CAS:528:DC%2BD2sXhtVSjsrbP
    • Roman LD, et al. A phase II study of Hsp-7 (SGN-00101) in women with high-grade cervical intraepithelial neoplasia. Gynecol Oncol. 2007;106(3):558-66.
    • (2007) Gynecol Oncol , vol.106 , Issue.3 , pp. 558-566
    • Roman, L.D.1
  • 51
    • 0032940888 scopus 로고    scopus 로고
    • Human papillomavirus vaccines for cervical cancer
    • 10335480 10.1097/00002371-199905000-00003 1:STN:280:DyaK1M3msl2lsw%3D%3D
    • Murakami M, Gurski KJ, Steller MA. Human papillomavirus vaccines for cervical cancer. J Immunother. 1999;22(3):212-8.
    • (1999) J Immunother , vol.22 , Issue.3 , pp. 212-218
    • Murakami, M.1    Gurski, K.J.2    Steller, M.A.3
  • 52
    • 0032978854 scopus 로고    scopus 로고
    • Generation of anti-p53 cytotoxic T lymphocytes from human peripheral blood using autologous dendritic cells
    • 10389910 1:CAS:528:DyaK1MXkt1Oqurw%3D
    • Chikamatsu K, et al. Generation of anti-p53 cytotoxic T lymphocytes from human peripheral blood using autologous dendritic cells. Clin Cancer Res. 1999;5(6):1281-8.
    • (1999) Clin Cancer Res , vol.5 , Issue.6 , pp. 1281-1288
    • Chikamatsu, K.1
  • 53
    • 0030669142 scopus 로고    scopus 로고
    • P53-based immunotherapy of cancer
    • 9419445 10.1615/CritRevImmunol.v18.i1-2.40 1:CAS:528:DyaK1cXisVShtg%3D%3D
    • DeLeo AB. p53-based immunotherapy of cancer. Crit Rev Immunol. 1998;18(1-2):29-35.
    • (1998) Crit Rev Immunol , vol.18 , Issue.1-2 , pp. 29-35
    • Deleo, A.B.1
  • 54
    • 0034669973 scopus 로고    scopus 로고
    • Generation of T cells specific for the wild-type sequence p53(264-272) peptide in cancer patients: Implications for immunoselection of epitope loss variants
    • 11067956 1:CAS:528:DC%2BD3cXot1Grt7c%3D
    • Hoffmann TK, et al. Generation of T cells specific for the wild-type sequence p53(264-272) peptide in cancer patients: implications for immunoselection of epitope loss variants. J Immunol. 2000;165(10):5938-44.
    • (2000) J Immunol , vol.165 , Issue.10 , pp. 5938-5944
    • Hoffmann, T.K.1
  • 55
    • 1842339552 scopus 로고    scopus 로고
    • Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide
    • 8962118 10.1073/pnas.93.25.14704 1:CAS:528:DyaK28XnsVOjsLo%3D
    • Ropke M, et al. Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide. Proc Natl Acad Sci USA. 1996;93(25):14704-7.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.25 , pp. 14704-14707
    • Ropke, M.1
  • 56
    • 34248531439 scopus 로고    scopus 로고
    • An MVA vaccine overcomes tolerance to human p53 in mice and humans
    • 17219151 10.1007/s00262-006-0270-3 1:CAS:528:DC%2BD2sXltlSkt7s%3D
    • Song GY, et al. An MVA vaccine overcomes tolerance to human p53 in mice and humans. Cancer Immunol Immunother. 2007;56(8):1193-205.
    • (2007) Cancer Immunol Immunother , vol.56 , Issue.8 , pp. 1193-1205
    • Song, G.Y.1
  • 57
    • 79952816157 scopus 로고    scopus 로고
    • Treatment of vulvar intraepithelial neoplasia with topical imiquimod: Seven years median follow-up of a randomized clinical trial
    • 21239049 10.1016/j.ygyno.2010.12.340 1:CAS:528:DC%2BC3MXjs1Wrsro%3D
    • Terlou A, et al. Treatment of vulvar intraepithelial neoplasia with topical imiquimod: seven years median follow-up of a randomized clinical trial. Gynecol Oncol. 2011;121(1):157-62.
    • (2011) Gynecol Oncol , vol.121 , Issue.1 , pp. 157-162
    • Terlou, A.1
  • 58
    • 41649084839 scopus 로고    scopus 로고
    • Treatment of vulvar intraepithelial neoplasia with topical imiquimod
    • 18385498 10.1056/NEJMoa072685
    • van Seters M, et al. Treatment of vulvar intraepithelial neoplasia with topical imiquimod. N Engl J Med. 2008;358(14):1465-73.
    • (2008) N Engl J Med , vol.358 , Issue.14 , pp. 1465-1473
    • Van Seters, M.1
  • 59
    • 77955804299 scopus 로고    scopus 로고
    • The efficacy of imiquimod on dysplastic lesions of the oral mucosa: An experimental model
    • 20683029 1:CAS:528:DC%2BC3cXhtFWgurnL
    • Gkoulioni V, et al. The efficacy of imiquimod on dysplastic lesions of the oral mucosa: an experimental model. Anticancer Res. 2010;30(7):2891-6.
    • (2010) Anticancer Res , vol.30 , Issue.7 , pp. 2891-2896
    • Gkoulioni, V.1
  • 60
    • 0025967645 scopus 로고
    • Antiproliferative effects of cytokines on squamous cell carcinoma
    • 1900161 10.1001/archotol.1991.01870150089012 1:STN:280: DyaK3M7ltFKmsg%3D%3D
    • Sacchi M, et al. Antiproliferative effects of cytokines on squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 1991;117(3):321-6.
    • (1991) Arch Otolaryngol Head Neck Surg , vol.117 , Issue.3 , pp. 321-326
    • Sacchi, M.1
  • 61
    • 0024206262 scopus 로고
    • Treatment of recurrent squamous cell carcinoma of the head and neck with low doses of interleukin-2 injected perilymphatically
    • 3263896 10.1002/1097-0142(19881215)62:12<2482: AID- CNCR2820621205>3.0.CO;2-9 1:STN:280:DyaL1M%2FltFOjtQ%3D%3D
    • Cortesina G, et al. Treatment of recurrent squamous cell carcinoma of the head and neck with low doses of interleukin-2 injected perilymphatically. Cancer. 1988;62(12):2482-5.
    • (1988) Cancer , vol.62 , Issue.12 , pp. 2482-2485
    • Cortesina, G.1
  • 62
    • 7844234373 scopus 로고    scopus 로고
    • Neo-adjuvant chemo-(immuno-)therapy of advanced squamous-cell head and neck carcinoma: A multicenter, phase III, randomized study comparing cisplatin + 5-fluorouracil (5-FU) with cisplatin + 5-FU + recombinant interleukin 2
    • 9829840 10.1007/s002620050515 1:CAS:528:DyaK1MXitVaj
    • Mantovani G, et al. Neo-adjuvant chemo-(immuno-)therapy of advanced squamous-cell head and neck carcinoma: a multicenter, phase III, randomized study comparing cisplatin + 5-fluorouracil (5-FU) with cisplatin + 5-FU + recombinant interleukin 2. Cancer Immunol Immunother. 1998;47(3):149-56.
    • (1998) Cancer Immunol Immunother , vol.47 , Issue.3 , pp. 149-156
    • Mantovani, G.1
  • 63
    • 0026026671 scopus 로고
    • Clinical and immunopathological results of a phase II study of perilymphatically injected recombinant interleukin-2 in locally far advanced, nonpretreated head and neck squamous cell carcinoma
    • 2012800 10.1097/00002371-199102000-00009 1:STN:280:DyaK3M7ptVyrsA%3D%3D
    • Mattijssen V, et al. Clinical and immunopathological results of a phase II study of perilymphatically injected recombinant interleukin-2 in locally far advanced, nonpretreated head and neck squamous cell carcinoma. J Immunother. 1991;10(1):63-8.
    • (1991) J Immunother , vol.10 , Issue.1 , pp. 63-68
    • Mattijssen, V.1
  • 64
    • 0034125451 scopus 로고    scopus 로고
    • Clinical significance of defective dendritic cell differentiation in cancer
    • 10815894 1:STN:280:DC%2BD3cvhtVOhsw%3D%3D
    • Almand B, et al. Clinical significance of defective dendritic cell differentiation in cancer. Clin Cancer Res. 2000;6(5):1755-66.
    • (2000) Clin Cancer Res , vol.6 , Issue.5 , pp. 1755-1766
    • Almand, B.1
  • 65
    • 53349099219 scopus 로고    scopus 로고
    • Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
    • 18809714 10.1084/jem.20080132 1:CAS:528:DC%2BD1cXht1SrtLvE
    • Cheng P, et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med. 2008;205(10):2235-49.
    • (2008) J Exp Med , vol.205 , Issue.10 , pp. 2235-2249
    • Cheng, P.1
  • 66
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • 20876310 10.1084/jem.20100587 1:CAS:528:DC%2BC3cXhsVSktLzE
    • Corzo CA, et al. HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med. 2010;207(11):2439-53.
    • (2010) J Exp Med , vol.207 , Issue.11 , pp. 2439-2453
    • Corzo, C.A.1
  • 67
    • 10044275221 scopus 로고    scopus 로고
    • Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization
    • 15548611 10.1073/pnas.0407697101 1:CAS:528:DC%2BD2cXhtFansr3L
    • LeCouter J, et al. Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization. Proc Natl Acad Sci USA. 2004;101(48):16813-8.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.48 , pp. 16813-16818
    • Lecouter, J.1
  • 68
    • 38049181485 scopus 로고    scopus 로고
    • Reversion of immune tolerance in advanced malignancy: Modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function
    • 17885078 10.1182/blood-2007-04-086835 1:CAS:528:DC%2BD1cXjtVKitg%3D%3D
    • Pan PY, et al. Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Blood. 2008;111(1):219-28.
    • (2008) Blood , vol.111 , Issue.1 , pp. 219-228
    • Pan, P.Y.1
  • 69
    • 27144538568 scopus 로고    scopus 로고
    • Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway
    • 16230418 10.1158/0008-5472.CAN-05-0529 1:CAS:528:DC%2BD2MXhtFWmu7rL
    • Nefedova Y, et al. Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res. 2005;65(20):9525-35.
    • (2005) Cancer Res , vol.65 , Issue.20 , pp. 9525-9535
    • Nefedova, Y.1
  • 70
    • 65549141834 scopus 로고    scopus 로고
    • The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies
    • 19276342 10.1158/0008-5472.CAN-08-4709 1:CAS:528:DC%2BD1MXjtFyqurY%3D
    • Ozao-Choy J, et al. The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res. 2009;69(6):2514-22.
    • (2009) Cancer Res , vol.69 , Issue.6 , pp. 2514-2522
    • Ozao-Choy, J.1
  • 71
    • 84866874594 scopus 로고    scopus 로고
    • Immunological effects of multikinase inhibitors for kidney cancer: A clue for integration with cellular therapies?
    • 21716852 10.7150/jca.2.333 1:CAS:528:DC%2BC3MXnslCnt7c%3D
    • Porta C, et al. Immunological effects of multikinase inhibitors for kidney cancer: a clue for integration with cellular therapies? J Cancer. 2011;2:333-8.
    • (2011) J Cancer , vol.2 , pp. 333-338
    • Porta, C.1
  • 72
    • 77956056104 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate in head and neck squamous cell carcinoma
    • 19649772 10.1007/s10637-009-9296-7 1:CAS:528:DC%2BC3cXoslymsbc%3D
    • Choong NW, et al. Phase II study of sunitinib malate in head and neck squamous cell carcinoma. Invest New Drugs. 2010;28(5):677-83.
    • (2010) Invest New Drugs , vol.28 , Issue.5 , pp. 677-683
    • Choong, N.W.1
  • 73
    • 75749105462 scopus 로고    scopus 로고
    • A phase II study of sunitinib in patients with recurrent and/or metastatic non-nasopharyngeal head and neck cancer
    • 19655144 10.1007/s00280-009-1070-1 1:CAS:528:DC%2BC3cXotVGktA%3D%3D
    • Fountzilas G, et al. A phase II study of sunitinib in patients with recurrent and/or metastatic non-nasopharyngeal head and neck cancer. Cancer Chemother Pharmacol. 2010;65(4):649-60.
    • (2010) Cancer Chemother Pharmacol , vol.65 , Issue.4 , pp. 649-660
    • Fountzilas, G.1
  • 74
    • 73949143686 scopus 로고    scopus 로고
    • Phase II study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01
    • 19917865 10.1200/JCO.2009.23.8584 1:CAS:528:DC%2BC3cXhtF2ku7o%3D
    • Machiels JP, et al. Phase II study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01. J Clin Oncol. 2010;28(1):21-8.
    • (2010) J Clin Oncol , vol.28 , Issue.1 , pp. 21-28
    • MacHiels, J.P.1
  • 75
    • 68149170060 scopus 로고    scopus 로고
    • Phase 1 study of concurrent sunitinib and image-guided radiotherapy followed by maintenance sunitinib for patients with oligometastases: Acute toxicity and preliminary response
    • 19536893 10.1002/cncr.24412 1:CAS:528:DC%2BD1MXpslOnuro%3D
    • Kao J, et al. Phase 1 study of concurrent sunitinib and image-guided radiotherapy followed by maintenance sunitinib for patients with oligometastases: acute toxicity and preliminary response. Cancer. 2009;115(15):3571-80.
    • (2009) Cancer , vol.115 , Issue.15 , pp. 3571-3580
    • Kao, J.1
  • 76
    • 33846891555 scopus 로고    scopus 로고
    • Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma
    • 17255300 10.1158/1078-0432.CCR-06-2197 1:CAS:528:DC%2BD2sXoslSqsQ%3D%3D
    • Ochoa AC, et al. Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma. Clin Cancer Res. 2007;13(2 Pt 2):721s-6s.
    • (2007) Clin Cancer Res , vol.13 , Issue.2 PART 2
    • Ochoa, A.C.1
  • 77
    • 34249300128 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
    • 17483367 10.1158/0008-5472.CAN-06-4174 1:CAS:528:DC%2BD2sXltVyrtrY%3D
    • Sinha P, et al. Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. Cancer Res. 2007;67(9):4507-13.
    • (2007) Cancer Res , vol.67 , Issue.9 , pp. 4507-4513
    • Sinha, P.1
  • 78
    • 33845997430 scopus 로고    scopus 로고
    • Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansion
    • 17178380 10.1016/j.intimp.2006.09.021 1:CAS:528:DC%2BD28XhtlaltL7N
    • Talmadge JE, et al. Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansion. Int Immunopharmacol. 2007;7(2):140-51.
    • (2007) Int Immunopharmacol , vol.7 , Issue.2 , pp. 140-151
    • Talmadge, J.E.1
  • 79
    • 27244432279 scopus 로고    scopus 로고
    • Phase i study of gefitinib plus celecoxib in recurrent or metastatic squamous cell carcinoma of the head and neck
    • 16172459 10.1200/JCO.2005.02.4182 1:CAS:528:DC%2BD2MXhtFCrsbjK
    • Wirth LJ, et al. Phase I study of gefitinib plus celecoxib in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol. 2005;23(28):6976-81.
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 6976-6981
    • Wirth, L.J.1
  • 80
    • 79959958162 scopus 로고    scopus 로고
    • Phase 1 trial of concurrent erlotinib, celecoxib, and reirradiation for recurrent head and neck cancer
    • 21246519 10.1002/cncr.25786 1:CAS:528:DC%2BC3MXot1ansbw%3D
    • Kao J, et al. Phase 1 trial of concurrent erlotinib, celecoxib, and reirradiation for recurrent head and neck cancer. Cancer. 2011;117(14):3173-81.
    • (2011) Cancer , vol.117 , Issue.14 , pp. 3173-3181
    • Kao, J.1
  • 81
    • 33751531874 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
    • 17101732 10.1084/jem.20061104 1:CAS:528:DC%2BD28Xht12htLfL
    • Serafini P, et al. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J Exp Med. 2006;203(12):2691-702.
    • (2006) J Exp Med , vol.203 , Issue.12 , pp. 2691-2702
    • Serafini, P.1
  • 82
    • 35948952840 scopus 로고    scopus 로고
    • The frequency and suppressor function of CD4+ CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck
    • 17975141 10.1158/1078-0432.CCR-07-1403 1:CAS:528:DC%2BD2sXht1Cgtb%2FM
    • Strauss L, et al. The frequency and suppressor function of CD4+ CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck. Clin Cancer Res. 2007;13(21):6301-11.
    • (2007) Clin Cancer Res , vol.13 , Issue.21 , pp. 6301-6311
    • Strauss, L.1
  • 84
    • 77951968197 scopus 로고    scopus 로고
    • Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck
    • 19183242 10.1111/j.1582-4934.2008.00650.x 1:CAS:528:DC%2BC3cXlt1OqsLk%3D
    • Boucek J, et al. Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck. J Cell Mol Med. 2010;14(1-2):426-33.
    • (2010) J Cell Mol Med , vol.14 , Issue.1-2 , pp. 426-433
    • Boucek, J.1
  • 85
    • 0026084407 scopus 로고
    • Observations on preprofessional education: Is there a major difference?
    • 2001260 1:STN:280:DyaK3M7lvVOnsg%3D%3D
    • Cunningham DR. Observations on preprofessional education: is there a major difference? ASHA. 1991;33(1):37-9.
    • (1991) ASHA , vol.33 , Issue.1 , pp. 37-39
    • Cunningham, D.R.1
  • 86
    • 77950992076 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes, particularly the balance between CD8(+) T cells and CCR4(+) regulatory T cells, affect the survival of patients with oral squamous cell carcinoma
    • 20303300 10.1016/j.tripleo.2009.12.015
    • Watanabe Y, et al. Tumor-infiltrating lymphocytes, particularly the balance between CD8(+) T cells and CCR4(+) regulatory T cells, affect the survival of patients with oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(5):744-52.
    • (2010) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.109 , Issue.5 , pp. 744-752
    • Watanabe, Y.1
  • 87
    • 0242383230 scopus 로고    scopus 로고
    • Ifosfamide in the treatment of head and neck cancer
    • 14586145 10.1159/000073356 1:CAS:528:DC%2BD3sXosF2ms7c%3D
    • Airoldi M, et al. Ifosfamide in the treatment of head and neck cancer. Oncology. 2003;65(Suppl 2):37-43.
    • (2003) Oncology , vol.65 , Issue.SUPPL. 2 , pp. 37-43
    • Airoldi, M.1
  • 88
    • 85027957593 scopus 로고    scopus 로고
    • Immunomodulatory effects of cyclophosphamide and implementations for vaccine design
    • 21611872 10.1007/s00281-011-0245-0 1:CAS:528:DC%2BC3MXptFaitLw%3D
    • Sistigu A, et al. Immunomodulatory effects of cyclophosphamide and implementations for vaccine design. Semin Immunopathol. 2011;33(4):369-83.
    • (2011) Semin Immunopathol , vol.33 , Issue.4 , pp. 369-383
    • Sistigu, A.1
  • 89
    • 78449243489 scopus 로고    scopus 로고
    • Immune checkpoint proteins: A new therapeutic paradigm for cancer-preclinical background: CTLA-4 and PD-1 blockade
    • 21074057 10.1053/j.seminoncol.2010.09.005 1:CAS:528:DC%2BC3cXhsVWrtbfI
    • Weber J. Immune checkpoint proteins: a new therapeutic paradigm for cancer-preclinical background: CTLA-4 and PD-1 blockade. Semin Oncol. 2010;37(5):430-9.
    • (2010) Semin Oncol , vol.37 , Issue.5 , pp. 430-439
    • Weber, J.1
  • 90
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • 20525992 10.1056/NEJMoa1003466 1:CAS:528:DC%2BC3cXhtVCrtrbN
    • Hodi FS, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711-23.
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1
  • 91
    • 84855438473 scopus 로고    scopus 로고
    • Validation of genetic sequence variants as prognostic factors in early-stage head and neck squamous cell cancer survival
    • 22076708 10.1158/1078-0432.CCR-11-1759 1:CAS:528:DC%2BC38XhvFWgtg%3D%3D
    • Azad AK, et al. Validation of genetic sequence variants as prognostic factors in early-stage head and neck squamous cell cancer survival. Clin Cancer Res. 2012;18(1):196-206.
    • (2012) Clin Cancer Res , vol.18 , Issue.1 , pp. 196-206
    • Azad, A.K.1
  • 92
    • 77953360527 scopus 로고    scopus 로고
    • Association of T-cell regulatory gene polymorphisms with oral squamous cell carcinoma
    • 20435510 10.1016/j.oraloncology.2010.03.025
    • Kammerer PW, et al. Association of T-cell regulatory gene polymorphisms with oral squamous cell carcinoma. Oral Oncol. 2010;46(7):543-8.
    • (2010) Oral Oncol , vol.46 , Issue.7 , pp. 543-548
    • Kammerer, P.W.1
  • 93
    • 79959765108 scopus 로고    scopus 로고
    • Enhanced programmed death 1 (PD-1) and PD-1 ligand (PD-L1) expression in patients with actinic cheilitis and oral squamous cell carcinoma
    • 21442435 10.1007/s00262-011-1007-5 1:CAS:528:DC%2BC3MXnslOrs7w%3D
    • Malaspina TS, et al. Enhanced programmed death 1 (PD-1) and PD-1 ligand (PD-L1) expression in patients with actinic cheilitis and oral squamous cell carcinoma. Cancer Immunol Immunother. 2011;60(7):965-74.
    • (2011) Cancer Immunol Immunother , vol.60 , Issue.7 , pp. 965-974
    • Malaspina, T.S.1
  • 94
    • 32644484710 scopus 로고    scopus 로고
    • Predominant expression of B7-H1 and its immunoregulatory roles in oral squamous cell carcinoma
    • 16271509 10.1016/j.oraloncology.2005.07.013 1:CAS:528: DC%2BD28XhsFOju74%3D
    • Tsushima F, et al. Predominant expression of B7-H1 and its immunoregulatory roles in oral squamous cell carcinoma. Oral Oncol. 2006;42(3):268-74.
    • (2006) Oral Oncol , vol.42 , Issue.3 , pp. 268-274
    • Tsushima, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.