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Volumn 56, Issue 8, 2007, Pages 1193-1205

An MVA vaccine overcomes tolerance to human p53 in mice and humans

Author keywords

Animal models of cancer; Cancer vaccines; Immune response to cancer; p53

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; PEPTIDE LIBRARY; PROTEIN P53; VACCINIA VACCINE;

EID: 34248531439     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-006-0270-3     Document Type: Article
Times cited : (24)

References (47)
  • 1
    • 0033992478 scopus 로고    scopus 로고
    • p53 and human cancer: The first ten thousand mutations
    • Hainaut P, Hollstein M (2000) p53 and human cancer: the first ten thousand mutations. Adv Cancer Res 77:81-137
    • (2000) Adv Cancer Res , vol.77 , pp. 81-137
    • Hainaut, P.1    Hollstein, M.2
  • 2
    • 33644557403 scopus 로고    scopus 로고
    • Visualization of p53(264-272)/HLA-A*0201 complexes naturally presented on tumor cell surface by a multimeric soluble single-chain T cell receptor
    • Zhu X, Belmont HJ, Price-Schiavi S, Liu B, Lee HI, Fernandez M, et al (2006) Visualization of p53(264-272)/HLA-A*0201 complexes naturally presented on tumor cell surface by a multimeric soluble single-chain T cell receptor. J Immunol 176:3223-3232
    • (2006) J Immunol , vol.176 , pp. 3223-3232
    • Zhu, X.1    Belmont, H.J.2    Price-Schiavi, S.3    Liu, B.4    Lee, H.I.5    Fernandez, M.6
  • 5
    • 0029978501 scopus 로고    scopus 로고
    • p53 as a target for cancer vaccines: Recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge
    • Roth J, Dittmer D, Rea D, Tartaglia J, Paoletti E, Levine AJ (1996) p53 as a target for cancer vaccines: recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge. Proc Natl Acad Sci USA 93:4781-4786
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4781-4786
    • Roth, J.1    Dittmer, D.2    Rea, D.3    Tartaglia, J.4    Paoletti, E.5    Levine, A.J.6
  • 6
  • 7
    • 0031986115 scopus 로고    scopus 로고
    • The mode of presentation and route of administration are critical for the induction of immune responses to p53 and antitumor immunity
    • Hurpin C, Rotarioa C, Bisceglia H, Chevalier M, Tartaglia J, Erdile L (1998) The mode of presentation and route of administration are critical for the induction of immune responses to p53 and antitumor immunity. Vaccine 16:208-215
    • (1998) Vaccine , vol.16 , pp. 208-215
    • Hurpin, C.1    Rotarioa, C.2    Bisceglia, H.3    Chevalier, M.4    Tartaglia, J.5    Erdile, L.6
  • 8
    • 0035890587 scopus 로고    scopus 로고
    • Immunization with wild-type p53 gene sequences coadministered with Flt3 ligand induces an antigen-specific type 1 T-cell response
    • Parajuli P, Pisarev V, Sublet J, SteVel A, Varney M, Singh R, et al (2001) Immunization with wild-type p53 gene sequences coadministered with Flt3 ligand induces an antigen-specific type 1 T-cell response. Cancer Res 61:8227-8234
    • (2001) Cancer Res , vol.61 , pp. 8227-8234
    • Parajuli, P.1    Pisarev, V.2    Sublet, J.3    SteVel, A.4    Varney, M.5    Singh, R.6
  • 9
    • 1842370254 scopus 로고    scopus 로고
    • Genetically modified bone marrow-derived dendritic cells expressing tumor-associated viral or "self" antigens induce antitumor immunity in vivo
    • Tuting T, DeLeo AB, Lotze MT, Storkus WJ (1997) Genetically modified bone marrow-derived dendritic cells expressing tumor-associated viral or "self" antigens induce antitumor immunity in vivo. Eur J Immunol 27:2702-2707
    • (1997) Eur J Immunol , vol.27 , pp. 2702-2707
    • Tuting, T.1    DeLeo, A.B.2    Lotze, M.T.3    Storkus, W.J.4
  • 10
    • 0035103277 scopus 로고    scopus 로고
    • Canarypox virus expressing wild type p53 for gene therapy in murine tumors mutated in p53
    • Odin L, Favrot M, Poujol D, Michot JP, Moingeon P, Tartaglia J, et al (2001) Canarypox virus expressing wild type p53 for gene therapy in murine tumors mutated in p53. Cancer Gene Ther 8:87-98
    • (2001) Cancer Gene Ther , vol.8 , pp. 87-98
    • Odin, L.1    Favrot, M.2    Poujol, D.3    Michot, J.P.4    Moingeon, P.5    Tartaglia, J.6
  • 11
    • 0034307171 scopus 로고    scopus 로고
    • High steady-state levels of p53 are not a prerequisite for tumor eradication by wild-type p53-specific cytotoxic T lymphocytes
    • Vierboom MP, Zwaveling S, Bos GMJ, Ooms M, Krietemeijer GM, Melief CJ, et al (2000) High steady-state levels of p53 are not a prerequisite for tumor eradication by wild-type p53-specific cytotoxic T lymphocytes. Cancer Res 60:5508-5513
    • (2000) Cancer Res , vol.60 , pp. 5508-5513
    • Vierboom, M.P.1    Zwaveling, S.2    Bos, G.M.J.3    Ooms, M.4    Krietemeijer, G.M.5    Melief, C.J.6
  • 12
    • 0034662114 scopus 로고    scopus 로고
    • Cyclophosphamide enhances anti-tumor effect of wild-type p53-specific CTL
    • Vierboom MP, Bos GM, Ooms M, Offringa R, Melief CJ (2000) Cyclophosphamide enhances anti-tumor effect of wild-type p53-specific CTL. Int J Cancer 87:253-260
    • (2000) Int J Cancer , vol.87 , pp. 253-260
    • Vierboom, M.P.1    Bos, G.M.2    Ooms, M.3    Offringa, R.4    Melief, C.J.5
  • 13
    • 0030769148 scopus 로고    scopus 로고
    • Vierboom MP, Nijman HW, Offringa R, van der Voort EI, van HT, van dB, et al (1997) Tumor eradication by wild-type p53-specific cytotoxic T lymphocytes. J Exp Med 186:695-704
    • Vierboom MP, Nijman HW, Offringa R, van der Voort EI, van HT, van dB, et al (1997) Tumor eradication by wild-type p53-specific cytotoxic T lymphocytes. J Exp Med 186:695-704
  • 14
    • 2042495412 scopus 로고    scopus 로고
    • + cytotoxic T lymphocyte/tumor cell interactions reflecting recognition of an endogenously expressed murine wild-type p53 determinant
    • + cytotoxic T lymphocyte/tumor cell interactions reflecting recognition of an endogenously expressed murine wild-type p53 determinant. Cancer Immunol Immunother 49:603-612
    • (2001) Cancer Immunol Immunother , vol.49 , pp. 603-612
    • Hilburger, R.M.1    Abrams, S.I.2
  • 16
    • 0028944328 scopus 로고
    • Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcoma
    • Noguchi Y, Richards EC, Chen YT, Old LJ (1995) Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcoma. Proc Natl Acad Sci USA 92:2219-2223
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2219-2223
    • Noguchi, Y.1    Richards, E.C.2    Chen, Y.T.3    Old, L.J.4
  • 17
    • 0037443573 scopus 로고    scopus 로고
    • CTLA-4 blockade enhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model
    • Espenschied J, Lamont J, Longmate J, Pendas S, Wang Z, Diamond DJ, et al (2003) CTLA-4 blockade enhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model. J Immunol 170:3401-3407
    • (2003) J Immunol , vol.170 , pp. 3401-3407
    • Espenschied, J.1    Lamont, J.2    Longmate, J.3    Pendas, S.4    Wang, Z.5    Diamond, D.J.6
  • 18
    • 0036289020 scopus 로고    scopus 로고
    • Generating p53-specific cytotoxic T lymphocytes by recombinant adenoviral vector-based vaccination in mice, but not man
    • Kuball J, Schuler M, Antunes FE, Herr W, Neumann M, Obenauer-Kutner L, et al (2002) Generating p53-specific cytotoxic T lymphocytes by recombinant adenoviral vector-based vaccination in mice, but not man. Gene Ther 9:833-843
    • (2002) Gene Ther , vol.9 , pp. 833-843
    • Kuball, J.1    Schuler, M.2    Antunes, F.E.3    Herr, W.4    Neumann, M.5    Obenauer-Kutner, L.6
  • 19
    • 3042728833 scopus 로고    scopus 로고
    • Vaccination with p53-peptide-pulsed dendritic cells, of patients with advanced breast cancer: Report from a phase I study
    • Svane IM, Pedersen AE, Johnsen HE, Nielsen D, Kamby C, Gaarsdal E, et al (2004) Vaccination with p53-peptide-pulsed dendritic cells, of patients with advanced breast cancer: report from a phase I study. Cancer Immunol Immunother 53:633-641
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 633-641
    • Svane, I.M.1    Pedersen, A.E.2    Johnsen, H.E.3    Nielsen, D.4    Kamby, C.5    Gaarsdal, E.6
  • 20
    • 32944468708 scopus 로고    scopus 로고
    • Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer
    • Antonia SJ, Mirza N, Fricke I, Chiappori A, Thompson P, Williams N, et al (2006) Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer. Clin Cancer Res 12:878-887
    • (2006) Clin Cancer Res , vol.12 , pp. 878-887
    • Antonia, S.J.1    Mirza, N.2    Fricke, I.3    Chiappori, A.4    Thompson, P.5    Williams, N.6
  • 21
    • 0343938862 scopus 로고    scopus 로고
    • The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire
    • Hernandez J, Lee PP, Davis MM, Sherman LA (2000) The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire. J Immunol 164:596-602
    • (2000) J Immunol , vol.164 , pp. 596-602
    • Hernandez, J.1    Lee, P.P.2    Davis, M.M.3    Sherman, L.A.4
  • 22
    • 0034669973 scopus 로고    scopus 로고
    • Generation of T cells specific for the wild-type sequence p53(264-272) peptide in cancer patients: Implications for immunoselection of epitope loss variants
    • Hoffmann TK, Nakano K, Elder EM, Dworacki G, Finkelstein SD, Appella E, et al (2000) Generation of T cells specific for the wild-type sequence p53(264-272) peptide in cancer patients: implications for immunoselection of epitope loss variants. J Immunol 165:5938-5944
    • (2000) J Immunol , vol.165 , pp. 5938-5944
    • Hoffmann, T.K.1    Nakano, K.2    Elder, E.M.3    Dworacki, G.4    Finkelstein, S.D.5    Appella, E.6
  • 23
    • 33646454992 scopus 로고    scopus 로고
    • Induction of multifunctional human immunodeficiency virus type 1 (HIV-1)-specific T cells capable of proliferation in healthy subjects by using a prime-boost regimen of DNA- and modified vaccinia virus Ankara-vectored vaccines expressing HIV-1 gag coupled to CD8+ T-Cell epitopes
    • Goonetilleke N, Moore S, Dally L, Winstone N, Cebere I, Mahmoud A, et al (2006) Induction of multifunctional human immunodeficiency virus type 1 (HIV-1)-specific T cells capable of proliferation in healthy subjects by using a prime-boost regimen of DNA- and modified vaccinia virus Ankara-vectored vaccines expressing HIV-1 gag coupled to CD8+ T-Cell epitopes. J Virol 80:4717-4728
    • (2006) J Virol , vol.80 , pp. 4717-4728
    • Goonetilleke, N.1    Moore, S.2    Dally, L.3    Winstone, N.4    Cebere, I.5    Mahmoud, A.6
  • 24
    • 33646449925 scopus 로고    scopus 로고
    • Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 gag vaccine
    • Dorrell L, Yang H, Ondondo B, Dong T, di GK, Suttill A, et al (2006) Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 gag vaccine. J Virol 80:4705-4716
    • (2006) J Virol , vol.80 , pp. 4705-4716
    • Dorrell, L.1    Yang, H.2    Ondondo, B.3    Dong, T.4    di, G.K.5    Suttill, A.6
  • 26
    • 3442883353 scopus 로고    scopus 로고
    • Two distinct pathways of immunomodulation improve potency of p53 immunization in rejecting established tumors
    • Daftarian P, Song G, Ali S, Faynsod M, Longmate J, Diamond DJ, et al (2004) Two distinct pathways of immunomodulation improve potency of p53 immunization in rejecting established tumors. Cancer Res 64:5407-5414
    • (2004) Cancer Res , vol.64 , pp. 5407-5414
    • Daftarian, P.1    Song, G.2    Ali, S.3    Faynsod, M.4    Longmate, J.5    Diamond, D.J.6
  • 27
    • 0016400312 scopus 로고
    • MVA vaccination against smallpox: Clinical tests with an attenuated live vaccinia virus strain (MVA) (author's transl)
    • Stickl H, Hochstein-Mintzel V, Mayr A, Huber HC, Schafer H, Holzner A (1974) MVA vaccination against smallpox: clinical tests with an attenuated live vaccinia virus strain (MVA) (author's transl). Dtsch Med Wochenschr 99:2386-2392
    • (1974) Dtsch Med Wochenschr , vol.99 , pp. 2386-2392
    • Stickl, H.1    Hochstein-Mintzel, V.2    Mayr, A.3    Huber, H.C.4    Schafer, H.5    Holzner, A.6
  • 28
    • 0037449091 scopus 로고    scopus 로고
    • Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers
    • Moorthy VS, McConkey S, Roberts M, Gothard P, Arulanantham N, Degano P, et al (2003) Safety of DNA and modified vaccinia virus Ankara vaccines against liver-stage P. falciparum malaria in non-immune volunteers. Vaccine 21:2004-2011
    • (2003) Vaccine , vol.21 , pp. 2004-2011
    • Moorthy, V.S.1    McConkey, S.2    Roberts, M.3    Gothard, P.4    Arulanantham, N.5    Degano, P.6
  • 29
    • 0038714287 scopus 로고    scopus 로고
    • Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans
    • McConkey SJ, Reece WH, Moorthy VS, Webster D, Dunachie S, Butcher G, et al (2003) Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans. Nat Med 9:729-735
    • (2003) Nat Med , vol.9 , pp. 729-735
    • McConkey, S.J.1    Reece, W.H.2    Moorthy, V.S.3    Webster, D.4    Dunachie, S.5    Butcher, G.6
  • 30
    • 0242384126 scopus 로고    scopus 로고
    • Therapeutic vaccination with MVA-HIV-1 nef elicits Nef-specific T-helper cell responses in chronically HIV-1 infected individuals
    • Cosma A, Nagaraj R, Buhler S, Hinkula J, Busch DH, Sutter G, et al (2003) Therapeutic vaccination with MVA-HIV-1 nef elicits Nef-specific T-helper cell responses in chronically HIV-1 infected individuals. Vaccine 22:21-29
    • (2003) Vaccine , vol.22 , pp. 21-29
    • Cosma, A.1    Nagaraj, R.2    Buhler, S.3    Hinkula, J.4    Busch, D.H.5    Sutter, G.6
  • 31
    • 4344713204 scopus 로고    scopus 로고
    • Phase I trial of antigen-specific gene therapy using a recombinant vaccinia virus encoding MUC-1 and IL-2 in MUC-1-positive patients with advanced prostate cancer
    • Pantuck AJ, van Ophoven A, Gitlitz BJ, Tso CL, Acres B, Squiban P, et al (2004) Phase I trial of antigen-specific gene therapy using a recombinant vaccinia virus encoding MUC-1 and IL-2 in MUC-1-positive patients with advanced prostate cancer. J Immunother 27:240-253
    • (2004) J Immunother , vol.27 , pp. 240-253
    • Pantuck, A.J.1    van Ophoven, A.2    Gitlitz, B.J.3    Tso, C.L.4    Acres, B.5    Squiban, P.6
  • 32
    • 0035905749 scopus 로고    scopus 로고
    • Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: A new biomedical research tool
    • Luo JL, Yang Q, Tong WM, Hergenhahn M, Wang ZQ, Hollstein M (2001) Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool. Oncogene 20:320-328
    • (2001) Oncogene , vol.20 , pp. 320-328
    • Luo, J.L.1    Yang, Q.2    Tong, W.M.3    Hergenhahn, M.4    Wang, Z.Q.5    Hollstein, M.6
  • 33
    • 3242805242 scopus 로고    scopus 로고
    • Attenuated poxviruses generate clinically relevant frequencies of CMV-specific T cells
    • Wang Z, La Rosa C, Mekhoubad S, Lacey SF, Villacres MC, Markel S, et al (2004) Attenuated poxviruses generate clinically relevant frequencies of CMV-specific T cells. Blood 104:847-856
    • (2004) Blood , vol.104 , pp. 847-856
    • Wang, Z.1    La Rosa, C.2    Mekhoubad, S.3    Lacey, S.F.4    Villacres, M.C.5    Markel, S.6
  • 34
    • 0026503190 scopus 로고
    • Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
    • Aslakson CJ, Miller FR (1992) Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res 52:1399-1405
    • (1992) Cancer Res , vol.52 , pp. 1399-1405
    • Aslakson, C.J.1    Miller, F.R.2
  • 35
    • 33645214733 scopus 로고    scopus 로고
    • In vitro expansion of polyclonal T-cell subsets for adoptive immunotherapy by recombinant modified vaccinia Ankara
    • La Rosa C, Wang Z, Lacey SF, Lalimarmo MM, Krishnan A, Longmate J, et al (2006) In vitro expansion of polyclonal T-cell subsets for adoptive immunotherapy by recombinant modified vaccinia Ankara. Exp Hematol 34:497-507
    • (2006) Exp Hematol , vol.34 , pp. 497-507
    • La Rosa, C.1    Wang, Z.2    Lacey, S.F.3    Lalimarmo, M.M.4    Krishnan, A.5    Longmate, J.6
  • 36
    • 0031800888 scopus 로고    scopus 로고
    • CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
    • Moldoveanu Z, Love-Homan L, Huang WQ, Krieg AM (1998) CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine 16:1216-1224
    • (1998) Vaccine , vol.16 , pp. 1216-1224
    • Moldoveanu, Z.1    Love-Homan, L.2    Huang, W.Q.3    Krieg, A.M.4
  • 37
    • 24644522923 scopus 로고    scopus 로고
    • Immunization with mutant p53-and K-ras-derived peptides in cancer patients: Immune response and clinical outcome
    • Carbone DP, Ciernik IF, Kelley MJ, Smith MC, Nadaf S, Kavanaugh D, et al (2005) Immunization with mutant p53-and K-ras-derived peptides in cancer patients: immune response and clinical outcome. J Clin Oncol 23:5099-5107
    • (2005) J Clin Oncol , vol.23 , pp. 5099-5107
    • Carbone, D.P.1    Ciernik, I.F.2    Kelley, M.J.3    Smith, M.C.4    Nadaf, S.5    Kavanaugh, D.6
  • 38
    • 0036093592 scopus 로고    scopus 로고
    • Induction of p53-specific immune responses in colorectal cancer patients receiving a recombinant ALVAC-p53 candidate vaccine
    • van der Burg SH, Menon AG, Redeker A, Bonnet MC, Drijfhout JW, Tollenaar RA, et al (2002) Induction of p53-specific immune responses in colorectal cancer patients receiving a recombinant ALVAC-p53 candidate vaccine. Clin Cancer Res 8:1019-1027
    • (2002) Clin Cancer Res , vol.8 , pp. 1019-1027
    • van der Burg, S.H.1    Menon, A.G.2    Redeker, A.3    Bonnet, M.C.4    Drijfhout, J.W.5    Tollenaar, R.A.6
  • 39
    • 20244375365 scopus 로고    scopus 로고
    • UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin
    • Luo JL, Tong WM, Yoon JH, Hergenhahn M, Koomagi R, Yang Q, et al (2001) UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin. Cancer Res 61:8158-8163
    • (2001) Cancer Res , vol.61 , pp. 8158-8163
    • Luo, J.L.1    Tong, W.M.2    Yoon, J.H.3    Hergenhahn, M.4    Koomagi, R.5    Yang, Q.6
  • 40
    • 0031147763 scopus 로고    scopus 로고
    • The use of transgenic mice to generate high affinity p53-specific cytolytic T cells
    • Yu Z, Liu X, McCarty TM, Diamond DJ, Ellenhorn JD (1997) The use of transgenic mice to generate high affinity p53-specific cytolytic T cells. J Surg Res 69:337-343
    • (1997) J Surg Res , vol.69 , pp. 337-343
    • Yu, Z.1    Liu, X.2    McCarty, T.M.3    Diamond, D.J.4    Ellenhorn, J.D.5
  • 42
    • 0027489384 scopus 로고
    • Clinical implications of the p53 tumor-suppressor gene
    • Harris CC, Hollstein M (1993) Clinical implications of the p53 tumor-suppressor gene. N Engl J Med 329:1318-1327
    • (1993) N Engl J Med , vol.329 , pp. 1318-1327
    • Harris, C.C.1    Hollstein, M.2
  • 43
    • 0032813181 scopus 로고    scopus 로고
    • Exploiting the p53 pathway for cancer diagnosis and therapy
    • Lane DP (1999) Exploiting the p53 pathway for cancer diagnosis and therapy. Br J Cancer 80(Suppl 1):1-5
    • (1999) Br J Cancer , vol.80 , Issue.SUPPL. 1 , pp. 1-5
    • Lane, D.P.1
  • 44
    • 0031046562 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte responses to wild-type and mutant mouse p53 peptides
    • Bertholet S, Iggo R, Corradin G (1997) Cytotoxic T lymphocyte responses to wild-type and mutant mouse p53 peptides. Eur J Immunol 27:798-801
    • (1997) Eur J Immunol , vol.27 , pp. 798-801
    • Bertholet, S.1    Iggo, R.2    Corradin, G.3
  • 46
    • 0034093051 scopus 로고    scopus 로고
    • Analysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides
    • Kern F, Faulhaber N, Frommel C, Khatamzas E, Prosch S, Schonemann C, et al (2000) Analysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides. Eur J Immunol 30:1676-1682
    • (2000) Eur J Immunol , vol.30 , pp. 1676-1682
    • Kern, F.1    Faulhaber, N.2    Frommel, C.3    Khatamzas, E.4    Prosch, S.5    Schonemann, C.6
  • 47
    • 0026524347 scopus 로고
    • Extracellular processing of peptide antigens that bind class I major histocompatibility molecules
    • Sherman LA, Burke TA, Biggs JA (1992) Extracellular processing of peptide antigens that bind class I major histocompatibility molecules. J Exp Med 175:1221-1226
    • (1992) J Exp Med , vol.175 , pp. 1221-1226
    • Sherman, L.A.1    Burke, T.A.2    Biggs, J.A.3


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