Flavonoid dimers as novel, potent antileishmanial agents

Journal of Medicinal Chemistry

Volumn 55, Issue 20, 2012, Pages 8891-8902

  Wong, Iris L K ^a,b   Chan, Kin Fai ^a,b   Chan, Tak Hang ^a,b,c   Chow, Larry M C ^a,b  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b State Key Laboratory in Chinese Medicine and Molecular Pharmacology   (China)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1,13 BIS[2 (4 CHROMEN 4 ON 2 YL)PHENYL] 7 (4 PYRIDYLMETHYL) 1,4,10,13 TETRAOXA 7 AZATRIDECANE; 1,13 BIS[2 PHENYL 4H CHROMEN 4 ON 3 YL] 7 (4 PYRIDYLMETHYL) 1,4,10,13 TETRAOXA 7 AZATRIDECANE; 1,13 BIS[3' (4H CHROMEN 4 ON 2 YL)PHENYL] 7 (4 PYRIDYLMETHYL) 1,4,10,13 TETRAOXA 7 AZATRIDECANE; 1,13 BIS[4' (3 METHOXY 4H CHROMEN 4 ON 2 YL)PHENYL] 7 (4 PYRIDYLMETHYL) 1,4,10,13 TETRAOXA 7 AZATRIDECANE; 1,13 BIS[4' (4H CHROMEN 4 ON 2 YL) 2 METHOXYPHENYL] 7 (4 PYRIDYLMETHYL) 1,4,10,13 TETRAOXA 7 AZATRIDECANE; 1,13 BIS[4' (6 FLUORO 4H CHROMEN 4 ON 2 YL)PHENYL] 7 (4 PYRIDYL METHYL) 1,4,10,13 TETRAOXA 7 AZATRIDECANE; 1,7 BIS[4' (4H CHROMEN 4 ON 2 YL)PHENYL] 4 (4 PYRIDYLMETHYL)1,7 DIOXA 4 AZAHEPTANE; 2,2'[(PYRIDIN 4 YLMETHYL)AZANEDIYL]DIETHANOL; AMPHOTERICIN B; ANTILEISHMANIAL AGENT; DIMER; ETHYLENE GLYCOL; FLAVONOID; MACROGOL; N (2' CYANOPYRIDIN 4' YLMETHYL) 3,9 DIOXA 6 AZAUNDECANE 1,11 DIOL; N (3' BROMOPYRIDIN 4' YLMETHYL) 3,9 DIOXA 6 AZAUNDECANE 1,11 DIOL; N (PYRIDIN 3 YLMETHYL) 3,9 DIOXA 6 AZAUNDECANE 1,11 DIOL; N (PYRIDIN 4' YLMETHYL) 3,9 DIOXA 6 AZAUNDECANE 1,11 DIOL; N (PYRIMIDIN 4' YLMETHYL) 3,9 DIOXA 6 AZAUNDECANE 1,11 DIOL; N (QUINOLIN 4' YLMETHYL) 3,9 DIOXA 6 AZAUNDECANE 1,11 DIOL; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; IC 50; MACROPHAGE; MOUSE; NONHUMAN; PROMASTIGOTE;

AMINES; ANIMALS; ANTIPROTOZOAL AGENTS; CELL LINE; DIMERIZATION; DRUG RESISTANCE; FLAVONOIDS; LEISHMANIA; MACROPHAGES, PERITONEAL; MICE; POLYETHYLENE GLYCOLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867837865     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301172v     Document Type: Article

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