Interference with ATF5 function enhances the sensitivity of human pancreatic cancer cells to paclitaxel-induced apoptosis

Anticancer Research

Volumn 32, Issue 10, 2012, Pages 4385-4394

  Hu, Ming ^a   Wang, Bin ^a   Qian, Dongmeng ^a   Li, Ling ^a   Zhang, Li ^a   Song, Xuxia ^a   Liu, David X ^b  

^a QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; ASPC 1 cells; ATF5; BAX; BCL 2; Capan 2; Paclitaxel; Pancreatic carcinoma; SW1990

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACTIVATING TRANSCRIPTION FACTOR 5; PACLITAXEL; PROTEIN BAX; PROTEIN BCL 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; MALE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTORS; ADULT; AGED; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; MIDDLE AGED; PACLITAXEL; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; UP-REGULATION;

EID: 84867817901     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Jemal A, Siegel R, Xu J and Ward E: CA: A Cancer Journal for Clinicians 2010. Cancer Statistics 60: 277-300, 2010.
2. Igney FH and Krammer PH: Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer 2(4): 277-288, 2002. (Pubitemid 37328781)
3. Gervasoni JE, Jr., Hindenburg AA, Vezeridis MP, Schulze S, Wanebo HJ and Mehta S: An effective in vitro antitumor response against human pancreatic carcinoma with paclitaxel and daunorubicin by induction of both necrosis and apoptosis. Anticancer Res 24(5A): 2617-2626, 2004. (Pubitemid 39407135)
4. Maeda S, Motoi F, Onogawa T, Morikawa T, Shigeru O, Sakata N, Takadate T, Naitoh T, Rikiyama T, Katayose Y, Egawa S and Unno M: Paclitaxel as second-line chemotherapy in patients with gemcitabine-refractory pancreatic cancer: a retrospective study. Int J Clin Oncol 16(5): 539-545, 2011.
5. Oettle H, Arnold D, Esser M, Huhn D and Riess H: Paclitaxel as weekly second-line therapy in patients with advanced pancreatic carcinoma. Anticancer Drugs 11(8): 635-638, 2000.
6. Hai TW, Liu F, Coukos WJ and Green MR: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev 3(12B): 2083-2090, 1989. (Pubitemid 20023233)
7. Angelastro JM, Canoll PD, Kuo J, Weicker M, Costa A, Bruce JN and Greene LA: Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5. Oncogene 25(6): 907-916, 2006. (Pubitemid 43237709)
8. Dluzen D, Li G, Tacelosky D, Moreau M and Liu DX: BCL-2 Is a Downstream Target of ATF5 That Mediates the Prosurvival Function of ATF5 in a Cell Type-dependent Manner. J Biol Chem 286(9): 7705-7713, 2011.
9. Monaco SE, Angelastro JM, Szabolcs M and Greene LA: The transcription factor ATF5 is widely expressed in carcinomas, and interference with its function selectively kills neoplastic, but not nontransformed, breast cell lines. Int J Cancer 120(9): 1883-1890, 2007. (Pubitemid 46418363)
10. Li G, Xu Y, Guan D, Liu Z and Liu DX: HSP70 protein promotes survival of C6 and U87 glioma cells by inhibition of ATF5 degradation. J Biol Chem 286(23): 20251-20259, 2011.
11. Liu DX, Qian D, Wang B, Yang JM and Lu Z: p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival. Mol Cell Biol 31(18): 3906-3916, 2011.
12. Persengiev SP, Devireddy LR and Green MR: Inhibition of apoptosis by ATFx: A novel role for a member of the ATF/CREB family of mammalian bZIP transcription factors. Genes Dev 16(14): 1806-1814, 2002. (Pubitemid 34803896)
13. Gho JW, Ip WK, Chan KY, Law PT, Lai PB and Wong N: Re-expression of transcription factor ATF5 in hepatocellular carcinoma induces G2-M arrest. Cancer research 68(16): 6743-6751, 2008.
14. Liu X, Liu D, Qian D, Dai J, An Y, Jiang S, Stanley B, Yang J, Wang B, Liu X and Liu DX: Nucleophosmin (NPM1/B23) interacts with ATF5 and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells. J Biol Chem 287(23): 19599-609, 2012.
15. Li G, Li W, Angelastro JM, Greene LA and Liu DX: Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells. Mol Cancer Res 7(6): 933-943, 2009.
16. Li Y, Yin W, Wang X, Zhu W, Huang Y and Yan G: Cholera toxin induces malignant glioma cell differentiation via the PKA/CREB pathway. Proc Natl Acad Sci USA 104: 13438-13443, 2007. (Pubitemid 47293963)
17. Dong S, Nutt CL, Betensky RA, Stemmer-Rachamimov AO, Denko NC, Ligon KL, Rowitch DH and Louis DN: Histology-based expression profiling yields novel prognostic markers in human glioblastoma. J Neuropathol Exp Neurol 64(11): 948-955, 2005. (Pubitemid 41668924)
18. Sheng Z, Li L, Zhu LJ, Smith TW, Demers A, Ross AH, Moser RP and Green MR: A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications. Nat Med 16(6): 671-677, 2010.
19. Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M and Letai A: BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Cancer Cell 12(2): 171-185, 2007. (Pubitemid 47199122)
20. Cheng S, Gao N, Zhang Z, Chen G, Budhraja A, Ke Z, Son YO, Wang X, Luo J and Shi X: Quercetin induces tumor-selective apoptosis through down-regulation of Mcl-1 and activation of Bax. Clin Cancer Res 16(23): 5679-5691, 2010.
21. + regulatory T cells by paclitaxel is explained by Bcl-2/Bax mediated apoptosis. Intl Immunopharmacol 11(2): 212-219, 2011.
22. Xi G, Hu X, Wu B, Jiang H, Young CY, Pang Y and Yuan H: Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells. Cancer Lett 307(2): 141-148, 2011.
23. Ajabnoor GM, Crook T and Coley HM: Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells. Cell Death Dis 3: e260, 2012.
24. Sheng Z, Ma L, Sun JE, Zhu LJ and Green MR: BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription. Blood 118(10): 2840-2848, 2011.
25. Dumontet C, Duran GE, Steger KA, Beketic-Oreskovic L and Sikic BI: Resistance mechanisms in human sarcoma mutants derived by single-step exposure to paclitaxel (Taxol). Cancer Res 56(5): 1091-1097, 1996. (Pubitemid 26065405)