WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3

Genomics

Volumn 76, Issue 1-3, 2001, Pages 5-8

  Stec, Ingrid ^a   Van Ommen, Gert Jan B ^a   Den Dunnen, Johan T ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; PROLINE; TRYPTOPHAN; ZINC FINGER PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CARCINOGENESIS; CHROMOSOME 17Q; CHROMOSOME 4P; CHROMOSOME 8P; EMBRYO DEVELOPMENT; GENE; GENE EXPRESSION; GENE LOCATION; GENE MAPPING; GENE REARRANGEMENT; GENETIC ANALYSIS; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; WOLF HIRSCHHORN SYNDROME CANDIDATE GENE 1;

CANIS;

EID: 0035878457     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2001.6581     Document Type: Article

References (13)

1. WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma
2. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts
3. A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription
4. The PWWP domain: A potential protein-protein interaction domain in nuclear proteins influencing differentiation?
5. The PHD finger: Implications for chromatin-mediated transcriptional regulation
6. Two distinct nuclear receptor interaction domains in NSDI, a novel SET protein that exhibits characteristics of both corepressors and coactivators
7. The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes
8. Differential expression assay of chromosome arm 8p genes identities Frizzled-related (FRP1/FRZB) and fibroblast growth factor receptor 1 (FGFR1) as candidate breast cancer genes
9. Strong indication for a breast cancer susceptibility gene on chromosome 8p12-p22: Linkage analysis in German breast cancer families
10. Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon
11. Silencing of TGF-β signalling by the pseudoreceptor BAMBI
12. LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients
13. Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region