Molecular insights into the biosynthesis of guadinomine: A type III secretion system inhibitor

Journal of the American Chemical Society

Volumn 134, Issue 42, 2012, Pages 17797-17806

  Holmes, Tracy C ^a   May, Aaron E ^a   Zaleta Rivera, Kathia ^a   Ruby, J Graham ^b   Skewes Cox, Peter ^b   Fischbach, Michael A ^b   Derisi, Joseph L ^b   Iwatsuki, Masato ^c   Omura, Satoshi ^c   Khosla, Chaitan ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHETIC GENE CLUSTER; BIOSYNTHETIC PATHWAY; CARRIER PROTEINS; GENE CLUSTERS; GRAM-NEGATIVE BACTERIA; GUADINOMINES; HETEROLOGOUS EXPRESSION; KEY ENZYMES; MODE OF ACTION; MOLECULAR INSIGHTS; MULTI-MODULAR; NATURAL PRODUCTS; NONRIBOSOMAL PEPTIDE SYNTHETASES; OPEN READING FRAME; POLYKETIDE SYNTHASES; PSEUDOMONAS SPP; SALMONELLA SPP; STREPTOMYCES SP; TYPE III SECRETION SYSTEM; VIBRIO SPP;

BACTERIA; BIOCHEMISTRY; CLONING; ESCHERICHIA COLI; GENE EXPRESSION; PLANTS (BOTANY);

BIOSYNTHESIS;

ANTIBIOTIC AGENT; GUADINOMINE A; GUADINOMINE B; GUADINOMINE C; GUADINOMINE E; GUADINOMINE F; GUADINOMINE G; GUADINOMINE H; GUADINOMINE T; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL VIRULENCE; CHLAMYDIA; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; GENE CLUSTER; IC 50; NONHUMAN; PROTEIN EXPRESSION; PSEUDOMONAS; SALMONELLA; VIBRIO; YERSINIA;

BACTERIAL SECRETION SYSTEMS; DIPEPTIDES; IMIDAZOLIDINES; MOLECULAR CONFORMATION; STREPTOMYCES;

EID: 84867785420     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja308622d     Document Type: Article

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