Toxicity of deoxynivalenol and its acetylated derivatives on the intestine: Differential effects on morphology, barrier function, tight junction proteins, and mitogen-activated protein kinases

Toxicological Sciences

Volumn 130, Issue 1, 2012, Pages 180-190

  Pinton, Philippe ^a   Tsybulskyy, Dima ^a   Lucioli, Joelma ^a,b   Laffitte, Joëlle ^a   Callu, Patrick ^c   Lyazhri, Faouzi ^d   Grosjean, François ^c   Bracarense, Ana Paula ^b   Kolf clauw, Martine ^a,d   Oswald, Isabelle P ^a,b  

^a TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

^b STATE UNIVERSITY OF LONDRINA   (Brazil)

^c ARVALIS Inst Vegetal   (France)

^d UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Acetyl deoxynivalenol; Intestinal epithelial cells; Intestine; MAP Kinase; Tight junction proteins; Trichothecenes

Indexed keywords

15 ACETYL DEOXYNIVALENOL; 3 ACETYL DEOXYNIVALENOL; ACETIC ACID DERIVATIVE; BETA ACTIN; CLAUDIN 3; CLAUDIN 4; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; VOMITOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CEREAL; COMPARATIVE STUDY; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; EX VIVO STUDY; EXPLANT; FOOD CONTAMINATION; GASTROENTERITIS; GASTROINTESTINAL TOXICITY; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE EPITHELIUM; JEJUNUM; MALE; MORPHOLOGY; NEWBORN; NONHUMAN; PIGLET; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TIGHT JUNCTION;

ANIMALS; ANIMALS, NEWBORN; CELL LINE; CELL PROLIFERATION; ELECTROPHYSIOLOGICAL PHENOMENA; FOOD CONTAMINATION; INTESTINAL MUCOSA; INTESTINE, SMALL; MITOGEN-ACTIVATED PROTEIN KINASES; PATCH-CLAMP TECHNIQUES; SWINE; TIGHT JUNCTION PROTEINS; TIGHT JUNCTIONS; TRICHOTHECENES;

EID: 84867749654     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs239     Document Type: Article

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