Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation

AIDS

Volumn 26, Issue 16, 2012, Pages 1995-2006

  Stankov, Metodi V ^a   Panayotova Dimitrova, Diana ^b   Leverkus, Martin ^b   Vondran, Florian W R ^a   Bauerfeind, Rudolf ^a   Binz, Annerose ^a   Behrens, Georg M N ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

antiretroviral therapy; autophagy; hepatocytes; HIV infection; liver; steatosis

Indexed keywords

LAMIVUDINE; REACTIVE OXYGEN METABOLITE; STAVUDINE; THYMIDINE DERIVATIVE; ZIDOVUDINE;

APOPTOSIS; AUTOPHAGY; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG POTENTIATION; ELECTRON MICROSCOPY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIPID METABOLISM; LIPID STORAGE; LIVER CELL; PRIORITY JOURNAL; REVIEW; WESTERN BLOTTING;

ANTI-HIV AGENTS; AUTOPHAGY; BLOTTING, WESTERN; CELLS, CULTURED; DNA, MITOCHONDRIAL; FATTY LIVER; FEMALE; FLOW CYTOMETRY; HEP G2 CELLS; HIV INFECTIONS; HUMANS; LIPID METABOLISM; MALE; MICROSCOPY, ELECTRON; MITOCHONDRIA, LIVER; STAVUDINE; THYMIDINE; ZIDOVUDINE;

EID: 84867746835     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32835804f9     Document Type: Review

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