메뉴 건너뛰기




Volumn 3, Issue 5, 2010, Pages 436-441

Pharmacodynamic effects of concomitant versus staggered clopidogrel and omeprazole intake : Results of a prospective randomized crossover study

Author keywords

Clopidogrel; Drug interactions; Omeprazole

Indexed keywords

CLOPIDOGREL; OMEPRAZOLE; PURINERGIC P2Y12 RECEPTOR; VASODILATOR STIMULATED PHOSPHOPROTEIN;

EID: 78650113666     PISSN: 19417640     EISSN: 19417632     Source Type: Journal    
DOI: 10.1161/CIRCINTERVENTIONS.110.957829     Document Type: Article
Times cited : (59)

References (38)
  • 3
    • 59849120163 scopus 로고    scopus 로고
    • Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: A 12-month follow-up
    • Marcucci R, Gori AM, Paniccia R, Giusti B, Valente S, Giglioli C, Buonamici P, Antoniucci D, Abbate R, Gensini GF. Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: A 12-month follow-up. Circulation. 2009;119:237-242.
    • (2009) Circulation. , vol.119 , pp. 237-242
    • Marcucci, R.1    Gori, A.M.2    Paniccia, R.3    Giusti, B.4    Valente, S.5    Giglioli, C.6    Buonamici, P.7    Antoniucci, D.8    Abbate, R.9    Gensini, G.F.10
  • 6
    • 67749117943 scopus 로고    scopus 로고
    • Clopidogrel response variability: Current status and future directions
    • Ferreiro JL, Angiolillo DJ. Clopidogrel response variability: Current status and future directions. Thromb Haemost. 2009;102:7-14.
    • (2009) Thromb Haemost. , vol.102 , pp. 7-14
    • Ferreiro, J.L.1    Angiolillo, D.J.2
  • 7
    • 69249206873 scopus 로고    scopus 로고
    • Antiplatelet therapy: Clopidogrel plus PPIs - A dangerous combination?
    • Ferreiro JL, Angiolillo DJ. Antiplatelet therapy: Clopidogrel plus PPIs-a dangerous combination? Nat Rev Cardiol. 2009;6:392-394.
    • (2009) Nat Rev Cardiol. , vol.6 , pp. 392-394
    • Ferreiro, J.L.1    Angiolillo, D.J.2
  • 8
    • 3242676832 scopus 로고    scopus 로고
    • Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities
    • DOI 10.1124/dmd.32.8.821
    • Li XQ, Andersson TB, Ahlström M, Weidolf L. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004;32:821-827. (Pubitemid 38955611)
    • (2004) Drug Metabolism and Disposition , vol.32 , Issue.8 , pp. 821-827
    • Li, X.-Q.1    Andersson, T.B.2    Ahlstrom, M.3    Weidolf, L.4
  • 9
    • 33750079553 scopus 로고    scopus 로고
    • Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin [8]
    • DOI 10.1111/j.1538-7836.2006.02162.x
    • Gilard M, Arnaud B, Le Gal G, Abgrall JF, Boschat J. Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin. J Thromb Haemost. 2006;4:2508-2509. (Pubitemid 44575451)
    • (2006) Journal of Thrombosis and Haemostasis , vol.4 , Issue.11 , pp. 2508-2509
    • Gilard, M.1    Arnaud, B.2    Le Gal, G.3    Abgrall, J.F.4    Boschat, J.5
  • 10
    • 38349065084 scopus 로고    scopus 로고
    • Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: The randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study
    • Gilard M, Arnaud B, Cornily JC, Le Gal G, Lacut K, Le Calvez G, Mansourati J, Mottier D, Abgrall JF, Boschat J. Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: The randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. J Am Coll Cardiol. 2008;51:256-260.
    • (2008) J Am Coll Cardiol. , vol.51 , pp. 256-260
    • Gilard, M.1    Arnaud, B.2    Cornily, J.C.3    Le Gal, G.4    Lacut, K.5    Le Calvez, G.6    Mansourati, J.7    Mottier, D.8    Abgrall, J.F.9    Boschat, J.10
  • 11
    • 73149119363 scopus 로고    scopus 로고
    • Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
    • Kazui M, Nishiya Y, Ishizuka T, Hagihara K, Farid NA, Okazaki O, Ikeda T, Kurihara A. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab Dispos. 2010;38:92-99.
    • (2010) Drug Metab Dispos. , vol.38 , pp. 92-99
    • Kazui, M.1    Nishiya, Y.2    Ishizuka, T.3    Hagihara, K.4    Farid, N.A.5    Okazaki, O.6    Ikeda, T.7    Kurihara, A.8
  • 12
    • 57749097363 scopus 로고    scopus 로고
    • Abstract 3998: Proton pump inhibitors effect on clopidogrel effectiveness: The Clopidogrel Medco Outcomes study (abstract 3998)
    • Aubert R, Epstein R, Teagarden J, Xia F, Yao J, Desta Z, Skaar T, Flockhart DA. Abstract 3998: Proton pump inhibitors effect on clopidogrel effectiveness: The Clopidogrel Medco Outcomes study (abstract 3998). Circulation. 2008;118:S815.
    • (2008) Circulation. , vol.118
    • Aubert, R.1    Epstein, R.2    Teagarden, J.3    Xia, F.4    Yao, J.5    Desta, Z.6    Skaar, T.7    Flockhart, D.A.8
  • 13
    • 64849116567 scopus 로고    scopus 로고
    • Abstract 3999: Baseline proton pump inhibitor use is associated with increased cardiovascular events with and without the use of clopidogrel in the CREDO trial
    • Dunn SP, Macaulay TE, Brennan DM. Abstract 3999: Baseline proton pump inhibitor use is associated with increased cardiovascular events with and without the use of clopidogrel in the CREDO trial. Circulation. 2008;118:S815.
    • (2008) Circulation. , vol.118
    • Dunn, S.P.1    Macaulay, T.E.2    Brennan, D.M.3
  • 14
    • 61549124132 scopus 로고    scopus 로고
    • Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome
    • Ho PM, Maddox TM, Wang L, Fihn SD, Jesse RL, Peterson ED, Rumsfeld JS. Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA. 2009;301:937-944.
    • (2009) JAMA. , vol.301 , pp. 937-944
    • Ho, P.M.1    Maddox, T.M.2    Wang, L.3    Fihn, S.D.4    Jesse, R.L.5    Peterson, E.D.6    Rumsfeld, J.S.7
  • 17
    • 73449122247 scopus 로고    scopus 로고
    • Cardiovascular outcomes and mortality in patients using clopidogrel with proton pump inhibitors after percutaneous coronary intervention or acute coronary syndrome
    • Rassen JA, Choudhry NK, Avorn J, Schneeweiss S. Cardiovascular outcomes and mortality in patients using clopidogrel with proton pump inhibitors after percutaneous coronary intervention or acute coronary syndrome. Circulation. 2009;120:2322-2329.
    • (2009) Circulation. , vol.120 , pp. 2322-2329
    • Rassen, J.A.1    Choudhry, N.K.2    Avorn, J.3    Schneeweiss, S.4
  • 20
    • 78650118562 scopus 로고    scopus 로고
    • Food and Drug Administration Public-health advisory: updated safety information about a drug interaction between clopidogrel bisulfate (marketed as Plavix) and omeprazole (marketed as Prilosec and Prilosec OTC). http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ 2009/ucm191169.htm -https://swa.shandsjacksonville.com/exchweb/ bin/redir.asp?URL, htm Published November 17, 2009. Accessed November 19, 2009
    • Food and Drug Administration. Public-health advisory: updated safety information about a drug interaction between clopidogrel bisulfate (marketed as Plavix) and omeprazole (marketed as Prilosec and Prilosec OTC). http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ 2009/ucm191169.htm -https://swa.shandsjacksonville.com/exchweb/ bin/redir.asp?URL-http://www.fda. gov/NewsEvents/Newsroom/ PressAnnouncements/2009/ucm191169.htm- Published November 17, 2009. Accessed November 19, 2009.
  • 21
    • 78650147984 scopus 로고    scopus 로고
    • European Medicines Agency Public statement on possible interaction between clopidogrel and proton-pump inhibitors.Published May 29, Accessed November 30, 2009
    • European Medicines Agency. Public statement on possible interaction between clopidogrel and proton-pump inhibitors. http://www.ema.europa. eu/humandocs/PDFs/EPAR/Plavix/32895609en.pdf. Published May 29, 2009. Accessed November 30, 2009.
    • (2009)
  • 22
    • 73449130146 scopus 로고    scopus 로고
    • Proton pump inhibitors and clopidogrel: Putting the interaction in perspective
    • Juurlink DN. Proton pump inhibitors and clopidogrel: Putting the interaction in perspective. Circulation. 2009;120:2310-2312.
    • (2009) Circulation. , vol.120 , pp. 2310-2312
    • Juurlink, D.N.1
  • 23
    • 73849084548 scopus 로고    scopus 로고
    • Proton pump inhibitor and clopidogrel interaction: Fact or fiction?
    • Laine L, Hennekens C. Proton pump inhibitor and clopidogrel interaction: Fact or fiction? Am J Gastroenterol. 2010;105:34-41.
    • (2010) Am J Gastroenterol. , vol.105 , pp. 34-41
    • Laine, L.1    Hennekens, C.2
  • 24
    • 15944383861 scopus 로고    scopus 로고
    • Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases
    • DOI 10.1111/j.1538-7836.2004.01063.x
    • Aleil B, Ravanat C, Cazenave JP, Rochoux G, Heitz A, Gachet C. Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases. J Thromb Haemost. 2005;3:85-92. (Pubitemid 41647119)
    • (2005) Journal of Thrombosis and Haemostasis , vol.3 , Issue.1 , pp. 85-92
    • Aleil, B.1    Ravanat, C.2    Cazenave, J.P.3    Rochoux, G.4    Heitz, A.5    Gachet, C.6
  • 25
    • 33847130538 scopus 로고    scopus 로고
    • Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: Results of the optimizing antiplatelet therapy in diabetes mellitus (OPTIMUS) study
    • DOI 10.1161/CIRCULATIONAHA.106.667741, PII 0000301720070213000008
    • Angiolillo DJ, Shoemaker SB, Desai B, Yuan H, Charlton RK, Bernardo E, Zenni MM, Guzman LA, Bass TA, Costa MA. Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: Results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) study. Circulation. 2007; 115:708-716. (Pubitemid 46294761)
    • (2007) Circulation , vol.115 , Issue.6 , pp. 708-716
    • Angiolillo, D.J.1    Shoemaker, S.B.2    Desai, B.3    Yuan, H.4    Charlton, R.K.5    Bernardo, E.6    Zenni, M.M.7    Guzman, L.A.8    Bass, T.A.9    Costa, M.A.10
  • 27
    • 0347359012 scopus 로고    scopus 로고
    • 1
    • DOI 10.1016/S0143-4160(03)00170-2
    • 12 receptor antagonists AR-C69931MX and clopidogrel is enhanced by prostaglandin E1. Cell Calcium. 2004;35:39-46. (Pubitemid 38054787)
    • (2004) Cell Calcium , vol.35 , Issue.1 , pp. 39-46
    • Fox, S.C.1    Behan, M.W.H.2    Heptinstall, S.3
  • 28
    • 70049098599 scopus 로고    scopus 로고
    • Comparison of omeprazole and pantoprazole influence on a high 150-mg clopidogrel maintenance dose the PACA (Proton Pump Inhibitors And Clopidogrel Association) prospective randomized study
    • Cuisset T, Frere C, Quilici J, Poyet R, Gaborit B, Bali L, Brissy O, Morange PE, Alessi MC, Bonnet JL. Comparison of omeprazole and pantoprazole influence on a high 150-mg clopidogrel maintenance dose the PACA (Proton Pump Inhibitors And Clopidogrel Association) prospective randomized study. J Am Coll Cardiol. 2009;54:1149-1153.
    • (2009) J Am Coll Cardiol. , vol.54 , pp. 1149-1153
    • Cuisset, T.1    Frere, C.2    Quilici, J.3    Poyet, R.4    Gaborit, B.5    Bali, L.6    Brissy, O.7    Morange, P.E.8    Alessi, M.C.9    Bonnet, J.L.10
  • 30
    • 0242298647 scopus 로고    scopus 로고
    • Effects of Statins on Platelet Inhibition by a High Loading Dose of Clopidogrel
    • DOI 10.1161/01.CIR.0000099507.32936.C0
    • Müller I, Besta F, Schulz C, Li Z, Massberg S, Gawaz M. Effects of statins on platelet inhibition by a high loading dose of clopidogrel. Circulation. 2003;108:2195-2197. (Pubitemid 37363034)
    • (2003) Circulation , vol.108 , Issue.18 , pp. 2195-2197
    • Muller, I.1    Besta, F.2    Schulz, C.3    Li, Z.4    Massberg, S.5    Gawaz, M.6
  • 31
    • 76349116477 scopus 로고    scopus 로고
    • Genotyping, clopidogrel metabolism, and the search for the therapeutic window of thienopyridines
    • Steinhubl SR. Genotyping, clopidogrel metabolism, and the search for the therapeutic window of thienopyridines. Circulation. 2010;121:481-483.
    • (2010) Circulation. , vol.121 , pp. 481-483
    • Steinhubl, S.R.1
  • 37
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators
    • Simon T, Verstuyft C, Mary-Krause M, Quteineh L, Drouet E, Méneveau N, Steg PG, Ferrières J, Danchin N, Becquemont L; French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med. 2009;360:363-375.
    • (2009) N Engl J Med. , vol.360 , pp. 363-375
    • Simon, T.1    Verstuyft, C.2    Mary-Krause, M.3    Quteineh, L.4    Drouet, E.5    Méneveau, N.6    Steg, P.G.7    Ferrières, J.8    Danchin, N.9    Becquemont, L.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.