Tetraspanins in cancer

Cell-Extracellular Matrix Interactions in Cancer

Volumn , Issue , 2010, Pages 217-243

  Zijlstra, Andries ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

Cancer; Migration Tetraspanin Enriched Microdomain (TERM); Scaffold; Tetraspanin; TM4SF; TSPAN

Indexed keywords

EID: 84867693718     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-0814-8_10     Document Type: Chapter

References (170)

1. Abe M, Sugiura T, Takahashi M, Ishii K, Shimoda M, Shirasuna K (2008) A novel function of CD82/KAI-1 on E-cadherin-mediated homophilic cellular adhesion of cancer cells. Cancer Lett 266(2):163-170
2. Andre F, Schartz NE et al (2002) Malignant effusions and immunogenic tumour-derived exosomes. Lancet 360(9329):295-305
3. André M, Le Caer JP, Greco C, Planchon S, El Nemer W, Boucheix C, Rubinstein E, Chamot-Rooke J, Le Naour F (2006) Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS. Proteomics 6(5):1437-1449
4. Ang J, Lijovic M, Ashman LK, Kan K, Frauman AG (2004) CD151 protein expression predicts the clinical outcome of low-grade primary prostate cancer better than histologic grading: A new prognostic indicator?. Cancer Epidemiol Biomarkers Prev 13(11 Pt 1):1717-1721
5. Arduise C, Abache T et al (2008) Tetraspanins regulate ADAM10-mediated cleavage of TNFalpha and epidermal growth factor. J Immunol 181(10):7002-7013
6. Baleato RM, Guthrie PL, Gubler MC, Ashman LK, Roselli S (2008) Deletion of CD151 results in a strain-dependent glomerular disease due to severe alterations of the glomerular basement membrane. Am J Pathol 173(4):927-937
7. Berditchevski F (2001) Complexes of tetraspanins with integrins: More than meets the eye. J Cell Sci 114(Pt 23):4143-4151
8. Berditchevski F, Odintsova E (1999) Characterization of integrin-Tetraspanin adhesion complexes: Role of tetraspanins in integrin signaling. J Cell Biol 146(2):477-492
9. Berditchevski F, Odintsova E (2007) Tetraspanins as regulators of protein trafficking. Traffic 8(2):89-96
10. Berditchevski F, Zutter MM, Hemler ME (1996) Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins). Mol Biol Cell 7(2):193-207
11. Berditchevski F, Gilbert E, Griffiths MR, Fitter S, Ashman L, Jenner SJ (2001) Analysis of the CD151-Alpha3beta1 integrin and CD151-Tetraspanin interactions by mutagenesis. J Biol Chem 276(44):41165-41174
12. Berditchevski F, Odintsova E, Sawada S, Gilbert E (2002) Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling. J Biol Chem 277(40):36991-37000
13. Bienstock RJ, Barrett JC (2001) KAI1, a prostate metastasis suppressor: Prediction of solvated structure and interactions with binding partners; integrins, cadherins, and cell-surface receptor proteins. Mol Carcinog 32(3):139-153
14. Caby MP, Lankar D, Vincendeau-Scherrer C, Raposo G, Bonnerot C (2005) Exosomal-like vesicles are present in human blood plasma. Int Immunol 17(7):879-887
15. Carloni V, Mazzocca A, Ravichandran KS (2004) Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells. Oncogene 23(8):1566-1574
16. Charrin S, Manié S, Billard M, Ashman L, Gerlier D, Boucheix C, Rubinstein E (2003) Multiple levels of interactions within the tetraspanin web. Biochem Biophys Res Commun 304(1):107-112
17. Chattopadhyay N, Wang Z, Ashman LK, Brady-Kalnay SM, Kreidberg JA (2003) alpha3beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPmu expression and cell-cell adhesion. J Cell Biol 163(6):1351-1362
18. Chen Z, Mustafa T et al (2004) CD82, and CD63 in thyroid cancer. Int J Mol Med 14(4):517-527
19. Chen L, Wang Z, Zhan X, Li DC, Zhu YY, Zhu J (2007) Association of NET-1 gene expression with human hepatocellular carcinoma. Int J Surg Pathol 15(4):346-353
20. Chen L, Li X, Wang GL, Wang Y, Zhu YY, Zhu J (2008) Clinicopathological significance of overexpression of TSPAN1, Ki67 and CD34 in gastric carcinoma. Tumori 94(4):531-538
21. Claas C, Seiter S, Claas A, Savelyeva L, Schwab M, Zöller M (1998) Association between the rat homologue of CO-029, a metastasis-Associated tetraspanin molecule and consumption coagulopathy. J Cell Biol 141(1):267-280
22. Deng J, Yeung VP, Tsitoura D, DeKruyff RH, Umetsu DT, Levy S (2000) Allergen-induced airway hyperreactivity is diminished in CD81-deficient mice. J Immunol 165(9):5054-5061
23. Dong JT, Lamb PW, Rinker-Schaeffer CW, Vukanovic J, Ichikawa T, Isaacs JT, Barrett JC (1995) KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 268(5212):884-886
24. Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, Geuze HJ (1998) Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem 273(32):20121-20127
25. Feigelson SW, Grabovsky V, Shamri R, Levy S, Alon R (2003) The CD81 tetraspanin facilitates instantaneous leukocyte VLA-4 adhesion strengthening to vascular cell adhesion molecule 1 (VCAM-1) under shear flow. J Biol Chem 278(51):51203-51212
26. Funakoshi T, Tachibana I et al (2003) Expression of tetraspanins in human lung cancer cells: Frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer. Oncogene 22(5):674-687
27. Garcia-España A, Chung PJ, Sarkar IN, Stiner E, Sun TT, Desalle R (2008) Appearance of new tetraspanin genes during vertebrate evolution. Genomics 91(4):326-334
28. Geary SM, Cambareri AC, Sincock PM, Fitter S, Ashman LK (2001) Differential tissue expression of epitopes of the tetraspanin CD151 recognised by monoclonal antibodies. Tissue Antigens 58(3):141-153
29. Gesierich S, Paret C et al (2005) Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: Impact on cell motility. Clin Cancer Res 11(8):2840-2852
30. Gesierich S, Berezovskiy I, Ryschich E, Zöller M (2006) Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029. Cancer Res 66(14):7083-7094
31. Griffith L, Slupsky J, Seehafer J, Boshkov L, Shaw AR (1991) Platelet activation by immobilized monoclonal antibody: Evidence for a CD9 proximal signal. Blood 78(7):1753-1759
32. Guindon S, Gascuel O (2003) A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 52(5):696-704
33. Guo X, Friess H, Graber HU, Kashiwagi M, Zimmermann A, Korc M, BÜchler MW (1996) KAI1 expression is up-regulated in early pancreatic cancer and decreased in the presence of metastases. Cancer Res 56(21):4876-4880
34. Guo XZ, Friess H et al (1998) KAI1 is unchanged in metastatic and nonmetastatic esophageal and gastric cancers. Cancer Res 58(4):753-758
35. Hadjiargyrou M, Patterson PH (1995) An anti-CD9 monoclonal antibody promotes adhesion and induces proliferation of Schwann cells in vitro. J Neurosci 15(1 Pt 2):574-583
36. Hashida H, Takabayashi A et al (2003) Clinical significance of transmembrane 4 superfamily in colon cancer. Br J Cancer 89(1):158-167
37. Hemler ME (2005) Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol 6(10):801-811
38. Hemler ME (2008) Targeting of tetraspanin proteins - potential benefits and strategies. Nat Rev Drug Discov 7(9):747-758
39. Higashiyama M, Taki T, Ieki Y, Adachi M, Huang CL, Koh T, Kodama K, Doi O, Miyake M (1995a) Reduced motility related protein-1 (MRP-1/CD9) gene expression as a factor of poor prognosis in non-small cell lung cancer. Cancer Res 55(24):6040-6044
40. Higashiyama S, Iwamoto R, Goishi K, Raab G, Taniguchi N, Klagsbrun M, Mekada E (1995b) The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-Anchored heparin-binding EGF-like growth factor. J Cell Biol 128(5):929-938
41. Hinoda Y, Adachi Y, Takaoka A, Mitsuuchi H, Satoh Y, Itoh F, Kondoh Y, Imai K (1998) Decreased expression of the metastasis suppressor gene KAI1 in gastric cancer. Cancer Lett 129(2):229-234
42. Hirano T, Higuchi T et al (1999) CD9 is involved in invasion of human trophoblast-like choriocarcinoma cell line, BeWo cells. Mol Hum Reprod 5(2):168-174
43. Hood JD, Cheresh DA (2002) Role of integrins in cell invasion and migration. Nat Rev Cancer 2(2):91-100
44. Hori H, Yano S, Koufuji K, Takeda J, Shirouzu K (2004) CD9 expression in gastric cancer and its significance. J Surg Res 117(2):208-215
45. Hotta H, Takahashi N, Homma M (1989) Transcriptional enhancement of the human gene encoding for a melanoma-Associated antigen (ME491) in association with malignant transformation. Jpn J Cancer Res 80(12):1186-1191
46. Hotta H, Hara I, Miyamoto H, Homma M (1991) Overexpression of the human melanoma-Associated antigen ME491 partially suppresses in vivo malignant phenotypes of H-ras-Transformed NIH3T3 cells in athymic nude mice. Melanoma Res 1(2):125-132
47. Huang CI, Kohno N, Ogawa E, Adachi M, Taki T, Miyake M (1998) Correlation of reduction in MRP-1/CD9 and KAI1/CD82 expression with recurrences in breast cancer patients. Am J Pathol 153(3):973-983
48. Huang S, Yuan S et al (2005a) The phylogenetic analysis of tetraspanins projects the evolution of cell-cell interactions from unicellular to multicellular organisms. Genomics 86(6):674-684
49. Huang H, Groth J, Sossey-Alaoui K, Hawthorn L, Beall S, Geradts J (2005b) Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors. Clin Cancer Res 11(12):4357-4364
50. Huang H, Sossey-Alaoui K, Beachy SH, Geradts J (2007) The tetraspanin superfamily member NET-6 is a new tumor suppressor gene. J Cancer Res Clin Oncol 133(10):761-769
51. Ikeyama S, Koyama M, Yamaoko M, Sasada R, Miyake M (1993) Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. J Exp Med 177(5):1231-1237
52. Ito E, Honma R et al (2003) A tetraspanin-family protein, T-cell acute lymphoblastic leukemiaassociated antigen 1, is induced by the Ewing's sarcoma-Wilms' tumor 1 fusion protein of desmoplastic small round-cell tumor. Am J Pathol 163(6):2165-2172
53. Jackson P, Kingsley EA, Russell PJ (2000) Inverse correlation between KAI1 mRNA levels and invasive behaviour in bladder cancer cell lines. Cancer Lett 156(1):9-17
54. Jackson P, Marreiros A, Russell PJ (2005) KAI1 tetraspanin and metastasis suppressor. Int J Biochem Cell Biol 37(3):530-534
55. Jankowski SA, Mitchell DS, Smith SH, Trent JM, Meltzer PS (1994) SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins. Oncogene 9(4):1205-1211
56. Janowska-Wieczorek A, Wysoczynski M, Kijowski J, Marquez-Curtis L, Machalinski B, Ratajczak J, Ratajczak MZ (2005) Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer. Int J Cancer 113(5):752-760
57. Jee BK, Lee JY, Lim Y, Lee KH, Jo YH (2007) Effect of KAI1/CD82 on the beta1 integrin maturation in highly migratory carcinoma cells. Biochem Biophys Res Commun 359(3):703-708
58. Kanetaka K, Sakamoto M, Yamamoto Y, Yamasaki S, Lanza F, Kanematsu T, Hirohashi S (2001) Overexpression of tetraspanin CO-029 in hepatocellular carcinoma. J Hepatol 35(5):637-642
59. Kanetaka K, Sakamoto M, Yamamoto Y, Takamura M, Kanematsu T, Hirohashi S (2003) Possible involvement of tetraspanin CO-029 in hematogenous intrahepatic metastasis of liver cancer cells. J Gastroenterol Hepatol 18(11):1309-1314
60. Karamatic Crew V, Burton N, Kagan A, Green CA, Levene C, Flinter F, Brady RL, Daniels G, Anstee DJ (2004) CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin. Blood 104(8):2217-2223
61. Karamatic Crew V, Poole J et al (2008) Two MER2-negative individuals with the same novel CD151 mutation and evidence for clinical significance of anti-MER2. Transfusion 48(9):1912-1916
62. Kazarov AR, Yang X, Stipp CS, Sehgal B, Hemler ME (2002) An extracellular site on tetraspanin CD151 determines alpha 3 and alpha 6 integrin-dependent cellular morphology. J Cell Biol 158(7):1299-1309
63. Klosek SK, Nakashiro K, Hara S, Shintani S, Hasegawa H, Hamakawa H (2005) CD151 forms a functional complex with c-Met in human salivary gland cancer cells. Biochem Biophys Res Commun 336(2):408-416
64. Kobayashi T, Vischer UM, Rosnoblet C, Lebrand C, Lindsay M, Parton RG, Kruithof EK, Gruenberg J (2000) The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells. Mol Biol Cell 11(5):1829-1843
65. Koenig-Hoffmann K, Bonin-Debs AL et al (2005) High throughput functional genomics: Identification of novel genes with tumor suppressor phenotypes. Int J Cancer 113(3):434-439
66. Kohl S, Giddings I, Besch D, Apfelstedt-Sylla E, Zrenner E, Wissinger B (1998) The role of the peripherin/RDS gene in retinal dystrophies. Acta Anat (Basel) 162(2-3):75-84
67. Kohno M, Hasegawa H, Miyake M, Yamamoto T, Fujita S (2002) CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase. Int J Cancer 97(3):336-343
68. Kolesnikova TV, Kazarov AR, Lemieux ME, Lafleur MA, Kesari S, Kung AL, Hemler ME (2009) Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo. Neoplasia 11(1):77-86 74p following 86
69. Kondoh M, Ueda M, Ichihashi M, Mishima Y (1993) Decreased expression of human melanomaassociated antigen ME491 along the progression of melanoma pre-canceroses to invasive and metastatic melanomas. Melanoma Res 3(4):241-245
70. Kovalenko OV, Yang XH, Hemler ME (2007) A novel cysteine cross-linking method reveals a direct association between claudin-1 and tetraspanin CD9. Mol Cell Proteomics 6(11):1855-1867
71. Kubista B, Erovic BM, Klinger H, Sulzbacher I, Trieb K (2004) CD9 expression is not a prognostic factor in human osteosarcoma. Cancer Lett 209(1):105-110
72. Kuhn S, Koch M, Nubel T, Ladwein M, Antolovic D (2007a) A Complex of EpCAM, Claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer. Mol Cancer Res 5(6):553-567
73. Kuhn S, Koch M et al (2007b) A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression. Mol Cancer Res 5(6):553-567
74. Kwon MS, Shin SH, Yim SH, Lee KY, Kang HM, Kim TM, Chung YJ (2007) CD63 as a biomarker for predicting the clinical outcomes in adenocarcinoma of lung. Lung Cancer 57(1):46-53
75. Lafleur MA, Xu D, Hemler ME (2009) Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase (MT1-MMP)-dependent pericellular proteolysis. Mol Biol Cell 20:2030-2040
76. Lammerding J, Kazarov AR, Huang H, Lee RT, Hemler ME (2003) Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening. Proc Natl Acad Sci USA 100(13):7616-7621
77. Lazo PA (2007) Functional implications of tetraspanin proteins in cancer biology. Cancer Sci 98(11):1666-1677
78. Le Naour F, Zoller M (2008) The tumor antigen EpCAM: Tetraspanins and the tight junction protein claudin-7, new partners, new functions. Front Biosci 13:5847-5865
79. Le Naour F, Rubinstein E, Jasmin C, Prenant M, Boucheix C (2000) Severely reduced female fertility in CD9-deficient mice. Science 287(5451):319-321
80. Le Naour F, André M, Greco C, Billard M, Sordat B, Emile JF, Lanza F, Boucheix C, Rubinstein E (2006) Profiling of the tetraspanin web of human colon cancer cells. Mol Cell Proteomics 5(5):845-857
81. Lekishvili T, Fromm E, Mujoomdar M, Berditchevski F (2008) The tumour-Associated antigen L6 (L6-Ag) is recruited to the tetraspanin-enriched microdomains: Implication for tumour cell motility. J Cell Sci 121(5):685
82. Levy S, Shoham T (2005) The tetraspanin web modulates immune-signalling complexes. Nat Rev Immunol 5(2):136-148
83. Ley K, Zhang H (2008) Dances with leukocytes: How tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms. J Cell Biol 183(3):375-376
84. Li J, Li W et al (2003) Recombinant CD63/ME491/neuroglandular/NKI/C-3 antigen inhibits growth of established tumors in transgenic mice. J Immunol 171(6):2922-2929
85. Liu WM, Zhang XA (2006) KAI1/CD82, a tumor metastasis suppressor. Cancer Lett 240(2):183-194
86. Liu FS, Chen JT, Dong JT, Hsieh YT, Lin AJ, Ho ES, Hung MJ, Lu CH (2001) KAI1 metastasis suppressor gene is frequently down-regulated in cervical carcinoma. Am J Pathol 159(5):1629-1634
87. Liu L, He B, Liu WM, Zhou D, Cox JV, Zhang XA (2007) Tetraspanin CD151 Promotes Cell Migration by Regulating Integrin Trafficking. J Biol Chem 282(43):31631-31642
88. Lombardi DP, Geradts J, Foley JF, Chiao C, Lamb PW, Barrett JC (1999) Loss of KAI1 expression in the progression of colorectal cancer. Cancer Res 59(22):5724-5731
89. Maecker HT, Todd SC, Levy S (1997) The tetraspanin superfamily: Molecular facilitators. FASEB J 11(6):428-442
90. Mantegazza AR, Barrio MM, Moutel S, Bover L, Weck M, Brossart P, Teillaud JL, Mordoh J (2004) CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells. Blood 104(4):1183-1190
91. Masellis-Smith A, Shaw AR (1994) CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin. J Immunol 152(6):2768-2777
92. Mazzocca A, Liotta F, Carloni V (2008) Tetraspanin CD81-regulated cell motility plays a critical role in intrahepatic metastasis of hepatocellular carcinoma. Gastroenterology 135(1):244-256. e241
93. Mhawech P, Herrmann F, Coassin M, Guillou L, Iselin CE (2003) Motility-related protein 1 (MRP-1/CD9) expression in urothelial bladder carcinoma and its relation to tumor recurrence and progression. Cancer 98(8):1649-1657
94. Mhawech P, Dulguerov P, Tschanz E, Verdan C, Ares C, Allal AS (2004) Motility-related protein-1 (MRP-1/CD9) expression can predict disease-free survival in patients with squamous cell carcinoma of the head and neck. Br J Cancer 90(2):471-475
95. Miranti CK (2009) Controlling cell surface dynamics and signaling: How CD82/KAI1 suppresses metastasis. Cell Signal 21(2):196-211
96. Miyado K, Mekada E, Kobayashi K (2000) A crucial role of tetraspanin, CD9 in fertilization. Tanpakushitsu Kakusan Koso 45(10):1728-1734
97. Miyake M, Koyama M, Seno M, Ikeyama S (1991) Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility. J Exp Med 174(6):1347-1354
98. Miyake M, Nakano K, Ieki Y, Adachi M, Huang CL, Itoi S, Koh T, Taki T (1995) Motility related protein 1 (MRP-1/CD9) expression: Inverse correlation with metastases in breast cancer. Cancer Res 55(18):4127-4131
99. Miyake M, Nakano K, Itoi SI, Koh T, Taki T (1996) Motility-related protein-1 (MRP-1/CD9) reduction as a factor of poor prognosis in breast cancer. Cancer Res 56(6):1244-1249
100. Miyamoto S, Maruyama A, Okugawa K, Akazawa K, Baba H, Maehara Y, Mekada E (2001) Loss of motility-related protein 1 (MRP1/CD9) and integrin alpha3 expression in endometrial cancers. Cancer 92(3):542-548
101. Miyazaki T, MÜller U, Campbell KS (1997) Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81. EMBO J 16(14):4217-4225
102. Miyazaki T, Kato H et al (2000) Mutation and expression of the metastasis suppressor gene KAI1 in esophageal squamous cell carcinoma. Cancer 89(5):955-962
103. Miyazaki T, Kato H et al (2005) Evaluation of tumor malignancy in esophageal squamous cell carcinoma using different characteristic factors. Anticancer Res 25(6B):4005-4011
104. Murayama Y, Miyagawa J et al (2004) CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells. J Cell Sci 117(Pt 15):3379-3388
105. Murayama Y, Shinomura Y et al (2008) The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells. J Cell Physiol 216(1):135-143
106. Nishiuchi R, Sanzen N, Nada S, Sumida Y, Wada Y, Okada M, Takagi J, Hasegawa H, Sekiguchi K (2005) Potentiation of the ligand-binding activity of integrin alpha3beta1 via association with tetraspanin CD151. Proc Natl Acad Sci USA 102(6):1939-1944
107. Odintsova E, Sugiura T, Berditchevski F (2000) Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1. Curr Biol 10(16):1009-1012
108. Odintsova E, Voortman J, Gilbert E, Berditchevski F (2003) Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR. J Cell Sci 116(Pt 22):4557-4566
109. Oren R, Takahashi S, Doss C, Levy R, Levy S (1990) TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. Mol Cell Biol 10(8):4007-4015
110. Puls KL, Ni J, Liu D, Morahan G, Wright MD (1999) The molecular characterisation of a novel tetraspanin protein, TM4-B(1). Biochim Biophys Acta 1447(1):93-99
111. Radford KJ, Mallesch J, Hersey P (1995) Suppression of human melanoma cell growth and metastasis by the melanoma-Associated antigen CD63 (ME491). Int J Cancer 62(5):631-635
112. Radford KJ, Thorne RF, Hersey P (1996) CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma. Biochem Biophys Res Commun 222(1):13-18
113. Radford KJ, Thorne RF, Hersey P (1997) Regulation of tumor cell motility and migration by CD63 in a human melanoma cell line. J Immunol 158(7):3353-3358
114. Regina Todeschini A, Hakomori SI (2008) Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains. Biochim Biophys Acta 1780(3):421-433
115. Rous BA, Reaves BJ, Ihrke G, Briggs JA, Gray SR, Stephens DJ, Banting G, Luzio JP (2002) Role of adaptor complex AP-3 in targeting wild-Type and mutated CD63 to lysosomes. Mol Biol Cell 13(3):1071-1082
116. Rubinstein E, Boucheix C (1999) 'Tetraspans.' InGuidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins. books.google.com Oxford University Press, Oxford, pp 321-324
117. Ryu F, Takahashi T, Nakamura K, Takahashi Y, Kobayashi T, Shida S, Kameyama T, Mekada E (2000) Domain analysis of the tetraspanins: Studies of CD9/CD63 chimeric molecules on subcellular localization and upregulation activity for diphtheria toxin binding. Cell Struct Funct 25(5):317-327
118. Sachs N, Kreft M, van Den Bergh Weerman MA, Beynon AJ, Peters TA, Weening JJ, Sonnenberg A (2006) Kidney failure in mice lacking the tetraspanin CD151. J Cell Biol 175(1):33-39
119. Sala-Valdés M, Ursa A, Charrin S, Rubinstein E, Hemler ME, Sánchez-Madrid F, Yáñez-Mó M (2006) EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. J Biol Chem 281(28):19665-19675
120. Sanyal S, De Ruiter A, Hawkins RK (1980) Development and degeneration of retina in rds mutant mice: Light microscopy. J Comp Neurol 194(1):193-207
121. Sawada S, Yoshimoto M, Odintsova E, Hotchin NA, Berditchevski F (2003) The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras. J Biol Chem 278(29):26323-26326
122. Schöniger-Hekele M, Hänel S, Wrba F, MÜller C (2005) Hepatocellular carcinoma-survival and clinical characteristics in relation to various histologic molecular markers in Western patients. Liver Int 25(1):62-69
123. Schorey JS, Bhatnagar S (2008) Exosome function: From tumor immunology to pathogen biology. Traffic 9(6):871-881
124. Serru V, Dessen P, Boucheix C, Rubinstein E (2000) Sequence and expression of seven new tetraspans. Biochim Biophys Acta 1478(1):159-163
125. Sharma C, Yang XH, Hemler ME (2008) DHHC2 Affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151. Mol Biol Cell 19:3415-3425
126. Shen SQ, Li K, Zhu N, Nakao A (2008) Expression and clinical significance of NET-1 and PCNA in hepatocellular carcinoma. Med Oncol 25(3):341-345
127. Shigeta M, Sanzen N, Ozawa M, Gu J, Hasegawa H, Sekiguchi K (2003) CD151 regulates epithelial cell-cell adhesion through PKC- And Cdc42-dependent actin cytoskeletal reorganization. J Cell Biol 163(1):165-176
128. Shinohara T, Nishimura N, Hanibuchi M, Nokihara H, Miki T, Hamada H, Sone S (2001) Transduction of KAI1/CD82 cDNA promotes hematogenous spread of human lung-cancer cells in natural killer cell-depleted SCID mice. Int J Cancer 94(1):16-23
129. Si Z, Hersey P (1993) Expression of the neuroglandular antigen and analogues in melanoma. CD9 expression appears inversely related to metastatic potential of melanoma. Int J Cancer 54(1):37-43
130. Silvie O, Charrin S et al (2006) Cholesterol contributes to the organization of tetraspanin-enriched microdomains and to CD81-dependent infection by malaria sporozoites. J Cell Sci 119(Pt 10):1992-2002
131. Sincock PM, Mayrhofer G, Ashman LK (1997) Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: Comparison with CD9, CD63, and alpha5beta1 integrin. J Histochem Cytochem 45(4):515-525
132. Sridhar SC, Miranti CK (2006) Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases. Oncogene 25(16):2367-2378
133. Sterk LM, Geuijen CA, van Den Berg JG, Claessen N, Weening JJ, Sonnenberg A (2002) Association of the tetraspanin CD151 with the laminin-binding integrins alpha3beta1, alpha-6beta1, alpha6beta4 and alpha7beta1 in cells in culture and in vivo. J Cell Sci 115(Pt 6):1161-1173
134. Sun TT, Zhao H, Provet J, Aebi U, Wu XR (1996) Formation of asymmetric unit membrane during urothelial differentiation. Mol Biol Rep 23(1):3-11
135. Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ (1990) Molecular cloning of cDNA for the human tumor-Associated antigen CO-029 and identification of related transmembrane antigens. Proc Natl Acad Sci USA 87(17):6833-6837
136. Takagi S, Fujikawa K et al (1995) Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily. Int J Cancer 61(5):706-715
137. Takaoka A, Hinoda Y, Sato S, Itoh F, Adachi M, Hareyama M, Imai K (1998a) Reduced invasive and metastatic potentials of KAI1-Transfected melanoma cells. Jpn J Cancer Res 89(4):397-404
138. Takaoka A, Hinoda Y, Satoh S, Adachi Y, Itoh F, Adachi M, Imai K (1998b) Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene. Oncogene 16(11):1443-1453
139. Takeda Y, Kazarov AR, Butterfield CE, Hopkins BD, Benjamin LE, Kaipainen A, Hemler ME (2007) Deletion of tetraspanin Cd151 results in Decreased pathologic angiogenesis in vivo and in vitro. Blood 109(4):1524-1532
140. Todd SC, Doctor VS, Levy S (1998) Sequences and expression of six new members of the tetraspanin/ TM4SF family. Biochim Biophys Acta 1399(1):101-104
141. Todeschini AR, Dos Santos JN, Handa K, Hakomori SI (2007) Ganglioside GM2-Tetraspanin CD82 complex inhibits met and its cross-Talk with integrins, providing a basis for control of cell motility through glycosynapse. J Biol Chem 282(11):8123-8133
142. Todeschini AR, Dos Santos JN, Handa K, Hakomori SI (2008) Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway. Proc Natl Acad Sci USA 105(6):1925-1930
143. Tokuhara T, Hasegawa H, Hattori N, Ishida H, Taki T, Tachibana S, Sasaki S, Miyake M (2001) Clinical significance of CD151 gene expression in non-small cell lung cancer. Clin Cancer Res 7(12):4109-4114
144. Tsitsikov EN, Gutierrez-Ramos JC, Geha RS (1997) Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. Proc Natl Acad Sci USA 94(20):10844-10849
145. Uchida S, Shimada Y, Watanabe G, Li ZG, Hong T, Miyake M, Imamura M (1999) Motilityrelated protein (MRP-1/CD9) and KAI1/CD82 expression inversely correlate with lymph node metastasis in oesophageal squamous cell carcinoma. Br J Cancer 79(7-8):1168-1173
146. van Soest S, Westerveld A, de Jong PT, Bleeker-Wagemakers EM, Bergen AA (1999) Retinitis pigmentosa: Defined from a molecular point of view. Surv Ophthalmol 43(4):321-334
147. van Spriel AB, Puls KL, Sofi M, Pouniotis D, Hochrein H, Orinska Z, Knobeloch KP, Plebanski M, Wright MD (2004) A regulatory role for CD37 in T cell proliferation. J Immunol 172(5):2953-2961
148. VanCompernolle SE, Levy S, Todd SC (2001) Anti-CD81 activates LFA-1 on T cells and promotes T cell-B cell collaboration. Eur J Immunol 31(3):823-831
149. Wang XQ, Yan Q, Sun P, Liu JW, Go L, McDaniel SM, Paller AS (2007) Suppression of epidermal growth factor receptor signaling by protein kinase C-Alpha activation requires CD82, caveolin-1, and ganglioside. Cancer Res 67(20):9986-9995
150. Winterwood NE, Varzavand A, Meland MN, Ashman LK, Stipp CS (2006) A critical role for tetraspanin CD151 in {alpha}3{beta}1 and {alpha}6{beta}4 integrin-dependent tumor cell functions on laminin-5. Mol Biol Cell 17(6):2707-2721
151. Wright MD, Tomlinson MG (1994) The ins and outs of the transmembrane 4 superfamily. Immunol Today 15(12):588-594
152. Wright MD, Geary SM et al (2004) Characterization of mice lacking the tetraspanin superfamily member CD151. Mol Cell Biol 24(13):5978-5988
153. Xu L, Hynes RO (2007) GPR56 and TG2: Possible roles in suppression of tumor growth by the microenvironment. Cell Cycle 6(2):160-165
154. Xu L, Begum S, Hearn JD, Hynes RO (2006) GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proc Natl Acad Sci USA 103(24):9023-9028
155. Yamada M, Tamura Y et al (2008) Probing the interaction of tetraspanin CD151 with integrin alpha3beta1 using a panel of monoclonal antibodies with distinct reactivities toward the CD151-integrin alpha3beta1 complex. Biochem J 415(3):417-427
156. Yanez-Mo M, Barreiro O et al (2008) MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells. Blood 112:3217-3226
157. Yang XH, Welch DR, Phillips KK, Weissman BE, Wei LL (1997) KAI1, a putative marker for metastatic potential in human breast cancer. Cancer Lett 119(2):149-155
158. Yang X, Kovalenko OV, Tang W, Claas C, Stipp CS, Hemler ME (2004) Palmitoylation supports assembly and function of integrin-Tetraspanin complexes. J Cell Biol 167(6):1231-1240
159. Yang XH, Kovalenko OV, Kolesnikova TV, Andzelm MM, Rubinstein E, Strominger JL, Hemler ME (2006) Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization. J Biol Chem 281(18):12976-12985
160. Yang JM, Peng ZH, Si SH, Liu WW, Luo YH, Ye ZY (2008) KAI1 gene suppresses invasion and metastasis of hepatocellular carcinoma MHCC97-H cells in vitro and in animal models. Liver Int 28(1):132-139
161. Yauch RL, Hemler ME (2000) Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoinositide 4-kinase. Biochem J 351(Pt 3):629-637
162. Zemni R, Bienvenu T et al (2000) A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation. Nat Genet 24(2):167-170
163. Zhang XA, Bontrager AL, Hemler ME (2001a) Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. J Biol Chem 276(27):25005-25013
164. Zhang XA, Bontrager AL, Hemler ME (2001b) Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. J Biol Chem 276(27):25005-25013
165. Zhang XA, Kazarov AR, Yang X, Bontrager AL, Stipp CS, Hemler ME (2002) Function of the tetraspanin CD151-Alpha6beta1 integrin complex during cellular morphogenesis. Mol Biol Cell 13(1):1-11
166. Zheng R, Yano S, Zhang H, Nakataki E, Tachibana I, Kawase I, Hayashi S, Sone S (2005) CD9 overexpression suppressed the liver metastasis and malignant ascites via inhibition of proliferation and motility of small-cell lung cancer cells in NK cell-depleted SCID mice. Oncol Res 15(7-8):365-372
167. Zhou B, Liu L, Reddivari M, Zhang XA (2004) The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- And invasiveness-inhibitory activity. Cancer Res 64(20):7455-7463
168. Zijlstra A, Lewis J, Degryse B, Stuhlmann H, Quigley JP (2008) The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151. Cancer Cell 13(3):221-234
169. Zöller M (2006) Gastrointestinal tumors: Metastasis and tetraspanins. Zeitschrift fÜr Gastroenterologie 44(7):573-586
170. Zöller M (2009) Tetraspanins: Push and pull in suppressing and promoting metastasis. Nat Rev Cancer 9(1):40-55