Refractory Celiac Disease

Gastrointestinal Endoscopy Clinics of North America

Volumn 22, Issue 4, 2012, Pages 759-772

  Malamut, Georgia ^a,b,c   Murray, Joseph A ^d   Cellier, Christophe ^a,b,c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^c Insem U989 ^*  (France)

^d MAYO CLINIC   (United States)

Author keywords

Aberrant intraepithelial lymphocytes; Immunosuppressive treatments; Refractory celiac disease

Indexed keywords

AZATHIOPRINE; BUDESONIDE; CLADRIBINE; CYCLOSPORIN; CYTOKINE ANTIBODY; INTERLEUKIN 15; PENTOSTATIN; STEROID; TUMOR NECROSIS FACTOR ANTIBODY;

ABSENCE OF SIDE EFFECTS; APOPTOSIS; AUTOIMMUNITY; CANCER GRADING; CELIAC DISEASE; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC PROCEDURE; DISEASE PREDISPOSITION; DISEASE SEVERITY; FLOW CYTOMETRY; GASTROINTESTINAL ENDOSCOPY; HIGH RISK PATIENT; HUMAN; IMMUNOHISTOCHEMISTRY; INTESTINE ENDOSCOPY; LYMPHOMA; MALNUTRITION; MOLECULAR BIOLOGY; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; REFRACTORY CELIAC DISEASE; REVIEW; SIGNAL TRANSDUCTION; SURVIVAL; TREATMENT FAILURE;

CELIAC DISEASE; DIET, GLUTEN-FREE; HUMANS; INTERLEUKIN-15; INTESTINAL MUCOSA; LYMPHOCYTES; TREATMENT FAILURE;

EID: 84867686509     PISSN: 10525157     EISSN: 15581950     Source Type: Journal    
DOI: 10.1016/j.giec.2012.07.007     Document Type: Review

References (54)

1. Rubio-Tapia A., Kelly D.G., Lahr B.D., et al. Clinical staging and survival in refractory celiac disease: a single center experience. Gastroenterology 2009, 136:99-107.
2. Malamut G., Afchain P., Verkarre V., et al. Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II. Gastroenterology 2009, 136:81-90.
3. Rubio-Tapia A., Kyle R.A., Kaplan E.L., et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology 2009, 137:88-93.
4. Rubio-Tapia A., Ludvigsson J., Brantner T.L., et al. The prevalence of celiac disease in the United States. Am J Gastroenterol 2012, [Epub ahead of print].
5. Murray J.A., Van Dyke C., Plevak M.F., et al. Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001. Clin Gastroenterol Hepatol 2003, 1:19-27.
6. Green P.H., Cellier C. Celiac disease. N Engl J Med 2007, 357:1731-1743.
7. Vahedi K., Mascart F., Mary J.Y., et al. Reliability of antitransglutaminase antibodies as predictors of gluten-free diet compliance in adult celiac disease. Am J Gastroenterol 2003, 98:1079-1087.
8. Akram S., Murray J.A., Pardi D.S., et al. Adult autoimmune enteropathy: Mayo Clinic Rochester experience. Clin Gastroenterol Hepatol 2007, 5:1282-1290.
9. Khokhar N., Gill M.L. Tropical sprue: revisited. J Pak Med Assoc 2004, 54:133-134.
10. Malamut G., Verkarre V., Suarez F., et al. The enteropathy associated with common variable immunodeficiency: the delineated frontiers with celiac disease. Am J Gastroenterol 2010, 105:2262-2275.
11. Cellier C., Patey N., Mauvieux L., et al. Abnormal intestinal intraepithelial lymphocytes in refractory sprue. Gastroenterology 1998, 114:471-481.
12. Cellier C., Delabesse E., Helmer C., et al. Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet 2000, 356:203-208.
13. West J., Holmes G. Celiac disease and its complications: a time traveller's perspective. Gastroenterology 2009, 136:32-34.
14. Egan L.J., Walsh S.V., Stevens F.M., et al. Celiac-associated lymphoma. A single institution experience of 30 cases in the combination chemotherapy era. J Clin Gastroenterol 1995, 21:123-129.
15. Askling J., Linet M., Gridley G., et al. Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis. Gastroenterology 2002, 123:1428-1435.
16. Al-Toma A., Goerres M.S., Meijer J.W., et al. Human leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma. Clin Gastroenterol Hepatol 2006, 4:315-319.
17. Smyth D.J., Plagnol V., Walker N.M., et al. Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med 2008, 359:2767-2777.
18. Wijmenga C. Genetics and risk for associated autoimmune disorders and refractory coeliac disease (abstract). Mastering the coeliac condition. 2012; Florence, Italy.
19. Holmes G.K., Prior P., Lane M.R., et al. Malignancy in coeliac disease-effect of a gluten free diet. Gut 1989, 30:333-338.
20. Biagi F., Corazza G.R. Mortality in celiac disease. Nat Rev Gastroenterol Hepatol 2011, 7:158-162.
21. Jamma S., Rubio-Tapia A., Kelly C.P., et al. Celiac crisis is a rare but serious complication of celiac disease in adults. Clin Gastroenterol Hepatol 2010, 8:587-590.
22. Daum S., Cellier C., Mulder C.J. Refractory coeliac disease. Best Pract Res Clin Gastroenterol 2005, 19:413-424.
23. Murray J.A., Rubio-Tapia A., Van Dyke C.T., et al. Mucosal atrophy in celiac disease: extent of involvement, correlation with clinical presentation, and response to treatment. Clin Gastroenterol Hepatol 2008, 6:186-193.
24. Daum S., Wahnschaffe U., Glasenapp R., et al. Capsule endoscopy in refractory celiac disease. Endoscopy 2007, 39:455-458.
25. Barret M., Malamut G., Rahmi G., et al. Diagnostic yield of capsule endoscopy in refractory celiac disease. Am J Gastroenterol 2012, in press.
26. Huppert B.J., Farrell M.A., Kawashima A., et al. Diagnosis of cavitating mesenteric lymph node syndrome in celiac disease using MRI. AJR Am J Roentgenol 2004, 183:1375-1377.
27. Roshan B., Leffler D.A., Jamma S., et al. The incidence and clinical spectrum of refractory celiac disease in a North American referral center. Am J Gastroenterol 2011, 106:923-928.
28. Malamut G., Cellier C. Is refractory celiac disease more severe in old Europe?. Am J Gastroenterol 2010, 106:929-932.
29. Perfetti V., Brunetti L., Biagi F., et al. TCRβ clonality improves diagnostic yield of TCRγ clonality in refractory celiac disease. J Clin Gastroenterol 2012, 46(8):675-679.
30. Al-Toma A., Verbeek W.H., Hadithi M., et al. Survival in refractory coeliac disease and enteropathy associated T cell Lymphoma: retrospective evaluation of single centre experience. Gut 2007, 56:1373-1378.
31. Daum S., Ipczynski R., Schumann M., et al. High rates of complications and substantial mortality in both types of refractory sprue. Eur J Gastroenterol Hepatol 2009, 21:66-70.
32. Goerres M.S., Meijer J.W., Wahab P.J., et al. Azathioprine and prednisone combination therapy in refractory coeliac disease. Aliment Pharmacol Ther 2003, 18:487-494.
33. Verkarre V., Romana S.P., Cellier C., et al. Recurrent partial trisomy 1q22-q44 in clonal intraepithelial lymphocytes in refractory celiac sprue. Gastroenterology 2003, 125:40-46.
34. Malamut G., Verkarre V., Meresse B., et al. High rate of abnormal intestinal intraepithelial lymphocytes is predictive of extra-digestive diffusion in refractory coeliac disease. Gut 2008, 57(Suppl II):A30. [abstract].
35. Malamut G, Meresse B, Verkarre V, et al. A low rate of gamma-delta intraepithelial lymphocytes is predictive of onset of overt lymphoma in refractory celiac disease of type II [abstract]. Presented at 14th International Celiac Disease Symposium; 2011; Oslo, Norway.
36. Hoffmann M., Vogelsang H., Kletter K., et al. 18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) for assessment of enteropathy-type T cell lymphoma. Gut 2003, 52:347-351.
37. Mention J.J., Ben Ahmed M., Begue B., et al. Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. Gastroenterology 2003, 125:730-745.
38. Ciccocioppo R., Di Sabatino A., Parroni R., et al. Increased enterocyte apoptosis and Fas-Fas ligand system in celiac disease. Am J Clin Pathol 2001, 115:494-503.
39. Di Sabatino A., Ciccocioppo R., D'Alo S., et al. Intraepithelial and lamina propria lymphocytes show distinct patterns of apoptosis whereas both populations are active in Fas based cytotoxicity in coeliac disease. Gut 2001, 49:380-386.
40. Hue S., Mention J.J., Monteiro R.C., et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity 2004, 21(3):367-377.
41. Fehniger T.A., Suzuki K., Ponnappan A., et al. Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8 + T cells. J Exp Med 2001, 193:219-231.
42. Malamut G., El Machhour R., Montcuquet N., et al. IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J Clin Invest 2010, 120:2131-2143.
43. Stene L.C., Honeyman M.C., Hoffenberg E.J., et al. Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol 2006, 101:2333-2340.
44. Doherty T.M., Seder R.A., Sher A. Induction and regulation of IL-15 expression in murine macrophages. J Immunol 1996, 156:735-741.
45. Flamand L., Stefanescu I., Menezes J. Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15. J Clin Invest 1996, 97:1373-1381.
46. Vazquez N., Walsh T.J., Friedman D., et al. Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against candida albicans. Infect Immun 1998, 66:145-150.
47. Waldmann T.A., Tagaya Y. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol 1999, 17:19-49.
48. Dray X., Joly F., Lavergne-Slove A., et al. A severe but reversible refractory sprue. Gut 2006, 55:1210-1211.
49. Al-Toma A., Goerres M.S., Meijer J.W., et al. Cladribine therapy in refractory celiac disease with aberrant T cells. Clin Gastroenterol Hepatol 2006, 4:1322-1327.
50. Al-Toma A., Visser O.J., van Roessel H.M., et al. Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T-cells. Blood 2006, 34:27.
51. Tack G.J., Wondergem M.J., Al-Toma A., et al. Auto-SCT in refractory celiac disease type II patients unresponsive to cladribine therapy. Bone Marrow Transplant 2011, 46:840-846.
52. Gale J., Simmonds P.D., Mead G.M., et al. Enteropathy-type intestinal T-cell lymphoma: clinical features and treatment of 31 patients in a single center. J Clin Oncol 2000, 18:795-803.
53. Daum S., Ullrich R., Heise W., et al. Intestinal non-Hodgkin's lymphoma: a multicenter prospective clinical study from the German Study Group on Intestinal non-Hodgkin's Lymphoma. J Clin Oncol 2003, 21:2740-2746.
54. Waldmann T.A. Targeting the interleukin-15 system in rheumatoid arthritis. Arthritis Rheum 2005, 52:2585-2588.