-
1
-
-
0037145037
-
Integrins: bidirectional, allosteric signaling machines
-
Hynes RO, (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687.
-
(2002)
Cell
, vol.110
, pp. 673-687
-
-
Hynes, R.O.1
-
2
-
-
0029062761
-
Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine
-
Lefkovits J, Plow EF, Topol EJ, (1995) Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine. N Engl J Med 332: 1553-1559.
-
(1995)
N Engl J Med
, vol.332
, pp. 1553-1559
-
-
Lefkovits, J.1
Plow, E.F.2
Topol, E.J.3
-
3
-
-
0028285015
-
Integrin cytoplasmic domains mediate inside-out signal transduction
-
O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, et al. (1994) Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol. 124: 1047-1059.
-
(1994)
J Cell Biol
, vol.124
, pp. 1047-1059
-
-
O'Toole, T.E.1
Katagiri, Y.2
Faull, R.J.3
Peter, K.4
Tamura, R.5
-
4
-
-
0029966310
-
Breaking the integrin hinge. A defined structural constraint regulates integrin signaling
-
Hughes PE, Diaz-Gonzalez F, Leong L, Wu C, McDonald JA, et al. (1996) Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J Biol Chem 271: 6571-6574.
-
(1996)
J Biol Chem
, vol.271
, pp. 6571-6574
-
-
Hughes, P.E.1
Diaz-Gonzalez, F.2
Leong, L.3
Wu, C.4
McDonald, J.A.5
-
5
-
-
0035805633
-
Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state
-
Lu C, Takagi J, Springer TA, (2001) Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state. J Biol Chem 276: 14642-14648.
-
(2001)
J Biol Chem
, vol.276
, pp. 14642-14648
-
-
Lu, C.1
Takagi, J.2
Springer, T.A.3
-
6
-
-
0037031551
-
A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face
-
Vinogradova O, Velyvis A, Velyviene A, Hu B, Haas T, et al. (2002) A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face. Cell 110: 587-597.
-
(2002)
Cell
, vol.110
, pp. 587-597
-
-
Vinogradova, O.1
Velyvis, A.2
Velyviene, A.3
Hu, B.4
Haas, T.5
-
7
-
-
0038644597
-
Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations
-
Li R, Mitra N, Gratkowski H, Vilaire G, Litvinov R, et al. (2003) Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science 300: 795-798.
-
(2003)
Science
, vol.300
, pp. 795-798
-
-
Li, R.1
Mitra, N.2
Gratkowski, H.3
Vilaire, G.4
Litvinov, R.5
-
8
-
-
16644396938
-
A specific interface between integrin transmembrane helices and affinity for ligand
-
Luo BH, Springer TA, (2004) Takagi (2004) A specific interface between integrin transmembrane helices and affinity for ligand. PLoS Biol 2: e153.
-
(2004)
PLoS Biol
, vol.2
-
-
Luo, B.H.1
Springer, T.A.2
Takagi3
-
9
-
-
37549064277
-
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis
-
Petrich BG, Marchese P, Ruggeri ZM, Spiess S, Weichert RA, et al. (2007) Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med 204: 3103-3111.
-
(2007)
J Exp Med
, vol.204
, pp. 3103-3111
-
-
Petrich, B.G.1
Marchese, P.2
Ruggeri, Z.M.3
Spiess, S.4
Weichert, R.A.5
-
10
-
-
43149085289
-
Kindlin-2 (Mig-2): a co-activator of beta3 integrins
-
Ma YQ, Qin J, Wu C, Plow EF, (2008) Kindlin-2 (Mig-2): a co-activator of beta3 integrins. J Cell Biol 181: 439-446.
-
(2008)
J Cell Biol
, vol.181
, pp. 439-446
-
-
Ma, Y.Q.1
Qin, J.2
Wu, C.3
Plow, E.F.4
-
11
-
-
16644368209
-
Integrin bidirectional signaling: a molecular view
-
Qin J, Vinogradova O, Plow EF, (2004) Integrin bidirectional signaling: a molecular view. PLoS Biol 2: e169.
-
(2004)
PLoS Biol
, vol.2
-
-
Qin, J.1
Vinogradova, O.2
Plow, E.F.3
-
12
-
-
0037512367
-
The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation
-
Cho MJ, Liu J, Pestina TI, Steward SA, Thomas DW, et al. (2003) The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. Blood 101: 2646-2651.
-
(2003)
Blood
, vol.101
, pp. 2646-2651
-
-
Cho, M.J.1
Liu, J.2
Pestina, T.I.3
Steward, S.A.4
Thomas, D.W.5
-
13
-
-
78650415748
-
Signaling during platelet adhesion and activation
-
Li Z, Delaney MK, O'Brien KA, Du X, (2010) Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol 30: 2341-2349.
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 2341-2349
-
-
Li, Z.1
Delaney, M.K.2
O'Brien, K.A.3
Du, X.4
-
14
-
-
74549184087
-
G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling
-
Gong H, Shen B, Flevaris P, Chow C, Lam SC, et al. (2010) G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling. Science 327: 340-3.
-
(2010)
Science
, vol.327
, pp. 340-343
-
-
Gong, H.1
Shen, B.2
Flevaris, P.3
Chow, C.4
Lam, S.C.5
-
15
-
-
81755181674
-
Tyrosine phosphorylation as a conformational switch: a case study of integrin beta3 cytoplasmic tail
-
Deshmukh L, Meller N, Alder N, Byzova T, Vinogradova O, (2011) Tyrosine phosphorylation as a conformational switch: a case study of integrin beta3 cytoplasmic tail. J Biol Chem 286: 40943-40953.
-
(2011)
J Biol Chem
, vol.286
, pp. 40943-40953
-
-
Deshmukh, L.1
Meller, N.2
Alder, N.3
Byzova, T.4
Vinogradova, O.5
-
16
-
-
67849097363
-
The beta3 integrin cytoplasmic tail: protein scaffold and control freak
-
Shattil SJ, (2009) The beta3 integrin cytoplasmic tail: protein scaffold and control freak. J Thromb Haemost 7Suppl 1: 210-213.
-
(2009)
J Thromb Haemost
, vol.7
, pp. 210-213
-
-
Shattil, S.J.1
-
17
-
-
23744451167
-
Integrins and Src: dynamic duo of adhesion signaling
-
Shattil SJ, (2005) Integrins and Src: dynamic duo of adhesion signaling. Trends Cell Biol 15: 399-403.
-
(2005)
Trends Cell Biol
, vol.15
, pp. 399-403
-
-
Shattil, S.J.1
-
18
-
-
35948942682
-
A molecular switch that controls cell spreading and retraction
-
Flevaris P, Stojanovic A, Gong H, Chishti A, Welch E, et al. (2007) A molecular switch that controls cell spreading and retraction. J Cell Biol 179: 553-565.
-
(2007)
J Cell Biol
, vol.179
, pp. 553-565
-
-
Flevaris, P.1
Stojanovic, A.2
Gong, H.3
Chishti, A.4
Welch, E.5
-
19
-
-
0031046185
-
Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain
-
Naik UP, Patel PM, Parise LV, (1997) Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J Biol Chem 272: 4651-4654.
-
(1997)
J Biol Chem
, vol.272
, pp. 4651-4654
-
-
Naik, U.P.1
Patel, P.M.2
Parise, L.V.3
-
20
-
-
0043240190
-
Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen
-
Naik UP, Naik MU, (2003) Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen. Blood 102: 1355-1362.
-
(2003)
Blood
, vol.102
, pp. 1355-1362
-
-
Naik, U.P.1
Naik, M.U.2
-
21
-
-
0242579243
-
Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen
-
Naik MU, Naik UP, (2003) Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen. Blood 102: 3629-3636.
-
(2003)
Blood
, vol.102
, pp. 3629-3636
-
-
Naik, M.U.1
Naik, U.P.2
-
22
-
-
80455143827
-
SHARPIN is an endogenous inhibitor of beta1-integrin activation
-
Rantala JK, Pouwels J, Pellinen T, Veltel S, Laasola P, et al. (2011) SHARPIN is an endogenous inhibitor of beta1-integrin activation. Nat Cell Biol 13: 1315-1324.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1315-1324
-
-
Rantala, J.K.1
Pouwels, J.2
Pellinen, T.3
Veltel, S.4
Laasola, P.5
-
23
-
-
19344365790
-
The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling
-
Liu J, Jackson CW, Gruppo RA, Jennings LK, Gartner TK, (2005) The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling. Blood 105: 4345-4352.
-
(2005)
Blood
, vol.105
, pp. 4345-4352
-
-
Liu, J.1
Jackson, C.W.2
Gruppo, R.A.3
Jennings, L.K.4
Gartner, T.K.5
-
24
-
-
36348981019
-
Protease-activated receptor-induced Akt activation-regulation and possible function
-
Resendiz JC, Kroll MH, Lassila R, (2007) Protease-activated receptor-induced Akt activation-regulation and possible function. J Thromb Haemost 5: 2484-2493.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 2484-2493
-
-
Resendiz, J.C.1
Kroll, M.H.2
Lassila, R.3
-
25
-
-
59649099584
-
Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway
-
Flevaris P, Li Z, Zhang G, Zheng Y, Liu J, et al. (2009) Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway. Blood 113: 893-901.
-
(2009)
Blood
, vol.113
, pp. 893-901
-
-
Flevaris, P.1
Li, Z.2
Zhang, G.3
Zheng, Y.4
Liu, J.5
-
26
-
-
0032514474
-
A dual thrombin receptor system for platelet activation
-
Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, et al. (1998) A dual thrombin receptor system for platelet activation. Nature 394: 690-694.
-
(1998)
Nature
, vol.394
, pp. 690-694
-
-
Kahn, M.L.1
Zheng, Y.W.2
Huang, W.3
Bigornia, V.4
Zeng, D.5
-
27
-
-
84858779307
-
Kindlins, integrin activation and the regulation of talin recruitment to alphaIIbbeta3
-
Kahner BN, Kato H, Banno A, Ginsberg MH, Shattil SJ, et al. (2012) Kindlins, integrin activation and the regulation of talin recruitment to alphaIIbbeta3. PLoS One 7: e34056.
-
(2012)
PLoS One
, vol.7
-
-
Kahner, B.N.1
Kato, H.2
Banno, A.3
Ginsberg, M.H.4
Shattil, S.J.5
-
28
-
-
0030664425
-
Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex
-
Wang R, Shattil SJ, Ambruso DR, Newman PJ, (1997) Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex. J Clin Invest 100: 2393-2403.
-
(1997)
J Clin Invest
, vol.100
, pp. 2393-2403
-
-
Wang, R.1
Shattil, S.J.2
Ambruso, D.R.3
Newman, P.J.4
-
29
-
-
0034741711
-
Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an alphaIIbbeta3 interacting peptide
-
Derrick JM, Shattil SJ, Poncz M, Gruppo RA, Gartner TK, (2001) Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an alphaIIbbeta3 interacting peptide. Thromb Haemost 86: 894-901.
-
(2001)
Thromb Haemost
, vol.86
, pp. 894-901
-
-
Derrick, J.M.1
Shattil, S.J.2
Poncz, M.3
Gruppo, R.A.4
Gartner, T.K.5
-
30
-
-
0032499696
-
Cloning and characterization of human protease-activated receptor 4
-
Xu WF, Andersen H, Whitmore TE, Presnell SR, Yee DP, et al. (1998) Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci U S A 95: 6642-6646.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 6642-6646
-
-
Xu, W.F.1
Andersen, H.2
Whitmore, T.E.3
Presnell, S.R.4
Yee, D.P.5
-
31
-
-
77956466304
-
A G(i) -independent mechanism mediating Akt phosphorylation in platelets
-
Xiang B, Zhang G, Liu J, Morris AJ, Smyth SS, et al. (2010) A G(i)-independent mechanism mediating Akt phosphorylation in platelets. J Thromb Haemost 8: 2032-2041.
-
(2010)
J Thromb Haemost
, vol.8
, pp. 2032-2041
-
-
Xiang, B.1
Zhang, G.2
Liu, J.3
Morris, A.J.4
Smyth, S.S.5
-
32
-
-
0018857958
-
Interaction of normal, thrombasthenic, and Bernard-Soulier platelets with immobilized fibrinogen: defective platelet-fibrinogen interaction in thrombasthenia
-
Coller BS, (1980) Interaction of normal, thrombasthenic, and Bernard-Soulier platelets with immobilized fibrinogen: defective platelet-fibrinogen interaction in thrombasthenia. Blood 55: 169-178.
-
(1980)
Blood
, vol.55
, pp. 169-178
-
-
Coller, B.S.1
-
33
-
-
0025810562
-
Adhesive properties of the beta 3 integrins: comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cells
-
Kieffer N, Fitzgerald LA, Wolf D, Cheresh DA, Phillips DR, (1991) Adhesive properties of the beta 3 integrins: comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cells. J Cell Biol 113: 451-461.
-
(1991)
J Cell Biol
, vol.113
, pp. 451-461
-
-
Kieffer, N.1
Fitzgerald, L.A.2
Wolf, D.3
Cheresh, D.A.4
Phillips, D.R.5
-
34
-
-
0027253781
-
Characterization of adhesion of "resting". and stimulated platelets to fibrinogen and its fragments
-
Gartner TK, Amrani DL, Derrick JM, Kirschbaum NE, Matsueda GR, et al. (1993) Characterization of adhesion of "resting". and stimulated platelets to fibrinogen and its fragments.Thromb Res 71: 47-60.
-
(1993)
Thromb Res
, vol.71
, pp. 47-60
-
-
Gartner, T.K.1
Amrani, D.L.2
Derrick, J.M.3
Kirschbaum, N.E.4
Matsueda, G.R.5
-
35
-
-
54149086513
-
Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling J Thromb Haemost
-
Liu J, Joglekar M, Ware J, Fitzgerald ME, Lowell CA, et al. (2008) Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling J Thromb Haemost. 6: 1915-1922.
-
(2008)
, vol.6
, pp. 1915-1922
-
-
Liu, J.1
Joglekar, M.2
Ware, J.3
Fitzgerald, M.E.4
Lowell, C.A.5
-
36
-
-
27144451443
-
Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner
-
Liu J, Pestina TI, Berndt MC, Jackson CW, Gartner TK, (2005) Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner. Blood 106: 2750-2756.
-
(2005)
Blood
, vol.106
, pp. 2750-2756
-
-
Liu, J.1
Pestina, T.I.2
Berndt, M.C.3
Jackson, C.W.4
Gartner, T.K.5
-
37
-
-
13244284711
-
The roles of ADP and TXA in botrocetin/VWF-induced aggregation of washed platelets
-
Liu J, Pestina TI, Berndt MC, Steward SA, Jackson CW, et al. (2004) The roles of ADP and TXA in botrocetin/VWF-induced aggregation of washed platelets. J Thromb Haemost 2: 2213-2222.
-
(2004)
J Thromb Haemost
, vol.2
, pp. 2213-2222
-
-
Liu, J.1
Pestina, T.I.2
Berndt, M.C.3
Steward, S.A.4
Jackson, C.W.5
-
38
-
-
0025222804
-
A conformation-dependent epitope of human platelet glycoprotein IIIa
-
Kouns WC, Wall CD, White MM, Fox CF, Jennings LK, (1990) A conformation-dependent epitope of human platelet glycoprotein IIIa. J Biol Chem 265: 20594-20601.
-
(1990)
J Biol Chem
, vol.265
, pp. 20594-20601
-
-
Kouns, W.C.1
Wall, C.D.2
White, M.M.3
Fox, C.F.4
Jennings, L.K.5
-
39
-
-
0021965983
-
A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex
-
Coller BS, (1985) A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex. J Clin Invest 76: 101-108.
-
(1985)
J Clin Invest
, vol.76
, pp. 101-108
-
-
Coller, B.S.1
-
40
-
-
0032407666
-
Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2
-
Thomas DW, Mannon RB, Mannon PJ, Latour A, Oliver JA, et al. (1998) Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. J Clin Invest 102: 1994-2001.
-
(1998)
J Clin Invest
, vol.102
, pp. 1994-2001
-
-
Thomas, D.W.1
Mannon, R.B.2
Mannon, P.J.3
Latour, A.4
Oliver, J.A.5
-
41
-
-
77957742466
-
PTEN regulates collagen-induced platelet activation
-
Weng Z, Li D, Zhang L, Chen J, Ruan C, et al. (2010) PTEN regulates collagen-induced platelet activation. Blood 116: 2579-2581.
-
(2010)
Blood
, vol.116
, pp. 2579-2581
-
-
Weng, Z.1
Li, D.2
Zhang, L.3
Chen, J.4
Ruan, C.5
-
42
-
-
0141561935
-
AlphaIIbbeta3-mediated outside-in signaling induced by the agonist peptide LSARLAF utilizes ADP and thromboxane A2 receptors to cause alpha-granule secretion by platelets
-
Cho MJ, Liu J, Pestina TI, Steward SA, Jackson CW, et al. (2003) AlphaIIbbeta3-mediated outside-in signaling induced by the agonist peptide LSARLAF utilizes ADP and thromboxane A2 receptors to cause alpha-granule secretion by platelets. J Thromb Haemost 1: 363-373.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 363-373
-
-
Cho, M.J.1
Liu, J.2
Pestina, T.I.3
Steward, S.A.4
Jackson, C.W.5
-
43
-
-
0030790357
-
The peptide LSARLAF causes platelet secretion and aggregation by directly activating the integrin alphaIIbbeta3
-
Derrick JM, Taylor DB, Loudon RG, Gartner TK, (1997) The peptide LSARLAF causes platelet secretion and aggregation by directly activating the integrin alphaIIbbeta3. Biochem J 325: 309-313.
-
(1997)
Biochem J
, vol.325
, pp. 309-313
-
-
Derrick, J.M.1
Taylor, D.B.2
Loudon, R.G.3
Gartner, T.K.4
|