CD200R1 Supports HSV-1 Viral Replication and Licenses Pro-Inflammatory Signaling Functions of TLR2

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Soberman, Roy J ^a   MacKay, Christopher R ^b   Vaine, Christine A ^a   Ryan, Glennice Bowen ^b   Cerny, Anna M ^b   Thompson, Mikayla R ^b   Nikolic, Boris ^a   Primo, Valeria ^a   Christmas, Peter ^a   Sheiffele, Paul ^c   Aronov, Lisa ^c   Knipe, David M ^d   Kurt Jones, Evelyn A ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c inGenious Targeting Laboratory Inc   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLAMMASOME; PROTEIN CD200R1; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; FIBROBLAST; GENE CASSETTE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; MACROPHAGE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN ANALYSIS; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS TITRATION;

ANIMALS; ANTIGENS, SURFACE; BRAIN; EMBRYO, MAMMALIAN; ENCEPHALITIS; FIBROBLASTS; GENE TARGETING; HERPESVIRUS 1, HUMAN; INFLAMMATION; INTERFERON TYPE I; MACROPHAGES, PERITONEAL; MICE; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; VIRAL LOAD; VIRUS REPLICATION;

EID: 84867649478     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047740     Document Type: Article

References (54)

1. Creagh EM, O'Neill LA, (2006) TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends in immunology 27: 352-357.
2. Dunne A, O'Neill LA, (2003) The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Science's STKE: signal transduction knowledge environment 2003: re3.
3. Medzhitov R, (2007) Recognition of microorganisms and activation of the immune response. Nature 449: 819-826.
4. Fields BN, Knipe DM, Howley PM, Griffin DE (2001) Fields' virology. Philadelphia: Lippincott Williams & Wilkins. 2 v. (xix, 3087, 3072 p.) p.
5. Kurt-Jones EA, Belko J, Yu C, Newburger PE, Wang J, et al. (2005) The role of toll-like receptors in herpes simplex infection in neonates. J Infect Dis 191: 746-748.
6. Kurt-Jones EA, Chan M, Zhou S, Wang J, Reed G, et al. (2004) Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci U S A 101: 1315-1320.
7. Kurt-Jones EA, Belko J, Yu C, Newburger PE, Wang J, et al. (2005) The role of toll-like receptors in herpes simplex infection in neonates. The Journal of infectious diseases 191: 746-748.
8. Lundberg P, Ramakrishna C, Brown J, Tyszka JM, Hamamura M, et al. (2008) The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis. Journal of virology 82: 7078-7088.
9. Wang JP, Bowen GN, Zhou S, Cerny A, Zacharia A, et al. (2012) Role of specific innate immune responses in herpes simplex virus infection of the central nervous system. J Virol 86: 2273-2281.
10. Whitley R, Arvin A, Prober C, Corey L, Burchett S, et al. (1991) Predictors of morbidity and mortality in neonates with herpes simplex virus infections. The National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. The New England journal of medicine 324: 450-454.
11. Fields BN, Knipe DM, Howley PM, Griffin DE (2001) Fields virology. Philadelphia: Lippincott Williams & Wilkins. xix, 3087 p. p.
12. Carr DJ, Campbell IL, (1999) Transgenic expression of interleukin-6 in the central nervous system confers protection against acute herpes simplex virus type-1 infection. Journal of neurovirology 5: 449-457.
13. Vilela MC, Mansur DS, Lacerda-Queiroz N, Rodrigues DH, Lima GK, et al. (2009) The chemokine CCL5 is essential for leukocyte recruitment in a model of severe Herpes simplex encephalitis. Annals of the New York Academy of Sciences 1153: 256-263.
14. Melchjorsen J, Paludan SR, (2003) Induction of RANTES/CCL5 by herpes simplex virus is regulated by nuclear factor kappa B and interferon regulatory factor 3. The Journal of general virology 84: 2491-2495.
15. Cook WJ, Kramer MF, Walker RM, Burwell TJ, Holman HA, et al. (2004) Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection. Virology journal 1: 5.
16. Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, et al. (2000) Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity 13: 233-242.
17. Hoek RM, Ruuls SR, Murphy CA, Wright GJ, Goddard R, et al. (2000) Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 290: 1768-1771.
18. Snelgrove RJ, Goulding J, Didierlaurent AM, Lyonga D, Vekaria S, et al. (2008) A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nature immunology 9: 1074-1083.
19. Zhang S, Cherwinski H, Sedgwick JD, Phillips JH, (2004) Molecular mechanisms of CD200 inhibition of mast cell activation. Journal of immunology 173: 6786-6793.
20. Mihrshahi R, Barclay AN, Brown MH, (2009) Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells. Journal of immunology 183: 4879-4886.
21. Mihrshahi R, Brown MH, (2010) Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling. Journal of immunology 185: 7216-7222.
22. Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, et al. (2003) Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. Journal of immunology 171: 3034-3046.
23. Mukhopadhyay S, Pluddemann A, Hoe JC, Williams KJ, Varin A, et al. (2010) Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage activation to protect the host from meningococcal septicemia. Cell host & microbe 8: 236-247.
24. Deckert M, Sedgwick JD, Fischer E, Schluter D, (2006) Regulation of microglial cell responses in murine Toxoplasma encephalitis by CD200/CD200 receptor interaction. Acta neuropathologica 111: 548-558.
25. Cortez M, Huynh C, Fernandes MC, Kennedy KA, Aderem A, et al. (2011) Leishmania Promotes Its Own Virulence by Inducing Expression of the Host Immune Inhibitory Ligand CD200. Cell host & microbe 9: 463-471.
26. Karnam G, Rygiel TP, Raaben M, Grinwis GC, Coenjaerts FE, et al. (2012) CD200 Receptor Controls Sex-Specific TLR7 Responses to Viral Infection. PLoS pathogens 8: e1002710.
27. Shlapatska LM, Mikhalap SV, Berdova AG, Zelensky OM, Yun TJ, et al. (2001) CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A. Journal of immunology 166: 5480-5487.
28. Kurt-Jones EA, Sandor F, Ortiz Y, Bowen GN, Counter SL, et al. (2004) Use of murine embryonic fibroblasts to define Toll-like receptor activation and specificity. J Endotoxin Res 10: 419-424.
29. St Leger AJ, Peters B, Sidney J, Sette A, Hendricks RL, (2011) Defining the herpes simplex virus-specific CD8+ T cell repertoire in C57BL/6 mice. Journal of immunology 186: 3927-3933.
30. Sheridan BS, Cherpes TL, Urban J, Kalinski P, Hendricks RL, (2009) Reevaluating the CD8 T-cell response to herpes simplex virus type 1: involvement of CD8 T cells reactive to subdominant epitopes. Journal of virology 83: 2237-2245.
31. Taylor TJ, McNamee EE, Day C, Knipe DM, (2003) Herpes simplex virus replication compartments can form by coalescence of smaller compartments. Virology 309: 232-247.
32. Boudakov I, Liu J, Fan N, Gulay P, Wong K, et al. (2007) Mice lacking CD200R1 show absence of suppression of lipopolysaccharide-induced tumor necrosis factor-alpha and mixed leukocyte culture responses by CD200. Transplantation 84: 251-257.
33. Young JL, Mora A, Cerny A, Czech MP, Woda B, et al. (2012) CD14 Deficiency Impacts Glucose Homeostasis in Mice through Altered Adrenal Tone. PloS one 7: e29688.
34. McGinnes LW, Gravel KA, Finberg RW, Kurt-Jones EA, Massare MJ, et al. (2011) Assembly and immunological properties of Newcastle disease virus-like particles containing the respiratory syncytial virus F and G proteins. Journal of virology 85: 366-377.
35. Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, et al. (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440: 228-232.
36. Burckstummer T, Baumann C, Bluml S, Dixit E, Durnberger G, et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol.
37. Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature.
38. Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, et al. (2009) AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458: 514-518.
39. Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, et al. (2010) The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol 11: 395-402.
40. Muruve DA, Petrilli V, Zaiss AK, White LR, Clark SA, et al. (2008) The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 452: 103-107.
41. Vollstedt S, Franchini M, Alber G, Ackermann M, Suter M, (2001) Interleukin-12- and gamma interferon-dependent innate immunity are essential and sufficient for long-term survival of passively immunized mice infected with herpes simplex virus type 1. Journal of virology 75: 9596-9600.
42. Menachery VD, Pasieka TJ, Leib DA, (2010) Interferon regulatory factor 3-dependent pathways are critical for control of herpes simplex virus type 1 central nervous system infection. Journal of virology 84: 9685-9694.
43. Detje CN, Meyer T, Schmidt H, Kreuz D, Rose JK, et al. (2009) Local type I IFN receptor signaling protects against virus spread within the central nervous system. Journal of immunology 182: 2297-2304.
44. Eidson KM, Hobbs WE, Manning BJ, Carlson P, DeLuca NA, (2002) Expression of herpes simplex virus ICP0 inhibits the induction of interferon-stimulated genes by viral infection. Journal of virology 76: 2180-2191.
45. Perry AK, Chen G, Zheng D, Tang H, Cheng G, (2005) The host type I interferon response to viral and bacterial infections. Cell research 15: 407-422.
46. Tabeta K, Georgel P, Janssen E, Du X, Hoebe K, et al. (2004) Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proceedings of the National Academy of Sciences of the United States of America 101: 3516-3521.
47. Hochrein H, Schlatter B, O'Keeffe M, Wagner C, Schmitz F, et al. (2004) Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and-independent pathways. Proceedings of the National Academy of Sciences of the United States of America 101: 11416-11421.
48. Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A, (2003) Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. The Journal of experimental medicine 198: 513-520.
49. Davey GM, Wojtasiak M, Proietto AI, Carbone FR, Heath WR, et al. (2010) Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo. Journal of immunology 184: 2243-2246.
50. Koning N, Swaab DF, Hoek RM, Huitinga I, (2009) Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. Journal of neuropathology and experimental neurology 68: 159-167.
51. Shrivastava K, Gonzalez P, Acarin L (2012) The immune inhibitory complex CD200/CD200R is developmentally regulated in the mouse brain. The Journal of comparative neurology.
52. Mott KR, Underhill D, Wechsler SL, Town T, Ghiasi H, (2009) A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages. Virology journal 6: 56.
53. van Lint AL, Murawski MR, Goodbody RE, Severa M, Fitzgerald KA, et al. (2010) Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling. J Virol 84: 10802-10811.
54. Semmling V, Lukacs-Kornek V, Thaiss CA, Quast T, Hochheiser K, et al. (2010) Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nature immunology 11: 313-320.