Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells

Journal of Immunology

Volumn 183, Issue 8, 2009, Pages 4879-4886

  Mihrshahi, Robin ^a   Barclay, A Neil ^a   Brown, Marion H ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CD200 RECEPTOR; DOWNSTREAM OF TYROSINE KINASE 1; DOWNSTREAM OF TYROSINE KINASE 2; PHOSPHATASE; PROTEIN DERIVATIVE; RAS P21 PROTEIN ACTIVATOR 1; SRC HOMOLOGY 2 DOMAIN CONTAINING PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BONE MARROW CELL; CELL ACTIVATION; CONTROLLED STUDY; CYTOPLASM; GENE EXPRESSION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD; ANTIGENS, SURFACE; CELL LINE, TUMOR; DNA-BINDING PROTEINS; EXTRACELLULAR MATRIX PROTEINS; GENE KNOCKDOWN TECHNIQUES; GLYCOPROTEINS; HUMANS; INTERLEUKIN-4; INTERLEUKIN-8; MACROPHAGES; MICE; MYELOID CELLS; P120 GTPASE ACTIVATING PROTEIN; PHOSPHOPROTEINS; RAS GTPASE-ACTIVATING PROTEINS; RATS; RECEPTORS, CELL SURFACE; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 77954127754     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901531     Document Type: Article

References (46)

1. Wright, G. J., M. J. Puklavec, A. C. Willis, R. M. Hoek, J. D. Sedgwick, M. H. Brown, and A. N. Barclay. 2000. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity 13: 233-242.
2. Wright, G. J., H. Cherwinski, M. Foster-Cuevas, G. Brooke, M. J. Puklavec, M. Bigler, Y. Song, M. Jenmalm, D. Gorman, T. McClanahan, et al. 2003. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J. Immunol. 171: 3034-3046.
3. Hatherley, D., and A. N. Barclay. 2004. The CD200 and CD200 receptor cell surface proteins interact through their N-terminal immunoglobulin-like domains. Eur. J. Immunol. 34: 1688-1694.
4. Hoek, R. M., S. R. Ruuls, C. A. Murphy, G. J. Wright, R. Goddard, S. M. Zurawski, B. Blom, M. E. Homola, W. J. Streit, M. H. Brown, et al. 2000. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 290: 1768-1771.
5. Snelgrove, R. J., J. Goulding, A. M. Didierlaurent, D. Lyonga, S. Vekaria, L. Edwards, E. Gwyer, J. D. Sedgwick, A. N. Barclay, and T. Hussell. 2008. A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nat. Immunol. 9: 1074-1083.
6. Boudakov, I., J. Liu, N. Fan, P. Gulay, K. Wong, and R. M. Gorczynski. 2007. Mice lacking CD200R1 show absence of suppression of lipopolysaccharide- induced tumor necrosis factor-α and mixed leukocyte culture responses by CD200. Transplantation 84: 251-257.
7. Cherwinski, H. M., C. A. Murphy, B. L. Joyce, M. E. Bigler, Y. S. Song, S. M. Zurawski, M. M. Moshrefi, D. M. Gorman, K. L. Miller, S. Zhang, et al. The CD200 receptor is a novel and potent regulator of murine and human mast cell function. J. Immunol. 174: 1348-1356.
8. Jenmalm, M. C., H. Cherwinski, E. P. Bowman, J. H. Phillips, and J. D. Sedgwick. 2006. Regulation of myeloid cell function through the CD200 receptor. J. Immunol. 176: 191-199.
9. Foster-Cuevas, M., G. J. Wright, M. J. Puklavec, M. H. Brown, and A. N. Barclay. 2004. Human herpesvirus 8 K14 protein mimics CD200 in downregulating macrophage activation through CD200 receptor. J. Virol. 78: 7667-7676.
10. Gorczynski, R. M. 2001. Transplant tolerance modifying antibody to CD200 receptor, but not CD200, alters cytokine production profile from stimulated macrophages. Eur. J. Immunol. 31: 2331-2337.
11. McWhirter, J. R., A. Kretz-Rommel, A. Saven, T. Maruyama, K. N. Potter, C. I. Mockridge, E. P. Ravey, F. Qin, and K. S. Bowdish. 2006. Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation. Proc. Natl. Acad. Sci. USA 103: 1041-1046.
12. Shiratori, I., M. Yamaguchi, M. Suzukawa, K. Yamamoto, L. L. Lanier, T. Saito, and H. Arase. 2005. Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. J. Immunol. 175: 4441-4449. (Pubitemid 41361980)
13. Cameron, C. M., J. W. Barrett, L. Liu, A. R. Lucas, and G. McFadden. 2005. Myxoma virus M141R expresses a viral CD200 (vOX-2) that is responsible for down-regulation of macrophage and T-cell activation in vivo. J. Virol. 79: 6052-6067.
14. Voigt, S., G. R. Sandford, G. S. Hayward, and W. H. Burns. 2005. The English strain of rat cytomegalovirus (CMV) contains a novel captured CD200 (vOX2) gene and a spliced CC chemokine upstream from the major immediate-early region: further evidence for a separate evolutionary lineage from that of rat CMV Maastricht. J. Gen. Virol. 86: 263-274.
15. Langlais, C. L., J. M. Jones, R. D. Estep, and S. W. Wong. 2006. Rhesus rhadinovirus R15 encodes a functional homologue of human CD200. J. Virol. 80: 3098-3103.
16. Moreaux, J., D. Hose, T. Reme, E. Jourdan, M. Hundemer, E. Legouffe, P. Moine, P. Bourin, M. Moos, J. Corre, et al. 2006. CD200 is a new prognostic factor in multiple myeloma. Blood 108: 4194-4197.
17. Kawasaki, B. T., T. Mistree, E. M. Hurt, M. Kalathur, and W. L. Farrar. 2007. Co-expression of the toleragenic glycoprotein, CD200, with markers for cancer stem cells. Biochem. Biophys. Res. Commun. 364: 778-782.
18. Kretz-Rommel, A., F. Qin, N. Dakappagari, E. P. Ravey, J. McWhirter, D. Oltean, S. Frederickson, T. Maruyama, M. A. Wild, M. J. Nolan, D. Wu, et al. 2007. CD200 expression on tumor cells suppresses antitumor immunity: new approaches to cancer immunotherapy. J. Immunol. 178: 5595-5605.
19. Tonks, A., R. Hills, P. White, B. Rosie, K. I. Mills, A. K. Burnett, and R. L. Darley. 2007. CD200 as a prognostic factor in acute myeloid leukaemia. Leukemia 21: 566-568.
20. Daeron, M., S. Jaeger, L. Du Pasquier, and E. Vivier. 2008. Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future. Immunol. Rev. 224: 11-43.
21. Smith, M. J., W. R. Hardy, J. M. Murphy, N. Jones, and T. Pawson. 2006. Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays. Mol. Cell. Biol. 26: 8461-8474.
22. Viertlboeck, B. C., M. A. Hanczaruk, F. C. Schmitt, R. Schmitt, and T. W. Gobel. 2008. Characterization of the chicken CD200 receptor family. Mol. Immunol. 45: 2097-2105.
23. Zhang, S., H. Cherwinski, J. D. Sedgwick, and J. H. Phillips. 2004. Molecular mechanisms of CD200 inhibition of mast cell activation. J. Immunol. 173: 6786-6793. (Pubitemid 39545181)
24. Zhang, S., and J. H. Phillips. 2006. Identification of tyrosine residues crucial for CD200R-mediated inhibition of mast cell activation. J. Leukocyte Biol. 79: 363-368.
25. Lemay, S., D. Davidson, S. Latour, and A. Veillette. 2000. Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. Mol. Cell. Biol. 20: 2743-2754.
26. Voulgaraki, D., R. Mitnacht-Kraus, M. Letarte, M. Foster-Cuevas, M. H. Brown, and A. N. Barclay. 2005. Multivalent recombinant proteins for probing functions of leucocyte surface proteins such as the CD200 receptor. Immunology 115: 337-346.
27. Locati, M., U. Deuschle, M. L. Massardi, F. O. Martinez, M. Sironi, S. Sozzani, T. Bartfai, and A. Mantovani. 2002. Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes. J. Immunol. 168: 3557-3562.
28. Mukhopadhyay, S., L. Peiser, and S. Gordon. 2004. Activation of murine macrophages by Neisseria meningitidis and IFN-γ in vitro: distinct roles of class A scavenger and Toll-like pattern recognition receptors in selective modulation of surface phenotype. J. Leukocyte Biol. 76: 577-584.
29. Dong, S., B. Corre, E. Foulon, E. Dufour, A. Veillette, O. Acuto, and F. Michel. 2006. T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2. J. Exp. Med. 203: 2509-2518.
30. Pamonsinlapatham, P., B. Gril, S. Dufour, R. Hadj-Slimane, V. Gigoux, S. Pethe, S. L'Hoste, J. Camonis, C. Garbay, F. Raynaud, and M. Vidal. 2008. Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration. Cell. Signal. 20: 2119-2126.
31. Clarkson, N. G., S. J. Simmonds, M. J. Puklavec, and M. H. Brown. 2007. Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase. J. Biol. Chem. 282: 25385-25394.
32. Songyang, Z., Y. Yamanashi, D. Liu, and D. Baltimore. 2001. Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling. J. Biol. Chem. 276: 2459-2465.
33. Boulay, I., J. G. Nemorin, and P. Duplay. 2005. Phosphotyrosine binding-mediated oligomerization of downstream of tyrosine kinase (Dok)-1 and Dok-2 is involved in CD2-induced Dok phosphorylation. J. Immunol. 175: 4483-4489. (Pubitemid 41361985)
34. Dunant, N. M., D. Wisniewski, A. Strife, B. Clarkson, and M. D. Resh. 2000. The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells. Cell Signal 12: 317-326.
35. Sweeney, M. C., A. S. Wavreille, J. Park, J. P. Butchar, S. Tridandapani, and D. Pei. 2005. Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains. Biochemistry 44: 14932-14947.
36. Lock, P., F. Casagranda, and A. R. Dunn. 1999. Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck. J. Biol. Chem. 274: 22775-22784.
37. Hassan, N. J., S. J. Simmonds, N. G. Clarkson, S. Hanrahan, M. J. Puklavec, M. Bomb, A. N. Barclay, and M. H. Brown. 2006. CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. Mol. Cell. Biol. 26: 6727-6738.
38. Zhou, M. M., J. E. Harlan, W. S. Wade, S. Crosby, K. S. Ravichandran, S. J. Burakoff, and S. W. Fesik. 1995. Binding affinities of tyrosine- phosphorylated peptides to the COOH-terminal SH2 and NH2-terminal phosphotyrosine binding domains of Shc. J. Biol. Chem. 270: 31119-31123.
39. Liang, X., D. Wisniewski, A. Strife, Shivakrupa, B. Clarkson, and M. D. Resh. 2002. Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling. J. Biol. Chem. 277: 13732-13738.
40. Yamanashi, Y., T. Tamura, T. Kanamori, H. Yamane, H. Nariuchi, T. Yamamoto, and D. Baltimore. 2000. Role of the rasGAP-associated docking protein p62dok in negative regulation of B cell receptor-mediated signaling. Genes Dev. 14: 11-16.
41. Yasuda, T., K. Bundo, A. Hino, K. Honda, A. Inoue, M. Shirakata, M. Osawa, T. Tamura, H. Nariuchi, H. Oda, et al. 2007. Dok-1 and Dok-2 are negative regulators of T cell receptor signaling. Int. Immunol. 19: 487-495.
42. dok: a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 88: 197-204.
43. Yamanashi, Y., and D. Baltimore. 1997. Identification of the Abl- and rasGAPassociated 62 kDa protein as a docking protein, Dok. Cell 88: 205-211. (Pubitemid 28015869)
44. bcr-abl inhibits RasGAP activity. Proc. Natl. Acad. Sci. USA 97: 2093-2098.
45. Chakrabarty, K., and R. Heumann. 2008. Prospective of Ras signaling in stem cells. Biol. Chem. 389: 791-798.
46. Pamonsinlapatham, P., R. Hadj-Slimane, Y. Lepelletier, B. Allain, M. Toccafondi, C. Garbay, and F. Raynaud. 2009. P120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling. Biochimie 91: 320-328.