CD200 receptor controls sex-specific TLR7 responses to viral infection

PLoS Pathogens

Volumn 8, Issue 5, 2012, Pages

  Karnam, Guruswamy ^a   Rygiel, Tomasz P ^a   Raaben, Matthijs ^b,c   Grinwis, Guy C M ^b   Coenjaerts, Frank E ^a   Ressing, Maaike E ^a   Rottier, Peter J M ^b   de Haan, Cornelis A M ^b   Meyaard, Linde ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD200 RECEPTOR; INTERFERON; TOLL LIKE RECEPTOR 7; ANTIGENS, CD200; CD200 RECEPTOR, MOUSE; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; TLR7 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IN VIVO STUDY; INFLUENZA A; INFLUENZA VIRUS A; MALE; MOUSE; MURINE HEPATITIS CORONAVIRUS; MURINE HEPATITIS CORONAVIRUS INFECTION; NEUTROPHIL; NONHUMAN; SEX DIFFERENCE; SIGNAL TRANSDUCTION; VIRAL CLEARANCE; VIRUS INFECTION; VIRUS REPLICATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CORONAVIRUS INFECTION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; NEUTROPHIL CHEMOTAXIS; ORTHOMYXOVIRUS INFECTION; PATHOGENICITY; SEXUAL DEVELOPMENT;

CORONAVIRUS; INFLUENZA A VIRUS; MURINE HEPATITIS VIRUS; MUS;

ANIMALS; ANTIGENS, CD; CORONAVIRUS INFECTIONS; FEMALE; INFLUENZA A VIRUS; INTERFERON TYPE I; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MURINE HEPATITIS VIRUS; NEUTROPHIL INFILTRATION; NEUTROPHILS; ORTHOMYXOVIRIDAE INFECTIONS; SEX CHARACTERISTICS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 7;

EID: 84863702228     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002710     Document Type: Article

References (38)

1. Gorczynski RM, (2005) CD200 and its receptors as targets for immunoregulation. Curr Opin Investig Drugs 6: 483-488.
2. Preston S, Wright GJ, Starr K, Barclay AN, Brown MH, (1997) The leukocyte/neuron cell surface antigen OX2 binds to a ligand on macrophages. Eur J Immmunol 27: 1911-1918.
3. Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, et al. (2003) Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J Immunol 171: 3034-3046.
4. Rijkers ESK, De Ruiter T, Baridi A, Veninga H, Hoek RM, et al. (2008) The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes. Mol Immunol 45: 1126-1135.
5. Mihrshahi R, Barclay AN, Brown MH, (2009) Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells. J Immunol 183: 4879-4886.
6. Barclay AN, Wright GJ, Brooke G, Brown MH, (2002) CD200 and membrane protein interactions in the control of myeloid cells. Trends Immunol 23: 285-290.
7. Hatherley D, Cherwinski H, Moshref M, Barclay AN, (2005) Recombinant CD200 protein does not bind activating proteins closely related to CD200 receptor. J Immunol 175: 2469-2474.
8. Hoek RM, Ruuls SR, Murphy CA, Wright GJ, Goddard R, et al. (2000) Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 290: 1768-1771.
9. Mukhopadhyay S, Pluddemann A, Hoe JC, Williams KJ, Varin A, et al. (2010) Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage activation to protect the host from meningococcal septicemia. Cell Host Microbe 8: 236-247.
10. Snelgrove RJ, Goulding J, Didierlaurent AM, Lyonga D, Vekaria S, et al. (2008) A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nat Immunol 9: 1074-1083.
11. Rygiel TP, Rijkers ES, de RT, Stolte EH, van d V, et al. (2009) Lack of CD200 enhances pathological T cell responses during influenza infection. J Immunol 183: 1990-1996.
12. Cervantes-Barragan L, Zust R, Weber F, Spiegel M, Lang KS, et al. (2007) Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon. Blood 109: 1131-1137.
13. Lang PA, Cervantes-Barragan L, Verschoor A, Navarini AA, Recher M, et al. (2009) Hematopoietic cell-derived interferon controls viral replication and virus-induced disease. Blood 113: 1045-1052.
14. Raaben M, Prins HJ, Martens AC, Rottier PJ, de Haan CA, (2009) Non-invasive imaging of mouse hepatitis coronavirus infection reveals determinants of viral replication and spread in vivo. Cell Microbiol 11: 825-841.
15. Raaben M, Grinwis GC, Rottier PJ, de Haan CA, (2010) The proteasome inhibitor Velcade enhances rather than reduces disease in mouse hepatitis coronavirus-infected mice. J Virol 84: 7880-7885.
16. Berghofer B, Frommer T, Haley G, Fink L, Bein G, et al. (2006) TLR7 ligands induce higher IFN-alpha production in females. J Immunol 177: 2088-2096.
17. Meier A, Chang JJ, Chan ES, Pollard RB, Sidhu HK, et al. (2009) Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1. Nat Med 15: 955-959.
18. Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, et al. (2002) Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3: 196-200.
19. Klein SL, Jedlicka A, Pekosz A, (2010) The Xs and Y of immune responses to viral vaccines. Lancet Infect Dis 10: 338-349.
20. Carrel L, Willard HF, (2005) X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 434: 400-404.
21. Boudakov I, Liu J, Fan N, Gulay P, Wong K, et al. (2007) Mice lacking CD200R1 show absence of suppression of lipopolysaccharide-induced tumor necrosis factor-alpha and mixed leukocyte culture responses by CD200. Transplantation 84: 251-257.
22. Costello DA, Lyons A, Denieffe S, Browne TC, Cox FF, et al. (2011) Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: A role for Toll-like receptor activation. J Biol Chem 286: 34722-34732.
23. Zhang S, Phillips JH, (2006) Identification of tyrosine residues crucial for CD200R-mediated inhibition of mast cell activation. J Leukoc Biol 79: 363-368.
24. Zhang S, Cherwinski H, Sedgwick JD, Phillips JH, (2004) Molecular mechanisms of CD200 inhibition of mast cell activation. J Immunol 173: 6786-6793.
25. Wang JP, Bowen GN, Padden C, Cerny A, Finberg RW, et al. (2008) Toll-like receptor-mediated activation of neutrophils by influenza A virus. Blood 112: 2028-2034.
26. GeurtsvanKessel CH, Willart MA, van Rijt LS, Muskens F, Kool M, et al. (2008) Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells. J Exp Med 205: 1621-1634.
27. Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C, (2004) Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA. Science 303: 1529-1531.
28. Jewell NA, Vaghefi N, Mertz SE, Akter P, Peebles RS Jr, et al. (2007) Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo. J Virol 81: 9790-9800.
29. Tonks A, Hills R, White P, Rosie B, Mills KI, et al. (2007) CD200 as a prognostic factor in acute myeloid leukaemia. Leukemia 21: 566-568.
30. Moreaux J, Hose D, Reme T, Jourdan E, Hundemer M, et al. (2006) CD200 is a new prognostic factor in multiple myeloma. Blood 108: 4194-4197.
31. Klein SL, Passaretti C, Anker M, Olukoya P, Pekosz A, (2010) The impact of sex, gender and pregnancy on 2009 H1N1 disease. Biol Sex Differ 1: 5.
32. Kayali G, Webby RJ, Ducatez MF, El Shesheny RA, Kandeil AM, et al. (2011) The epidemiological and molecular aspects of influenza H5N1 viruses at the human-animal interface in Egypt. PLoS One 6: e17730.
33. Leong HN, Earnest A, Lim HH, Chin CF, Tan CS, et al. (2006) SARS in Singapore-predictors of disease severity. Ann Acad Med Singapore 35: 326-331.
34. Karlberg J, Chong DS, Lai WY, (2004) Do men have a higher case fatality rate of severe acute respiratory syndrome than women do? Am J Epidemiol 159: 229-231.
35. Fish EN, (2008) The X-files in immunity: sex-based differences predispose immune responses. Nat Rev Immunol 8: 737-744.
36. Farzadegan H, Hoover DR, Astemborski J, Lyles CM, Margolick JB, et al. (1998) Sex differences in HIV-1 viral load and progression to AIDS. Lancet 352: 1510-1514.
37. Kim AM, Tingen CM, Woodruff TK, (2010) Sex bias in trials and treatment must end. Nature 465: 688-689.
38. Raaben M, Einerhand AW, Taminiau LJ, van HM, Bouma J, et al. (2007) Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection. Virol J 4: 55.