Hepatitis B viral core protein disrupts human host gene expression by binding to promoter regions

BMC Genomics

Volumn 13, Issue 1, 2012, Pages

  Guo, Yanhai ^a   Kang, Wei ^b   Lei, Xiaoying ^a   Li, Yongnian ^c   Xiang, An ^a   Liu, Yonglan ^a   Zhao, Jinrong ^a   Zhang, Ju ^a   Yan, Zhen ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b XI'AN MEDICAL UNIVERSITY   (China)

^c Department of Infectious Diseases   (China)

Author keywords

ChIP on chip; Chromatin immunoprecipitation microarray; DNA protein interaction; Gene expression; Hepatitis B core protein; Hepatitis B virus

Indexed keywords

BETA CATENIN; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CORE PROTEIN; HEPATITIS B CORE ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; SOMATOMEDIN C RECEPTOR; WNT PROTEIN;

ADULT; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CARCINOGENESIS; CELL DISRUPTION; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE CONTROL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE TARGETING; GENETIC ANALYSIS; GENETIC ASSOCIATION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN GENOME; HUMAN TISSUE; LIVER CELL CARCINOMA; MALE; MOLECULAR MECHANICS; MOLECULARLY TARGETED THERAPY; ONCOGENE HRAS; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTO ONCOGENE; REPORTER GENE; STRUCTURE ANALYSIS; UPREGULATION; VIRUS ONCOGENE; WNT SIGNALING PATHWAY;

ADULT; CHROMATIN IMMUNOPRECIPITATION; FEMALE; GENE EXPRESSION REGULATION, VIRAL; GENOME, HUMAN; HEPATITIS B; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; VIRAL CORE PROTEINS; YOUNG ADULT;

HEPATITIS B VIRUS; RATTUS;

EID: 84867639836     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-13-563     Document Type: Article

References (40)

1. Ganem D, Prince AM. Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med 2004, 350:1118-1129. 10.1056/NEJMra031087, 15014185.
2. Shepard CW, Simard EP, Finelli L, Fiore AE, Bell BP. Hepatitis B virus infection: epidemiology and vaccination. Epidemiologic reviews 2006, 28:112-125. 10.1093/epirev/mxj009, 16754644.
3. Bock CT, Schwinn S, Locarnini S, Fyfe J, Manns MP, Trautwein C, Zentgraf H. Structural organization of the hepatitis B virus minichromosome. J Mol Biol 2001, 307:183-196. 10.1006/jmbi.2000.4481, 11243813.
4. Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell 2009, 16:295-308. 10.1016/j.ccr.2009.08.021, 19800575.
5. Brechot C. Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigms. Gastroenterology 2004, 127:S56-S61. 10.1053/j.gastro.2004.09.016, 15508104.
6. Lee AT, Lee CG. Oncogenesis and transforming viruses: the hepatitis B virus and hepatocellularcarcinoma-the etiopathogenic link. Front Biosci 2007, 12:234-245. 10.2741/2061, 17127296.
7. Murakami S. Hepatitis B virus X protein: structure, function and biology. Intervirology 1999, 42:81-99. 10.1159/000024969, 10516464.
8. Petit MA, Pillot J. HBc and HBe antigenicity and DNA-binding activity of major core protein P22 in hepatitis B virus core particles isolated from the cytoplasm of human liver cells. J Virol 1985, 53:543-551. 254669, 2578575.
9. Michalak T, Nowoslawski A. Crystalline aggregates of hepatitis B core particles in cytoplasm of hepatocytes. Intervirology 1982, 17:247-252. 10.1159/000149295, 7129825.
10. Du J, Liang X, Liu Y, Qu Z, Gao L, Han L, Liu S, Cui M, Shi Y, Zhang Z, et al. Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression. Cell death and differentiation 2009, 16:219-229. 10.1038/cdd.2008.144, 18927587.
11. Kim JH, Kang S, Kim J, Ahn BY. Hepatitis B virus core protein stimulates the proteasome-mediated degradation of viral X protein. J Virol 2003, 77:7166-7173. 10.1128/JVI.77.13.7166-7173.2003, 164777, 12805415.
12. Kwon JA, Rho HM. Transcriptional repression of the human p53 gene by hepatitis B viral core protein (HBc) in human liver cells. Biol Chem 2003, 384:203-212.
13. Elmore LW, Hancock AR, Chang SF, Wang XW, Chang S, Callahan CP, Geller DA, Will H, Harris CC. Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc Natl Acad Sci U S A 1997, 94:14707-14712. 10.1073/pnas.94.26.14707, 25100, 9405677.
14. Fernandez M, Quiroga JA, Carreno V. Hepatitis B virus downregulates the human interferon-inducible MxA promoter through direct interaction of precore/core proteins. J Gen Virol 2003, 84:2073-2082. 10.1099/vir.0.18966-0, 12867637.
15. Liao W, Ou JH. Phosphorylation and nuclear localization of the hepatitis B virus core protein: significance of serine in the three repeated SPRRR motifs. J Virol 1995, 69:1025-1029. 188672, 7815479.
16. Zheng J, Schodel F, Peterson DL. The structure of hepadnaviral core antigens. Identification of free thiols and determination of the disulfide bonding pattern. J Biol Chem 1992, 267:9422-9429.
17. Gallina A, Bonelli F, Zentilin L, Rindi G, Muttini M, Milanesi G. A recombinant hepatitis B core antigen polypeptide with the protamine-like domain deleted self-assembles into capsid particles but fails to bind nucleic acids. J Virol 1989, 63:4645-4652. 251098, 2677399.
18. Ren B, Robert F, Wyrick JJ, Aparicio O, Jennings EG, Simon I, Zeitlinger J, Schreiber J, Hannett N, Kanin E, et al. Genome-wide location and function of DNA binding proteins. Science 2000, 290:2306-2309. 10.1126/science.290.5500.2306, 11125145.
19. Chinese Society of Hepatology CMACSoID, Chinese Medical Association Guideline on prevention and treatment of chronic hepatitis B in China (2005). Chin Med J (Engl) 2007, 120:2159-2173. Chinese Society of Hepatology CMACSoID, Chinese Medical Association.
20. Yan Z, Tan W, Zhao W, Dan Y, Wang X, Mao Q, Wang Y, Deng G. Regulatory polymorphisms in the IL-10 gene promoter and HBV-related acute liver failure in the Chinese population. J Viral Hepat 2009, 16:775-783. 10.1111/j.1365-2893.2009.01139.x, 19413695.
21. Hatzis P, van der Flier LG, van Driel MA, Guryev V, Nielsen F, Denissov S, Nijman IJ, Koster J, Santo EE, Welboren W, et al. Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol 2008, 28:2732-2744. 10.1128/MCB.02175-07, 2293123, 18268006.
22. Pathak S, D'Souza R, Ankolkar M, Gaonkar R, Balasinor NH. Potential role of estrogen in regulation of the insulin-like growth factor2-H19 locus in the rat testis. Mol Cell Endocrinol 2010, 314:110-117. 10.1016/j.mce.2009.08.005, 19683557.
23. Kim SK, Jang SK, Rho HM. Effect of frameshift mutation in the pre-C region of hepatitis B virus on the X and C genes. J Gen Virol 1994, 75(Pt 4):917-923.
24. Kanehisa M, Goto S, Kawashima S, Okuno Y, Hattori M. The KEGG resource for deciphering the genome. Nucleic Acids Res 2004, 32:D277-D280. 10.1093/nar/gkh063, 308797, 14681412.
25. Guo YH, Li YN, Zhao JR, Zhang J, Yan Z. HBc binds to the CpG islands of HBV cccDNA and promotes an epigenetic permissive state. Epigenetics: official journal of the DNA Methylation Society 2011, 6:720-726.
26. Buck MJ, Lieb JD. ChIP-chip: considerations for the design, analysis, and application of genome-wide chromatin immunoprecipitation experiments. Genomics 2004, 83:349-360. 10.1016/j.ygeno.2003.11.004, 14986705.
27. Dere E, Lo R, Celius T, Matthews J, Zacharewski TR. Integration of genome-wide computation DRE search, AhR ChIP-chip and gene expression analyses of TCDD-elicited responses in the mouse liver. BMC Genomics 2011, 12:365. 10.1186/1471-2164-12-365, 3160422, 21762485.
28. Koudritsky M, Domany E. Positional distribution of human transcription factor binding sites. Nucleic Acids Res 2008, 36:6795-6805. 10.1093/nar/gkn752, 2588498, 18953043.
29. O'Geen H, Nicolet CM, Blahnik K, Green R, Farnham PJ. Comparison of sample preparation methods for ChIP-chip assays. Biotechniques 2006, 41:577-580. 10.2144/000112268, 2268903, 17140114.
30. Blanchet M, Sureau C. Analysis of the cytosolic domains of the hepatitis B virus envelope proteins for their function in viral particle assembly and infectivity. J Virol 2006, 80:11935-11945. 10.1128/JVI.00621-06, 1676254, 17020942.
31. Kock J, Nassal M, Deres K, Blum HE, von Weizsacker F. Hepatitis B virus nucleocapsids formed by carboxy-terminally mutated core proteins contain spliced viral genomes but lack full-size DNA. J Virol 2004, 78:13812-13818. 10.1128/JVI.78.24.13812-13818.2004, 533894, 15564489.
32. Yeh CT, Liaw YF, Ou JH. The arginine-rich domain of hepatitis B virus precore and core proteins contains a signal for nuclear transport. J Virol 1990, 64:6141-6147. 248788, 2243390.
33. Lu L, Liu W, Yang X. A novel method for characterizing the multi-functional C-terminal domain of the Hepadnavirus core protein. J Virol Methods 2009, 158:195-198. 10.1016/j.jviromet.2009.01.025, 19428590.
34. Kwon JA, Rho HM. Hepatitis B viral core protein activates the hepatitis B viral enhancer II/pregenomic promoter through the nuclear factor kappaB binding site. Biochemistry and cell biology = Biochimie et biologie cellulaire 2002, 80:445-455. 10.1139/o02-133, 23097094.
35. Chemin I, Zoulim F. Hepatitis B virus induced hepatocellular carcinoma. Cancer Lett 2009, 286:52-59. 10.1016/j.canlet.2008.12.003, 19147276.
36. Locarnini S, Shaw T, Dean J, Colledge D, Thompson A, Li K, Lemon SM, Lau GG, Beard MR. Cellular response to conditional expression of the hepatitis B virus precore and core proteins in cultured hepatoma (Huh-7) cells. J Clin Virol 2005, 32:113-121. 10.1016/j.jcv.2004.10.002, 15653413.
37. Kim EK, Choi EJ. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 2010, 1802:396-405. 10.1016/j.bbadis.2009.12.009, 20079433.
38. Fatima S, Lee NP, Luk JM. Dickkopfs and Wnt/beta-catenin signalling in liver cancer. World journal of clinical oncology 2011, 2:311-325. 10.5306/wjco.v2.i8.311, 3163259, 21876852.
39. Zheng Y, Chen WL, Louie SG, Yen TS, Ou JH. Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice. Hepatology 2007, 45:16-21. 10.1002/hep.21445, 17187428.
40. Brown MT, Cooper JA. Regulation, substrates and functions of src. Biochim Biophys Acta 1996, 1287:121-149.