Microfractionation bioactivity-based ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry for the identification of nuclear factor-κB inhibitors and β2 adrenergic receptor agonists in an alkaloidal extract of the folk herb Alstonia scholaris

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 908, Issue , 2012, Pages 98-104

  Hou, Yuanyuan ^a   Cao, Xuelin ^b   Wang, Liqiang ^a   Cheng, Binfeng ^a   Dong, Linyi ^b   Luo, Xiaodong ^c   Bai, Gang ^a   Gao, Wenyuan ^b  

^a NANKAI UNIVERSITY   (China)

^b TIANJIN UNIVERSITY   (China)

^c KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

2 Adrenergic receptor agonist; Constituent identification; Dual bioactivity integrated fingerprinting; Nuclear factor B inhibitor; Ultra performance liquid chromatography quadrupole time of flight mass spectrometry

Indexed keywords

ADRENERGIC RECEPTORS; ANTI-INFLAMMATORIES; BIOLOGICAL EVALUATION; CHEMICAL MAKEUP; DUAL-BIOACTIVITY-INTEGRATED FINGERPRINTING; HERBAL MEDICINES; IN-VITRO; INDOLE ALKALOIDS; LEAF EXTRACTS; MEDICINAL HERB; NUCLEAR FACTORS; PLANT MATERIAL; REPORTER ASSAY; TIME OF FLIGHT MASS SPECTROMETRY; TRADITIONAL CHINESE MEDICINE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; WESTERN COUNTRIES;

BIOACTIVITY; CHROMATOGRAPHY; ENZYME INHIBITION; LEAD COMPOUNDS; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; MEDICINE;

PLANT EXTRACTS;

AKUAMMIDINE; ALSTONIA SCHOLARIS EXTRACT; ALSTOSCHOLARINE; ANTIASTHMATIC AGENT; ANTIINFLAMMATORY AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; HERBACEOUS AGENT; I KAPPA B; INTERLEUKIN 6; INTERLEUKIN 8; LACTATE DEHYDROGENASE; LUCIFERASE; NARELINE; PICRALINAL; PICRININE; SCHOLARICINE; STRICTAMINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VALLESAMINE;

ALSTONIA SCHOLARIS; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOASSAY; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY TEST; DRUG IDENTIFICATION; DRUG PURITY; DRUG STRUCTURE; EMBRYO; ENZYME INHIBITION; FRACTIONATION; FRAGMENTATION REACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROFRACTIONATION; PLANT LEAF; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUADRUPOLE MASS SPECTROMETRY; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY QUADRUPOLE TIME OF FLIGHT MASS SPECTROMETRY;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ALSTONIA; ANALYSIS OF VARIANCE; ANTI-INFLAMMATORY AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INDOLE ALKALOIDS; MASS SPECTROMETRY; NF-KAPPA B; PLANT EXTRACTS; PLANT LEAVES;

ALSTONIA SCHOLARIS;

EID: 84867638958     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.10.004     Document Type: Article

References (37)

1. Mullard A. Nat. Rev. Drug Discov. 2012, 11:91-94.
2. Clark R.D. Curr. Top. Med. Chem. 2009, 9:791-810.
3. Hughes B. Nat. Rev. Drug Discov. 2009, 8:93-96.
4. Keith C.T., Borisy A.A., Stockwell B.R. Nat. Rev. Drug Discov. 2005, 4:71-78.
5. Csermely P., Agoston V., Pongor S. Trends Pharmacol. Sci. 2005, 26:178-182.
6. Petrelli A., Giordano S. Curr. Med. Chem. 2008, 15:422-432.
7. Newman D.J., Cragg G.M., Snader K.M. Nat. Prod. Rep. 2000, 17:215-234.
8. Njuguna N.M., Masimirembwa C., Chibale K. J. Nat. Prod. 2012, 75:507-513.
9. Wang M., Lamers R.J., Korthout H.A., van Nesselrooij J.H., Witkamp R.F., van der Heijden R., Voshol P.J., Havekes L.M., Verpoorte R., van der Greef J. Phytother. Res. 2005, 19:173-182.
10. Tian P. Nature 2011, 480:S84-S86.
11. Guan T., Liang Y., Li C., Xie L., Wang G., Sheng L. Chin. J. Nat. Med. 2011, 9:385-400.
12. Zhou J.L., Qi L.W., Li P. J. Chromatogr. A 2009, 1216:7582-7594.
13. Yang M., Sun J., Lu Z., Chen G., Guan S., Liu X., Jiang B., Ye M., Guo D.A. J. Chromatogr. A 2009, 1216:2045-2062.
14. Steinmann D., Ganzera M. J. Pharm. Biomed. Anal. 2011, 55:744-757.
15. Gray M.J., Chang D., Zhang Y., Liu J., Bensoussan A. Biomed. Chromatogr. 2010, 24:91-103.
16. Kay A.B. J. Allergy Clin. Immunol. 1991, 87:893-910.
17. Gouwy M., Struyf S., Proost P., van Damme J. Cytokine Growth Factor Rev. 2005, 16:561-580.
18. Vignola A.M., la Grutta S., Chiappara G., Benkeder A., Bellia V., Bonsiqnore G. Paediatr. Respir. Rev. 2002, 3:41-46.
19. Barnes P.J. Br. J. Pharmacol. 2006, 147:S297-S303.
20. Viola A., Luster A.D. Annu. Rev. Pharmacol. Toxicol. 2008, 48:171-197.
21. Mapel D.W., Hurley J.S., Dalal A.A., Blanchette C.M. Prim. Care Respir. J. 2010, 19:93-103.
22. O'Neill L.A. Nat. Rev. Drug Discov. 2006, 5:549-563.
23. Hai C.M. Curr. Med. Chem. 2007, 14:67-76.
24. Shang J.H., Cai X.H., Zhao Y.L., Feng T., Luo X.D. J. Ethnopharmacol. 2010, 129:293-298.
25. Shang J.H., Cai X.H., Feng T., Zhao Y.L., Wang J.K., Zhang L.Y., Yan M., Luo X.D. J. Ethnopharmacol. 2010, 129:174-181.
26. Khan M.R., Omoloso A.D., Kihara M. Fitoterapia 2003, 74:736-740.
27. Cai X.H., Du Z.Z., Luo X.D. Org. Lett. 2007, 9:1817-1820.
28. Kamarajan P., Sekar N., Mathuram V., Govindasamy S. Biochem. Int. 1991, 25:491-498.
29. Hou Y., Cao X., Dong L., Wang L., Cheng B., Shi Q., Luo X., Bai G. J. Chromatogr. A 2012, 1227:203-209.
30. Barnes P.J., Karin M. N. Engl. J. Med. 1997, 336:1066-1071.
31. Ghosh S., Ma M.J., Kopp E.B. Annu. Rev. Immunol. 1998, 16:225-260.
32. Bai G., Yang Y., Shi Q., Liu Z., Zhang Q., Zhu Y.Y. Acta Pharmacol. Sin. 2008, 29:1187-1194.
33. Jain L., Pandey M.B., Singh S., Singh A.K., Pandey V.B. Nat. Prod. Res. 2009, 23:1599-1602.
34. Arulmozhi S., Mazumder P.M., Ashok P., Hulkoti B., Narayanan L.S. Pharmacogn. Mag. 2007, 3:106-111.
35. Martel-Pelletier J., Pelletier J.P., Fahmi H. Semin. Arthritis Rheum. 2003, 33:155-167.
36. Ke J., Long X., Liu Y., Zhang Y.F., Li J., Fang W., Meng Q.G. J. Dent. Res. 2007, 86:363-367.
37. Gerfaud T., Xie C., Neuville L., Zhu J. Angew. Chem. Int. Ed. Engl. 2011, 50:3954-3957.