Bioactivity-based liquid chromatography-coupled electrospray ionization tandem ion trap/time of flight mass spectrometry for β 2AR agonist identification in alkaloidal extract of Alstonia scholaris

Journal of Chromatography A

Volumn 1227, Issue , 2012, Pages 203-209

  Hou, Yuanyuan ^a   Cao, Xuelin ^b   Dong, Linyi ^b   Wang, Liqiang ^a   Cheng, Binfeng ^a   Shi, Qian ^a   Luo, Xiaodong ^c   Bai, Gang ^a  

^a NANKAI UNIVERSITY   (China)

^b TIANJIN UNIVERSITY   (China)

^c KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

2 adrenergic receptor agonist; Bioactivity integrated fingerprinting; Constituent identification; LCMS IT TOF

Indexed keywords

ADRENERGIC RECEPTORS; BIOACTIVE COMPOUNDS; BIOACTIVITY-INTEGRATED FINGERPRINTING; CELL-BASED; CHEMICAL INFORMATION; CHEMICAL MARKERS; CHEMOMETRICS; CHROMATOGRAPHIC FINGERPRINTING; FLIGHT MASS SPECTROMETRY; FRAGMENTATION PATTERNS; FUNCTIONAL EVALUATION; GUINEA PIGS; HIGH SENSITIVITY; IN-VIVO; INDOLE ALKALOIDS; ION TRAPS; LCMS-IT-TOF; POTENTIAL ACTIVITIES; RATIONAL METHODS; TANDEM MASS SPECTROMETRY; THERAPEUTIC MATERIALS; TIME OF FLIGHT MASS SPECTROMETRY; TRADITIONAL CHINESE MEDICINE;

BIOACTIVITY; CHEMICAL COMPOUNDS; ELECTROSPRAY IONIZATION; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LEAD COMPOUNDS; MASS SPECTROMETERS; MASS SPECTROMETRY; QUALITY CONTROL;

CHROMATOGRAPHY;

12 HYDROXYECHITAMIDINE NIOBIUM OXIDE; 19,20 ALSTOSCHOLARINE; 19,20 VALLESAMINE; AKUAMMIDINE; ALKALOID DERIVATIVE; ALSTONIA SCHOLARIS EXTRACT; ALSTOSCHOLARINE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; PICRININE; SCHOLARICINE; UNCLASSIFIED DRUG;

ALSTONIA SCHOLARIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; EXPERIMENTAL GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INTERMETHOD COMPARISON; ION TRAP MASS SPECTROMETRY; MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; TEMPERATURE SENSITIVITY; TIME OF FLIGHT MASS SPECTROMETRY; TRACHEA MUSCLE;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ALKALOIDS; ALSTONIA; ANALYSIS OF VARIANCE; ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG DISCOVERY; DRUGS, CHINESE HERBAL; GUINEA PIGS; HEK293 CELLS; HUMANS; MUSCLE, SMOOTH; PLANT LEAVES; RECEPTORS, ADRENERGIC, BETA-2; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

ALSTONIA SCHOLARIS; CAVIA;

EID: 84862800839     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.01.008     Document Type: Article

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