Prenatal exposure to polychlorinated biphenyls and dioxins from the maternal diet may be associated with immunosuppressive effects that persist into early childhood

Food and Chemical Toxicology

Volumn 51, Issue 1, 2013, Pages 165-172

  Stølevik, Solvor Berntsen ^a   Nygaard, Unni Cecilie ^a   Namork, Ellen ^a   Haugen, Margaretha ^a   Meltzer, Helle Margrete ^a   Alexander, Jan ^a   Knutsen, Helle Katrine ^a   Aaberge, Ingeborg ^a   Vainio, Kirsti ^a   van Loveren, Henk ^b,c   Løvik, Martinus ^a,d   Granum, Berit ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^d NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Diet; Dioxins; Immunotoxicity; Polychlorinated biphenyls; Prenatal

Indexed keywords

DIOXIN; HAEMOPHILUS INFLUENZAE TYPE B VACCINE; MEASLES VACCINE; POLYCHLORINATED BIPHENYL; RUBELLA VACCINE; TETANUS TOXOID;

ADULT; ALLERGY; ANTIBODY RESPONSE; ARTICLE; CHILD; FEMALE; FOOD FREQUENCY QUESTIONNAIRE; HAEMOPHILUS INFECTION; HUMAN; IMMUNE DEFICIENCY; IMMUNOPHENOTYPING; INFANT; MAJOR CLINICAL STUDY; MALE; MATERNAL NUTRITION; MEASLES; NORWAY; PRENATAL EXPOSURE; PRESCHOOL CHILD; RISK FACTOR; RUBELLA; TETANUS; UPPER RESPIRATORY TRACT INFECTION; VACCINATION; WHEEZING;

ANTIBODY FORMATION; CHILD, PRESCHOOL; DIOXINS; ENVIRONMENTAL POLLUTANTS; FEMALE; FOOD CONTAMINATION; HUMANS; INFANT; MATERNAL EXPOSURE; MEASLES VACCINE; NORWAY; POLYCHLORINATED BIPHENYLS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; QUESTIONNAIRES; REGRESSION ANALYSIS; RESPIRATORY SOUNDS; RESPIRATORY TRACT INFECTIONS;

EID: 84867598535     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.09.027     Document Type: Article

References (30)

1. Brantsaeter A.L., Haugen M., Alexander J., Meltzer H.M. Validity of a new food frequency questionnaire for pregnant women in the Norwegian Mother and Child Cohort Study (MoBa). Matern. Child Nutr. 2008, 4:28-43.
2. Chapkin R.S., Kim W., Lupton J.R., McMurray D.N. Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation. Prostaglandins Leukot. Essent. Fatty Acids 2009, 81:187-191.
3. Covaci A., Jorens P., Jacquemyn Y., Schepens P. Distribution of PCBs and organochlorine pesticides in umbilical cord and maternal serum. Sci. Total Environ. 2002, 298:45-53.
4. Crozier S.R., Robinson S.M., Godfrey K.M., Cooper C., Inskip H.M. Women's dietary patterns change little from before to during pregnancy. J. Nutr. 2009, 139:1956-1963.
5. Dallaire F., Dewailly E., Muckle G., Vezina C., Jacobson S.W., Jacobson J.L., Ayotte P. Acute infections and environmental exposure to organochlorines in Inuit infants from Nunavik. Environ. Health Perspect. 2004, 112:1359-1365.
6. Dallaire F., Dewailly E., Vezina C., Muckle G., Weber J.P., Bruneau S., Ayotte P. Effect of prenatal exposure to polychlorinated biphenyls on incidence of acute respiratory infections in preschool Inuit children. Environ. Health Perspect. 2006, 114:1301-1305.
7. Domingo J.L., Bocio A. Levels of PCDD/PCDFs and PCBs in edible marine species and human intake: a literature review. Environ. Int. 2007, 33:397-405.
8. Glynn A., Thuvander A., Aune M., Johannisson A., Darnerud P.O., Ronquist G., Cnattingius S. Immune cell counts and risks of respiratory infections among infants exposed pre- and postnatally to organochlorine compounds: a prospective study. Environ. Health 2008, 7:62.
9. Haugen M., Brantsaeter A.L., Alexander J., Meltzer H.M. Dietary supplements contribute substantially to the total nutrient intake in pregnant Norwegian women. Ann. Nutr. Metab. 2008, 52:272-280.
10. Heilmann C., Budtz-Jorgensen E., Nielsen F., Heinzow B., Weihe P., Grandjean P. Serum concentrations of antibodies against vaccine toxoids in children exposed perinatally to immunotoxicants. Environ. Health Perspect. 2010, 118:1434-1438.
11. Heilmann C., Grandjean P., Weihe P., Nielsen F., Budtz-Jorgensen E. Reduced antibody responses to vaccinations in children exposed to polychlorinated biphenyls. PLoS. Med. 2006, 3:e311.
12. Hochstenbach K., van Leeuwen D., Gmuender H., Gottschalk R., Stolevik S.B., Nygaard U.C., Lovik M., Granum B., Namork E., Meltzer H.M., Kleinjans J., van Delft J., van Loveren H. Toxicogenomic profiles in relation to maternal immunotoxic exposure and immune functionality in newborns. Toxicol. Sci. 2012, 129:315-324.
13. Holsapple M.P., Paustenbach D.J., Charnley G., West L.J., Luster M.I., Dietert R.R., Burns-Naas L.A. Symposium summary: children's health risk - what's so special about the developing immune system?. Toxicol. Appl. Pharmacol. 2004, 199:61-70.
14. Kerkvliet N.I., Steppan L.B., Vorachek W., Oda S., Farrer D., Wong C.P., Pham D., Mourich D.V. Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes. Immunotherapy 2009, 1:539-547.
15. Kvalem H.E., Knutsen H.K., Thomsen C., Haugen M., Stigum H., Brantsaeter A.L., Froshaug M., Lohmann N., Papke O., Becher G., Alexander J., Meltzer H.M. Role of dietary patterns for dioxin and PCB exposure. Mol. Nutr. Food Res. 2009, 53:1438-1451.
16. Magnus P., Irgens L.M., Haug K., Nystad W., Skjaerven R., Stoltenberg C. Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa). Int. J. Epidemiol. 2006, 35:1146-1150.
17. Meltzer H.M., Brantsaeter A.L., Ydersbond T.A., Alexander J., Haugen M. Methodological challenges when monitoring the diet of pregnant women in a large study: experiences from the Norwegian Mother and Child Cohort Study (MoBa). Matern. Child. Nutr. 2008, 4:14-27.
18. Miyashita C., Sasaki S., Saijo Y., Washino N., Okada E., Kobayashi S., Konishi K., Kajiwara J., Todaka T., Kishi R. Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy. Environ. Res. 2011, 111:551-558.
19. Nilsen R.M., Vollset S.E., Gjessing H.K., Skjaerven R., Melve K.K., Schreuder P., Alsaker E.R., Haug K., Daltveit A.K., Magnus P. Self-selection and bias in a large prospective pregnancy cohort in Norway. Paediatr. Perinat. Epidemiol. 2009, 23:597-608.
20. Peat J., Barton B. Medical statistics: a guide to data analysis and critical appraisal 2005, Blackwell Publishing Ltd., Oxford. first ed.
21. Phipps D.C., West J., Eby R., Koster M., Madore D.V., Quataert S.A. An ELISA employing a Haemophilus influenzae type b oligosaccharide-human serum albumin conjugate correlates with the radioantigen binding assay. J. Immunol. Methods 1990, 135:121-128.
22. Quintana F.J., Basso A.S., Iglesias A.H., Korn T., Farez M.F., Bettelli E., Caccamo M., Oukka M., Weiner H.L. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 2008, 453:65-71.
23. Scientific Committee on Food, 2001. Opinion for the SCF on the risk assessment of dioxins and dioxin-like PCBs in food. Update based on new scientific information available since the SCF opinion of 22nd November 2000.
24. Simonsen O., Bentzon M.W., Heron I. ELISA for the routine determination of antitoxic immunity to tetanus. J. Biol. Stand. 1986, 14:231-239.
25. Stolevik S.B., Nygaard U.C., Namork E., Haugen M., Kvalem H.E., Meltzer H.M., Alexander J., van Delft J.H., van Loveren H., Lovik M., Granum B. Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants. Food Chem. Toxicol. 2011, 49:1843-1848.
26. Suzuki G., Nakano M., Nakano S. Distribution of PCDDs/PCDFs and Co-PCBs in human maternal blood, cord blood, placenta, milk, and adipose tissue: dioxins showing high toxic equivalency factor accumulate in the placenta. Biosci. Biotechnol. Biochem. 2005, 69:1836-1847.
27. van den Berg M., Birnbaum L.S., Denison M., De Vito M., Farland W., Feeley M., Fiedler H., Hakansson H., Hanberg A., Haws L., Rose M., Safe S., Schrenk D., Tohyama C., Tritscher A., Tuomisto J., Tysklind M., Walker N., Peterson R.E. The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol. Sci. 2006, 93:223-241.
28. van Loveren H., Piersma A. Immunotoxicological consequences of perinatal chemical exposures. Toxicol. Lett. 2004, 149:141-145.
29. Weisglas-Kuperus N., Patandin S., Berbers G.A., Sas T.C., Mulder P.G., Sauer P.J., Hooijkaas H. Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ. Health Perspect. 2000, 108:1203-1207.
30. Weisglas-Kuperus N., Vreugdenhil H.J., Mulder P.G. Immunological effects of environmental exposure to polychlorinated biphenyls and dioxins in Dutch school children. Toxicol. Lett. 2004, 149:281-285.