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Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 29, 2009, Pages 3506-3514

Development and validation of a semi-automated assay for the highly sensitive quantification of Biolimus A9 in human whole blood using high-performance liquid chromatography-tandem mass spectrometry

(7) Clavijo, Claudia a Strom, Tobin a Moll, Vanessa a Betts, Ronald b Zhang, Yan Ling c Christians, Uwe a Bendrick Peart, Jamie d

a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE (United States)

b Biosensors International (United States)

c BioNovo Inc (United States)

d Eurofins Medinet Inc (Germany)

Author keywords

Biolimus A9; Column switching; Drug eluting stents; Human whole blood; LC MS MS

Indexed keywords

AUTOSAMPLERS; CLINICAL TRIAL; COLUMN SWITCHING; DRUG-ELUTING STENTS; FREEZE-THAW CYCLES; HIGH SENSITIVITY; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; HIGHLY SENSITIVE; HUMAN PHARMACOKINETICS; INTERNAL STANDARDS; ION SUPPRESSION; LC-MS/MS; LOWER LIMIT OF DETECTIONS; LOWER LIMIT OF QUANTITATIONS; MATRIX INTERFERENCE; PERFORMANCE CHARACTERISTICS; PROTEIN PRECIPITATION; SEMI-AUTOMATED; STENT IMPLANTATION; SUSTAINED-RELEASE; WHOLE BLOOD;

ARTIFICIAL ORGANS; ASSAYS; BLOOD; CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ZINC;

EXTRACTION;

BIOLIMUS A9; RAPAMYCIN DERIVATIVE; UNCLASSIFIED DRUG; ZOTAROLIMUS;

ARTICLE; ASSAY; AUTOMATION; CORONARY STENT; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELUTING STENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMPLANTATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATERIAL COATING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG-ELUTING STENTS; HUMANS; REPRODUCIBILITY OF RESULTS; SIROLIMUS; TANDEM MASS SPECTROMETRY;

EID: 72049086018 PISSN: 15700232 EISSN: None Source Type: Journal
DOI: 10.1016/j.jchromb.2009.08.020 Document Type: Article

Times cited : (12)

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