Quantitative determination of sirolimus in dog blood using liquid chromatography-tandem mass spectrometry, and its applications to pharmacokinetic studies

Journal of Pharmaceutical and Biomedical Analysis

Volumn 53, Issue 4, 2010, Pages 1042-1047

  Lee, Jong Hwa ^a   Cha, Kwang Ho ^b   Cho, Wonkyung ^b   Park, Junsung ^b   Park, Hee Jun ^b   Cho, Youngseok ^c   Hwang, Sung Joo ^b  

^a Korea Institute of Toxicology   (South Korea)

^b Chungnam National University   (South Korea)

^c Gyeonggi Institute of Science and Technology Promotion   (South Korea)

Author keywords

Basic mobile phase; Dog blood; LC MS MS; Pharmacokinetics; Sirolimus

Indexed keywords

RAPAMYCIN; TACROLIMUS; WATER;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG DETERMINATION; HEMOLYSIS; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

ANIMALS; CALIBRATION; CHROMATOGRAPHY, LIQUID; DOGS; DRUG STABILITY; IMMUNOSUPPRESSIVE AGENTS; LIMIT OF DETECTION; SIROLIMUS; TANDEM MASS SPECTROMETRY;

EID: 77955587164     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.06.030     Document Type: Article

References (17)

1. Calne R.Y., Collier D.S., Lim S., Pollard S.G., Samaan A., White D.J., Thiru S. Rapamycin for immunosuppression in organ allografting. Lancet 1989, 2:443-444.
2. Eng C.P., Sehgal S.N., Vezina C. Activity of rapamycin (AY-22,989) against transplanted tumors. J. Antibiot. (Tokyo) 1984, 37:1231-1237.
3. Kimball P.M., Kerman R.H., Kahan B.D. Production of synergistic but nonidentical mechanisms of immunosuppression by rapamycin and cyclosporine. Transplantation 1991, 51:486-490.
4. Sehgal S.N. Sirolimus: its discovery, biological properties, and mechanism of action. Transplant. Proc. 2003, 35:7S-14S.
5. Chen H.F., Wu J.P., Luo H.Y., Daloze P.M. The immunosuppressive effect of rapamycin on pancreaticoduodenal transplants in the rat. Transplant. Proc. 1991, 23:2239-2240.
6. Stepkowski S.M. Sirolimus, a potent new immunosuppressive drug for organ transplantation. Ann. Transplant. 1996, 1:19-25.
7. Yang Y.J., Chen D.Z., Li L.X., Kou J.T., Lang R., Jin Z.K., Han D.D., He Q. Sirolimus-based immunosuppressive therapy in liver transplant recipient with tacrolimus-related chronic renal insufficiency. Transplant. Proc. 2008, 40:1541-1544.
8. Ansermot N., Fathi M., Veuthey J.L., Desmeules J., Rudaz S., Hochstrasser D. Simultaneous quantification of cyclosporine, tacrolimus, sirolimus and everolimus in whole blood by liquid chromatography-electrospray mass spectrometry. Clin. Biochem. 2008, 41:728-735.
9. Bogusz M.J., Enazi E.A., Hassan H., Abdel-Jawaad J., Ruwaily J.A., Tufail M.A. Simultaneous LC-MS-MS determination of cyclosporine A, tacrolimus, and sirolimus in whole blood as well as mycophenolic acid in plasma using common pretreatment procedure. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2007, 850:471-480.
10. Taylor P.J., Salm P., Lynch S.V., Pillans P.I. Simultaneous quantification of tacrolimus and sirolimus, in human blood, by high-performance liquid chromatography-tandem mass spectrometry. Ther. Drug Monit. 2000, 22:608-612.
11. Zhang J., Rodila R., Watson P., Ji Q., El-Shourbagy T.A. Determination of sirolimus in rabbit arteries using liquid chromatography separation and tandem mass spectrometric detection. Biomed. Chromatogr. 2007, 21:1036-1044.
12. Guidance for Industry: Bioanalytical Method Validation 2001, U.S. Department of Health and Human Services, Food and Drug Administration Centre for Drug Evaluation and Research (CDER), Centre for Veterinary Medicine (CVM), May. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM070107.pdf.
13. Cattaneo D., Perico N., Gaspari F. Assessment of sirolimus concentrations in whole blood by high-performance liquid chromatography with ultraviolet detection. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2002, 774:187-194.
14. Koster R.A., Dijkers E.C., Uges D.R. Robust, high-throughput LC-MS/MS method for therapeutic drug monitoring of cyclosporine, tacrolimus, everolimus, and sirolimus in whole blood. Ther. Drug Monit. 2009, 31:116-125.
15. Wang S., Magill J.E., Vicente F.B. A fast and simple high-performance liquid chromatography/mass spectrometry method for simultaneous measurement of whole blood tacrolimus and sirolimus. Arch. Pathol. Lab. Med. 2005, 129:661-665.
16. Matuszewski B.K., Constanzer M.L., Chavez-Eng C.M. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem. 2003, 75:3019-3030.
17. Gibaldi M., Perrier D. Pharmacokinetics 1982, Marcel-Dekker, New York. 2nd ed.