SCOPUS 정보 검색 플랫폼

Volumn 20, Issue 21, 2012, Pages 6375-6383

Design, synthesis and in vitro evaluation of a series of α-substituted phenylpropanoic acid PPARγ agonists to further investigate the stereochemistry-activity relationship

(9) Ohashi, Masao a Nakagome, Izumi b Kasuga, Jun Ichi c Nobusada, Hiromi a Matsuno, Kenji a Makishima, Makoto d Hirono, Shuichi b Hashimoto, Yuichi c Miyachi, Hiroyuki a

a OKAYAMA UNIVERSITY (Japan)

b KITASATO UNIVERSITY (Japan)

c UNIVERSITY OF TOKYO (Japan)

d NIHON UNIVERSITY (Japan)

Author keywords

Peroxisome proliferator activated receptor; Phenylpropanoic acid; PPAR; PPAR ; SAR

Indexed keywords

2 [[3 [[[4 (1 ADAMANTYL)BENZOYL]AMINO]METHYL] 4 PROPOXYPHENYL]METHYL] 3 CYCLOHEXYLPROPANOIC ACID; 2 [[3 [[[4 (1 ADAMANTYL)BENZOYL]AMINO]METHYL] 4 PROPOXYPHENYL]METHYL] 4 PHENYLBUTANOIC ACID; ALPHA CYCLOHEXYLMETHYLPHENYLPROPANOIC ACID DERIVATIVE; ALPHA PHENETHYLPHENYLPROPANOIC ACID DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CHEMICAL MODIFICATION; COMPLEX FORMATION; COMPUTER SIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENYLPROPIONATES; PPAR GAMMA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867583280 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.08.061 Document Type: Article

Times cited : (11)

References (26)

1
- 0033305213
- B. Desvergne, and W. Wahli Endocr. Rev. 20 1999 649
- (1999) Endocr. Rev. , vol.20 , pp. 649
- Desvergne, B.¹ Wahli, W.²

2
- 0026517010
- C. Dreyer, G. Krey, H. Keller, F. Givel, G. Helftenbein, and W. Wahli Cell 68 1992 879
- (1992) Cell , vol.68 , pp. 879
- Dreyer, C.¹ Krey, G.² Keller, H.³ Givel, F.⁴ Helftenbein, G.⁵ Wahli, W.⁶

3
- 0025132245
- I. Issemann, and S. Green Nature 347 1990 645
- (1990) Nature , vol.347 , pp. 645
- Issemann, I.¹ Green, S.²

4
- 0027161015
- O. Bardot, T.C. Aldridge, N. Latruffe, and S. Green Biochem. Biophys. Res. Commun. 192 1993 37
- (1993) Biochem. Biophys. Res. Commun. , vol.192 , pp. 37
- Bardot, O.¹ Aldridge, T.C.² Latruffe, N.³ Green, S.⁴

5
- 0242676571
- Nuclear Receptors Nomenclature Committee
- Nuclear Receptors Nomenclature Committee. Cell 1999, 97, 1.
- (1999) Cell , vol.97 , pp. 1

6
- 0037160785
- W. Wahli Swiss. Med. Wkly. 132 2002 83
- (2002) Swiss. Med. Wkly. , vol.132 , pp. 83
- Wahli, W.¹

7
- 0141928147
- M. Mendez, and M.C. LaPointe Hypertension 42 2003 844
- (2003) Hypertension , vol.42 , pp. 844
- Mendez, M.¹ Lapointe, M.C.²

8
- 0033546003
- R.F. Morrison, and S.R. Farmer J. Biol. Chem. 274 1999 17088
- (1999) J. Biol. Chem. , vol.274 , pp. 17088
- Morrison, R.F.¹ Farmer, S.R.²

9
- 33746746418
- J.W. Huang, C.W. Shiau, J. Yang, D.S. Wang, H.C. Chiu, C.Y. Chen, and C.S. Chen J. Med. Chem. 49 2006 4684
- (2006) J. Med. Chem. , vol.49 , pp. 4684
- Huang, J.W.¹ Shiau, C.W.² Yang, J.³ Wang, D.S.⁴ Chiu, H.C.⁵ Chen, C.Y.⁶ Chen, C.S.⁷

10
- 79952337610
- N. Wang, R. Yin, Y. Liu, G. Mao, and F. Xi Circ. J. 75 2011 528
- (2011) Circ. J. , vol.75 , pp. 528
- Wang, N.¹ Yin, R.² Liu, Y.³ Mao, G.⁴ Xi, F.⁵

11
- 77954589341
- R.K. Kaundal, and S.S. Sharma Drug News Perspect. 23 2010 241
- (2010) Drug News Perspect. , vol.23 , pp. 241
- Kaundal, R.K.¹ Sharma, S.S.²

12
- 34147102288
- G. Landreth Curr. Alzheimer Res. 4 2007 159
- (2007) Curr. Alzheimer Res. , vol.4 , pp. 159
- Landreth, G.¹

13
- 22844440938
- Y. Hashimoto, and H. Miyachi Bioorg. Med. Chem. 13 2005 5080
- (2005) Bioorg. Med. Chem. , vol.13 , pp. 5080
- Hashimoto, Y.¹ Miyachi, H.²

14
- 79956214170
- S. Ban, J. Kasuga, I. Nakagome, H. Nobusada, F. Takayama, S. Hirono, H. Kawasaki, Y. Hashimoto, and H. Miyachi Bioorg. Med. Chem. 19 2011 3183
- (2011) Bioorg. Med. Chem. , vol.19 , pp. 3183
- Ban, S.¹ Kasuga, J.² Nakagome, I.³ Nobusada, H.⁴ Takayama, F.⁵ Hirono, S.⁶ Kawasaki, H.⁷ Hashimoto, Y.⁸ Miyachi, H.⁹

15
- 0042732947
- M. Nomura, T. Tanase, T. Ide, M. Tsunoda, M. Suzuki, H. Uchiki, K. Murakami, and H. Miyachi J. Med. Chem. 46 2003 3581
- (2003) J. Med. Chem. , vol.46 , pp. 3581
- Nomura, M.¹ Tanase, T.² Ide, T.³ Tsunoda, M.⁴ Suzuki, M.⁵ Uchiki, H.⁶ Murakami, K.⁷ Miyachi, H.⁸

16
- 33751065860
- J. Kasuga, D. Yamasaki, Y. Araya, A. Nakagawa, M. Makishima, T. Doi, Y. Hashimoto, and H. Miyachi Bioorg. Med. Chem. 14 2006 8405
- (2006) Bioorg. Med. Chem. , vol.14 , pp. 8405
- Kasuga, J.¹ Yamasaki, D.² Araya, Y.³ Nakagawa, A.⁴ Makishima, M.⁵ Doi, T.⁶ Hashimoto, Y.⁷ Miyachi, H.⁸

17
- 51349131065
- Y. Araya, J. Kasuga, K. Toyota, Y. Hirakawa, T. Oyama, M. Makishima, K. Morikawa, Y. Hashimoto, and H. Miyachi Chem. Pharm. Bull. 56 2008 1357
- (2008) Chem. Pharm. Bull. , vol.56 , pp. 1357
- Araya, Y.¹ Kasuga, J.² Toyota, K.³ Hirakawa, Y.⁴ Oyama, T.⁵ Makishima, M.⁶ Morikawa, K.⁷ Hashimoto, Y.⁸ Miyachi, H.⁹

18
- 34249977052
- J. Kasuga, I. Nakagome, A. Aoyama, K. Sako, M. Ishizawa, M. Ogura, M. Makishima, S. Hirono, Y. Hashimoto, and H. Miyachi Bioorg. Med. Chem. 15 2007 5177
- (2007) Bioorg. Med. Chem. , vol.15 , pp. 5177
- Kasuga, J.¹ Nakagome, I.² Aoyama, A.³ Sako, K.⁴ Ishizawa, M.⁵ Ogura, M.⁶ Makishima, M.⁷ Hirono, S.⁸ Hashimoto, Y.⁹ Miyachi, H.¹⁰

19
- 55949098730
- J. Kasuga, T. Oyama, I. Nakagome, M. Makishima, S. Hirono, K. Morikawa, Y. Hashimoto, and H. Miyachi ChemMedChem 3 2008 1662
- (2008) ChemMedChem , vol.3 , pp. 1662
- Kasuga, J.¹ Oyama, T.² Nakagome, I.³ Makishima, M.⁴ Hirono, S.⁵ Morikawa, K.⁶ Hashimoto, Y.⁷ Miyachi, H.⁸

20
- 38849125598
- J. Kasuga, D. Yamasaki, K. Ogura, M. Shimizu, M. Sato, M. Makishima, T. Doi, Y. Hashimoto, and H. Miyachi Bioorg. Med. Chem. Lett. 18 2008 1110
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 1110
- Kasuga, J.¹ Yamasaki, D.² Ogura, K.³ Shimizu, M.⁴ Sato, M.⁵ Makishima, M.⁶ Doi, T.⁷ Hashimoto, Y.⁸ Miyachi, H.⁹

21
- 7844232968
- J.E. Cobb, S.G. Blanchard, E.G. Boswell, K.K. Brown, P.S. Charifson, J.P. Cooper, J.L. Collins, M. Dezube, B.R. Henke, E.A. Hull-Ryde, D.H. Lake, J.M. Lenhard, W. Oliver Jr., J. Oplinger, M. Pentti, D.J. Parks, K.D. Plunket, and W.Q. Tong J. Med. Chem. 41 1998 5055
- (1998) J. Med. Chem. , vol.41 , pp. 5055
- Cobb, J.E.¹ Blanchard, S.G.² Boswell, E.G.³ Brown, K.K.⁴ Charifson, P.S.⁵ Cooper, J.P.⁶ Collins, J.L.⁷ Dezube, M.⁸ Henke, B.R.⁹ Hull-Ryde, E.A.¹⁰ Lake, D.H.¹¹ Lenhard, J.M.¹² Oliver Jr., W.¹³ Oplinger, J.¹⁴ Pentti, M.¹⁵ Parks, D.J.¹⁶ Plunket, K.D.¹⁷ Tong, W.Q.¹⁸

22
- 0029793540
- B. Hulin, L.S. Newton, D.M. Lewis, P.E. Genereux, E.M. Gibbs, and D.A. Clark J. Med. Chem. 39 1996 3897
- (1996) J. Med. Chem. , vol.39 , pp. 3897
- Hulin, B.¹ Newton, L.S.² Lewis, D.M.³ Genereux, P.E.⁴ Gibbs, E.M.⁵ Clark, D.A.⁶

23
- 78651111373
- M. Ohashi, T. Oyama, I. Nakagome, M. Sato, Y. Nishio, H. Nobusada, S. Hirono, K. Morikawa, Y. Hashimoto, and H. Miyachi J. Med. Chem. 54 2011 331
- (2011) J. Med. Chem. , vol.54 , pp. 331
- Ohashi, M.¹ Oyama, T.² Nakagome, I.³ Sato, M.⁴ Nishio, Y.⁵ Nobusada, H.⁶ Hirono, S.⁷ Morikawa, K.⁸ Hashimoto, Y.⁹ Miyachi, H.¹⁰

24
- 33845554892
- D.A. Evans, M.D. Ennis, and D.J. Mathre J. Am. Chem. Soc. 104 1982 1737
- (1982) J. Am. Chem. Soc. , vol.104 , pp. 1737
- Evans, D.A.¹ Ennis, M.D.² Mathre, D.J.³

25
- 12144289984
- R.A. Friesner, J.L. Banks, R.B. Murphy, T.A. Halgren, and J.J. Klicic J. Med. Chem. 47 2004 1739
- (2004) J. Med. Chem. , vol.47 , pp. 1739
- Friesner, R.A.¹ Banks, J.L.² Murphy, R.B.³ Halgren, T.A.⁴ Klicic, J.J.⁵

26
- 33750124980
- R.A. Friesner, R.B. Murphy, M.P. Repasky, L.L. Frye, and J.R. Greenwood J. Med. Chem. 49 2006 6177
- (2006) J. Med. Chem. , vol.49 , pp. 6177
- Friesner, R.A.¹ Murphy, R.B.² Repasky, M.P.³ Frye, L.L.⁴ Greenwood, J.R.⁵

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