Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator- activated receptor (PPAR) α-selective agonists

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 10, 2011, Pages 3183-3191

  Ban, Shintaro ^a   Kasuga, Jun Ichi ^b   Nakagome, Izumi ^c   Nobusada, Hiromi ^a   Takayama, Fusako ^a   Hirono, Shuichi ^c   Kawasaki, Hiromu ^a   Hashimoto, Yuichi ^b   Miyachi, Hiroyuki ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [3 (4 METHYLBENZAMIDOMETHYL) 4 METHOXYBENZYL]BUTANOIC ACID; 2 [3 (BENZAMIDOMETHYL) 4 METHOXYBENZYL]BUTANOIC ACID; 2 [3 [[4 (4 BROPHENOXY)BENZAMIDO]METHYL] 4 METHOXYBENZYL]BUTANOIC ACID; 2 [3 [[4 (4 CHLOROPHENOXY)BENZAMIDO]METHYL] 4 METHOXYBENZYL]BUTANOIC ACID; 2 [3 [[4 (4 FLUOROPHENOXY)BENZAMIDO]METHYL] 4 METHOXYBENZYL]BUTANOIC ACID; 2 [4 METHOXY 3 [(2 PHENOXYBENZAMIDO)METHYL]BENZYL]BUTANOIC ACID; 2 [4 METHOXY 3 [(2 PHENYLBENZAMIDO)METHYL]BENZYL]BUTANOIC ACID; 2 [4 METHOXY 3 [(3 PHENOXYBENZAMIDO)METHYL]BENZYL]BUTANOIC ACID; 2 [4 METHOXY 3 [(3 PHENYLBENZAMIDO)METHYL]BENZYL]BUTANOIC ACID; 2 [4 METHOXY 3 [(4 PHENETHOXYBENZAMIDO)METHYL]4 METHOXYBENZYL]BUTANOIC ACID; 2 [4 METHOXY 3 [(4 PHENOXYBENZAMIDO)METHYL]BENZYL]BUTANOIC ACID; 2 [4 METHOXY 3 [(4 PHENYLBENZAMIDO)METHYL]BENZYL]BUTANOIC ACID; 2 [4 METHOXY 3 [[4 (BENZYLOXY)BENZAMIDO]METHYL]4 METHOXYBENZYL]BUTANOIC ACID; 2 [4 METHOXY 3 [[4 (TRIFLUROMETHOXY)BENZAMIDO]METHYL]BENZYL]BUTANOIC ACID; ETHYL 2 (3 FORMYL 4 METHOXYBENZYL)BUTANOIC ACID; ETHYL 2 (4 METHOXYBENZYL)BUTANOIC ACID; ETHYL 2 (4 METHOXYBENZYLIDENE)BUTANOIC ACID; ETHYL 2 [3 (AMINOMETHYL) 4 METHOXYBENZYL]BUTANOATE HYDROCHLORIDE; ETHYL 2 [3[( HYDROXYAMINO)METHYL] 4 METHOXYBENZYL]BUTANOIC ACID; N [5 [2 (4 BENZYL 2 OXO OXAZOLIDINE 3 CARBONYL)BUTYL] 2 METHOXYBENZYL] 4 (4 BROMOPHENOXY)BENZAMIDE; N [5 [2 (4 BENZYL 2 OXO OXAZOLIDINE 3 CARBONYL)BUTYL] 2 METHOXYBENZYL] 4 (4 CHLOROPHENOXY)BENZAMIDE; N [5 [2 (4 BENZYL 2 OXO OXAZOLIDINE 3 CARBONYL)BUTYL] 2 METHOXYBENZYL] 4 (4 FLUOROPHENOXY)BENZAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; LIGAND BINDING; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PHARMACOLOGICAL BLOCKING; RAT; STRUCTURE ACTIVITY RELATION; TREATMENT RESPONSE;

ANIMALS; DRUG DESIGN; FATTY LIVER; HUMANS; MALE; MODELS, MOLECULAR; PHENYLPROPIONATES; PPAR ALPHA; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 79956214170     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.064     Document Type: Article

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