The discovery of CCR3/H 1 dual antagonists with reduced hERG risk

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 21, 2012, Pages 6688-6693

  Bahl, Ash ^a   Barton, Patrick ^a   Bowers, Keith ^a   Brough, Steven ^a   Evans, Richard ^a   Luckhurst, Christopher A ^a   Mochel, Tobias ^a   Perry, Matthew W D ^a   Rigby, Aaron ^a   Riley, Robert J ^a   Sanganee, Hitesh ^a   Sisson, Adam ^a   Springthorpe, Brian ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Antagonist; Chemokine; hERG

Indexed keywords

ANTIHISTAMINIC AGENT; AZ 10565259; BISPIPERIDINE; CHEMOKINE RECEPTOR CCR ANTAGONIST; CHEMOKINE RECEPTOR CCR3 ANTAGONIST; HISTAMINE H1 RECEPTOR ANTAGONIST; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG; CCR3 PROTEIN, HUMAN; CHEMOKINE RECEPTOR CCR3; KCNH1 PROTEIN, HUMAN; PIPERIDINE;

ACIDITY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IC 50; MALE; NONHUMAN; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DEVELOPMENT; DRUG INTERACTION; RISK FACTOR;

ANIMALS; DRUG DISCOVERY; DRUG INTERACTIONS; ETHER-A-GO-GO POTASSIUM CHANNELS; HISTAMINE H1 ANTAGONISTS; MOLECULAR STRUCTURE; PIPERIDINES; RATS; RECEPTORS, CCR3; RISK FACTORS;

EID: 84867582657     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.124     Document Type: Article

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