From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3S)-3-benzylpiperidine in a series of potent CCR3 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 2, 2008, Pages 586-595

  Gardner, Daniel S ^a   Santella III, Joseph B ^a   Tebben, Andrew J ^a   Batt, Douglas G ^a   Ko, Soo S ^a   Traeger, Sarah C ^a   Welch, Patricia K ^a   Wadman, Eric A ^a   Davies, Paul ^a   Carter, Percy H ^a   Duncia, John V ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

3 Benzylpiperidine; Ab initio; Acyclic scaffold; Asthma; CCR3 antagonist; Conformational analysis; Eosinophil chemotaxis

Indexed keywords

3 BENZYLPIPERIDINE DERIVATIVE; BMS 639623; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR3; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ARTICLE; CHEMOTAXIS; CONFORMATIONAL TRANSITION; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOSELECTIVITY;

CYCLIZATION; HYDROGEN BONDING; MOLECULAR CONFORMATION; PIPERIDINES; RECEPTORS, CCR3; UREA;

EID: 38349028685     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.087     Document Type: Article

References (19)

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