CCR3 antagonists: A potential new therapy for the treatment of asthma. Discovery and structure-activity relationships

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 13, 2002, Pages 1785-1789

  Wacker, Dean A ^a   Santella, III, Joseph B ^a   Gardner, Daniel S ^a   Varnes, Jeffrey G ^a   Estrella, Melissa ^a   DeLucca, George V ^a   Ko, Soo S ^a   Tanabe, Keiichi ^a   Watson, Paul S ^a   Welch, Patricia K ^a   Covington, Maryanne ^a   Stowell, Nicole C ^a   Wadman, Eric A ^a   Davies, Paul ^a   Solomon, Kimberly A ^a   Newton, Robert C ^a   Trainor, George L ^a   Friedman, Steven M ^a   Decicco, Carl P ^a   Duncia, John V ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIASTHMATIC AGENT; CHEMOKINE RECEPTOR CCR3 ANTAGONIST; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG; AMIDE; BETA CHEMOKINE; CALCIUM; CC CHEMOKINE RECEPTOR 3; CHEMOKINE RECEPTOR; EOTAXIN; LIGAND;

ALKYLATION; ARTICLE; ASTHMA; DIASTEREOISOMER; DRUG BINDING; DRUG POTENCY; EOSINOPHIL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; NEUTROPHIL CHEMOTAXIS; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; STEREOISOMERISM;

ALKYLATION; AMIDES; ANTI-ASTHMATIC AGENTS; CALCIUM; CHEMOKINES, CC; CHEMOTAXIS, LEUKOCYTE; HUMAN; INHIBITORY CONCENTRATION 50; LIGANDS; PIPERIDINES; RECEPTORS, CHEMOKINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; HUMANS;

EID: 0037042780     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00206-8     Document Type: Article

References (23)