Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an 'upside-down' binding pose

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 21, 2012, Pages 6621-6627

  Vaidya, Aditya Sudheer ^a   Neelarapu, Raghupathi ^a   Madriaga, Antonett ^a   Bai, He ^a   Mendonca, Emma ^b   Abdelkarim, Hazem ^a   Van Breemen, Richard B ^a   Blond, Sylvie Y ^a   Petukhov, Pavel A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b University of Illinois at Chicago   (United States)

Author keywords

HDAC8; Photolabeling; Secondary binding site; Upside down; Zinc chelating group

Indexed keywords

ALPHA TUBULIN; CHELATING AGENT; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE 8 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; HISTONE H4; HYDROXAMIC ACID; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DEACETYLATION; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR MODEL; PHOTOAFFINITY LABELING;

BINDING SITES; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CHELATING AGENTS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; LIGANDS; MOLECULAR STRUCTURE; PROTEIN BINDING; REPRESSOR PROTEINS; ZINC;

EID: 84867581157     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.104     Document Type: Article

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