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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 21, 2012, Pages 6651-6655

(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2, 5-dimethyl phenylamino)pyrazin-2(1H)-one: Introduction of N 3- phenylpyrazinones as potential CRF-R1 PET imaging agents

(27) Deskus, Jeffrey A a Dischino, Douglas D a Mattson, Ronald J a Ditta, Jonathan L a Parker, Michael F a Denhart, Derek J a Zuev, Dmitry a Huang, Hong a Hartz, Richard A a Ahuja, Vijay T a Wong, Henry a Mattson, Gail K a Molski, Thaddeus F a Grace Jr , James E a Zueva, Larisa b Nielsen, Julia M b Dulac, Heidi a Li, Yu Wen a Guaraldi, Mary a Azure, Michael a more..

a BRISTOL MYERS SQUIBB (United States)

b Spectrix Analytical Services (United States)

Author keywords

Antidepressants; Anxiolytics; Corticotropin releasing factor; Positron Emission Tomography; Radioligand

Indexed keywords

5 CHLORO 1 (1 CYCLOPROPYL 2 METHOXYETHYL) 3 (4 (2 FLUOROETHOXY) 2,5 DIMETHYL PHENYLAMINO)PYRAZIN 2 (1H)ONE F 18; N3 PHENYLPYRAZINONE; PYRAZINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; (18F)(R) 5 CHLORO 1 (1 CYCLOPROPYL 2 METHOXYETHYL) 3 (4 (2 FLUOROETHOXY) 2,5 DIMETHYL PHENYLAMINO)PYRAZIN 2(1H) ONE; (18F)(R)-5-CHLORO-1-(1-CYCLOPROPYL-2-METHOXYETHYL)-3-(4-(2-FLUOROETHOXY)-2,5-DIMETHYL PHENYLAMINO)PYRAZIN-2(1H)-ONE; ANILINE DERIVATIVE; DIAGNOSTIC AGENT; FLUORINE; PYRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BRAIN; DRUG BINDING; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG PURITY; DRUG STABILITY; HUMAN; LIPOPHILICITY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RAT; ANIMAL; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; SCINTISCANNING; THREE DIMENSIONAL IMAGING; TISSUE DISTRIBUTION;

RATTUS;

ANILINE COMPOUNDS; ANIMALS; BRAIN; FLUORINE RADIOISOTOPES; IMAGING, THREE-DIMENSIONAL; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; PYRAZINES; PYRAZOLES; RATS; TISSUE DISTRIBUTION;

EID: 84867579627 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.08.112 Document Type: Article

Times cited : (7)

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