Synthesis of 3′-deoxy-3′-C-hydroxymethyl analogues of tiazofurin and ribavirin

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 975-977

  Chun, Moon Woo ^a   Kim, Myong Jung ^a   Shin, Ji Hye ^a   Jeong, Lak Shin ^b  

^a Seoul National University   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3' DEOXY 3' C HYDROXYMETHYLRIBAVIRIN; 3' DEOXY 3' C HYDROXYMETHYLTIAZOFURIN; RIBAVIRIN DERIVATIVE; TIAZOFURIN; UNCLASSIFIED DRUG; XYLOSE; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; DRUG DERIVATIVE; FURAN DERIVATIVE; NUCLEOSIDE; RIBAVIRIN;

CONFERENCE PAPER; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; POLYMERIZATION; ARTICLE; CHEMICAL MODEL; CHEMISTRY; CONFORMATION; METHODOLOGY; MOLECULAR BIOLOGY; SYNTHESIS;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; FURANS; MODELS, CHEMICAL; MOLECULAR BIOLOGY; NUCLEIC ACID CONFORMATION; NUCLEOSIDES; RIBAVIRIN; XYLOSE;

EID: 26644464171     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200059338     Document Type: Conference Paper

References (4)

1. Wray, S.K.; Gilbert, B.E.; Noall, M.W.; Knight, V. Mode of action of ribavirin: effect of nucleotide pool alterations on influenza virus ribonucleoprotein synthesis. Antiviral Res. 1985, 5, 29.
2. Weber, G.; Prajda, N.; Abonyi, M.; Look, K.Y.; Tricot, G. Tiazofurin: molecular and clinical action. Anticancer Res. 1996, 16, 3313.
3. Acton, E.M.; Goerner, R.N.; Uh, H.S.; Ryan, K.J.; Henry, D.W. Improved antitumor effects in 3′-branched homologues of 2′- deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. J. Med. Chem. 1979, 22, 518.
4. Lin, T.-S.; Zhu, J.-L.; Dutschmann, G.E.; Cheng, Y.-C.; Prusoff, W.H. Syntheses and biological evaluations of 3′-deoxy-3′-C-branched- chain-substituted nucleosides. J. Med. Chem. 1993, 36, 353.