A novel player in inflammation and cancer: The deubiquitinase CYLD controls HCC development

Journal of Hepatology

Volumn 57, Issue 5, 2012, Pages 937-939

  Gautheron, Jeremie ^a   Luedde, Tom ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN CYLD; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG;

INFLAMMATION; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; PRIORITY JOURNAL; REVIEW; UBIQUITINATION;

EID: 84867574017     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.07.039     Document Type: Editorial

References (21)

1. M. Sherman Hepatocellular carcinoma: epidemiology, surveillance, and diagnosis Semin Liver Dis 30 2010 3 16
2. G. Cabibbo, and A. Craxi Epidemiology, risk factors and surveillance of hepatocellular carcinoma Eur Rev Med Pharmacol Sci 14 2010 352 355
3. C.R. de Lope, S. Tremosini, A. Forner, M. Reig, and J. Bruix Management of HCC J Hepatol 56 2012 S75 S87
4. A. Villanueva, and J.M. Llovet Targeted therapies for hepatocellular carcinoma Gastroenterology 140 2011 1410 1426
5. M. Vucur, C. Roderburg, K. Bettermann, F. Tacke, M. Heikenwalder, and C. Trautwein Mouse models of hepatocarcinogenesis: what can we learn for the prevention of human hepatocellular carcinoma? Oncotarget 1 2010 373 378
6. F. Tacke, T. Luedde, and C. Trautwein Inflammatory pathways in liver homeostasis and liver injury Clin Rev Allergy Immunol 36 2009 4 12
7. T. Luedde, and R.F. Schwabe NF-kappaB in the liver-linking injury, fibrosis and hepatocellular carcinoma Nat Rev Gastroenterol Hepatol 8 2011 108 118
8. M. Karin, and E. Gallagher TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes Immunol Rev 228 2009 225 240
9. G.R. Bignell, W. Warren, S. Seal, M. Takahashi, E. Rapley, and R. Barfoot Identification of the familial cylindromatosis tumour-suppressor gene Nat Genet 25 2000 160 165
10. A. Kovalenko, C. Chable-Bessia, G. Cantarella, A. Israel, D. Wallach, and G. Courtois The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination Nature 424 2003 801 805
11. G. Courtois Tumor suppressor CYLD: negative regulation of NF-kappaB signaling and more Cell Mol Life Sci 65 2008 1123 1132
12. R. Massoumi CYLD: a deubiquitination enzyme with multiple roles in cancer Future Oncol 7 2011 285 297
13. T. Urbanik, R.J. Boger, T. Longerich, K. Becker, K.R. Ehrenberg, and N. Hovelmeyer Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice J Hepatol 57 2012 995 1003
14. E. Trompouki, E. Hatzivassiliou, T. Tsichritzis, H. Farmer, A. Ashworth, and G. Mosialos CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members Nature 424 2003 793 796
15. K. Bettermann, M. Vucur, J. Haybaeck, C. Koppe, J. Janssen, and F. Heymann TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer Cancer Cell 17 2010 481 496
16. T. Luedde, N. Beraza, V. Kotsikoris, G. van Loo, A. Nenci, and R. De Vos Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma Cancer Cell 11 2007 119 132
17. X. Xu, S. Kobayashi, W. Qiao, C. Li, C. Xiao, and S. Radaeva Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice J Clin Invest 116 2006 1843 1852
18. B. Fan, Y. Malato, D.F. Calvisi, S. Naqvi, N. Razumilava, and S. Ribback Cholangiocarcinomas can originate from hepatocytes in mice J Clin Invest 2012
19. S. Maeda, H. Kamata, J.L. Luo, H. Leffert, and M. Karin IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis Cell 121 2005 977 990
20. K. Nikolaou, A. Tsagaratou, C. Eftychi, G. Kollias, G. Mosialos, and I. Talianidis Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer Cancer Cell 21 2012 738 750
21. E. Trompouki, A. Tsagaratou, S.K. Kosmidis, P. Dolle, J. Qian, and D.L. Kontoyiannis Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation Neoplasia 11 2009 469 476