Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice

Journal of Hepatology

Volumn 57, Issue 5, 2012, Pages 995-1003

  Urbanik, Toni ^a   Boger, Regina Johanna ^a   Longerich, Thomas ^a   Becker, Katharina ^a   Ehrenberg, Karl Roland ^a   Hövelmeyer, Nadine ^b   Hahn, Matthias ^b   Schuchmann, Marcus ^b   Jäger, Dirk ^a   Waisman, Ari ^b   Wörns, Marcus Alexander ^b   Schulze Bergkamen, Henning ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Cholangiocellular carcinoma; DEN; Fibrosis; Hepatocellular carcinoma; NF B; Oval cells; TNF

Indexed keywords

DIETHYLNITROSAMINE; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NUCLEOLIN; PHENOBARBITAL; PROTEIN BCL 3; PROTEIN CYLD; PROTEIN P100; PROTEIN P105; PROTEIN P50; PROTEIN P52; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUBULIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT CARCINOMA; BILE DUCT INJURY; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; CYLD GENE; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXON; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; HISTOPATHOLOGY; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLAMMATION; LIVER CARCINOGENESIS; LIVER CELL; LIVER FIBROSIS; LIVER HISTOLOGY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

ANIMALS; BILIARY TRACT DISEASES; CYSTEINE ENDOPEPTIDASES; DIMETHYLNITROSAMINE; DISEASE MODELS, ANIMAL; EXONS; FIBROSIS; GENE DELETION; GENETIC PREDISPOSITION TO DISEASE; HOMEOSTASIS; LIVER; LIVER NEOPLASMS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PHENOBARBITAL; PHENOTYPE; RISK FACTORS;

EID: 84867572416     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.06.017     Document Type: Article

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