Human hepatoma cell line HuH-7 is an effective cellular system to produce recombinant factor IX with improved post-translational modifications

Thrombosis Research

Volumn 130, Issue 5, 2012, Pages

  Enjolras, Nathalie ^a   Dargaud, Yesim ^a   Pérot, Eloïse ^a   Guillaume, Florine ^a   Becchi, Michel ^b   Négrier, Claude ^a  

^a HOSPICES CIVILS DE LYON   (France)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

ESI MS; Hemophilia B; HuH 7 cell line; Post translational modifications (PTM); Recombinant Factor IX (rFIX)

Indexed keywords

RECOMBINANT BLOOD CLOTTING FACTOR 9;

ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG SYNTHESIS; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN SECRETION; SIALYLATION; SULFATION;

ANIMALS; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; FACTOR IX; GLYCOSYLATION; HUMANS; LIVER NEOPLASMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 84867573609     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2012.08.313     Document Type: Article

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