Inhibition of a cold-active alkaline phosphatase by imipenem revealed by in silico modeling of metallo-β-lactamase active sites

FEBS Letters

Volumn 586, Issue 20, 2012, Pages 3710-3715

  Chakraborty, Sandeep ^a   Ásgeirsson, Bjarni ^b   Minda, Renu ^c   Salaye, Lipika ^a   Frère, Jean Marie ^c   Rao, Basuthkar J ^a  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^b UNIVERSITY OF ICELAND   (Iceland)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Active site prediction; Alkaline phosphatase; Antibiotic resistance; Carbapenemases; Cold active Vibrio; Computational biology; Finite difference Poisson Boltzmann (FDPB); Imipenem; Inhibition; Metallo betalactamase; Promiscuous active site

Indexed keywords

ALKALINE PHOSPHATASE; IMIPENEM; METAL ION; METALLO BETA LACTAMASE;

AEROMONAS HYDROPHILA; ARTICLE; BINDING SITE; COMPUTER MODEL; CONCENTRATION (PARAMETERS); ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; HYDROLYSIS; IC 50; IN VITRO STUDY; LIGAND BINDING; METAL BINDING; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; STATIC ELECTRICITY; STEREOCHEMISTRY; VIBRIO;

AEROMONAS HYDROPHILA; ALKALINE PHOSPHATASE; AMINO ACID MOTIFS; ANIMALS; BETA-LACTAMASES; CATALYTIC DOMAIN; COLD TEMPERATURE; COMPUTATIONAL BIOLOGY; ENZYME INHIBITORS; HYDROLYSIS; IMIPENEM; MODELS, MOLECULAR; PENICILLIN G; STATIC ELECTRICITY;

AEROMONAS HYDROPHILA; DECAPODA (CRUSTACEA); ESCHERICHIA COLI; VIBRIO;

EID: 84867572130     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.08.030     Document Type: Article

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